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Connection

Co-Authors

This is a "connection" page, showing publications co-authored by Zhigang Xiong and Roger Simon.
Connection Strength

2.899
  1. Xiong ZG, Pignataro G, Li M, Chang SY, Simon RP. Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases. Curr Opin Pharmacol. 2008 Feb; 8(1):25-32.
    View in: PubMed
    Score: 0.311
  2. Xiong ZG, Chu XP, Simon RP. Acid sensing ion channels--novel therapeutic targets for ischemic brain injury. Front Biosci. 2007 Jan 01; 12:1376-86.
    View in: PubMed
    Score: 0.294
  3. Xiong ZG, Zhu XM, Chu XP, Minami M, Hey J, Wei WL, MacDonald JF, Wemmie JA, Price MP, Welsh MJ, Simon RP. Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell. 2004 Sep 17; 118(6):687-98.
    View in: PubMed
    Score: 0.251
  4. Li MH, Leng TD, Feng XC, Yang T, Simon RP, Xiong ZG. Modulation of Acid-sensing Ion Channel 1a by Intracellular pH and Its Role in Ischemic Stroke. J Biol Chem. 2016 08 26; 291(35):18370-83.
    View in: PubMed
    Score: 0.142
  5. Leng TD, Si HF, Li J, Yang T, Zhu M, Wang B, Simon RP, Xiong ZG. Amiloride Analogs as ASIC1a Inhibitors. CNS Neurosci Ther. 2016 06; 22(6):468-76.
    View in: PubMed
    Score: 0.138
  6. Li MH, Liu SQ, Inoue K, Lan J, Simon RP, Xiong ZG. Acid-sensing ion channels in mouse olfactory bulb M/T neurons. J Gen Physiol. 2014 Jun; 143(6):719-31.
    View in: PubMed
    Score: 0.122
  7. Lin J, Chu X, Maysami S, Li M, Si H, Cottrell JE, Simon RP, Xiong Z. Inhibition of acid sensing ion channel currents by lidocaine in cultured mouse cortical neurons. Anesth Analg. 2011 Apr; 112(4):977-81.
    View in: PubMed
    Score: 0.098
  8. Coombes E, Jiang J, Chu XP, Inoue K, Seeds J, Branigan D, Simon RP, Xiong ZG. Pathophysiologically relevant levels of hydrogen peroxide induce glutamate-independent neurodegeneration that involves activation of transient receptor potential melastatin 7 channels. Antioxid Redox Signal. 2011 May 15; 14(10):1815-27.
    View in: PubMed
    Score: 0.097
  9. Li M, Kratzer E, Inoue K, Simon RP, Xiong ZG. Developmental change in the electrophysiological and pharmacological properties of acid-sensing ion channels in CNS neurons. J Physiol. 2010 Oct 15; 588(Pt 20):3883-900.
    View in: PubMed
    Score: 0.095
  10. Li M, Inoue K, Branigan D, Kratzer E, Hansen JC, Chen JW, Simon RP, Xiong ZG. Acid-sensing ion channels in acidosis-induced injury of human brain neurons. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1247-60.
    View in: PubMed
    Score: 0.092
  11. Chai S, Li M, Branigan D, Xiong ZG, Simon RP. Activation of acid-sensing ion channel 1a (ASIC1a) by surface trafficking. J Biol Chem. 2010 Apr 23; 285(17):13002-11.
    View in: PubMed
    Score: 0.091
  12. Meller R, Thompson SJ, Lusardi TA, Ordonez AN, Ashley MD, Jessick V, Wang W, Torrey DJ, Henshall DC, Gafken PR, Saugstad JA, Xiong ZG, Simon RP. Ubiquitin proteasome-mediated synaptic reorganization: a novel mechanism underlying rapid ischemic tolerance. J Neurosci. 2008 Jan 02; 28(1):50-9.
    View in: PubMed
    Score: 0.079
  13. Pignataro G, Meller R, Inoue K, Ordonez AN, Ashley MD, Xiong Z, Gala R, Simon RP. In vivo and in vitro characterization of a novel neuroprotective strategy for stroke: ischemic postconditioning. J Cereb Blood Flow Metab. 2008 Feb; 28(2):232-41.
    View in: PubMed
    Score: 0.077
  14. Chai S, Li M, Lan J, Xiong ZG, Saugstad JA, Simon RP. A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a. J Biol Chem. 2007 Aug 03; 282(31):22668-77.
    View in: PubMed
    Score: 0.076
  15. Bottlang M, Sommers MB, Lusardi TA, Miesch JJ, Simon RP, Xiong ZG. Modeling neural injury in organotypic cultures by application of inertia-driven shear strain. J Neurotrauma. 2007 Jun; 24(6):1068-77.
    View in: PubMed
    Score: 0.076
  16. Hey JG, Chu XP, Seeds J, Simon RP, Xiong ZG. Extracellular zinc protects against acidosis-induced injury of cells expressing Ca2+-permeable acid-sensing ion channels. Stroke. 2007 Feb; 38(2 Suppl):670-3.
    View in: PubMed
    Score: 0.074
  17. Pignataro G, Simon RP, Xiong ZG. Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia. Brain. 2007 Jan; 130(Pt 1):151-8.
    View in: PubMed
    Score: 0.073
  18. Wang WZ, Chu XP, Li MH, Seeds J, Simon RP, Xiong ZG. Modulation of acid-sensing ion channel currents, acid-induced increase of intracellular Ca2+, and acidosis-mediated neuronal injury by intracellular pH. J Biol Chem. 2006 Sep 29; 281(39):29369-78.
    View in: PubMed
    Score: 0.071
  19. Chu XP, Wemmie JA, Wang WZ, Zhu XM, Saugstad JA, Price MP, Simon RP, Xiong ZG. Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels. J Neurosci. 2004 Oct 06; 24(40):8678-89.
    View in: PubMed
    Score: 0.063
  20. Zhou A, Minami M, Zhu X, Bae S, Minthorne J, Lan J, Xiong ZG, Simon RP. Altered biosynthesis of neuropeptide processing enzyme carboxypeptidase E after brain ischemia: molecular mechanism and implication. J Cereb Blood Flow Metab. 2004 Jun; 24(6):612-22.
    View in: PubMed
    Score: 0.061
  21. Sun H, Yang T, Simon R, Xiong ZG, Leng T. Cholestane-3?,5a,6?-Triol Inhibits Acid-Sensing Ion Channels and Reduces Acidosis-Mediated Ischemic Brain Injury. Stroke. 2024 Jun; 55(6):1660-1671.
    View in: PubMed
    Score: 0.061
  22. Stenzel-Poore MP, Stevens SL, Xiong Z, Lessov NS, Harrington CA, Mori M, Meller R, Rosenzweig HL, Tobar E, Shaw TE, Chu X, Simon RP. Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states. Lancet. 2003 Sep 27; 362(9389):1028-37.
    View in: PubMed
    Score: 0.059
  23. Chu XP, Zhu XM, Wei WL, Li GH, Simon RP, MacDonald JF, Xiong ZG. Acidosis decreases low Ca(2+)-induced neuronal excitation by inhibiting the activity of calcium-sensing cation channels in cultured mouse hippocampal neurons. J Physiol. 2003 Jul 15; 550(Pt 2):385-99.
    View in: PubMed
    Score: 0.057
  24. Chen D, Jin K, Kawaguchi K, Nakayama M, Zhou X, Xiong Z, Zhou A, Mao XO, Greenberg DA, Graham SH, Simon RP. Ero1-L, an ischemia-inducible gene from rat brain with homology to global ischemia-induced gene 11 (Giig11), is localized to neuronal dendrites by a dispersed identifier (ID) element-dependent mechanism. J Neurochem. 2003 May; 85(3):670-9.
    View in: PubMed
    Score: 0.057
  25. Sun HW, Chu XP, Simon RP, Xiong ZG, Leng TD. Inhibition of Acid-Sensing Ion Channels by KB-R7943, a Reverse Na+/Ca2+ Exchanger Inhibitor. Biomolecules. 2023 03 10; 13(3).
    View in: PubMed
    Score: 0.056
  26. Xie M, Leng T, Maysami S, Pearson A, Simon R, Xiong ZG, Meller R. Changes in NMDA Receptor Function in Rapid Ischemic Tolerance: A Potential Role for Tri-Heteromeric NMDA Receptors. Biomolecules. 2022 09 01; 12(9).
    View in: PubMed
    Score: 0.054
  27. Wang T, Zhou G, He M, Xu Y, Rusyniak WG, Xu Y, Ji Y, Simon RP, Xiong ZG, Zha XM. GPR68 Is a Neuroprotective Proton Receptor in Brain Ischemia. Stroke. 2020 12; 51(12):3690-3700.
    View in: PubMed
    Score: 0.048
  28. Jiang N, Wu J, Leng T, Yang T, Zhou Y, Jiang Q, Wang B, Hu Y, Ji YH, Simon RP, Chu XP, Xiong ZG, Zha XM. Region specific contribution of ASIC2 to acidosis-and ischemia-induced neuronal injury. J Cereb Blood Flow Metab. 2017 Feb; 37(2):528-540.
    View in: PubMed
    Score: 0.036
  29. Duan B, Wang YZ, Yang T, Chu XP, Yu Y, Huang Y, Cao H, Hansen J, Simon RP, Zhu MX, Xiong ZG, Xu TL. Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J Neurosci. 2011 Feb 09; 31(6):2101-12.
    View in: PubMed
    Score: 0.024
  30. Stapels M, Piper C, Yang T, Li M, Stowell C, Xiong ZG, Saugstad J, Simon RP, Geromanos S, Langridge J, Lan JQ, Zhou A. Polycomb group proteins as epigenetic mediators of neuroprotection in ischemic tolerance. Sci Signal. 2010 Mar 02; 3(111):ra15.
    View in: PubMed
    Score: 0.023
  31. Zhan S, Zhao H, J White A, Minami M, Pignataro G, Yang T, Zhu X, Lan J, Xiong Z, Steiner DF, Simon RP, Zhou A. Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains. J Cereb Blood Flow Metab. 2009 Apr; 29(4):698-706.
    View in: PubMed
    Score: 0.021
  32. Murphy B, Dunleavy M, Shinoda S, Schindler C, Meller R, Bellver-Estelles C, Hatazaki S, Dicker P, Yamamoto A, Koegel I, Chu X, Wang W, Xiong Z, Prehn J, Simon R, Henshall D. Bcl-w protects hippocampus during experimental status epilepticus. Am J Pathol. 2007 Oct; 171(4):1258-68.
    View in: PubMed
    Score: 0.019
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
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