Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14a-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity.

Hargrove TY, Garvey EP, Hoekstra WJ, Yates CM, Wawrzak Z, Rachakonda G, Villalta F, Lepesheva GI. Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14a-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity. Antimicrob Agents Chemother. 2017 07; 61(7).

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subject areas

Antifungal Agents
Aspergillus fumigatus
Candida albicans
Drugs, Investigational
Fluconazole
Ketoconazole
Microbial Sensitivity Tests
Pyridines
Tetrazoles
Triazoles

authors with profiles

Fernando Villalta

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