Guangdi Wang to Structure-Activity Relationship
This is a "connection" page, showing publications Guangdi Wang has written about Structure-Activity Relationship.
Connection Strength
1.215
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Peng X, Guo S, Zheng S, Hossain A, Zhang C, Mottamal M, Skripnikova E, Ma P, Martinez-Carter K, Zhang Q, Abedin F, Huckaba T, Wang G. Discovery of Oral Degraders of the ROS1 Fusion Protein with Potent Activity against Secondary Resistance Mutations. J Med Chem. 2024 Oct 24; 67(20):18098-18123.
Score: 0.193
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Luo L, Zhong Q, Guo S, Zhang C, Zhang Q, Zheng S, He L, Wang G. Development of a bioavailable boron-containing PI-103 Bioisostere, PI-103BE. Bioorg Med Chem Lett. 2020 07 15; 30(14):127258.
Score: 0.143
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Zhao LM, Cao FX, Jin HS, Zhang JH, Szwaya J, Wang G. One-pot synthesis of 1,4-dihydroxy-2-((E)-1-hydroxy-4-phenylbut-3-enyl)anthracene-9,10-diones as novel shikonin analogs and evaluation of their antiproliferative activities. Bioorg Med Chem Lett. 2016 06 01; 26(11):2691-4.
Score: 0.107
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Zheng S, Liu J, Wu Y, Huang TL, Wang G. Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics. Future Med Chem. 2015; 7(18):2485-505.
Score: 0.105
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Zhao LM, Ma FY, Jin HS, Zheng S, Zhong Q, Wang G. Design and synthesis of novel hydroxyanthraquinone nitrogen mustard derivatives as potential anticancer agents via a bioisostere approach. Eur J Med Chem. 2015 Sep 18; 102:303-9.
Score: 0.102
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Zheng S, Zhong Q, Xi Y, Mottamal M, Zhang Q, Schroeder RL, Sridhar J, He L, McFerrin H, Wang G. Modification and biological evaluation of thiazole derivatives as novel inhibitors of metastatic cancer cell migration and invasion. J Med Chem. 2014 Aug 14; 57(15):6653-67.
Score: 0.095
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Zheng S, Zhong Q, Mottamal M, Zhang Q, Zhang C, Lemelle E, McFerrin H, Wang G. Design, synthesis, and biological evaluation of novel pyridine-bridged analogues of combretastatin-A4 as anticancer agents. J Med Chem. 2014 Apr 24; 57(8):3369-81.
Score: 0.093
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Jiang Q, Payton-Stewart F, Elliott S, Driver J, Rhodes LV, Zhang Q, Zheng S, Bhatnagar D, Boue SM, Collins-Burow BM, Sridhar J, Stevens C, McLachlan JA, Wiese TE, Burow ME, Wang G. Effects of 7-O substitutions on estrogenic and anti-estrogenic activities of daidzein analogues in MCF-7 breast cancer cells. J Med Chem. 2010 Aug 26; 53(16):6153-63.
Score: 0.073
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Zhang Q, Ma P, Iszard M, Cole RB, Wang W, Wang G. In vitro metabolism of R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo [1,2,3-de]1,4-benzoxazinyl]-(1-naphthalenyl) methanone mesylate, a cannabinoid receptor agonist. Drug Metab Dispos. 2002 Oct; 30(10):1077-86.
Score: 0.042
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Yin H, Chen Y, Zhong Q, Zheng S, Wang G, He L. Design, synthesis, and antitumor study of a series of novel 1-Oxa-4-azaspironenone derivatives. Bioorg Med Chem Lett. 2022 10 15; 74:128925.
Score: 0.042
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Chen C, Luo Y, Yin H, Zhong Q, Zheng S, Liu R, Zhao C, Wang G, He L. Design, synthesis, and antitumor activity evaluation of novel acyl sulfonamide spirodienones. Bioorg Med Chem. 2022 04 15; 60:116626.
Score: 0.040
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Luo L, Jia JJ, Zhong Q, Zhong X, Zheng S, Wang G, He L. Synthesis and anticancer activity evaluation of naphthalene-substituted triazole spirodienones. Eur J Med Chem. 2021 Mar 05; 213:113039.
Score: 0.037
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Yang Z, Zhong Q, Zheng S, Wang G, He L. Synthesis and Antitumor Activity of a Series of Novel 1-Oxa-4-azaspiro[4,5]deca-6,9-diene-3,8-dione Derivatives. Molecules. 2019 Mar 07; 24(5).
Score: 0.033
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Vue B, Zhang S, Vignau A, Chen G, Zhang X, Diaz W, Zhang Q, Zheng S, Wang G, Chen QH. O-Aminoalkyl-O-Trimethyl-2,3-Dehydrosilybins: Synthesis and In Vitro Effects Towards Prostate Cancer Cells. Molecules. 2018 Nov 29; 23(12).
Score: 0.032
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Li Y, Cao TT, Guo S, Zhong Q, Li CH, Li Y, Dong L, Zheng S, Wang G, Yin SF. Discovery of Novel Allopurinol Derivatives with Anticancer Activity and Attenuated Xanthine Oxidase Inhibition. Molecules. 2016 Jun 20; 21(6).
Score: 0.027
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Liu J, Pham PT, Skripnikova EV, Zheng S, Lovings LJ, Wang Y, Goyal N, Bellow SM, Mensah LM, Chatters AJ, Bratton MR, Wiese TE, Zhao M, Wang G, Foroozesh M. A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2. J Med Chem. 2015 Aug 27; 58(16):6481-93.
Score: 0.026
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Wang R, Chen C, Zhang X, Zhang C, Zhong Q, Chen G, Zhang Q, Zheng S, Wang G, Chen QH. Structure-Activity Relationship and Pharmacokinetic Studies of 1,5-Diheteroarylpenta-1,4-dien-3-ones: A Class of Promising Curcumin-Based Anticancer Agents. J Med Chem. 2015 Jun 11; 58(11):4713-26.
Score: 0.025