"Glutamate Decarboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.
| Descriptor ID |
D005968
|
| MeSH Number(s) |
D08.811.520.224.125.250
|
| Concept/Terms |
Glutamate Decarboxylase- Glutamate Decarboxylase
- Decarboxylase, Glutamate
- Glutamic Acid Decarboxylase
- Acid Decarboxylase, Glutamic
- Decarboxylase, Glutamic Acid
- Glutamate Carboxy-Lyase
- Carboxy-Lyase, Glutamate
- Glutamate Carboxy Lyase
|
Below are MeSH descriptors whose meaning is more general than "Glutamate Decarboxylase".
Below are MeSH descriptors whose meaning is more specific than "Glutamate Decarboxylase".
This graph shows the total number of publications written about "Glutamate Decarboxylase" by people in this website by year, and whether "Glutamate Decarboxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Glutamate Decarboxylase" by people in Profiles.
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Boa-Amponsem O, Zhang C, Burton D, Williams KP, Cole GJ. Ethanol and Cannabinoids Regulate Zebrafish GABAergic Neuron Development and Behavior in a Sonic Hedgehog and Fibroblast Growth Factor-Dependent Mechanism. Alcohol Clin Exp Res. 2020 07; 44(7):1366-1377.
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Tao R, Davis KN, Li C, Shin JH, Gao Y, Jaffe AE, Gondr?-Lewis MC, Weinberger DR, Kleinman JE, Hyde TM. GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia. Mol Psychiatry. 2018 06; 23(6):1496-1505.
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Davis KN, Tao R, Li C, Gao Y, Gondr?-Lewis MC, Lipska BK, Shin JH, Xie B, Ye T, Weinberger DR, Kleinman JE, Hyde TM. GAD2 Alternative Transcripts in the Human Prefrontal Cortex, and in Schizophrenia and Affective Disorders. PLoS One. 2016; 11(2):e0148558.
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Pitts MW, Kremer PM, Hashimoto AC, Torres DJ, Byrns CN, Williams CS, Berry MJ. Competition between the Brain and Testes under Selenium-Compromised Conditions: Insight into Sex Differences in Selenium Metabolism and Risk of Neurodevelopmental Disease. J Neurosci. 2015 Nov 18; 35(46):15326-38.
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Zhang C, Frazier JM, Chen H, Liu Y, Lee JA, Cole GJ. Molecular and morphological changes in zebrafish following transient ethanol exposure during defined developmental stages. Neurotoxicol Teratol. 2014 Jul-Aug; 44:70-80.
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Yang K, Buhlman L, Khan GM, Nichols RA, Jin G, McIntosh JM, Whiteaker P, Lukas RJ, Wu J. Functional nicotinic acetylcholine receptors containing a6 subunits are on GABAergic neuronal boutons adherent to ventral tegmental area dopamine neurons. J Neurosci. 2011 Feb 16; 31(7):2537-48.
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S?nchez Montoya EL, Hern?ndez L, Barreto-Estrada JL, Ortiz JG, Jorge JC. The testosterone metabolite 3a-diol enhances female rat sexual motivation when infused in the nucleus accumbens shell. J Sex Med. 2010 Nov; 7(11):3598-609.
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Deister CA, Chan CS, Surmeier DJ, Wilson CJ. Calcium-activated SK channels influence voltage-gated ion channels to determine the precision of firing in globus pallidus neurons. J Neurosci. 2009 Jul 01; 29(26):8452-61.
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Radley JJ, Gosselink KL, Sawchenko PE. A discrete GABAergic relay mediates medial prefrontal cortical inhibition of the neuroendocrine stress response. J Neurosci. 2009 Jun 03; 29(22):7330-40.
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Patisaul HB, Fortino AE, Polston EK. Sex differences in serotonergic but not gamma-aminobutyric acidergic (GABA) projections to the rat ventromedial nucleus of the hypothalamus. Endocrinology. 2008 Jan; 149(1):397-408.