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Joann B. Powell

Faculty RankAssociate Professor
InstitutionClark Atlanta University
DepartmentBiological Sciences
Address223 James P. Brawley Drive
Atlanta GA 30314
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    Collapse Overview 
    Collapse overview
    Our lab aims to understand the molecular mechanisms by which cancer cells progress into advanced and malignant phenotypes. In particular, we focus on the role of the aryl hydrocarbon receptor (AhR) in prostate cancer progression. AhR is widely known for its role in mediating the harmful effects of a number of environmental toxins. However, evidence suggests that it may also play a key role in the progression of prostate cancer from castration dependent to castration independent. Specific goals of our lab are to:
    1. Determine the role of AhR in the development of castration independent prostate cancer via interaction with the androgen signaling pathway.

    2. Investigate the effects of environmental toxins (AhR agonist) on prostate cancer progression.

    3 Establish AhR as a potential therapeutic target in the treatment of castration independent prostate cancer.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ghotbaddini M, Moultrie V, Powell JB. Constitutive Aryl Hydrocarbon Receptor Signaling in Prostate Cancer Progression. J Cancer Treatment Diagn. 2018; 2(5):11-16. PMID: 31328183.
    2. Ghotbaddini M, Cisse K, Carey A, Powell JB. Simultaneous inhibition of aryl hydrocarbon receptor (AhR) and Src abolishes androgen receptor signaling. PLoS One. 2017; 12(7):e0179844. PMID: 28671964.
      Citations: 4     Fields:    Translation:HumansCells
    3. Ghotbaddini M, Powell JB. The AhR Ligand, TCDD, Regulates Androgen Receptor Activity Differently in Androgen-Sensitive versus Castration-Resistant Human Prostate Cancer Cells. Int J Environ Res Public Health. 2015 Jul 06; 12(7):7506-18. PMID: 26154658.
      Citations: 10     Fields:    Translation:HumansCells
    4. Richmond O, Ghotbaddini M, Allen C, Walker A, Zahir S, Powell JB. The aryl hydrocarbon receptor is constitutively active in advanced prostate cancer cells. PLoS One. 2014; 9(4):e95058. PMID: 24755659.
      Citations: 13     Fields:    Translation:HumansCells
    5. Powell JB, Ghotbaddini M. Cancer-promoting and Inhibiting Effects of Dietary Compounds: Role of the Aryl Hydrocarbon Receptor (AhR). Biochem Pharmacol (Los Angel). 2014 Mar 08; 3(1). PMID: 25258701.
    6. Ghotbaddini M, Powell JB. Biochem Pharmacol. Cancer-promoting and Inhibiting Effects of Dietary Compounds: Role of the Aryl Hydrocarbon Receptor (AhR). 2014; 131(3).
    7. Powell JB, Goode GD, Eltom SE. The Aryl Hydrocarbon Receptor: A Target for Breast Cancer Therapy. J Cancer Ther. 2013 Sep; 4(7):1177-1186. PMID: 25068070.
    8. Powell J.B., Goode G. and Eltom S. E. . Journal of Cancer Therapy. The Aryl Hydrocarbon Receptor: A Target for Breast Cancer Therapy. 2013; 4:1177-1186. View Publication.
    9. Tran C, Richmond O, Aaron L, Powell JB. Inhibition of constitutive aryl hydrocarbon receptor (AhR) signaling attenuates androgen independent signaling and growth in (C4-2) prostate cancer cells. Biochem Pharmacol. 2013 Mar 15; 85(6):753-62. PMID: 23266674.
      Citations: 15     Fields:    Translation:HumansCells
    10. Brooks J, Eltom SE. Malignant transformation of mammary epithelial cells by ectopic overexpression of the aryl hydrocarbon receptor. Curr Cancer Drug Targets. 2011 Jun; 11(5):654-69. PMID: 21486221.
      Citations: 27     Fields:    Translation:HumansCells
    11. Liang Z, Brooks J, Willard M, Liang K, Yoon Y, Kang S, Shim H. CXCR4/CXCL12 axis promotes VEGF-mediated tumor angiogenesis through Akt signaling pathway. Biochem Biophys Res Commun. 2007 Aug 03; 359(3):716-22. PMID: 17559806.
      Citations: 110     Fields:    Translation:HumansCells
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