Robert Kirken to T-Lymphocytes
This is a "connection" page, showing publications Robert Kirken has written about T-Lymphocytes.
Connection Strength
2.832
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Rodriguez G, Ross JA, Nagy ZS, Kirken RA. Forskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex. J Biol Chem. 2013 Mar 08; 288(10):7137-46.
Score: 0.359
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Ross JA, Nagy ZS, Kirken RA. The PHB1/2 phosphocomplex is required for mitochondrial homeostasis and survival of human T cells. J Biol Chem. 2008 Feb 22; 283(8):4699-713.
Score: 0.252
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Ross JA, Nagy ZS, Cheng H, Stepkowski SM, Kirken RA. Regulation of T cell homeostasis by JAKs and STATs. Arch Immunol Ther Exp (Warsz). 2007 Jul-Aug; 55(4):231-45.
Score: 0.245
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Stepkowski SM, Kirken RA. Janus tyrosine kinases and signal transducers and activators of transcription regulate critical functions of T cells in allograft rejection and transplantation tolerance. Transplantation. 2006 Aug 15; 82(3):295-303.
Score: 0.229
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Nagy ZS, Ross J, Cheng H, Stepkowski SM, Kirken RA. Regulation of lymphoid cell apoptosis by Jaks and Stats. Crit Rev Immunol. 2004; 24(2):87-110.
Score: 0.191
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Stepkowski SM, Erwin-Cohen RA, Behbod F, Wang ME, Qu X, Tejpal N, Nagy ZS, Kahan BD, Kirken RA. Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin. Blood. 2002 Jan 15; 99(2):680-9.
Score: 0.167
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Stepkowski SM, Nagy ZS, Kahan BD, Kirken RA. The role of signals 1, 2, and 3 in induction of transplantation tolerance. Transplant Proc. 2001 Nov-Dec; 33(7-8):3831-2.
Score: 0.165
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Kirken RA, Erwin-Cohen R, Behbod F, Wang M, Stepkowski SM, Kahan BD. Tyrphostin AG490 selectively inhibits activation of the JAK3/STAT5/MAPK pathway and rejection of rat heart allografts. Transplant Proc. 2001 Feb-Mar; 33(1-2):95.
Score: 0.156
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Kirken RA, Erwin RA, Wang L, Wang Y, Rui H, Farrar WL. Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells. J Immunol. 2000 Nov 01; 165(9):5097-104.
Score: 0.154
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Kirken RA, Erwin RA, Taub D, Murphy WJ, Behbod F, Wang L, Pericle F, Farrar WL. Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells. J Leukoc Biol. 1999 Jun; 65(6):891-9.
Score: 0.139
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Kirken RA, Rui H, Malabarba MG, Howard OM, Kawamura M, O'Shea JJ, Farrar WL. Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain. Cytokine. 1995 Oct; 7(7):689-700.
Score: 0.108
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Kirken RA, Rui H, Evans GA, Farrar WL. Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit. J Biol Chem. 1993 Oct 25; 268(30):22765-70.
Score: 0.094
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Zhang Y, Kirken RA, Furian L, Janczewska S, Qu X, Hancock WW, Wang M, Tejpal N, Kerman R, Kahan BD, Stepkowski SM. Allograft rejection requires STAT5a/b-regulated antiapoptotic activity in T cells but not B cells. J Immunol. 2006 Jan 01; 176(1):128-37.
Score: 0.055
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Wang Y, Malabarba MG, Nagy ZS, Kirken RA. Interleukin 4 regulates phosphorylation of serine 756 in the transactivation domain of Stat6. Roles for multiple phosphorylation sites and Stat6 function. J Biol Chem. 2004 Jun 11; 279(24):25196-203.
Score: 0.049
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Kirken RA, Wang YL. Molecular actions of sirolimus: sirolimus and mTor. Transplant Proc. 2003 May; 35(3 Suppl):227S-230S.
Score: 0.046
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Nagy ZS, Wang Y, Erwin-Cohen RA, Aradi J, Monia B, Wang LH, Stepkowski SM, Rui H, Kirken RA. Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways. J Leukoc Biol. 2002 Oct; 72(4):819-28.
Score: 0.044
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Kirken RA. Targeting Jak3 for immune suppression and allograft acceptance. Transplant Proc. 2001 Nov-Dec; 33(7-8):3268-70.
Score: 0.041
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Stepkowski SM, Nagy ZS, Wang ME, Behbod F, Erwin-Cohen R, Kahan BD, Kirken RA. PNU156804 inhibits Jak3 tyrosine kinase and rat heart allograft rejection. Transplant Proc. 2001 Nov-Dec; 33(7-8):3272-3.
Score: 0.041
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Stepkowski SM, Kirken RA, Nagy ZS, Trawick BW, Wang M, Tejpal N, Wang ME, Tian L, Clark J, Kahan BD. The role of Stat5 in the induction of regulatory T cells in transplantation tolerance. Transplant Proc. 2001 Nov-Dec; 33(7-8):3835-6.
Score: 0.041
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Behbod F, Erwin-Cohen RA, Wang ME, Trawick BW, Qu X, Verani R, Kahan BD, Stepkowski SM, Kirken RA. Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts. J Immunol. 2001 Mar 15; 166(6):3724-32.
Score: 0.039
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Tian L, Qu X, Wang ME, Kirken RA, Bennett FC, Stepkowski SM. Selective inhibition of IL-2 mRNA blocks allograft rejection by limiting T cell clonal expansion. Transplant Proc. 2001 Feb-Mar; 33(1-2):330.
Score: 0.039
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Wang LH, Kirken RA, Erwin RA, Yu CR, Farrar WL. JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response. J Immunol. 1999 Apr 01; 162(7):3897-904.
Score: 0.034
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Yu CR, Kirken RA, Malabarba MG, Young HA, Ortaldo JR. Differential regulation of the Janus kinase-STAT pathway and biologic function of IL-13 in primary human NK and T cells: a comparative study with IL-4. J Immunol. 1998 Jul 01; 161(1):218-27.
Score: 0.033
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Pericle F, Pinto LA, Hicks S, Kirken RA, Sconocchia G, Rusnak J, Dolan MJ, Shearer GM, Segal DM. HIV-1 infection induces a selective reduction in STAT5 protein expression. J Immunol. 1998 Jan 01; 160(1):28-31.
Score: 0.032
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Pericle F, Kirken RA, Bronte V, Sconocchia G, DaSilva L, Segal DM. Immunocompromised tumor-bearing mice show a selective loss of STAT5a/b expression in T and B lymphocytes. J Immunol. 1997 Sep 15; 159(6):2580-5.
Score: 0.031
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Kahan BD, Kirken RA, Stepkowski SM. New approaches to transplant immunosuppression. Transplant Proc. 2003 Aug; 35(5):1621-3.
Score: 0.012
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Stepkowski SM, Kirken RA, Trawick BW, Wang M, Tejpal N, Wang ME, Tian L, Clark J, Kahan BD. Allochimeric class I MHC protein-induced tolerance by partial TCR engagement requires activation of both CTL4- and common gamma-chain-dependent cytokine signals. Transplantation. 2002 Apr 27; 73(8):1227-35.
Score: 0.011
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Qu X, Kirken RA, Tian L, Wang M, Bennett CF, Stepkowski SM. Selective inhibition of IL-2 gene expression by IL-2 antisense oligonucleotides blocks heart allograft rejection. Transplantation. 2001 Sep 15; 72(5):915-23.
Score: 0.010
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Yen CH, Yang YC, Ruscetti SK, Kirken RA, Dai RM, Li CC. Involvement of the ubiquitin-proteasome pathway in the degradation of nontyrosine kinase-type cytokine receptors of IL-9, IL-2, and erythropoietin. J Immunol. 2000 Dec 01; 165(11):6372-80.
Score: 0.010
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Rui H, Kirken RA, Farrar WL. Activation of receptor-associated tyrosine kinase JAK2 by prolactin. J Biol Chem. 1994 Feb 18; 269(7):5364-8.
Score: 0.006