Connection | Profiles RNS

Search Result Details

Back to Search Results

This page shows the details of why an item matched the keywords from your search.

Search Results

Williams, Christopher C.

One or more keywords matched the following properties of Williams, Christopher C.

Property	Value
overview	Dr. Williams earned a Bachelor of Science degree in Biology from Southern University at New Orleans. As a graduate student at Tulane University in the department of pharmacology, Dr. Williams’ studies focused on the role of HIV Tat protein in mediating hematopoietic dysfunction of HIV infection. After matriculation in 2003, Dr. Williams began postdoctoral training in the Tulane University Cancer Center where his research focused on the novel role of the ERB4 tyrosine receptor kinase as a molecular chaperone and transcriptional co-activator for Stat5a and estrogen receptor in breast cancer. Later his studies centered on the identification and characterization of novel phosphorylation sites in estrogen receptor a, and how they correlate to disease progression and sensitivity to hormonal therapies. Dr. Williams joined Xavier University College of Pharmacy in 2009, where he currently serves as assistant professor of pharmacology. Dr. Williams' laboratory focuses on the roles of the NR4A family of orphan nuclear receptor in breast cancer etiology and sensitivity to antineoplastic/chemopreventive drugs. Additionally, the lab is currently investigating the molecular mechanisms underlying metformin’s antineoplastic effects in breast cancer.

Property

Value

overview

Dr. Williams earned a Bachelor of Science degree in Biology from Southern University at New Orleans. As a graduate student at Tulane University in the department of pharmacology, Dr. Williams’ studies focused on the role of HIV Tat protein in mediating hematopoietic dysfunction of HIV infection. After matriculation in 2003, Dr. Williams began postdoctoral training in the Tulane University Cancer Center where his research focused on the novel role of the ERB4 tyrosine receptor kinase as a molecular chaperone and transcriptional co-activator for Stat5a and estrogen receptor in breast cancer. Later his studies centered on the identification and characterization of novel phosphorylation sites in estrogen receptor a, and how they correlate to disease progression and sensitivity to hormonal therapies. Dr. Williams joined Xavier University College of Pharmacy in 2009, where he currently serves as assistant professor of pharmacology. Dr. Williams' laboratory focuses on the roles of the NR4A family of orphan nuclear receptor in breast cancer etiology and sensitivity to antineoplastic/chemopreventive drugs. Additionally, the lab is currently investigating the molecular mechanisms underlying metformin’s antineoplastic effects in breast cancer.

One or more keywords matched the following items that are connected to Williams, Christopher C.

Item Type	Name
Academic Article	Protein Kinase CK2 Expression Predicts Relapse Survival in ERa Dependent Breast Cancer, and Modulates ERa Expression in Vitro.
Concept	Estrogen Receptor alpha
Academic Article	Coregulation of estrogen receptor by ERBB4/HER4 establishes a growth-promoting autocrine signal in breast tumor cells.
Academic Article	Immunohistochemical validation of multiple phospho-specific epitopes for estrogen receptor alpha (ERalpha) in tissue microarrays of ERalpha positive human breast carcinomas.
Academic Article	The relevance of phosphorylated forms of estrogen receptor in human breast cancer in vivo.
Academic Article	Identification of four novel phosphorylation sites in estrogen receptor alpha: impact on receptor-dependent gene expression and phosphorylation by protein kinase CK2.
Academic Article	Phosphorylation of Estrogen Receptor a at serine 118 directs recruitment of promoter complexes and gene-specific transcription.
Academic Article	Stable inhibition of specific estrogen receptor a (ERa) phosphorylation confers increased growth, migration/invasion, and disruption of estradiol signaling in MCF-7 breast cancer cells.

Search Criteria

Estrogen Receptor beta