Depressive Disorder, Major

"Depressive Disorder, Major" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.

Descriptor ID	D003865
MeSH Number(s)	F03.600.300.375
Concept/Terms	Depressive Disorder, Major Depressive Disorder, Major Depressive Disorders, Major Disorder, Major Depressive Disorders, Major Depressive Major Depressive Disorders Major Depressive Disorder Psychosis, Involutional Psychosis, Involutional Involutional Psychoses Involutional Psychosis Psychoses, Involutional Paraphrenia, Involutional Paraphrenia, Involutional Involutional Paraphrenia Involutional Paraphrenias Paraphrenias, Involutional Depression, Involutional Depression, Involutional Involutional Depression Melancholia, Involutional Involutional Melancholia

Below are MeSH descriptors whose meaning is more general than "Depressive Disorder, Major".

Psychiatry and Psychology [F]
Mental Disorders [F03]
Mood Disorders [F03.600]
Depressive Disorder [F03.600.300]
Depressive Disorder, Major [F03.600.300.375]

Below are MeSH descriptors whose meaning is related to "Depressive Disorder, Major".

Below are MeSH descriptors whose meaning is more specific than "Depressive Disorder, Major".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Depressive Disorder, Major" by people in this website by year, and whether "Depressive Disorder, Major" was a major or minor topic of these publications.

Bar chart showing 113 publications over 25 distinct years, with a maximum of 11 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	1	0	1
2000	1	0	1
2003	1	0	1
2004	3	1	4
2005	6	3	9
2006	2	1	3
2007	2	1	3
2008	5	0	5
2009	3	2	5
2010	3	0	3
2011	3	3	6
2012	3	2	5
2013	1	1	2
2014	9	2	11
2015	6	0	6
2016	6	0	6
2017	3	1	4
2018	4	2	6
2019	1	0	1
2020	4	1	5
2021	9	0	9
2022	4	0	4
2023	8	0	8
2024	2	0	2
2025	2	1	3

Below are the most recent publications written about "Depressive Disorder, Major" by people in Profiles.

Musicaro RM, Valdespino-Hayden Z, Lozano MM, Ramos CN, Joshipura K, Lowe SR. Pre-disaster Health Vulnerabilities Predict Major Depressive Disorder Symptoms Among High-Risk Puerto Rican Adults after Hurricanes Maria and Irma. Disaster Med Public Health Prep. 2025 Feb 06; 19:e22.

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Ca?izares C, G?mez-Maquet Y, Ferro E, Torres CA, Agudelo DM, Odom G. Using tree-based models to identify factors contributing to trait negative affect in adults. BMC Psychol. 2025 Feb 01; 13(1):92.

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Liang J, Hussainy S, Lee SM, Wu G, Bautista N, Ding M, Wang H, LaFleur B, Perry G, Wang X. Association of Polygenic Risk Score for 5 Diseases With Alzheimer Disease Progression, Biomarkers, and Amyloid Deposition. Neurology. 2025 Feb 25; 104(4):e210250.

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Daskalakis NP, Iatrou A, Chatzinakos C, Jajoo A, Snijders C, Wylie D, DiPietro CP, Tsatsani I, Chen CY, Pernia CD, Soliva-Estruch M, Arasappan D, Bharadwaj RA, Collado-Torres L, Wuchty S, Alvarez VE, Dammer EB, Deep-Soboslay A, Duong DM, Eagles N, Huber BR, Huuki L, Holstein VL, Logue MW, Lugenb?hl JF, Maihofer AX, Miller MW, Nievergelt CM, Pertea G, Ross D, Sendi MSE, Sun BB, Tao R, Tooke J, Wolf EJ, Zeier Z, Berretta S, Champagne FA, Hyde T, Seyfried NT, Shin JH, Weinberger DR, Nemeroff CB, Kleinman JE, Ressler KJ. Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood. Science. 2024 05 24; 384(6698):eadh3707.

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VanBronkhorst SB, Abraham E, Dambreville R, Ramos-Olazagasti MA, Wall M, Saunders DC, Monk C, Alegr?a M, Canino GJ, Bird H, Duarte CS. Sociocultural Risk and Resilience in the Context of Adverse Childhood Experiences. JAMA Psychiatry. 2024 Apr 01; 81(4):406-413.

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Nayyar S, Archibong A, Nayyar T. Testosterone and Prolactin Perturbations Possibly Associated with Reduced Levels of ?-Arrestin1 in Mononuclear Leukocytes of Women with Premenstrual Dysphoric Disorder. Int J Mol Sci. 2023 Oct 22; 24(20).

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Wilson JB, Epstein M, Lopez B, Brown AK, Lutfy K, Friedman TC. The role of Neurochemicals, Stress Hormones and Immune System in the Positive Feedback Loops between Diabetes, Obesity and Depression. Front Endocrinol (Lausanne). 2023; 14:1224612.

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Chatzinakos C, Pernia CD, Morrison FG, Iatrou A, McCullough KM, Schuler H, Snijders C, Bajaj T, DiPietro CP, Soliva Estruch M, Gassen NC, Anastasopoulos C, Bharadwaj RA, Bowlby BC, Hartmann J, Maihofer AX, Nievergelt CM, Ressler NM, Wolf EJ, Carlezon WA, Krystal JH, Kleinman JE, Girgenti MJ, Huber BR, Kellis M, Logue MW, Miller MW, Ressler KJ, Daskalakis NP. Single-Nucleus Transcriptome Profiling of Dorsolateral Prefrontal Cortex: Mechanistic Roles for Neuronal Gene Expression, Including the 17q21.31 Locus, in PTSD Stress Response. Am J Psychiatry. 2023 10 01; 180(10):739-754.

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Lu W, Keyes KM. Major depression with co-occurring suicidal thoughts, plans, and attempts: An increasing mental health crisis in US adolescents, 2011-2020. Psychiatry Res. 2023 09; 327:115352.

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Chang CY, Park H, Hincapie-Castillo JM, Heldermon CD, Diaby V, Yang S, Wilson DL, Lo-Ciganic WH. Trends, characteristics, race, and ethnicity associated with nonadherence to antidepressants among breast cancer survivors with depression. J Manag Care Spec Pharm. 2023 Apr; 29(4):431-445.

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