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Javadov, Sabzali
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overview I have a broad background in medical biochemistry, with specific training and expertise in cardiac pathophysiology, with a focus on the roles of mitochondria in ischemia-reperfusion (IR), heart failure, and aging. My studies have been conducted on various model systems using in vivo (myocardial infarction in dogs and rats, alloxan-induced diabetes in rabbits), ex-vivo (global IR in Langendorff-perfused isolated rat and mouse heart), and in vitro (hypertrophy, hypoxia/reoxygenation in cultured cells) models. Different pharmacological agents and conditional approaches have been used in my studies to prevent mitochondria-mediated cell death in cardiac diseases. Since 1997, my research focuses on the role of mitochondrial permeability transition pore (PTP) opening and mitochondrial swelling during cardiac IR injury and post-myocardial infarction heart failure. I successfully administered several projects in Europe, Canada, and PR, collaborated with other researchers, and produced several peer-reviewed publications from each project. Currently, my research is supported by NIH and NSF grants.
One or more keywords matched the following items that are connected to Javadov, Sabzali
Item TypeName
Academic Article Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction.
Academic Article Mitochondrial permeability transition pore opening as a promising therapeutic target in cardiac diseases.
Academic Article Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition.
Academic Article Targeting the mitochondrial permeability transition: cardiac ischemia-reperfusion versus carcinogenesis.
Academic Article Mitochondrial permeability transition and cell death: the role of cyclophilin d.
Academic Article The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARa-cyclophilin D interaction in cardiomyocytes.
Academic Article The calcium-ROS-pH triangle and mitochondrial permeability transition: challenges to mimic cardiac ischemia-reperfusion.
Academic Article Angiotensin II and ischemic preconditioning synergize to improve mitochondrial function while showing additive effects on ventricular postischemic recovery.
Academic Article Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats.
Academic Article Mitochondrial permeability transition in cardiac ischemia-reperfusion: whether cyclophilin D is a viable target for cardioprotection?
Academic Article Elucidating Mitochondrial Electron Transport Chain Supercomplexes in the Heart During Ischemia-Reperfusion.
Academic Article Synchronism in mitochondrial ROS flashes, membrane depolarization and calcium sparks in human carcinoma cells.
Academic Article Angiotensin II-preconditioning is associated with increased PKCe/PKCd ratio and prosurvival kinases in mitochondria.
Academic Article Simple kinetic model of mitochondrial swelling in cardiac cells.
Academic Article Different approaches to modeling analysis of mitochondrial swelling.
Academic Article Divergent Effects of Cyclophilin-D Inhibition on the Female Rat Heart: Acute Versus Chronic Post-Myocardial Infarction.
Academic Article Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection.
Academic Article Ischaemic preconditioning inhibits opening of mitochondrial permeability transition pores in the reperfused rat heart.
Academic Article NHE-1 inhibition improves impaired mitochondrial permeability transition and respiratory function during postinfarction remodelling in the rat.
Academic Article Antihypertrophic effect of Na+/H+ exchanger isoform 1 inhibition is mediated by reduced mitogen-activated protein kinase activation secondary to improved mitochondrial integrity and decreased generation of mitochondrial-derived reactive oxygen species.
Academic Article NHE-1 inhibition-induced cardioprotection against ischaemia/reperfusion is associated with attenuation of the mitochondrial permeability transition.
Academic Article Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection.
Concept Cell Membrane Permeability
Concept Permeability
Academic Article Protection of hearts from reperfusion injury by propofol is associated with inhibition of the mitochondrial permeability transition.
Academic Article Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart.
Grant Crosstalk between mitochondrial permeability transition and ETC supercomplexes.
Academic Article Crosstalk between adenine nucleotide transporter and mitochondrial swelling: experimental and computational approaches.
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