Wayne W. Harding to Structure-Activity Relationship
This is a "connection" page, showing publications Wayne W. Harding has written about Structure-Activity Relationship.
Connection Strength
2.881
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Ponnala S, Kapadia N, Navarro HA, Harding WW. Aporphinoid antagonists of 5-HT2A receptors: further evaluation of ring A substituents and the size of ring C. Chem Biol Drug Des. 2014 Nov; 84(5):558-66.
Score: 0.452
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Giri R, Namballa HK, Emogaje V, Harding WW. Structure-Activity Relationship Studies on 6-Chloro-1-phenylbenzazepines Leads to the Identification of a New Dopamine D1 Receptor Antagonist. Molecules. 2023 Aug 11; 28(16).
Score: 0.213
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Cordone P, Namballa HK, Muniz B, Pal RK, Gallicchio E, Harding WW. New tetrahydroisoquinoline-based D3R ligands with an o-xylenyl linker motif. Bioorg Med Chem Lett. 2021 06 15; 42:128047.
Score: 0.182
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Karki A, Namballa HK, Alberts I, Harding WW. Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT7AR ligands. Bioorg Med Chem. 2020 08 01; 28(15):115578.
Score: 0.171
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Giri R, Namballa HK, Sarker A, Alberts I, Harding WW. Synthesis and dopamine receptor pharmacological evaluations on ring C ortho halogenated 1-phenylbenzazepines. Bioorg Med Chem Lett. 2020 08 15; 30(16):127305.
Score: 0.171
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Giri R, Alberts I, Harding WW. Synthesis, pharmacological evaluations, and molecular docking studies on a new 1,3,4,11b-tetrahydro-1H-fluoreno[9,1-cd]azepine framework: Rigidification of D1 receptor selective 1-phenylbenzazepines and discovery of a new 5-HT6 receptor scaffold. Chem Biol Drug Des. 2020 08; 96(2):825-835.
Score: 0.170
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Karki A, Juarez R, Namballa HK, Alberts I, Harding WW. Identification of C10 nitrogen-containing aporphines with dopamine D1 versus D5 receptor selectivity. Bioorg Med Chem Lett. 2020 04 15; 30(8):127053.
Score: 0.168
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Madapa S, Gadhiya S, Kurtzman T, Alberts IL, Ramsey S, Reith M, Harding WW. Synthesis and evaluation of C9 alkoxy analogues of (-)-stepholidine as dopamine receptor ligands. Eur J Med Chem. 2017 Jan 05; 125:255-268.
Score: 0.132
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Kapadia N, Ahmed S, Harding WW. New halogenated tris-(phenylalkyl)amines as h5-HT2B receptor ligands. Bioorg Med Chem Lett. 2016 07 15; 26(14):3216-3219.
Score: 0.130
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Ponnala S, Kapadia N, Madapa S, Alberts IL, Harding WW. Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT(2A) receptor. Bioorg Med Chem Lett. 2015 Nov 15; 25(22):5102-6.
Score: 0.124
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Kapadia N, Harding WW. C4 phenyl aporphines with selective h5-HT(2B) receptor affinity. Bioorg Med Chem Lett. 2015 Sep 01; 25(17):3451-4.
Score: 0.122
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Madapa S, Harding WW. Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors. J Nat Prod. 2015 Apr 24; 78(4):722-9.
Score: 0.119
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Ponnala S, Gonzales J, Kapadia N, Navarro HA, Harding WW. Evaluation of structural effects on 5-HT(2A) receptor antagonism by aporphines: identification of a new aporphine with 5-HT(2A) antagonist activity. Bioorg Med Chem Lett. 2014 Apr 01; 24(7):1664-7.
Score: 0.111
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He F, Lindqvist C, Harding WW. Leonurenones A-C: Labdane diterpenes from Leonotis leonurus. Phytochemistry. 2012 Nov; 83:168-72.
Score: 0.100
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Chaudhary S, Ponnala S, Legendre O, Gonzales JA, Navarro HA, Harding WW. New aporphinoid 5-HT2A and a1A antagonists via structural manipulations of nantenine. Bioorg Med Chem. 2011 Oct 01; 19(19):5861-8.
Score: 0.093
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Ponnala S, Chaudhary S, Gonz?lez-Sarrias A, Seeram NP, Harding WW. Cytotoxicity of aporphines in human colon cancer cell lines HCT-116 and Caco-2: an SAR study. Bioorg Med Chem Lett. 2011 Aug 01; 21(15):4462-4.
Score: 0.092
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Pecic S, McAnuff MA, Harding WW. Nantenine as an acetylcholinesterase inhibitor: SAR, enzyme kinetics and molecular modeling investigations. J Enzyme Inhib Med Chem. 2011 Feb; 26(1):46-55.
Score: 0.086
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Pecic S, Makkar P, Chaudhary S, Reddy BV, Navarro HA, Harding WW. Affinity of aporphines for the human 5-HT2A receptor: insights from homology modeling and molecular docking studies. Bioorg Med Chem. 2010 Aug 01; 18(15):5562-75.
Score: 0.086
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Chaudhary S, Pecic S, Legendre O, Navarro HA, Harding WW. (+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners. Bioorg Med Chem Lett. 2009 May 01; 19(9):2530-2.
Score: 0.079
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Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Dersch CM, Rothman RB, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: selective modification of the furan ring. Bioorg Med Chem Lett. 2006 Jun 15; 16(12):3170-4.
Score: 0.064
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Simpson DS, Katavic PL, Lozama A, Harding WW, Parrish D, Deschamps JR, Dersch CM, Partilla JS, Rothman RB, Navarro H, Prisinzano TE. Synthetic studies of neoclerodane diterpenes from Salvia divinorum: preparation and opioid receptor activity of salvinicin analogues. J Med Chem. 2007 Jul 26; 50(15):3596-603.
Score: 0.017