"alpha-Defensins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DEFENSINS found in azurophilic granules of neutrophils and in the secretory granules of intestinal PANETH CELLS.
| Descriptor ID |
D023084
|
| MeSH Number(s) |
D12.644.050.200.050 D12.776.543.695.054.200.050
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "alpha-Defensins".
Below are MeSH descriptors whose meaning is more specific than "alpha-Defensins".
This graph shows the total number of publications written about "alpha-Defensins" by people in this website by year, and whether "alpha-Defensins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "alpha-Defensins" by people in Profiles.
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Rana T, Korolkova OY, Rachakonda G, Williams AD, Hawkins AT, James SD, Sakwe AM, Hui N, Wang L, Yu C, Goodwin JS, Izban MG, Offodile RS, Washington MK, Ballard BR, Smoot DT, Shi XZ, Forbes DS, Shanker A, M'Koma AE. Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn's colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease. PLoS One. 2021; 16(3):e0246393.
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Williams AD, Korolkova OY, Sakwe AM, Geiger TM, James SD, Muldoon RL, Herline AJ, Goodwin JS, Izban MG, Washington MK, Smoot DT, Ballard BR, Gazouli M, M'Koma AE. Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease. PLoS One. 2017; 12(8):e0179710.
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Johnson CA, Rachakonda G, Kleshchenko YY, Nde PN, Madison MN, Pratap S, Cardenas TC, Taylor C, Lima MF, Villalta F. Cellular response to Trypanosoma cruzi infection induces secretion of defensin a-1, which damages the flagellum, neutralizes trypanosome motility, and inhibits infection. Infect Immun. 2013 Nov; 81(11):4139-48.
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Madison MN, Kleshchenko YY, Nde PN, Simmons KJ, Lima MF, Villalta F. Human defensin alpha-1 causes Trypanosoma cruzi membrane pore formation and induces DNA fragmentation, which leads to trypanosome destruction. Infect Immun. 2007 Oct; 75(10):4780-91.
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Boyaka PN, Lillard JW, McGhee J. Interleukin 12 and innate molecules for enhanced mucosal immunity. Immunol Res. 1999; 20(3):207-17.
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Aley SB, Zimmerman M, Hetsko M, Selsted ME, Gillin FD. Killing of Giardia lamblia by cryptdins and cationic neutrophil peptides. Infect Immun. 1994 Dec; 62(12):5397-403.