Dr. Ye’s research covers a wide range of areas in biomedical optics and nanobiotechnology, with special emphasis on the development of cutting-edge ultrasensitive and ultrafast laser-based detection techniques and methodologies to address critical issues at the frontier of biomedical research and applications. He has led multiple exciting research programs including the development of a novel optoacoustic sensor for high-frequency photoacoustic imaging, biomolecular assays with photonic-crystal based label-free sensors, in vivo fiber-optic biosensing and imaging of a multifunctional nano-device for targeted cancer drug delivery, ultrafast laser interaction with nanoparticle-targeted cancer cells, in vivo two-photon flow cytometry, adaptive optical aberration correction in multiphoton scanning microscopy, and single-molecule fluorescence imaging and spectroscopy. He has published 86 refereed articles, 150 conference papers, and two book chapters, and holds 12 patents. He serves as a reviewer for funding agencies including NIH, NSF, Petroleum Research Fund, United States-Israel Binational Science Foundation, the James & Esther King Biomedical Research Program and the Bankhead-Coley Cancer Research Program. Dr. Ye was elected as the president of Ann Arbor Section of Optical Society of American in 2008-2009. He also serves as a guest editor for three high-impact journals, as an advisory board member for a biotech company, as a professional consultant for five companies, as a reviewer for over 30 journals, and on technical program committee for conferences.