"Aldehyde Reductase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes reversibly the oxidation of an aldose to an alditol. It possesses broad specificity for many aldoses. EC 1.1.1.21.
| Descriptor ID |
D000449
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| MeSH Number(s) |
D08.811.682.047.150.700.156.500 D08.811.682.047.820.284.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Aldehyde Reductase".
Below are MeSH descriptors whose meaning is more specific than "Aldehyde Reductase".
This graph shows the total number of publications written about "Aldehyde Reductase" by people in this website by year, and whether "Aldehyde Reductase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2003 | 3 | 0 | 3 |
| 2004 | 1 | 1 | 2 |
| 2005 | 1 | 2 | 3 |
| 2006 | 3 | 1 | 4 |
| 2009 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
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Below are the most recent publications written about "Aldehyde Reductase" by people in Profiles.
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Yamamoto K, Wilson DK. Identification, characterization, and crystal structure of an aldo-keto reductase (AKR2E4) from the silkworm Bombyx mori. Arch Biochem Biophys. 2013 Oct 15; 538(2):156-63.
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Jinsmaa Y, Florang VR, Rees JN, Anderson DG, Strack S, Doorn JA. Products of oxidative stress inhibit aldehyde oxidation and reduction pathways in dopamine catabolism yielding elevated levels of a reactive intermediate. Chem Res Toxicol. 2009 May; 22(5):835-41.
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Di Luccio E, Elling RA, Wilson DK. Identification of a novel NADH-specific aldo-keto reductase using sequence and structural homologies. Biochem J. 2006 Nov 15; 400(1):105-14.
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Kratzer R, Wilson DK, Nidetzky B. Catalytic mechanism and substrate selectivity of aldo-keto reductases: insights from structure-function studies of Candida tenuis xylose reductase. IUBMB Life. 2006 Sep; 58(9):499-507.
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Robins LI, Dixon SM, Wilson DK, Kurth MJ. On-bead combinatorial techniques for the identification of selective aldose reductase inhibitors. Bioorg Med Chem. 2006 Dec 01; 14(23):7728-35.
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Kratzer R, Leitgeb S, Wilson DK, Nidetzky B. Probing the substrate binding site of Candida tenuis xylose reductase (AKR2B5) with site-directed mutagenesis. Biochem J. 2006 Jan 01; 393(Pt 1):51-8.
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Dixon S, Robins L, Elling RA, Liu R, Lam KS, Wilson DK, Kurth MJ. Discovery of selective aldo-keto reductase ligands--an on-bead assay strategy. Bioorg Med Chem Lett. 2005 Jun 02; 15(11):2938-42.
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Leitgeb S, Petschacher B, Wilson DK, Nidetzky B. Fine tuning of coenzyme specificity in family 2 aldo-keto reductases revealed by crystal structures of the Lys-274-->Arg mutant of Candida tenuis xylose reductase (AKR2B5) bound to NAD+ and NADP+. FEBS Lett. 2005 Jan 31; 579(3):763-7.
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Petschacher B, Leitgeb S, Kavanagh KL, Wilson DK, Nidetzky B. The coenzyme specificity of Candida tenuis xylose reductase (AKR2B5) explored by site-directed mutagenesis and X-ray crystallography. Biochem J. 2005 Jan 01; 385(Pt 1):75-83.
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Kratzer R, Kavanagh KL, Wilson DK, Nidetzky B. Studies of the enzymic mechanism of Candida tenuis xylose reductase (AKR 2B5): X-ray structure and catalytic reaction profile for the H113A mutant. Biochemistry. 2004 May 04; 43(17):4944-54.