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Identifying and mapping functional connections of feeding control neurons in the


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Collapse Overview 
Collapse abstract
Neuron populations in the hypothalamus and hindbrain form nodes within a larger distributed network to control multiple aspects of feeding behavior in mammals. The goal of this project is to identify and map arcade hypothalamic circuits that respond to circulating hormones that control feeding behavior. At the heart of this project lies a novel combination of functional neuroanatomical techniques: tract-tracing, wide-field and multi- fluorescence imaging, reference atlas-based mapping, and data deposition within an online neuron informatics database. These methods are being brought to bear on the arcuate hypothalamus, because it has remained a relatively uncharted and poorly defined brain structure that is otherwise critical for feeding behavior. Knowledge of the basic circuit organization of this structure, through its complete three dimensional expanse, is critical for scientists to be able to further experimentally manipulate selected sub-populations of neurons in this structure to study various aspects of feeding control. This, in turn, is expected to yield novl targets within the brain suitable for designing rationale therapeutics and treatments to help prevent or mitigate the effects of obesity, overeating, and metabolic disorders.
Collapse sponsor award id
SC3GM109817

Collapse Time 
Collapse start date
2014-04-01
Collapse end date
2018-05-31
RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

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