Neural Cell Adhesion Molecule L1
"Neural Cell Adhesion Molecule L1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
| Descriptor ID |
D039842
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| MeSH Number(s) |
D12.776.395.550.200.250.520.578 D12.776.543.550.200.250.520.578 D23.050.301.350.250.520.578
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| Concept/Terms |
Neural Cell Adhesion Molecule L1- Neural Cell Adhesion Molecule L1
- NILE Glycoprotein
- Glycoprotein, NILE
- Nerve Growth Factor-Inducible Large External Glycoprotein
- Nerve Growth Factor Inducible Large External Glycoprotein
- CALL Protein
- CamL1 Gene Product
- Neural Adhesion Molecule L1
- L1 Cell Adhesion Molecule
- L1CAM
- NILE Protein
- Cell Adhesion Molecule L1
- Cell Surface Glycoprotein L1
- NGF-Inducible Glycoprotein
- Glycoprotein, NGF-Inducible
- NGF Inducible Glycoprotein
- F11 Glycoprotein
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 |
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Below are the most recent publications written about "Neural Cell Adhesion Molecule L1" by people in Profiles.
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Jackson SR, Guner YS, Woo R, Randolph LM, Ford H, Shin CE. L1CAM mutation in association with X-linked hydrocephalus and Hirschsprung's disease. Pediatr Surg Int. 2009 Sep; 25(9):823-5.
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Koshimizu H, Araki T, Takai S, Yokomaku D, Ishikawa Y, Kubota M, Sano S, Hatanaka H, Yamada M. Expression of CD47/integrin-associated protein induces death of cultured cerebral cortical neurons. J Neurochem. 2002 Jul; 82(2):249-57.