"Phorbol 12,13-Dibutyrate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.
| Descriptor ID |
D015240
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| MeSH Number(s) |
D02.455.849.291.500.510.700
|
| Concept/Terms |
Phorbol 12,13-Dibutyrate- Phorbol 12,13-Dibutyrate
- 12,13-Dibutyrate, Phorbol
- Phorbol-12,13-Dibutyrate
- Phorbol 12,13 Dibutyrate
|
Below are MeSH descriptors whose meaning is more general than "Phorbol 12,13-Dibutyrate".
Below are MeSH descriptors whose meaning is more specific than "Phorbol 12,13-Dibutyrate".
This graph shows the total number of publications written about "Phorbol 12,13-Dibutyrate" by people in this website by year, and whether "Phorbol 12,13-Dibutyrate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phorbol 12,13-Dibutyrate" by people in Profiles.
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Hayoz S, Cubano L, Maldonado H, Bychkov R. Protein kinase A and C regulate leak potassium currents in freshly isolated vascular myocytes from the aorta. PLoS One. 2013; 8(9):e75077.
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Polzin A, Shipitsin M, Goi T, Feig LA, Turner TJ. Ral-GTPase influences the regulation of the readily releasable pool of synaptic vesicles. Mol Cell Biol. 2002 Mar; 22(6):1714-22.
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Ford BD, Ivy MT, Mtshali CP, Townsel JG. The involvement of protein kinase C in the regulation of choline cotransport in Limulus. Comp Biochem Physiol A Mol Integr Physiol. 1999 Jul; 123(3):255-61.
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McCrady CW, Staniswalis J, Pettit GR, Howe C, Grant S. Effect of pharmacologic manipulation of protein kinase C by phorbol dibutyrate and bryostatin 1 on the clonogenic response of human granulocyte-macrophage progenitors to recombinant GM-CSF. Br J Haematol. 1991 Jan; 77(1):5-15.