Connection | Profiles RNS

Search Result Details

Back to Search Results

This page shows the details of why an item matched the keywords from your search.

Search Results

Aguilera, Renato J.

One or more keywords matched the following properties of Aguilera, Renato J.

Property	Value
overview	As an Immunologist, the PI has extensive experience in cell culture, rodent husbandry and drug screening. With the use of recently acquired drug screening equipment within the Cytometry, Screening and Imaging Core, his group has recently developed assays for screening of chemical libraries on a variety of human cancer cells. The ultimate goal of these assays is to discover compounds that can kill specific cancer cells but not others. In recent months, the simultaneous screening of compounds of various human cancer cell lines has resulted in the detection of novel lead compounds with potent anti-lymphoma and anti-breast cancer activities. This research involves the participation and training of several undergraduates and graduate students; the majority of whom are from underrepresented minority groups. Short Biography: Dr. Renato Aguilera obtained his Ph.D. from U.C. Berkeley in 1987 and was a tenured professor at UCLA for 14 years. Dr. Aguilera's research has been continuously funded by federal grants since 1989 and he currently works on anticancer drug discovery. Dr. Aguilera obtained his BS and MS degrees in Microbiology from The University of Texas at El Paso (UTEP) and joined this university in 2002 as a Full Professor and Director of the Biology Graduate Program. He is the director of the Cytometry, Screening and Imaging Core facility and RCMI Program Director of the Border Biomedical Research Center at UTEP. Dr. Aguilera has been the director of the Research Initiative for Scientific Enhancement (RISE) Scholars training program since 2003 and will continue to direct this program till 2022. The recently renewed RISE program will train 25 undergraduates and 15 graduate students from underrepresented minority groups. For his long-standing commitment to student training and mentorship, he received the prestigious American Society for Microbiology William A. Hinton Research Training Award in 2010 and the SACNAS Distinguished Research Mentor Award in 2013 . Dr. Aguilera was the chair of the Minority Affairs Committee of the American Society for Cell Biology from 2010-16). In addition, he has served on the Board of Scientific Councilor’s of the NIEHS, on the Committee of Visitors of NSF, and on several NIH grant review panels.

Property

Value

overview

As an Immunologist, the PI has extensive experience in cell culture, rodent husbandry and drug screening. With the use of recently acquired drug screening equipment within the Cytometry, Screening and Imaging Core, his group has recently developed assays for screening of chemical libraries on a variety of human cancer cells. The ultimate goal of these assays is to discover compounds that can kill specific cancer cells but not others. In recent months, the simultaneous screening of compounds of various human cancer cell lines has resulted in the detection of novel lead compounds with potent anti-lymphoma and anti-breast cancer activities. This research involves the participation and training of several undergraduates and graduate students; the majority of whom are from underrepresented minority groups. Short Biography: Dr. Renato Aguilera obtained his Ph.D. from U.C. Berkeley in 1987 and was a tenured professor at UCLA for 14 years. Dr. Aguilera's research has been continuously funded by federal grants since 1989 and he currently works on anticancer drug discovery. Dr. Aguilera obtained his BS and MS degrees in Microbiology from The University of Texas at El Paso (UTEP) and joined this university in 2002 as a Full Professor and Director of the Biology Graduate Program. He is the director of the Cytometry, Screening and Imaging Core facility and RCMI Program Director of the Border Biomedical Research Center at UTEP. Dr. Aguilera has been the director of the Research Initiative for Scientific Enhancement (RISE) Scholars training program since 2003 and will continue to direct this program till 2022. The recently renewed RISE program will train 25 undergraduates and 15 graduate students from underrepresented minority groups. For his long-standing commitment to student training and mentorship, he received the prestigious American Society for Microbiology William A. Hinton Research Training Award in 2010 and the SACNAS Distinguished Research Mentor Award in 2013 . Dr. Aguilera was the chair of the Minority Affairs Committee of the American Society for Cell Biology from 2010-16). In addition, he has served on the Board of Scientific Councilor’s of the NIEHS, on the Committee of Visitors of NSF, and on several NIH grant review panels.

One or more keywords matched the following items that are connected to Aguilera, Renato J.

Item Type	Name
Academic Article	Cytotoxic effects of two organotin compounds and their mode of inflicting cell death on four mammalian cancer cells.
Academic Article	Bis[3,5-bis(benzylidene)-4-oxo-1-piperidinyl]amides: a novel class of potent cytotoxins.
Academic Article	Arene-Ru(II)-chloroquine complexes interact with DNA, induce apoptosis on human lymphoid cell lines and display low toxicity to normal mammalian cells.
Academic Article	Searching in mother nature for anti-cancer activity: anti-proliferative and pro-apoptotic effect elicited by green barley on leukemia/lymphoma cells.
Academic Article	Titanocene-phosphine derivatives as precursors to cytotoxic heterometallic TiAu2 and TiM (M = Pd, Pt) compounds. Studies of their interactions with DNA.
Academic Article	Analysis of the cytotoxic effects of ruthenium-ketoconazole and ruthenium-clotrimazole complexes on cancer cells.
Academic Article	The gender of cell lines matters when screening for novel anti-cancer drugs.
Academic Article	The cytotoxic effect of 2-acylated-1,4-naphthohydroquinones on leukemia/lymphoma cells.
Academic Article	Novel 3,5-bis(arylidene)-4-oxo-1-piperidinyl dimers: structure-activity relationships and potent antileukemic and antilymphoma cytotoxicity.
Academic Article	Cytotoxic activity of triazole-containing alkyl ?-D-glucopyranosides on a human T-cell leukemia cell line.
Academic Article	A novel curcumin-like dienone induces apoptosis in triple-negative breast cancer cells.
Academic Article	Use of non-selective ?-blockers is associated with decreased tumor proliferative indices in early stage breast cancer.
Academic Article	Induction of apoptosis via proteasome inhibition in leukemia/lymphoma cells by two potent piperidones.
Academic Article	Pyronaridine exerts potent cytotoxicity on human breast and hematological cancer cells through induction of apoptosis.
Academic Article	A new pyridazinone exhibits potent cytotoxicity on human cancer cells via apoptosis and poly-ubiquitinated protein accumulation.
Academic Article	The beta adrenergic receptor antagonist propranolol alters mitogenic and apoptotic signaling in late stage breast cancer.
Academic Article	Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation.
Academic Article	An acylhydroquinone derivative produces OXPHOS uncoupling and sensitization to BH3 mimetic ABT-199 (Venetoclax) in human promyelocytic leukemia cells.
Academic Article	Structure guided design and synthesis of furyl thiazolidinedione derivatives as inhibitors of GLUT 1 and GLUT 4, and evaluation of their anti-leukemic potential.
Academic Article	Recombinant human lactoferrin induces apoptosis, disruption of F-actin structure and cell cycle arrest with selective cytotoxicity on human triple negative breast cancer cells.
Academic Article	Green barley mitigates cytotoxicity in human lymphocytes undergoing aggressive oxidative stress, via activation of both the Lyn/PI3K/Akt and MAPK/ERK pathways.
Academic Article	RAG-1 and RAG-2 gene expression and V(D)J recombinase activity are enhanced by protein phosphatase 1 and 2A inhibition in lymphocyte cell lines.
Academic Article	A novel class of metal-directed supramolecular DNA-delivery systems.
Academic Article	Characterization of an endonuclease activity which preferentially cleaves the G-rich immunoglobulin switch repeat sequences.
Academic Article	Synthesis of apoptosis-inducing iminophosphorane organogold(III) complexes and study of their interactions with biomolecular targets.
Concept	Cell Line
Concept	Cell Line, Tumor
Academic Article	A pre-B cell nuclear protein that specifically interacts with the immunoglobulin V-J recombination sequences.
Academic Article	Characterization of immunoglobulin enhancer deletions in murine plasmacytomas.
Academic Article	Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities.
Academic Article	Permuted 2,4-thiazolidinedione (TZD) analogs as GLUT inhibitors and their in-vitro evaluation in leukemic cells.
Academic Article	Synthesis, Molecular Docking and Preliminary Antileukemic Activity of 4-Methoxybenzyl Derivatives Bearing Imidazo[2,1-b][1,3,4]thiadiazole.
Academic Article	Thiazolidinedione "Magic Bullets" Simultaneously Targeting PPAR? and HDACs: Design, Synthesis, and Investigations of their In Vitro and In Vivo Antitumor Effects.
Academic Article	Three novel piperidones exhibit tumor-selective cytotoxicity on leukemia cells via protein degradation and stress-mediated mechanisms.
Academic Article	Design, Synthesis and Tumour-Selective Toxicity of Novel 1-[3-{3,5-Bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone Oximes and Related Quaternary Ammonium Salts.
Academic Article	Novel Unsymmetric 3,5-Bis(benzylidene)-4-piperidones That Display Tumor-Selective Toxicity.
Academic Article	Identification of a Potent Cytotoxic Pyrazole with Anti-Breast Cancer Activity That Alters Multiple Pathways.
Academic Article	Two novel piperidones induce apoptosis and antiproliferative effects on human prostate and lymphoma cancer cell lines.
Academic Article	Synthesis of Novel Pyrazole-Oxindole Conjugates with Cytotoxicity in Human Cancer Cells via Apoptosis.
Academic Article	A photothermal driven chemotherapy for the treatment of metastatic melanoma.
Academic Article	Thiophene derivative inflicts cytotoxicity via an intrinsic apoptotic pathway on human acute lymphoblastic leukemia cells.

Search Criteria

Cell Line