PROFILES - Connect with RTRN Researchers

David A. Foster
Title Rosalyn Yalow Professor
Faculty Rank Professor
Degree Ph.D.
Institution Hunter College, CUNY
Department Biological Sciences
Clusters Cancer
Address
Room 432 Belfer Research building
413 East 69th Street
City New York
State NY
Postal Code 10021
Telephone (212) 896-0441
Fax (212) 772-5227
Email
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  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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1.
2018HEAD START CONNECTS: INDIVIDUALIZING AND CONNECTS FAMILIES TO FAMILY SUPPORT SERVICESHHSP233201500059I/HHSP233201500059I
2.
2018 EARLY CARE AND EDUCATION LEADERSHIP STUDY (EXCELS)HHSP233201500035I / HHSP23337038T
3.
2018WHAT WORKS CLEARINGHOUSE OF PROVEN AND PROMISING APPROACHES TO MOVE WELFARE RECIPIENTS TO WORKHHSP233201500035I_HHSP23337034T
4.
2018RACIAL AND ETHNIC DISPARITIES IN HUMAN SERVICES ANALYSIS EXECUTION PROJECTHHSP233201500064I_HHSP23337020T
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2018ASSESSING MODELS OF COORDINATED SERVICES FOR LOW-INCOME CHILDREN AND THEIR FAMILIESHHSP233201500035I/HHSP23337028T
6.
2018CHILD CARE INTERSTATE BACKGROUND CHECKS (CC-IBACS)HHSP233201500045I
7.
2018MOTHER AND INFANT HOME VISITING PROGRAM EVALUATION, LONG-TERM FOLLOW-UP 2 (MIHOPE-LT2)HHSP233201500059I/ HHSP23337010T
8.
2017EXPLORING THE RELATION BETWEEN POSITIVE BEHAVIOR SUPPORT AND LANGUAGE LEARNING OPPORTUNITIES IN PRESCHOOL CLASSROOMS.90YR0101-01
9.
2017ADDRESSING THE NEEDS OF INFANTS AND TODDLERS EXPOSED TO MALTREATMENT: EXAMINING THE IMPACT OF AN INTEGRATED EARLY HEAD START & CHILDREN AND YOUTH SERVICES PROGRAM90YR0102-01
10.
2017LEVERAGING HOME LANGUAGES TO PROMOTE EXECUTIVE FUNCTIONING90YR0103-01
11.
2017A STRENGTHS-BASED APPROACH TO EXAMINING SUPPORTS FOR SELF-REGULATION SKILLS OF LATINO CHILDREN RAISED IN POVERTY90YR0104-01
12.
2017OBSERVING SELF-REGULATION IN CONTEXT IN HEAD START CLASSROOMS AND DUAL LANGUAGE LEARNERS SCHOOL READINESS90YR0105-01
13.
2017IMPLEMENTATION AND ASSESSMENT OF COMPETENCIES FOR TEACHERS AND CAREGIVERS SERVING INFANTS AND TODDLERSHHSP233201500035I/HHSP23337021T
14.
2017ASSESSMENT AND MAPPING OF COMMUNITY CONNECTIONS IN HOME VISITING (AMC-HV)HHSP233201500034I/HHSP23337002T
15.
2017CHILD MALTREATMENT INCIDENCE DATA LINKAGES (CMI DATA LINKAGES)HHSP233201500035I/HHSP23337022T
16.
2017EVIDENCE BUILDING IN TANF: ADVANCING INNOVATIONS TO PROMOTE EMPLOYMENT AND ECONOMIC SECURITY FOR LOW-INCOME INDIVIDUALSHHSP233201500059I/HHSP23337006T
17.
2017HEAD START FAMILY AND CHILD EXPERIENCES SURVEY (FACES) 2019HHSP233201500035I/HHSP23337024T
18.
2016TWO-GENERATION APPROACHES TO IMPROVING FAMILY SELF-SUFFICIENCYHHSP233201500035I/HHSP23337003T
19.
2016BUILDING CAPACITY TO EVALUATE INTERVENTIONS FOR YOUTH/YOUNG ADULTS WITH CHILD WELFARE INVOLVEMENT AT-RISK OF HOMELESSNESS: PHASE IIHHSP233201500035I/HHSP23337013T
20.
2016PROFESSIONAL DEVELOPMENT TOOLS TO IMPROVE THE QUALITY OF INFANT AND TODDLER CAREHHSP233201500035I/HHSP23337007T
21.
2016ASSESSING THE EVIDENCE: HOME VISITING EVIDENCE OF EFFECTIVENESSGS-10F-0050L/HHSP233201500115G
22.
2016TRIBAL HOME VISITING EVALUATION INSTITUTEGS-10F-0204K/HHSP233201500114G
23.
2016FAMILY SELF-SUFFICIENCY DATA CENTER90PD0272-04
24.
2016EVALUATION OF GOAL-DIRECTED PSYCHOLOGICAL CAPITAL AND EMPLOYER COACHING IN HEALTH PROFESSION OPPORTUNITY DEVELOPMENT90HG1003-01
25.
2016CULTURE OF CONTINUOUS LEARNING PROJECT: A BREAKTHROUGH SERIES COLLABORATIVE FOR IMPROVING CHILD CARE AND HEAD START QUALITYHHSP233201500034I/HHSP23337001T
26.
2016DOMESTIC HUMAN TRAFFICKING AND THE CHILD WELFARE POPULATIONHHSP23320150039I/HHSP23337011T
27.
2016EVALUATION OF COACHING-FOCUSED INTERVENTIONS FOR HARD-TO-EMPLOY TANF CLIENTS AND OTHER LOW-INCOME POPULATIONSHHSP233201500035I/HHSP23337018T
28.
2016EVALUATION OF THE NATIONAL HUMAN TRAFFICKING HOTLINE PROGRAMHHSP233201500039I/ HHSP23337007T
29.
2016MULTI-SITE IMPLEMENTATION EVALUATION OF TRIBAL HOME VISITING (MUSE)HHSP233201500133I/HHSP23337004T
30.
2016VARIATIONS IN IMPLEMENTATION OF QUALITY INTERVENTIONS: EXAMINING THE QUALITY-CHILD OUTCOMES RELATIONSHIP IN CHILD CARE AND EARLY EDUCATION (VIQI)HHSP233201500059I/HHSP23337002T
31.
2016DESIGN OPTIONS FOR HOME VISITING EVALUATION (DOHVE) 2.0HHSP233201500133I/HHSP23337002T
32.
2016ADVANCING WELFARE AND FAMILY SELF-SUFFICIENCY RESEARCH PROJECT (FOLLOW-ON) HHSP233201500035I/HHSP23337017T
33.
2016HPOG UNIVERSITY PARTNERSHIPS 2.0 RESEARCH SUPPORTHHSP233201500071I/HHSP23337011T
34.
2015THE CHANGING LANDSCAPE OF PUBLICLY-FUNDED CENTER-BASED CHILD CARE: 1990 AND 2012.90YE0165-01
35.
2015SUBSIDY UTILIZATION AND IMPACT ON EARLY CARE AND EDUCATION OF LOW-INCOME CHILDREN WITH SPECIAL NEEDS90YE0166-01
36.
2015PROMOTING SOCIAL COMPETENCE IN ECE: PREDICTING THE DEVELOPMENT OF PROSOCIAL BEHAVIOR FROM EARLY EXPERIENCES IN CHILD CARE AND FAMILIES90YE0168-01
37.
2015THE IMPACT OF EARLY CARE AND EDUCATION IN CHILD NUTRITION, SEDENTARY BEHAVIOR AND OBESITY BY KINDERGARTEN90YE0170-01
38.
2015HOW PARENTAL PREFERENCES AND SUBSIDY RECEIPT SHAPE IMMIGRANT FAMILIES? CHILD CARE CHOICES90YE0171-01
39.
2015SUPPORTING LOW-INCOME FAMILIES: STATE VARIATIONS IN CHILD CARE SUBSIDIES AND TANF POLICIES AND CHILDREN'S DEVELOPMENTAL ECOLOGIES90YE0173-01
40.
2015MITIGATING SUSCEPTIBILITY WITH THE CHILD CARE DEVELOPMENT FUND: USING FOUR LARGE DATA SETS TO CLASSIFY RISK PROFILES AND RISK TRANSMISSION BY MODIFIABLE FACTORS90YE0175-01
41.
2015ARE HIGHER SUBSIDY PAYMENT RATES AND PROVIDER-FRIENDLY PAYMENT POLICIES ASSOCIATED WITH CHILD CARE QUALITY?90YE0177-01
42.
2015CHILD CARE FACTORS THAT INFLUENCE PARENTAL ENGAGEMENT: UNDERSTANDING LONGITUDINAL PATHWAYS TO CHILDREN?S SCHOOL READINESS90YE0178-01
43.
2015CONSTELLATIONS OF SUPPORT: TEACHER PROFESSIONAL DEVELOPMENT IN HEAD START AND CHILD OUTCOMES90YE0179-01
44.
2015SUHMRE: SAME-SEX RELATIONSHIPS: UPDATES TO HEALTHY MARRIAGE AND RELATIONSHIP EDUCATION PROGRAMMINGHHSP233201500064I/HHSP23337001T
45.
2014ASSESSING THE COST AND IMPLEMENTATION OF HIGH QUALITY EARLY CARE AND EDUCATION (ACIHQECE)HHSP23320095642WC-01
46.
2014INTERMEDIATE OUTCOMES OF CAREER PATHWAYS PROGRAMSHHSP233200956WC-01
47.
2014CHILD CARE AND DEVELOPMENT FUND (CCDF) POLICIES DATABASE PROJECTHHSP23320095654WC-01
48.
2014EVALUATION OF DOMESTIC HUMAN TRAFFICKING DEMONSTRATION PROJECTSHHSP23320095651WC-01
49.
2014HOMELESS FAMILIES RESEARCH BRIEFSHHSP23320095624WC-01
50.
2014RESPONDING TO INTIMATE VIOLENCE IN RELATIONSHIP PROGRAMS (RIVIR)HHSP23320095651WC-01
51.
2014UNDERSTANDING THE INTERSECTION BETWEEN TANF AND REFUGEE CASH ASSISTANCE SERVICESHHSP23320095624WC-01
52.
2014IMPROVING CHILDREN?S WELL-BEING: IDENTIFYING MECHANISMS AND TIMING OF FAMILY STRENGTHENING PROGRAMS FOR LOW-INCOME FAMILIES THROUGH DIFFERENTIAL EQUATION MODELING90PD0285-01
53.
2013MOTHER AND INFANT HOME VISITING PROGRAM EVALUATION (MIHOPE)HHSP23337003T-03
54.
2013STUDY OF EMPLOYMENT AND ADVANCEMENT OF RACIAL, ETHNIC AND LINGUISTIC MINORITIES90PH0021-02
55.
2013CHILD CARE AND EARLY EDUCATION POLICY AND RESEARCH ANALYSES (CCEEPRA)HHSP23320095631WC-01
56.
2013EARLY HEAD START-CHILD CARE PARTNERSHIPS STUDYHHSP23320095642WC-01
57.
2013EMPLOYMENT AND TRAINING EVIDENCE REVIEWHHSP23320095642WC-01
58.
2013MATERNAL, INFANT AND EARLY CHILDHOOD HOME VISITING EVALUATION (MIHOPE) IIHHSP23320095644WC-01
59.
2013JOB SEARCH ASSISTANCE EVALUATIONHHSP23320095624WC-01
60.
2013CHILD CARE ADMINISTRATIVE DATA ANALYSIS90YE0148-01
61.
2013HEAD START UNIVERSITY PARTNERSHIPS: DUAL GENERATION APPROACHES90YR0073-01
62.
2013HEAD START UNIVERSITY PARTNERSHIPS: DUAL GENERATION APPROACHES90YR0075-01
63.
2013HUMAN SERVICES RESEARCH PARTNERSHIPS: PUERTO RICO 90YR0072-01

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1. Frias MA, Mukhopadhyay S, Lehman E, Walasek A, Utter M, Menon D, Foster DA. Phosphatidic acid drives mTORC1 lysosomal translocation in the absence of amino acids. J Biol Chem. 2020 Jan 03; 295(1):263-274.
2. Goren L, Zhang G, Kaushik S, Breslin PAS, Du YN, Foster DA. (-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells. PLoS One. 2019; 14(8):e0216024.
3. Bernfeld E, Foster DA. Glutamine as an Essential Amino Acid for KRas-Driven Cancer Cells. Trends Endocrinol Metab. 2019 06; 30(6):357-368.
4. Bernfeld E, Menon D, Vaghela V, Zerin I, Faruque P, Frias MA, Foster DA. Phospholipase D-dependent mTOR complex 1 (mTORC1) activation by glutamine. J Biol Chem. 2018 10 19; 293(42):16390-16401.
5. Utter M, Chakraborty S, Goren L, Feuser L, Zhu YS, Foster DA. Elevated phospholipase D activity in androgen-insensitive prostate cancer cells promotes both survival and metastatic phenotypes. Cancer Lett. 2018 06 01; 423:28-35.
6. Menon D, Salloum D, Bernfeld E, Gorodetsky E, Akselrod A, Frias MA, Sudderth J, Chen PH, DeBerardinis R, Foster DA. Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid. J Biol Chem. 2017 04 14; 292(15):6303-6311.
7. Patel D, Salloum D, Saqcena M, Chatterjee A, Mroz V, Ohh M, Foster DA. A Late G1 Lipid Checkpoint That Is Dysregulated in Clear Cell Renal Carcinoma Cells. J Biol Chem. 2017 01 20; 292(3):936-944.
8. Patel D, Menon D, Bernfeld E, Mroz V, Kalan S, Loayza D, Foster DA. Aspartate Rescues S-phase Arrest Caused by Suppression of Glutamine Utilization in KRas-driven Cancer Cells. J Biol Chem. 2016 Apr 22; 291(17):9322-9.
9. Mukhopadhyay S, Frias MA, Chatterjee A, Yellen P, Foster DA. The Enigma of Rapamycin Dosage. Mol Cancer Ther. 2016 Mar; 15(3):347-53.
10. Mukhopadhyay S, Saqcena M, Foster DA. Synthetic lethality in KRas-driven cancer cells created by glutamine deprivation. Oncoscience. 2015; 2(10):807-8.
11. Saqcena M, Patel D, Menon D, Mukhopadhyay S, Foster DA. Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle. Cell Cycle. 2015; 14(14):2285-92.
12. Chatterjee A, Mukhopadhyay S, Tung K, Patel D, Foster DA. Rapamycin-induced G1 cell cycle arrest employs both TGF-ß and Rb pathways. Cancer Lett. 2015 May 01; 360(2):134-40.
13. Mukhopadhyay S, Saqcena M, Chatterjee A, Garcia A, Frias MA, Foster DA. Reciprocal regulation of AMP-activated protein kinase and phospholipase D. J Biol Chem. 2015 Mar 13; 290(11):6986-93.
14. Mukhopadhyay S, Chatterjee A, Kogan D, Patel D, Foster DA. 5-Aminoimidazole-4-carboxamide-1-ß-4-ribofuranoside (AICAR) enhances the efficacy of rapamycin in human cancer cells. Cell Cycle. 2015; 14(20):3331-9.
15. LeGendre O, Breslin PA, Foster DA. (-)-Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization. Mol Cell Oncol. 2015; 2(4):e1006077.
16. Foster DA. Metabolic vulnerability of KRAS-driven cancer cells. Mol Cell Oncol. 2014; 1(3).
17. Foster DA. In memoriam: Geoffrey Louis Zubay, 1931-2014. Pioneer in cell-free gene expression studies and molecular genetics. Trends Biochem Sci. 2014 Nov; 39(11):505-6.
18. Yellen P, Foster DA. Inhibition of fatty acid synthase induces pro-survival Akt and ERK signaling in K-Ras-driven cancer cells. Cancer Lett. 2014 Oct 28; 353(2):258-63.
19. Saqcena M, Mukhopadhyay S, Hosny C, Alhamed A, Chatterjee A, Foster DA. Blocking anaplerotic entry of glutamine into the TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs. Oncogene. 2015 May 14; 34(20):2672-80.
20. Foster DA, Salloum D, Menon D, Frias MA. Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR). J Biol Chem. 2014 Aug 15; 289(33):22583-8.
21. Legendre O, Sookdeo A, Foster DA. BxPC3 pancreatic cancer cells express a truncated Smad4 protein upon PI3K and mTOR inhibition. Oncol Lett. 2014 Apr; 7(4):1165-1168.
22. Salloum D, Mukhopadhyay S, Tung K, Polonetskaya A, Foster DA. Mutant ras elevates dependence on serum lipids and creates a synthetic lethality for rapamycin. Mol Cancer Ther. 2014 Mar; 13(3):733-41.
23. Einbond LS, Mighty J, Kashiwazaki R, Figueroa M, Jalees F, Acuna UM, Le Gendre O, Foster DA, Kennelly EJ. Garcinia benzophenones inhibit the growth of human colon cancer cells and synergize with sulindac sulfide and turmeric. Anticancer Agents Med Chem. 2013 Dec; 13(10):1540-50.
24. Saqcena M, Menon D, Patel D, Mukhopadhyay S, Chow V, Foster DA. Amino acids and mTOR mediate distinct metabolic checkpoints in mammalian G1 cell cycle. PLoS One. 2013; 8(8):e74157.
25. Foster DA. Phosphatidic acid and lipid-sensing by mTOR. Trends Endocrinol Metab. 2013 Jun; 24(6):272-8.
26. Le Gendre O, Sookdeo A, Duliepre SA, Utter M, Frias M, Foster DA. Suppression of AKT phosphorylation restores rapamycin-based synthetic lethality in SMAD4-defective pancreatic cancer cells. Mol Cancer Res. 2013 May; 11(5):474-81.
27. Yellen P, Chatterjee A, Preda A, Foster DA. Inhibition of S6 kinase suppresses the apoptotic effect of eIF4E ablation by inducing TGF-ß-dependent G1 cell cycle arrest. Cancer Lett. 2013 Jun 10; 333(2):239-43.
28. Yellen P, Saqcena M, Salloum D, Feng J, Preda A, Xu L, Rodrik-Outmezguine V, Foster DA. High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1. Cell Cycle. 2011 Nov 15; 10(22):3948-56.
29. Xu L, Salloum D, Medlin PS, Saqcena M, Yellen P, Perrella B, Foster DA. Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1). J Biol Chem. 2011 Jul 22; 286(29):25477-86.
30. Toschi A, Lee E, Thompson S, Gadir N, Yellen P, Drain CM, Ohh M, Foster DA. Phospholipase D-mTOR requirement for the Warburg effect in human cancer cells. Cancer Lett. 2010 Dec 18; 299(1):72-9.
31. Foster DA, Yellen P, Xu L, Saqcena M. Regulation of G1 Cell Cycle Progression: Distinguishing the Restriction Point from a Nutrient-Sensing Cell Growth Checkpoint(s). Genes Cancer. 2010 Nov; 1(11):1124-31.
32. Lyo D, Xu L, Foster DA. Phospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathway. Biochem Biophys Res Commun. 2010 May 28; 396(2):562-5.
33. Foster DA. Reduced mortality and moderate alcohol consumption: the phospholipase D-mTOR connection. Cell Cycle. 2010 Apr 01; 9(7):1291-4.
34. Roberts AM, Watson IR, Evans AJ, Foster DA, Irwin MS, Ohh M. Suppression of hypoxia-inducible factor 2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells. Cancer Res. 2009 Dec 01; 69(23):9056-64.
35. Foster DA, Darnell JE. Obituary: Hidesaburo Hanafusa (1929-2009). Nature. 2009 Apr 09; 458(7239):718.
36. Foster DA, Toschi A. Targeting mTOR with rapamycin: one dose does not fit all. Cell Cycle. 2009 Apr 01; 8(7):1026-9.
37. Foster DA. Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells. Biochim Biophys Acta. 2009 Sep; 1791(9):949-55.
38. Toschi A, Lee E, Xu L, Garcia A, Gadir N, Foster DA. Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin. Mol Cell Biol. 2009 Mar; 29(6):1411-20.
39. Toschi A, Lee E, Gadir N, Ohh M, Foster DA. Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2. J Biol Chem. 2008 Dec 12; 283(50):34495-9.
40. Thompson S, Chen X, Hui L, Toschi A, Foster DA, Drain CM. Low concentrations of a non-hydrolysable tetra-S-glycosylated porphyrin and low light induces apoptosis in human breast cancer cells via stress of the endoplasmic reticulum. Photochem Photobiol Sci. 2008 Nov; 7(11):1415-21.
41. Foster DA, Gadir N. [Can defective TGF-Beta signaling be an Achilles heel in human cancer?]. Ai Zheng. 2008 Aug; 27(8):882-4.
42. Garcia A, Zheng Y, Zhao C, Toschi A, Fan J, Shraibman N, Brown HA, Bar-Sagi D, Foster DA, Arbiser JL. Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells. Clin Cancer Res. 2008 Jul 01; 14(13):4267-74.
43. Toschi A, Edelstein J, Rockwell P, Ohh M, Foster DA. HIF alpha expression in VHL-deficient renal cancer cells is dependent on phospholipase D. Oncogene. 2008 Apr 24; 27(19):2746-53.
44. Shi M, Zheng Y, Garcia A, Xu L, Foster DA. Phospholipase D provides a survival signal in human cancer cells with activated H-Ras or K-Ras. Cancer Lett. 2007 Dec 18; 258(2):268-75.
45. Gadir N, Lee E, Garcia A, Toschi A, Foster DA. Suppression of TGF-beta signaling by phospholipase D. Cell Cycle. 2007 Nov 15; 6(22):2840-5.