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Bond, Vincent

One or more keywords matched the following properties of Bond, Vincent

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overview	Dr. Vincent Bond is an HIV/AIDS researcher, presenting his work at numerous national as well as international HIV meetings. He has served as ad hoc reviewer for several leading virological journals and has authored/co-authored over 125 scientific communications. These communications include: abstracts, six patent applications, two granted patents, and 45 publications, 31 of which are articles in peer-reviewed journals focused on aspects of HIV pathogenesis research. He received his B.S., M.S., and Ph.D. at the Pennsylvania State University in Viral Genetics, and subsequently, did a postdoctoral fellowship at the California Institute of Technology (Caltech). There he extended his knowledge of host systems through the study of basic cell biology processes. Simultaneously, the basic life processes of the Human Immunodeficiency Virus I (HIV-1) were being elucidated elsewhere. Interesting commonalities between his cell work at Caltech, and aspects of HIV biology, enticed him, on arriving at the Morehouse School of Medicine in 1990, to begin to look at host-HIV-1 interactions and the role, if any, this plays in progression to AIDS. Currently, a Professor of Microbiology, Biochemistry, and Immunology, he has studied HIV/AIDS for 20 years and is an expert in HIV pathogenesis. His lab has focused its efforts on understanding the role(s) played by HIV-1 accessory proteins in the pathogenic manipulation of host systems. Over the last decade his lab has focused on the role of extracellular Nef-containing exosomes in HIV/SIV infection and pathogenesis leading to AIDS. Publications arising out of grant funded research have shown that the Nef protein is released from viral-infected cells in exosomal vesicles that can induce apoptosis, or can cause gene dysregulation in bystander cells leading to immune depletion/dysfunction capable of causing the pathogenesis leading to AIDS. This work has the potential to lead to newly identified targets for AIDS therapy and a potential therapeutic antagonist. It also has therapeutic ramifications for cancer therapy.

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overview

Dr. Vincent Bond is an HIV/AIDS researcher, presenting his work at numerous national as well as international HIV meetings. He has served as ad hoc reviewer for several leading virological journals and has authored/co-authored over 125 scientific communications. These communications include: abstracts, six patent applications, two granted patents, and 45 publications, 31 of which are articles in peer-reviewed journals focused on aspects of HIV pathogenesis research. He received his B.S., M.S., and Ph.D. at the Pennsylvania State University in Viral Genetics, and subsequently, did a postdoctoral fellowship at the California Institute of Technology (Caltech). There he extended his knowledge of host systems through the study of basic cell biology processes. Simultaneously, the basic life processes of the Human Immunodeficiency Virus I (HIV-1) were being elucidated elsewhere. Interesting commonalities between his cell work at Caltech, and aspects of HIV biology, enticed him, on arriving at the Morehouse School of Medicine in 1990, to begin to look at host-HIV-1 interactions and the role, if any, this plays in progression to AIDS. Currently, a Professor of Microbiology, Biochemistry, and Immunology, he has studied HIV/AIDS for 20 years and is an expert in HIV pathogenesis. His lab has focused its efforts on understanding the role(s) played by HIV-1 accessory proteins in the pathogenic manipulation of host systems. Over the last decade his lab has focused on the role of extracellular Nef-containing exosomes in HIV/SIV infection and pathogenesis leading to AIDS. Publications arising out of grant funded research have shown that the Nef protein is released from viral-infected cells in exosomal vesicles that can induce apoptosis, or can cause gene dysregulation in bystander cells leading to immune depletion/dysfunction capable of causing the pathogenesis leading to AIDS. This work has the potential to lead to newly identified targets for AIDS therapy and a potential therapeutic antagonist. It also has therapeutic ramifications for cancer therapy.

One or more keywords matched the following items that are connected to Bond, Vincent

Item Type	Name
Academic Article	Genetic characterization of HIV type 1 Nef-induced vesicle secretion.
Academic Article	HIV Nef-M1 Effects on Colorectal Cancer Growth in Tumor-induced Spleens and Hepatic Metastasis.
Academic Article	Validation of a novel secretion modification region (SMR) of HIV-1 Nef using cohort sequence analysis and molecular modeling.
Academic Article	Peptide-based identification of functional motifs and their binding partners.
Academic Article	Nef exosomes isolated from the plasma of individuals with HIV-associated dementia (HAD) can induce A?(1-42) secretion in SH-SY5Y neural cells.
Academic Article	Characterizing the HIV/AIDS Epidemic in the United States and China.
Academic Article	Micro RNA in Exosomes from HIV-Infected Macrophages.
Academic Article	Secretion modification region-derived peptide blocks exosome release and mediates cell cycle arrest in breast cancer cells.
Academic Article	Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals.
Academic Article	The molecular epidemiology and drug resistance determination of HIV type 1 subtype B infection in Barbados.
Academic Article	Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptors.
Academic Article	Apoptotic effects in primary human umbilical vein endothelial cell cultures caused by exposure to virion-associated and cell membrane-associated HIV-1 gp120.
Academic Article	Effects of HIV-1 Nef, a cytotoxic viral protein, on the growth of primary colorectal cancer.
Academic Article	HLA-G DNA sequence variants and risk of perinatal HIV-1 transmission.
Academic Article	Examination of HIV type 1 variants in mother-child pairs.
Academic Article	CXCR4-gp120-IIIB interactions induce caspase-mediated apoptosis of prostate cancer cells and inhibit tumor growth.
Concept	HIV
Concept	HIV Seropositivity
Concept	HIV Antibodies
Concept	HIV-1
Concept	HIV-2
Concept	HIV Infections
Concept	HIV Envelope Protein gp120
Concept	HIV Protease
Concept	Anti-HIV Agents
Concept	HIV Reverse Transcriptase
Concept	nef Gene Products, Human Immunodeficiency Virus
Concept	rev Gene Products, Human Immunodeficiency Virus
Concept	tat Gene Products, Human Immunodeficiency Virus
Concept	vpr Gene Products, Human Immunodeficiency Virus
Academic Article	Chimeric human immunodeficiency virus type 1 (HIV-1) virions containing HIV-2 or simian immunodeficiency virus Nef are resistant to cyclosporine treatment.
Academic Article	Chimeric human immunodeficiency virus type 1 virions that contain the simian immunodeficiency virus nef gene are cyclosporin A resistant.
Academic Article	HIV-1 Nef protein is secreted into vesicles that can fuse with target cells and virions.
Academic Article	Apoptotic peptides derived from HIV-1 Nef induce lymphocyte depletion in mice.
Academic Article	HIV Type 1 Nef is released from infected cells in CD45(+) microvesicles and is present in the plasma of HIV-infected individuals.
Academic Article	Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release.
Academic Article	Association of Cytokines With Exosomes in the Plasma of HIV-1-Seropositive Individuals.
Academic Article	Hallmarks of HIV-1 pathogenesis are modulated by Nef's Secretion Modification Region.
Academic Article	Phylogenetic examination of HIV type 1 glycoprotein 120-V3 sequences in patients from rural Georgia.
Academic Article	HIV type 1 envelope sequences from seroconverting patients in Barbados.
Academic Article	Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase.
Academic Article	Proceedings of the 2017 ISEV symposium on "HIV, NeuroHIV, drug abuse, & EVs".
Academic Article	Proceedings of the ISEV symposium on "HIV, NeuroAIDS, drug abuse & EVs".
Academic Article	Small molecule CXCR4 antagonists block the HIV-1 Nef/CXCR4 axis and selectively initiate the apoptotic program in breast cancer cells.
Academic Article	HIV-2 infection detected in Canada.
Academic Article	Effect of extracellular human immunodeficiency virus type 1 glycoprotein 120 on primary human vascular endothelial cell cultures.
Academic Article	Effects of the human immunodeficiency virus type 1 Rev protein on reporter gene and host T-cell gene expression.
Academic Article	Epidemiology of HIV-1 infection in rural Georgia: demographic trends and analysis at the Medical College of Georgia.
Academic Article	Application of random amplified polymorphic DNA PCR for genomic analysis of HIV-1-infected individuals.
Academic Article	Characterization of a third CCR5 amplicon from CCR5-delta32-heterozygous HIV-1-infected individuals.
Academic Article	Effects of extracellular human immunodeficiency virus type 1 vpr protein in primary rat cortical cell cultures.
Academic Article	Identification of non-B human immunodeficiency virus type 1 subtypes in rural Georgia.
Academic Article	Involvement of protein kinase C in HIV-1 gp120-induced apoptosis in primary endothelium.
Academic Article	Mother-to-child discordance in HLA-G exon 2 is associated with a reduced risk of perinatal HIV-1 transmission.
Academic Article	Modulating Vaccine against HIV-1 Nef Protein Induced Lymphocyte Depletion
Academic Article	Harvard Journal of Minority Public Health
Academic Article	International Journal of Molecular Sciences
Academic Article	Journal of Extracellular Vesicles
Academic Article	Identification of a Novel Anti-HIV-1 Protein from Momordica balsamina Leaf Extract.
Academic Article	Anti-human immunodeficiency virus-1 activity of MoMo30 protein isolated from the traditional African medicinal plant Momordica balsamina.

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