Pyrophosphatases

"Pyrophosphatases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A group of enzymes within the class EC 3.6.1.- that catalyze the hydrolysis of diphosphate bonds, chiefly in nucleoside di- and triphosphates. They may liberate either a mono- or diphosphate. EC 3.6.1.-.

Descriptor ID	D011755
MeSH Number(s)	D08.811.277.040.600
Concept/Terms	Pyrophosphatases Pyrophosphatases

Below are MeSH descriptors whose meaning is more general than "Pyrophosphatases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
Pyrophosphatases [D08.811.277.040.600]

Below are MeSH descriptors whose meaning is related to "Pyrophosphatases".

Below are MeSH descriptors whose meaning is more specific than "Pyrophosphatases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Pyrophosphatases" by people in this website by year, and whether "Pyrophosphatases" was a major or minor topic of these publications.

Bar chart showing 7 publications over 7 distinct years, with a maximum of 1 publications in 2001 and 2004 and 2017 and 2018 and 2020 and 2021 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2004	0	1	1
2017	0	1	1
2018	1	0	1
2020	1	0	1
2021	0	1	1
2024	1	0	1

Below are the most recent publications written about "Pyrophosphatases" by people in Profiles.

Ioannou S, Beecham A, Gomez L, Dauer R, Khakoo N, Pascual L, Quintero M, Lopez J, Leavitt JS, Solis N, Ortega M, Deshpande AR, Kerman DH, Proksell S, Torres EA, Haritunians T, Li D, Abreu MT, McGovern DPB, McCauley JL, Damas OM. Ancestral Diversity in Pharmacogenomics Affects Treatment for Hispanic/Latine Populations With Inflammatory Bowel Disease. Clin Gastroenterol Hepatol. 2025 May; 23(6):1008-1018.e7.

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Shimada BK, Pomozi V, Zoll J, Kuo S, Martin L, Le Saux O. ABCC6, Pyrophosphate and Ectopic Calcification: Therapeutic Solutions. Int J Mol Sci. 2021 Apr 27; 22(9).

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Roberts FL, Rashdan NA, Phadwal K, Markby GR, Dillon S, Zoll J, Berger J, Milne E, Orriss IR, Karsenty G, Le Saux O, Morton NM, Farquharson C, MacRae VE. Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice. J Cell Physiol. 2021 06; 236(6):4614-4624.

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Pomozi V, Julian CB, Zoll J, Pham K, Kuo S, Tok?si N, Martin L, V?radi A, Le Saux O. Dietary Pyrophosphate Modulates Calcification in a Mouse Model of Pseudoxanthoma Elasticum: Implication for Treatment of Patients. J Invest Dermatol. 2019 05; 139(5):1082-1088.

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Dedinszki D, Szeri F, Koz?k E, Pomozi V, Tok?si N, Mezei TR, Merczel K, Letavernier E, Tang E, Le Saux O, Ar?nyi T, van de Wetering K, V?radi A. Oral administration of pyrophosphate inhibits connective tissue calcification. EMBO Mol Med. 2017 11; 9(11):1463-1470.

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Chen M, O'Connor KL. Integrin alpha6beta4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells. Oncogene. 2005 Jul 28; 24(32):5125-30.

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Doherty TM, Fitzpatrick LA, Shaheen A, Rajavashisth TB, Detrano RC. Genetic determinants of arterial calcification associated with atherosclerosis. Mayo Clin Proc. 2004 Feb; 79(2):197-210.

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Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes AJ, Zhu Q, Bessman MJ, Penner R, Kinet JP, Scharenberg AM. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature. 2001 May 31; 411(6837):595-9.

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