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One or more keywords matched the following properties of Verma, Saguna
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overview Short biography As a biochemist and molecular biologist by training, Dr. Verma obtained a Ph.D in Life Sciences from India (University of Indore). During her post doctoral training as a Project Scientist at the National Institute of Immunology, New Delhi, India worldwide known for applied and translational immunology research, she trained herself as an immunologist. She is currently working as an Associate Professor in the Department of Tropical Medicine, Medical Microbiology and Pharmacology at the Medical School of the University of Hawaii. Research interests Dr. Verma's research interest is to study various host cell-signaling pathways associated with infection with viral pathogens to ultimately design therapeutic interventions and/or adjunct therapies to improve disease pathology. Focus of her ongoing projects is to understand immunological events contributing to the pathogenesis of flaviviruses (dengue and West Nile virus), such as virus-CNS entry, induction of inflammation and neuronal death. Using in vitro and in vivo mouse models and human primary immune cells, her group has recently started characterizing novel innate immune responses to virus pathogens and vaccine candidates such as Ebola virus glycoprotein.
One or more keywords matched the following items that are connected to Verma, Saguna
Item TypeName
Academic Article Reversal of West Nile virus-induced blood-brain barrier disruption and tight junction proteins degradation by matrix metalloproteinases inhibitor.
Academic Article Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes.
Academic Article Pro-inflammatory cytokines derived from West Nile virus (WNV)-infected SK-N-SH cells mediate neuroinflammatory markers and neuronal death.
Academic Article West Nile virus-induced disruption of the blood-brain barrier in mice is characterized by the degradation of the junctional complex proteins and increase in multiple matrix metalloproteinases.
Academic Article Impaired virus clearance, compromised immune response and increased mortality in type 2 diabetic mice infected with West Nile virus.
Academic Article Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis.
Academic Article Reduced immune cell infiltration and increased pro-inflammatory mediators in the brain of Type 2 diabetic mouse model infected with West Nile virus.
Academic Article West Nile virus-induced cell adhesion molecules on human brain microvascular endothelial cells regulate leukocyte adhesion and modulate permeability of the in vitro blood-brain barrier model.
Academic Article Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection.
Academic Article Human testicular organoid system as a novel tool to study Zika virus pathogenesis.
Academic Article Immunoprofiles of human Sertoli cells infected with Zika virus reveals unique insights into host-pathogen crosstalk.
Academic Article Ebola Virus Glycoprotein Induces an Innate Immune Response In vivo via TLR4.
Academic Article Zika Virus Infects Human Sertoli Cells and Modulates the Integrity of the In Vitro Blood-Testis Barrier Model.
Academic Article Correction for Kumar et al., "Inflammasome Adaptor Protein Apoptosis-Associated Speck-Like Protein Containing CARD (ASC) Is Critical for the Immune Response and Survival in West Nile Virus Encephalitis".
Academic Article Axl Promotes Zika Virus Entry and Modulates the Antiviral State of Human Sertoli Cells.
Academic Article Comparison of real-time PCR and hemagglutination assay for quantitation of human polyomavirus JC.
Academic Article Polyomavirus JC infects human brain microvascular endothelial cells independent of serotonin receptor 2A.
Academic Article JC virus induces altered patterns of cellular gene expression: interferon-inducible genes as major transcriptional targets.
Academic Article Interferon- alpha and - beta restrict polyomavirus JC replication in primary human fetal glial cells: implications for progressive multifocal leukoencephalopathy therapy.
Academic Article In vitro effects of selenium deficiency on West Nile virus replication and cytopathogenicity.
Academic Article West Nile virus infection modulates human brain microvascular endothelial cells tight junction proteins and cell adhesion molecules: Transmigration across the in vitro blood-brain barrier.
Concept Dengue Virus
Concept JC Virus
Concept Virus Replication
Concept West Nile virus
Concept Virus Internalization
Grant Under attack: Modulation of the blood-testes barrier by Zika virus
Grant Human 3D testicular organoids as a model to dissect cell-type specific tropism and immune response to Zika virus
Academic Article RIG-I and MDA5 are modulated by bone morphogenetic protein (BMP6) and are essential for restricting Zika virus infection in human Sertoli cells.
Academic Article The Good, the Bad and the Ugly of Testicular Immune Regulation: A Delicate Balance Between Immune Function and Immune Privilege.
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