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One or more keywords matched the following properties of Brim, Hassan
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overview Research Interests: Genetics, Epigenetics and environmental factors in African American Colon Cancer Dr. Hassan Brim earned his PhD from the Free University of Brussels in the field of "Molecular Biology, Genetic Engineering and Environmental Microbiology." He then moved to the Naval Medical Center in Bethesda where he worked on the degradation and transformation of carcinogenic products in radioactive environments. This work was implemented in a radio resistant bacterium equipped with particular DNA repair mechanisms. This work has led to high profile publications in Nature Biotechnology and cited in Science Magazine. From there, Dr. Brim moved to study DNA repair in colon cancer specimens. He analyzed microsatellite instability, DNA methylation and chromosomal instability in colon cancer cases. He is currently addressing environmental factors that trigger and/or promote colon cancer among which the gut flora is a major player of which the role is yet to be defined. Dr. Brim is currently an Assistant professor at the Department of Pathology and has more than 30 publications.
One or more keywords matched the following items that are connected to Brim, Hassan
Item TypeName
Academic Article SLC5A8 gene, a transporter of butyrate: a gut flora metabolite, is frequently methylated in African American colon adenomas.
Academic Article Clinicopathological features of colon polyps from African-Americans.
Academic Article ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability.
Academic Article Role of life events in the presence of colon polyps among African Americans.
Academic Article Case-control study of vitamin D, dickkopf homolog 1 (DKK1) gene methylation, VDR gene polymorphism and the risk of colon adenoma in African Americans.
Academic Article Microbiome analysis of stool samples from African Americans with colon polyps.
Academic Article Increased MACC1 levels in tissues and blood identify colon adenoma patients at high risk.
Academic Article Can optical diagnosis of small colon polyps be accurate? Comparing standard scope without narrow banding to high definition scope with narrow banding.
Academic Article Reduced Representation Bisulfite Sequencing Determination of Distinctive DNA Hypermethylated Genes in the Progression to Colon Cancer in African Americans.
Academic Article GPNMB methylation: a new marker of potentially carcinogenic colon lesions.
Academic Article Can the rate and location of sessile serrated polyps be part of colorectal Cancer disparity in African Americans?
Academic Article Molecular Characterization of Sessile Serrated Adenoma/Polyps From a Large African American Cohort.
Academic Article Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects.
Academic Article Global histone H4 acetylation and HDAC2 expression in colon adenoma and carcinoma.
Concept Colon
Concept Colon, Sigmoid
Concept Colon, Ascending
Concept Colon, Transverse
Academic Article Saffron and Its Major Ingredients' Effect on Colon Cancer Cells with Mismatch Repair Deficiency and Microsatellite Instability.
Academic Article Protective Effect of Saffron in Mouse Colitis Models Through Immune Modulation.
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