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Damien Kuffler
Title Investigator
Faculty Rank Professor
Degree Ph.D.
Institution University of Puerto Rico
Department Neurobiology
Clusters Neurological Disorders and Mental Health
Institute of Neurobiology
201 Blvd. del Valle
City Old San Juan
State PR
Postal Code 00901
Telephone (787)721-4149 ext. 243
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  Area of Expertise: Biomedical Research Resources / Cell Culture.

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1. Kuffler DP, Foy C. Restoration of Neurological Function Following Peripheral Nerve Trauma. Int J Mol Sci. 2020 Mar 06; 21(5).
2. Kuffler DP. Mechanisms for Reducing Neuropathic Pain. Mol Neurobiol. 2020 Jan; 57(1):67-87.
3. Kuffler DP. Injury-Induced Effectors of Neuropathic Pain. Mol Neurobiol. 2020 Jan; 57(1):51-66.
4. Kuffler DP. Variables affecting the potential efficacy of PRP in providing chronic pain relief. J Pain Res. 2019; 12:109-116.
5. Kuffler DP. Differing efficacies of autologous platelet-rich plasma treatment in reducing pain following rotator-cuff injury in a single patient. J Pain Res. 2018; 11:2239-2245.
6. Kuffler DP. Coping with Phantom Limb Pain. Mol Neurobiol. 2018 01; 55(1):70-84.
7. Kuffler DP. Origins of Phantom Limb Pain. Mol Neurobiol. 2018 01; 55(1):60-69.
8. Kuffler DP. Photobiomodulation in promoting wound healing: a review. Regen Med. 2016 Jan; 11(1):107-22.
9. Kuffler DP. Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction. Mol Neurobiol. 2015 Oct; 52(2):990-1014.
10. Kuffler DP. Improving the ability to eliminate wounds and pressure ulcers. Wound Repair Regen. 2015 May-Jun; 23(3):312-7.
11. Fischman S, Kuffler DP, Bloch C. Disordered Sleep as a Cause of Attention Deficit/Hyperactivity Disorder: Recognition and Management. Clin Pediatr (Phila). 2015 Jul; 54(8):713-22.
12. Kuffler DP. An assessment of current techniques for inducing axon regeneration and neurological recovery following peripheral nerve trauma. Prog Neurobiol. 2014 May; 116:1-12.
13. Kuffler DP. Platelet-rich plasma and the elimination of neuropathic pain. Mol Neurobiol. 2013 Oct; 48(2):315-32.
14. Trueta C, Kuffler DP, De-Miguel FF. Cycling of dense core vesicles involved in somatic exocytosis of serotonin by leech neurons. Front Physiol. 2012; 3:175.
15. Kuffler DP. Maximizing neuroprotection: where do we stand? Ther Clin Risk Manag. 2012; 8:185-94.
16. Kuffler DP. Hyperbaric oxygen therapy: can it prevent irradiation-induced necrosis? Exp Neurol. 2012 Jun; 235(2):517-27.
17. Kuffler DP, Reyes O, Sosa IJ, Santiago-Figueroa J. Neurological recovery across a 12-cm-long ulnar nerve gap repaired 3.25 years post trauma: case report. Neurosurgery. 2011 Dec; 69(6):E1321-6.
18. Nazario J, Kuffler DP. Hyperbaric oxygen therapy and promoting neurological recovery following nerve trauma. Undersea Hyperb Med. 2011 Sep-Oct; 38(5):345-66.
19. Torres Martínez FJ, Kuffler DP. Hyperbaric oxygen treatment to eliminate a large venous air embolism: a case study. Undersea Hyperb Med. 2011 Jul-Aug; 38(4):297-304.
20. Kuffler DP. The role of hyperbaric oxygen therapy in enhancing the rate of wound healing with a focus on axon regeneration. P R Health Sci J. 2011 Mar; 30(1):35-42.
21. Kuffler DP. Neuroprotection by hypothermia plus alkalinization of dorsal root ganglia neurons through ischemia. Ann N Y Acad Sci. 2010 Jun; 1199:158-63.
22. Kuffler DP. Combinatorial techniques for enhancing neuroprotection: hypothermia and alkalinization. Ann N Y Acad Sci. 2010 Jun; 1199:164-74.
23. Kuffler DP. Ultrasound imaging of regenerating rat sciatic nerves in situ. J Neurosci Methods. 2010 May 15; 188(2):276-9.
24. Kuffler DP. Hyperbaric oxygen therapy: an overview. J Wound Care. 2010 Feb; 19(2):77-9.
25. Santiago-Figueroa J, Kuffler DP. Reducing and eliminating neuropathic pain. P R Health Sci J. 2009 Dec; 28(4):289-300.
26. Kuffler DP, Sosa IJ, Reyes O. Schwann cell chondroitin sulfate proteoglycan inhibits dorsal root ganglion neuron neurite outgrowth and substrate specificity via a soma and not a growth cone mechanism. J Neurosci Res. 2009 Oct; 87(13):2863-71.
27. Kuffler DP. Chapter 18: Enhancement of nerve regeneration and recovery by immunosuppressive agents. Int Rev Neurobiol. 2009; 87:347-62.
28. Berrios I, Castro C, Kuffler DP. Morphine: axon regeneration, neuroprotection, neurotoxicity, tolerance, and neuropathic pain. P R Health Sci J. 2008 Jun; 27(2):119-28.
29. Sosa IJ, Reyes O, Kuffler DP. Elimination of a pressure ulcer with electrical stimulation--a case study. P R Health Sci J. 2008 Jun; 27(2):175-9.
30. Berrios I, Castro C, Kuffler DP. Visualization of six unique morphological subpopulations of adult frog dorsal root ganglion neurons at the light microscopic level. P R Health Sci J. 2008 Mar; 27(1):55-9.
31. Reyes O, Sosa IJ, Santiago J, Kuffler DP. A novel technique leading to complete sensory and motor recovery across a long peripheral nerve gap. P R Health Sci J. 2007 Sep; 26(3):225-8.
32. Feliciano C, Sosa I, Reyes O, Berrios I, Kuffler DP. Morphological characterization of six subpopulations of adult human DRG neurons at the light microscopic level. P R Health Sci J. 2007 Mar; 26(1):7-11.
33. Castro C, Kuffler DP. Membrane-bound CSPG mediates growth cone outgrowth and substrate specificity by Schwann cell contact with the DRG neuron cell body and not via growth cone contact. Exp Neurol. 2006 Jul; 200(1):19-25.
34. Reyes O, Sosa I, Kuffler DP. Neuroprotection of adult human neurons against ischemia by hypothermia and alkalinization. P R Health Sci J. 2006 Mar; 25(1):43-50.
35. Menendez A, Kuffler D. Are there causal relationships between the development of the inflammatory diseases amyotrophic lateral sclerosis and asthma? P R Health Sci J. 2006 Mar; 25(1):51-66.
36. Sosa I, Reyes O, Kuffler DP. Immunosuppressants: neuroprotection and promoting neurological recovery following peripheral nerve and spinal cord lesions. Exp Neurol. 2005 Sep; 195(1):7-15.
37. Reyes O, Sosa I, Kuffler DP. Promoting neurological recovery following a traumatic peripheral nerve injury. P R Health Sci J. 2005 Sep; 24(3):215-23.
38. Cruz O, Kuffler DP. Neuroprotection of adult rat dorsal root ganglion neurons by combined hypothermia and alkalinization against prolonged ischemia. Neuroscience. 2005; 132(1):115-22.
39. Reyes O, Sosa I, Kuffler DP. Neuroprotection of spinal neurons against blunt trauma and ischemia. P R Health Sci J. 2003 Sep; 22(3):277-86.
40. Vyklický L, Lyfenko A, Kuffler DP, Vlachová V. Vanilloid receptor TRPV1 is not activated by vanilloids applied intracellularly. Neuroreport. 2003 May 23; 14(7):1061-5.
41. Kuffler DP, Lyfenko A, Vyklický L, Vlachová V. Cellular mechanisms of nociception in the frog. J Neurophysiol. 2002 Oct; 88(4):1843-50.
42. Kuffler D. Can regeneration be promoted within the spinal cord? P R Health Sci J. 2000 Sep; 19(3):241-52.
43. Zheng M, Kuffler DP. Guidance of regenerating motor axons in vivo by gradients of diffusible peripheral nerve-derived factors. J Neurobiol. 2000 Feb 05; 42(2):212-9.
44. Hill ES, Latalladi G, Kuffler DP. Dissociated adult Rana pipiens motoneuron growth cones turn up concentration gradients of denervated peripheral nerve-released factors. Neurosci Lett. 1999 Dec 24; 277(2):87-90.
45. Sosa IJ, Reyes O, Inserni J, Kuffler DP. Isolation and long-term survival of adult human sensory neurons in vitro. Neurosurgery. 1998 Mar; 42(3):681-5; discussion 685-6.
46. Xie FK, Latalladi G, Kuffler DP. Neurotrophic influence of sciatic nerve-released factors on isolated adult motoneurons in vitro. J Peripher Nerv Syst. 1998; 3(1):37-46.
47. Pérez NL, Sosa MA, Kuffler DP. Growth cones turn up concentration gradients of diffusible peripheral target-derived factors. Exp Neurol. 1997 May; 145(1):196-202.
48. Brösamle C, Kuffler DP. Rapid dispersal of clustered postsynaptic nuclei following dissociation of skeletal muscle fibers. J Exp Biol. 1996 Nov; 199(Pt 11):2359-67.
49. Kuffler DP. Chemoattraction of sensory neuron growth cones by diffusible concentration gradients of acetylcholine. Mol Chem Neuropathol. 1996 May-Aug; 28(1-3):199-208.
50. Philippi M, Vyklický L, Kuffler DP, Orkand RK. Serotonin- and proton-induced and modified ionic currents in frog sensory neurons. J Neurosci Res. 1995 Feb 15; 40(3):387-95.
51. Dobretsov M, Dobretsov A, Kuffler DP. Influence of factors released from sciatic nerve on adult dorsal root ganglion neurons. J Neurobiol. 1994 Oct; 25(10):1249-66.
52. Kuffler DP, Megwinoff O. Neurotrophic influence of denervated sciatic nerve on adult dorsal root ganglion neurons. J Neurobiol. 1994 Oct; 25(10):1267-82.
53. Skatchkov S, Brösamle C, Vyklický L, Kuffler DP, Orkand RK. NMDA receptors on adult frog spinal motoneurons in culture. Neurosci Lett. 1994 Aug 01; 176(2):251-4.
54. Kuffler DP. Promoting and directing axon outgrowth. Mol Neurobiol. 1994 Aug-Dec; 9(1-3):233-43.
55. Kuffler DP, Luethi T. Identification of molecules in a muscle extracellular matrix extract that promotes process outgrowth from cultured adult frog motoneurons. J Neurobiol. 1993 Apr; 24(4):515-27.
56. Vyklický L, Philippi M, Kuffler DP, Orkand RK. GABAA membrane currents are insensitive to extracellular acidification in cultured sensory neurons of the frog. Physiol Res. 1993; 42(5):313-7.
57. Kuffler DP. Regeneration of muscle axons in the frog is directed by diffusible factors from denervated muscle and nerve tubes. J Comp Neurol. 1989 Mar 15; 281(3):416-25.
58. Kuffler DP. Long-distance regulation of regenerating frog axons. J Exp Biol. 1987 Sep; 132:151-60.
59. Kuffler DP. Isolated satellite cells of a peripheral nerve direct the growth of regenerating frog axons. J Comp Neurol. 1986 Jul 01; 249(1):57-64.
60. McMahan UJ, Edgington DR, Kuffler DP. Factors that influence regeneration of the neuromuscular junction. J Exp Biol. 1980 Dec; 89:31-42.
61. Kuffler DP, Thompson W, Jansen JK. The fate of foreign endplates in cross-innervated rat soleus muscle. Proc R Soc Lond B Biol Sci. 1980 Jun 24; 208(1171):189-222.
62. Kuffler DP, Muller KJ. The properties and connections of supernumerary sensory and motor nerve cells in the central nervous system of an abnormal leech. J Neurobiol. 1974; 5(4):331-48.

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