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One or more keywords matched the following properties of Guentzel, M. Neal
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overview Dr. Guentzel’s research expertise is in microbial pathogenesis and immunology. Initially, he worked with cholera (Vibrio cholerae) and was the first to show motility as a virulence factor for any bacterial pathogen and extensively characterized an animal model for studies of cholera pathogenesis and putative vaccines for cholera. Motility has since been shown to be important in pathogenesis of a variety of microbes and the model is a mainstay for cholera studies. He also studied pathogenesis of the major fungal pathogen Candida albicans, developed a new animal model for candidiasis, and demonstrated systemic spread from the GI tract as a consequence of different treatments used in human patients. Current studies have focused on pathogenesis and putative vaccines for Chlamydia trachomatis, the world’s leading cause of bacterial STD, which is often asymptomatic but if left untreated can induce ascending infection in the uterus and fallopian tubes, causing pelvic inflammatory disease (PID) and complications such as ectopic pregnancy and infertility in women, and infant pneumonia in children with serious respiratory sequelae later in life. The lab's studies on the select agent Francisella tularensis have helped to define the virulence determinants of this pathogen and characterized the immune response and protection afforded by putative attenuated vaccine stains. Acinetobacter baumannii is a multi-drug resistant, important wound, nosocomial (hospital acquired), and pulmonary pathogen with a high mortality, which is being studied for mechanisms of colonization, pathogenesis and control.
One or more keywords matched the following items that are connected to Guentzel, M. Neal
Item TypeName
Academic Article Proteolytic bacteria in the lower digestive tract of poultry may affect avian influenza virus pathogenicity.
Academic Article The Fischer 344 rat reflects human susceptibility to francisella pulmonary challenge and provides a new platform for virulence and protection studies.
Academic Article Evasion of IFN-? signaling by Francisella novicida is dependent upon Francisella outer membrane protein C.
Academic Article Effects of bacterial microflora of the lower digestive tract of free-range waterfowl on influenza virus activation.
Academic Article Motility as a virulence factor for Vibrio cholerae.
Academic Article Virulence factors involved in the intraperitoneal infection of adult mice with Vibrio cholerae.
Academic Article Protection of suckling mice from experimental cholera by maternal immunization: comparison of the efficacy of whole-cell, ribosomal-derived, and enterotoxin immunogens.
Academic Article Vaccination with a live attenuated Acinetobacter baumannii deficient in thioredoxin provides protection against systemic Acinetobacter infection.
Academic Article Acinetobacter baumannii Gastrointestinal Colonization Is Facilitated by Secretory IgA Which Is Reductively Dissociated by Bacterial Thioredoxin A.
Academic Article Thioredoxin-A is a virulence factor and mediator of the type IV pilus system in Acinetobacter baumannii.
Academic Article Vaccination with a defined Francisella tularensis subsp. novicida pathogenicity island mutant (DeltaiglB) induces protective immunity against homotypic and heterotypic challenge.
Concept Virulence
Concept Virulence Factors
Academic Article Thioredoxin-mediated alteration of protein content and cytotoxicity of Acinetobacter baumannii outer membrane vesicles.
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  • Virulence
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