The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.

Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci PG. The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential. J Biol Chem. 2004 Jun 11; 279(24):25689-95.

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subject areas

Adaptor Proteins, Vesicular Transport
Aging
Animals
Apoptosis
Caspase 3
Caspases
Cells, Cultured
Cytochromes c
Endoplasmic Reticulum
HSP70 Heat-Shock Proteins
Membrane Potentials
Mice
Mitochondria
Oxidative Stress
Protein Transport
Ultraviolet Rays

authors with profiles

Monica Gabriela Ferrini, PhD

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