Adrenergic alpha-Antagonists
"Adrenergic alpha-Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
| Descriptor ID |
D000317
|
| MeSH Number(s) |
D27.505.519.625.050.200.100 D27.505.696.577.050.200.100
|
| Concept/Terms |
Adrenergic alpha-Antagonists- Adrenergic alpha-Antagonists
- Adrenergic alpha Antagonists
- alpha-Antagonists, Adrenergic
- Adrenergic alpha-Receptor Blockaders
- Adrenergic alpha Receptor Blockaders
- Blockaders, Adrenergic alpha-Receptor
- alpha-Receptor Blockaders, Adrenergic
- alpha-Adrenergic Blocking Agents
- Agents, alpha-Adrenergic Blocking
- Blocking Agents, alpha-Adrenergic
- alpha Adrenergic Blocking Agents
- alpha-Adrenergic Blockers
- Blockers, alpha-Adrenergic
- alpha Adrenergic Blockers
- alpha-Blockers, Adrenergic
- alpha Blockers, Adrenergic
- alpha-Adrenergic Receptor Blockaders
- Blockaders, alpha-Adrenergic Receptor
- Receptor Blockaders, alpha-Adrenergic
- alpha Adrenergic Receptor Blockaders
- Adrenergic alpha-Blockers
- Adrenergic alpha Blockers
|
Below are MeSH descriptors whose meaning is more general than "Adrenergic alpha-Antagonists".
Below are MeSH descriptors whose meaning is more specific than "Adrenergic alpha-Antagonists".
This graph shows the total number of publications written about "Adrenergic alpha-Antagonists" by people in this website by year, and whether "Adrenergic alpha-Antagonists" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 1 | 1 | 2 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 1 | 2 |
| 2008 | 0 | 2 | 2 |
| 2009 | 2 | 3 | 5 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Adrenergic alpha-Antagonists" by people in Profiles.
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Urushiyama H, Terasaki Y, Nagasaka S, Kokuho N, Endo Y, Terasaki M, Kunugi S, Makita K, Isago H, Hosoki K, Souma K, Ishii T, Matsuzaki H, Hiraishi Y, Mikami Y, Noguchi S, Tamiya H, Mitani A, Yamauchi Y, Shimizu A, Nagase T. Naftopidil reduced the proliferation of lung fibroblasts and bleomycin-induced lung fibrosis in mice. J Cell Mol Med. 2019 05; 23(5):3563-3571.
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Holmes A, Quirk GJ. Pharmacological facilitation of fear extinction and the search for adjunct treatments for anxiety disorders--the case of yohimbine. Trends Pharmacol Sci. 2010 Jan; 31(1):2-7.
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Nag S, Mokha SS. Testosterone is essential for alpha(2)-adrenoceptor-induced antinociception in the trigeminal region of the male rat. Neurosci Lett. 2009 Dec 18; 467(1):48-52.
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Grimm RH, Davis BR, Piller LB, Cutler JA, Margolis KL, Barzilay J, Dart RA, Graumlich JF, Murden RA, Randall OS. Heart failure in ALLHAT: did blood pressure medication at study entry influence outcome? J Clin Hypertens (Greenwich). 2009 Sep; 11(9):466-74.
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Miksa M, Das P, Zhou M, Wu R, Dong W, Ji Y, Goyert SM, Ravikumar TS, Wang P. Pivotal role of the alpha(2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsis. PLoS One. 2009; 4(5):e5504.
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Ajmo CT, Collier LA, Leonardo CC, Hall AA, Green SM, Womble TA, Cuevas J, Willing AE, Pennypacker KR. Blockade of adrenoreceptors inhibits the splenic response to stroke. Exp Neurol. 2009 Jul; 218(1):47-55.
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Mueller D, Olivera-Figueroa LA, Pine DS, Quirk GJ. The effects of yohimbine and amphetamine on fear expression and extinction in rats. Psychopharmacology (Berl). 2009 Jul; 204(4):599-606.
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Nag S, Wang Q, Limbird LE, Mokha SS. Knockout of spinophilin, an endogenous antagonist of arrestin-dependent alpha2-adrenoceptor functions, enhances receptor-mediated antinociception yet does not eliminate sex-related differences. Behav Brain Res. 2009 Feb 11; 197(2):457-61.
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Thompson AD, Angelotti T, Nag S, Mokha SS. Sex-specific modulation of spinal nociception by alpha2-adrenoceptors: differential regulation by estrogen and testosterone. Neuroscience. 2008 Jun 02; 153(4):1268-77.
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Taylor FB, Martin P, Thompson C, Williams J, Mellman TA, Gross C, Peskind ER, Raskind MA. Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: a placebo-controlled study. Biol Psychiatry. 2008 Mar 15; 63(6):629-32.