"Tryptophan Oxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is a LIVER-specific enzyme that is the first and rate limiting enzyme in the kynurenine pathway of TRYPTOPHAN catabolism.
| Descriptor ID |
D014366
|
| MeSH Number(s) |
D08.811.682.690.416.722
|
| Concept/Terms |
Tryptophan Oxygenase- Tryptophan Oxygenase
- Oxygenase, Tryptophan
- Tryptophan 2,3-Dioxygenase
- 2,3-Dioxygenase, Tryptophan
- Tryptophan 2,3 Dioxygenase
- TDO Dioxygenase
- Dioxygenase, TDO
- Tryptophan Pyrrolase
- Pyrrolase, Tryptophan
|
Below are MeSH descriptors whose meaning is more general than "Tryptophan Oxygenase".
Below are MeSH descriptors whose meaning is more specific than "Tryptophan Oxygenase".
This graph shows the total number of publications written about "Tryptophan Oxygenase" by people in this website by year, and whether "Tryptophan Oxygenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tryptophan Oxygenase" by people in Profiles.
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Chuang TD, Ton N, Rysling S, Quintanilla D, Boos D, Khorram O. Therapeutic effects of in?vivo administration of an inhibitor of tryptophan 2,3-dioxygenase (680c91) for the treatment of fibroids: a preclinical study. Fertil Steril. 2024 Apr; 121(4):669-678.
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Crawford K, Diaz Quiroz JF, Koenig KM, Ahuja N, Albertin CB, Rosenthal JJC. Highly Efficient Knockout of a Squid Pigmentation Gene. Curr Biol. 2020 09 07; 30(17):3484-3490.e4.
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Shin I, Ambler BR, Wherritt D, Griffith WP, Maldonado AC, Altman RA, Liu A. Stepwise O-Atom Transfer in Heme-Based Tryptophan Dioxygenase: Role of Substrate Ammonium in Epoxide Ring Opening. J Am Chem Soc. 2018 03 28; 140(12):4372-4379.
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Pellegrin K, Neurauter G, Wirleitner B, Fleming AW, Peterson VM, Fuchs D. Enhanced enzymatic degradation of tryptophan by indoleamine 2,3-dioxygenase contributes to the tryptophan-deficient state seen after major trauma. Shock. 2005 Mar; 23(3):209-15.