Antigens, Polyomavirus Transforming
"Antigens, Polyomavirus Transforming" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
| Descriptor ID |
D000952
|
| MeSH Number(s) |
D12.776.624.664.520.090 D12.776.964.700.090 D23.050.285.062.090 D23.050.327.062.090
|
| Concept/Terms |
Antigens, Polyomavirus Transforming- Antigens, Polyomavirus Transforming
- Polyomavirus Tumor Antigens
- Antigens, Polyomavirus Tumor
- Tumor Antigens, Polyomavirus
- Polyomavirus Transforming Antigens
- Transforming Antigens, Polyomavirus
SV40 T Proteins- SV40 T Proteins
- Proteins, SV40 T
- T Proteins, SV40
- SV40 T Antigens
- Antigens, SV40 T
- T Antigens, SV40
|
Below are MeSH descriptors whose meaning is more general than "Antigens, Polyomavirus Transforming".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Neoplasm Proteins [D12.776.624]
- Oncogene Proteins [D12.776.624.664]
- Oncogene Proteins, Viral [D12.776.624.664.520]
- Antigens, Polyomavirus Transforming [D12.776.624.664.520.090]
- Viral Proteins [D12.776.964]
- Oncogene Proteins, Viral [D12.776.964.700]
- Antigens, Polyomavirus Transforming [D12.776.964.700.090]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Neoplasm [D23.050.285]
- Antigens, Viral, Tumor [D23.050.285.062]
- Antigens, Polyomavirus Transforming [D23.050.285.062.090]
- Antigens, Viral [D23.050.327]
- Antigens, Viral, Tumor [D23.050.327.062]
- Antigens, Polyomavirus Transforming [D23.050.327.062.090]
Below are MeSH descriptors whose meaning is more specific than "Antigens, Polyomavirus Transforming".
This graph shows the total number of publications written about "Antigens, Polyomavirus Transforming" by people in this website by year, and whether "Antigens, Polyomavirus Transforming" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2008 | 2 | 1 | 3 |
| 2010 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Antigens, Polyomavirus Transforming" by people in Profiles.
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Guillory B, Sakwe AM, Saria M, Thompson P, Adhiambo C, Koumangoye R, Ballard B, Binhazim A, Cone C, Jahanen-Dechent W, Ochieng J. Lack of fetuin-A (alpha2-HS-glycoprotein) reduces mammary tumor incidence and prolongs tumor latency via the transforming growth factor-beta signaling pathway in a mouse model of breast cancer. Am J Pathol. 2010 Nov; 177(5):2635-44.
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Carbone M, Pannuti A, Zhang L, Testa JR, Bocchetta M. A novel mechanism of late gene silencing drives SV40 transformation of human mesothelial cells. Cancer Res. 2008 Nov 15; 68(22):9488-96.
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Bocchetta M, Eliasz S, De Marco MA, Rudzinski J, Zhang L, Carbone M. The SV40 large T antigen-p53 complexes bind and activate the insulin-like growth factor-I promoter stimulating cell growth. Cancer Res. 2008 Feb 15; 68(4):1022-9.
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Bocchetta M, Carbone M. SV40 Tag/p53 complexes actively promote malignant cell growth of human mesothelial cells. Cell Oncol. 2008; 30(5):455.
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Hui L, Rodrik V, Pielak RM, Knirr S, Zheng Y, Foster DA. mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells. J Biol Chem. 2005 Oct 28; 280(43):35829-35.
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Carbone M, Rudzinski J, Bocchetta M. High throughput testing of the SV40 Large T antigen binding to cellular p53 identifies putative drugs for the treatment of SV40-related cancers. Virology. 2003 Oct 25; 315(2):409-14.
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Ozer HL, Banga SS, Dasgupta T, Houghton J, Hubbard K, Jha KK, Kim SH, Lenahan M, Pang Z, Pardinas JR, Patsalis PC. SV40-mediated immortalization of human fibroblasts. Exp Gerontol. 1996 Jan-Apr; 31(1-2):303-10.
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Ferber A, Chang C, Sell C, Ptasznik A, Cristofalo VJ, Hubbard K, Ozer HL, Adamo M, Roberts CT, LeRoith D, et al. Failure of senescent human fibroblasts to express the insulin-like growth factor-1 gene. J Biol Chem. 1993 Aug 25; 268(24):17883-8.
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Bargonetti J, Reynisd?ttir I, Friedman PN, Prives C. Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53. Genes Dev. 1992 Oct; 6(10):1886-98.
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Farmer G, Bargonetti J, Zhu H, Friedman P, Prywes R, Prives C. Wild-type p53 activates transcription in vitro. Nature. 1992 Jul 02; 358(6381):83-6.