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Kurtz, Donald

One or more keywords matched the following properties of Kurtz, Donald

Property	Value
overview	A major aspect of our research focuses on the structure, function, and catalytic mechanisms of bacterial and archaeal non-heme iron enzymes that reductively scavenge diatomic oxygen and nitrogen species. These scavenging and sensing reactions require specialized active sites with novel iron coordination environments and novel mechanisms, which we follow by rapid kinetic and spectroscopic techniques as well as protein X-ray crystallography. We are also attempting to develop an oxygen-carrying protein as a blood substitute. A related project focuses on proteins that catalyze storage and release of intracellular iron. An exciting new development is the use of these iron storage proteins as scaffolds to enclose metal and semiconductor nanoparticles for photochemical H2 production and photo-initiated delivery of toxic iron to cancer cells.

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overview

A major aspect of our research focuses on the structure, function, and catalytic mechanisms of bacterial and archaeal non-heme iron enzymes that reductively scavenge diatomic oxygen and nitrogen species. These scavenging and sensing reactions require specialized active sites with novel iron coordination environments and novel mechanisms, which we follow by rapid kinetic and spectroscopic techniques as well as protein X-ray crystallography. We are also attempting to develop an oxygen-carrying protein as a blood substitute. A related project focuses on proteins that catalyze storage and release of intracellular iron. An exciting new development is the use of these iron storage proteins as scaffolds to enclose metal and semiconductor nanoparticles for photochemical H2 production and photo-initiated delivery of toxic iron to cancer cells.

One or more keywords matched the following items that are connected to Kurtz, Donald

Item Type	Name
Academic Article	An HD-GYP cyclic di-guanosine monophosphate phosphodiesterase with a non-heme diiron-carboxylate active site.
Academic Article	Spectroscopic characterization of 57Fe-reconstituted rubrerythrin, a non-heme iron protein with structural analogies to ribonucleotide reductase.
Academic Article	X-ray crystal structures of reduced rubrerythrin and its azide adduct: a structure-based mechanism for a non-heme diiron peroxidase.
Academic Article	Computational study of the non-heme iron active site in superoxide reductase and its reaction with superoxide.
Academic Article	Microbial detoxification of superoxide: the non-heme iron reductive paradigm for combating oxidative stress.
Academic Article	Geometries and electronic structures of cyanide adducts of the non-heme iron active site of superoxide reductases: vibrational and ENDOR studies.
Academic Article	Cytochrome bd oxidase, oxidative stress, and dioxygen tolerance of the strictly anaerobic bacterium Moorella thermoacetica.
Concept	Heme
Academic Article	Electrospray mass spectrometry studies of non-heme iron-containing proteins.
Academic Article	Vibrational circular dichroism measurements of ligand vibrations in haem and non-haem metalloenzymes.

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Heme