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keywords
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heart; mitochondria; oxidative stress; ischemia-reperfusion; modeling; cell death
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overview
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I have a broad background in medical biochemistry, with specific training and expertise in cardiac pathophysiology, with a focus on the roles of mitochondria in ischemia-reperfusion (IR), heart failure, and aging. My studies have been conducted on various model systems using in vivo (myocardial infarction in dogs and rats, alloxan-induced diabetes in rabbits), ex-vivo (global IR in Langendorff-perfused isolated rat and mouse heart), and in vitro (hypertrophy, hypoxia/reoxygenation in cultured cells) models. Different pharmacological agents and conditional approaches have been used in my studies to prevent mitochondria-mediated cell death in cardiac diseases. Since 1997, my research focuses on the role of mitochondrial permeability transition pore (PTP) opening and mitochondrial swelling during cardiac IR injury and post-myocardial infarction heart failure. I successfully administered several projects in Europe, Canada, and PR, collaborated with other researchers, and produced several peer-reviewed publications from each project. Currently, my research is supported by NIH and NSF grants.
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