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Tsin, Andrew

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overview	Research Interests – Dr. Andrew Tsin Eye Disease Development: Diabetic Retinopathy & Age-Related Macular Degeneration An recent emphasis of our vision research laboratory is to learn how hyperglycemia and/or insulin induce vascular endothelial growth factor (VEGF) secretion by retinal cells. Retinal pigment epithelial cells, retinal pericytes, and endothelial cells are maintained in culture. Growth factors such as VEGF, transforming growth factor (TGF), and bone morphological proteins (BMP) are assayed for protein end-product using ELISA. The expression of these proteins is measured by RNA protection assays. We are particularly interested in the effect of BMP-4, TGB-ß, and PEDF on the secretion of VEGF by retinal cells. Our long term goal is to learn how cytokines mediate angiogenesis leading to diabetic retinopathy or age-related macular degeneration. Biochemistry of the Cone Visual Cycle in the Eye A major emphasis of our laboratory is to investigate the mechanism of pigment regeneration in the cone visual system. Upon light adaptation, cone pigments are bleached to initiate electrical signals in the cone photoreceptors. These signals are then transmitted by neurons to the brain for color visual perception. In order to sustain such visual function, cone pigment must be regenerated in-situ but the underlying mechanism of this cone pigment regeneration is not known. Using animals models, the kinetics of cone pigment bleaching and regeneration are studied in details using biochemical methods. The cellular mechanisms of cone pigment regeneration are also studied using Muller cells and retinal pigment epithelial cells in culture. Specifically, we focus on the abilities of these cells to esterify, isomerize and oxidize the vitamin A (retinoid) chromophore of cone visual pigments.

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overview

Research Interests – Dr. Andrew Tsin Eye Disease Development: Diabetic Retinopathy & Age-Related Macular Degeneration An recent emphasis of our vision research laboratory is to learn how hyperglycemia and/or insulin induce vascular endothelial growth factor (VEGF) secretion by retinal cells. Retinal pigment epithelial cells, retinal pericytes, and endothelial cells are maintained in culture. Growth factors such as VEGF, transforming growth factor (TGF), and bone morphological proteins (BMP) are assayed for protein end-product using ELISA. The expression of these proteins is measured by RNA protection assays. We are particularly interested in the effect of BMP-4, TGB-ß, and PEDF on the secretion of VEGF by retinal cells. Our long term goal is to learn how cytokines mediate angiogenesis leading to diabetic retinopathy or age-related macular degeneration. Biochemistry of the Cone Visual Cycle in the Eye A major emphasis of our laboratory is to investigate the mechanism of pigment regeneration in the cone visual system. Upon light adaptation, cone pigments are bleached to initiate electrical signals in the cone photoreceptors. These signals are then transmitted by neurons to the brain for color visual perception. In order to sustain such visual function, cone pigment must be regenerated in-situ but the underlying mechanism of this cone pigment regeneration is not known. Using animals models, the kinetics of cone pigment bleaching and regeneration are studied in details using biochemical methods. The cellular mechanisms of cone pigment regeneration are also studied using Muller cells and retinal pigment epithelial cells in culture. Specifically, we focus on the abilities of these cells to esterify, isomerize and oxidize the vitamin A (retinoid) chromophore of cone visual pigments.

One or more keywords matched the following items that are connected to Tsin, Andrew

Item Type	Name
Academic Article	Effects of tamoxifen versus raloxifene on retinal capillary endothelial cell proliferation.
Academic Article	A possible role of acrolein in diabetic retinopathy: involvement of a VEGF/TGF? signaling pathway of the retinal pigment epithelium in hyperglycemia.
Academic Article	Estrogen-induced retinal endothelial cell proliferation: possible involvement of pigment epithelium-derived factor and phosphoinositide 3-kinase/mitogen-activated protein kinase pathways.
Academic Article	BIGH3 protein and macrophages in retinal endothelial cell apoptosis.
Academic Article	Autocrine and Paracrine Secretion of Vascular Endothelial Growth Factor in the Pre-Hypoxic Diabetic Retina.
Academic Article	Chemical Modification of Ginsenoside on Cell Viability and Cytokine Secretion.
Academic Article	Somatolactogens and diabetic retinopathy.
Academic Article	Expression of growth hormone gene in the baboon eye.
Academic Article	Epidermal-specific deletion of TC-PTP promotes UVB-induced epidermal cell survival through the regulation of Flk-1/JNK signaling.
Concept	Nerve Growth Factors
Concept	Growth Hormone
Concept	Transforming Growth Factor beta
Concept	Vascular Endothelial Growth Factor Receptor-2
Concept	Vascular Endothelial Growth Factors
Concept	Vascular Endothelial Growth Factor A
Concept	Transforming Growth Factor beta1
Concept	Transforming Growth Factor beta2
Academic Article	Retinoid uptake, processing, and secretion in human iPS-RPE support the visual cycle.
Academic Article	Bone morphogenetic protein-4 enhances vascular endothelial growth factor secretion by human retinal pigment epithelial cells.
Academic Article	ARPE-19 cell growth and cell functions in euglycemic culture media.
Academic Article	Glucose and TGFbeta2 modulate the viability of cultured human retinal pericytes and their VEGF release.
Academic Article	NBHA reduces acrolein-induced changes in ARPE-19 cells: possible involvement of TGF?.
Academic Article	TGF? induces BIGH3 expression and human retinal pericyte apoptosis: a novel pathway of diabetic retinopathy.
Grant	UTSA MBRS SCORE Program

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