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Braulio Jimenez

TitleToxicologist
InstitutionUniversity of Puerto Rico
DepartmentBiochemistry
AddressUniversity of Puerto Rico
Medical Sciences Campus, School of Medicine
Dep. of Biochemistry
San Juan PR 00936
Phone787-758-2525 x-1235
Fax787-274-8724
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    Other Positions
    TitleDirector
    InstitutionCenter for Environmental and Toxicological Research; University of Puerto Rico
    DepartmentBiochemistry

    TitleProfessor
    InstitutionUniversity of Puerto Rico
    DepartmentEnvironmental Health

    TitleDirector
    InstitutionUniversity of Puerto Rico
    DepartmentBiochemistry


    Collapse Biography 
    Collapse awards and honors
    1988Technical Communication Award, Society for Technical Communication (Tn)
    1994Postdoctoral Fellow in Toxicology, Ford Foundation
    1994Scholarly Productivity Award , University of Puerto Rico
    1996Scholarly Productivity Award , University of Puerto rico
    1999Glaxo Research Award, GlaxoSmithKline
    2007Toxicology lecture, University of Norbert Wiener (Peru)
    2010member , Puerto Rico Arts and Sciences Academy
    2011Merck Health Innovation Award, Merck
    2011Presidential Award, Hispanic Organization of Toxicologist

    Collapse Overview 
    Collapse overview
    We are interested in identifying and studying genes that are affected by environmental pollutants (particularly from exposure to airborne particulate matter). We have focused our research on environmental problems and issues that affect the Puerto Rican population. As an environmental toxicologist I have been studying the possible relationships between respiratory diseases and various constituents of local airborne particulate matter from various regions of Puerto Rico. Coupled to airborne particulates in Puerto Rico we have the influence of African dust and volcanic particles that seasonally and sporadically arrive to our island environment. We have been studying the effects of African Dust Storms that move across the Atlantic Ocean and impacts the island of Puerto Rico. Efforts are guided towards identifying chemical and biological constituents of airborne particles responsible for inducing toxicological and immune responses in the lung. To do this we use human bronchial epithelial cell lines as a research model. Our goal is to discover and identify the mechanisms by which various constituents modify biochemical responses that can induce the development of disease.

    Our laboratory has shown that particles originating from African dust as well as local urban dust strengthen the immunological responses of lung cells to release pro-inflammatory cytokines (IL6, and IL8). The mechanisms by which these responses are induced, involve the interactions of heavy metals, endotoxins and organics. We have found that both Nrf2 and NFkB are induced by local and African dust. We are currently studying the mechanisms by which these three constituents induce these immunological responses. In addition we are studying polymorphism in various genes identified by us by the effects of particle pollution using in vitro models on the Puerto Rican asthmatic population.

    We have also demonstrated that these constituents also affect the expression of other genes such as the Mayor Histocompatibility Complex Class II (MHCII) and the nuclear orphan receptor (PXR) from the detoxification system. Studies are currently being designed to explain these findings.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gioda A, Rodríguez-Cotto RI, Amaral BS, Encarnación-Medina J, Ortiz-Martínez MG, Jiménez-Vélez BD. Biodiesel from soybean promotes cell proliferation in vitro. Toxicol In Vitro. 2016 Aug; 34:283-288. PMID: 27179667.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    2. Ortiz-Martínez MG, Rodríguez-Cotto RI, Ortiz-Rivera MA, Pluguez-Turull CW, Jiménez-Vélez BD. Linking Endotoxins, African Dust PM10 and Asthma in an Urban and Rural Environment of Puerto Rico. Mediators Inflamm. 2015; 2015:784212. PMID: 26681839.
      Citations: 7     Fields:    Translation:Humans
    3. Rodríguez-Cotto RI, Ortiz-Martínez MG, Jiménez-Vélez BD. Organic extracts from African dust storms stimulate oxidative stress and induce inflammatory responses in human lung cells through Nrf2 but not NF-?B. Environ Toxicol Pharmacol. 2015 Mar; 39(2):845-56. PMID: 25769104.
      Citations: 5     Fields:    Translation:HumansCells
    4. Rodríguez-Cotto RI, Ortiz-Martínez MG, Rivera-Ramírez E, Mateus VL, Amaral BS, Jiménez-Vélez BD, Gioda A. Particle pollution in Rio de Janeiro, Brazil: increase and decrease of pro-inflammatory cytokines IL-6 and IL-8 in human lung cells. Environ Pollut. 2014 Nov; 194:112-120. PMID: 25106047.
      Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
    5. Ferguson KK, Cantonwine DE, Rivera-González LO, Loch-Caruso R, Mukherjee B, Anzalota Del Toro LV, Jiménez-Vélez B, Calafat AM, Ye X, Alshawabkeh AN, Cordero JF, Meeker JD. Urinary phthalate metabolite associations with biomarkers of inflammation and oxidative stress across pregnancy in Puerto Rico. Environ Sci Technol. 2014 Jun 17; 48(12):7018-25. PMID: 24845688.
      Citations: 33     Fields:    Translation:Humans
    6. Andrea R. da Silva, Ricardo Q. Aucélio, Rosa I. Rodríguez-Cotto, ?Mario G. Ortiz-Mart ínez, Evasomary Rivera-Ramírez, Daniela Perroni Frias, Mariangela Macchione, Braulio Jiménez-Vélez, and Adriana Gioda. J Nanopart Res. Physicochemical properties and toxicological assessment of modified CdS nanoparticles. 2014; 16:2655. View Publication.
    7. Cantonwine DE, Cordero JF, Rivera-González LO, Anzalota Del Toro LV, Ferguson KK, Mukherjee B, Calafat AM, Crespo N, Jiménez-Vélez B, Padilla IY, Alshawabkeh AN, Meeker JD. Urinary phthalate metabolite concentrations among pregnant women in Northern Puerto Rico: distribution, temporal variability, and predictors. Environ Int. 2014 Jan; 62:1-11. PMID: 24161445.
      Citations: 45     Fields:    Translation:Humans
    8. Rodríguez-Cotto RI, Ortiz-Martínez MG, Rivera-Ramírez E, Méndez LB, Dávila JC, Jiménez-Vélez BD. African Dust Storms Reaching Puerto Rican Coast Stimulate the Secretion of IL-6 and IL-8 and Cause Cytotoxicity to Human Bronchial Epithelial Cells (BEAS-2B). Health (Irvine Calif). 2013 Oct; 5(10B):14-28. PMID: 25002916.
      Citations:    
    9. Meeker JD, Cantonwine DE, Rivera-González LO, Ferguson KK, Mukherjee B, Calafat AM, Ye X, Anzalota Del Toro LV, Crespo-Hernández N, Jiménez-Vélez B, Alshawabkeh AN, Cordero JF. Distribution, variability, and predictors of urinary concentrations of phenols and parabens among pregnant women in Puerto Rico. Environ Sci Technol. 2013 Apr 02; 47(7):3439-47. PMID: 23469879.
      Citations: 85     Fields:    Translation:HumansPHPublic Health
    10. Gioda A, Fuentes-Mattei E, Jimenez-Velez B. Evaluation of cytokine expression in BEAS cells exposed to fine particulate matter (PM2.5) from specialized indoor environments. Int J Environ Health Res. 2011 Apr; 21(2):106-19. PMID: 21424968.
      Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
    11. M. Ortiz-Martínez, E. Rivera-Ramírez, L. Méndez-Torres, and B.D. Jiménez-Vélez. Biodiversity Science for Humanity. Role of chemical and biological constituents of PM10 from Saharan Dust in the exacerbation of asthma in Puerto Rico. 2010; 101-118.
    12. Fuentes-Mattei E, Rivera E, Gioda A, Sanchez-Rivera D, Roman-Velazquez FR, Jimenez-Velez BD. Use of human bronchial epithelial cells (BEAS-2B) to study immunological markers resulting from exposure to PM(2.5) organic extract from Puerto Rico. Toxicol Appl Pharmacol. 2010 Mar 15; 243(3):381-9. PMID: 20026096.
      Citations: 14     Fields:    Translation:HumansCellsPHPublic Health
    13. Braulio Jiménez-Vélez, Yasmin Detrés, Roy A. Armstrong, and Adriana Gioda. Atmospheric Environment. Characterization of African dust (PM2.5) across the Atlantic Ocean during AEROSE 2004. 2009; 43:2659-2664.
    14. Gioda A, Hanke G, Elias-Boneta A, Jiménez-Velez B. A pilot study to determine mercury exposure through vapor and bound to PM10 in a dental school environment. Toxicol Ind Health. 2007 Mar; 23(2):103-13. PMID: 18203562.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    15. Adriana Gioda, Gilberto Hanke, Augusto Elias, and Braulio Jiménez-Velez. Toxicology and Industrial Health. A pilot study to determine mercury levels in a dental environment at the School of Dentistry. 2007; 23:103-113.
    16. Molinelli AR, Santacana GE, Madden MC, Jiménez BD. Toxicity and metal content of organic solvent extracts from airborne particulate matter in Puerto Rico. Environ Res. 2006 Nov; 102(3):314-25. PMID: 16842771.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    17. Figueroa DA, Rodríguez-Sierra CJ, Jiménez-Velez BD. Concentrations of Ni and V, other heavy metals, arsenic, elemental and organic carbon in atmospheric fine particles (PM2.5) from Puerto Rico. Toxicol Ind Health. 2006 Mar; 22(2):87-99. PMID: 16716038.
      Citations: 5     Fields:    Translation:HumansPHPublic Health
    18. Acevedo-Figueroa D, Jiménez BD, Rodríguez-Sierra CJ. Trace metals in sediments of two estuarine lagoons from Puerto Rico. Environ Pollut. 2006 May; 141(2):336-42. PMID: 16249046.
      Citations: 27     Fields:    Translation:PHPublic Health
    19. Puig-Hernández JF, Jiménez-Velez BD. High pressure liquid chormatography determination of the concentration and integrity of L-thyroxine in free T4 stock solution. P R Health Sci J. 2005 Jun; 24(2):151-6. PMID: 16116934.
      Citations:    Fields:    Translation:Humans
    20. Torres-Pérez MI, Jiménez-Velez BD, Mansilla-Rivera I, Rodríguez-Sierra CJ. Effect of three extraction techniques on submitochondrial particle and Microtox bioassays for airborne particulate matter. P R Health Sci J. 2005 Mar; 24(1):35-9. PMID: 15895875.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    21. Kientz K, Jiménez BD, Pérez L, Rodríguez-Sierra CJ. In vitro bioaccessibility of metals in soils from a superfund site in Puerto Rico. Bull Environ Contam Toxicol. 2003 May; 70(5):927-34. PMID: 12719817.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    22. Rodriguez-Sierra CJ, Jiménez B. Trace metals in striped mojarra fish (Diapterus plumieri) from Puerto Rico. Mar Pollut Bull. 2002 Oct; 44(10):1039-45. PMID: 12474964.
      Citations:    Fields:    Translation:AnimalsPHPublic Health
    23. Jiménez BD, Maldonado L, Dahl RH, Quattrochi LC, Guzelian PS. Ectopic expression of MHC class II genes (RT1.B(I) beta/alpha) in rat hepatocytes in vivo and in culture can be elicited by treatment with the pregnane X receptor agonists pregnenolone 16 alpha-carbonitrile and dexamethasone. Life Sci. 2002 Jun 07; 71(3):311-23. PMID: 12034349.
      Citations: 1     Fields:    Translation:AnimalsCells
    24. Preston AM, Bercovitch FB, Jimenez BD, Rodriguez Orengo JF, Morales WD, Rodriguez CA, Lebron MR, Rivera CE. Plasma homocysteine concentrations in a population of rhesus monkeys (Macaca mulatta): reference ranges and accompanying plasma concentrations of folate and vitamin B12. Contemp Top Lab Anim Sci. 2002 Jan; 41(1):28-30. PMID: 11860255.
      Citations: 1     Fields:    Translation:Animals
    25. Pérez UJ, Jiménez B, Delgado W, Rodríguez-Sierra CJ. Heavy metals in the false mussel, Mytilopsis domingensis, from two tropical estuarine lagoons. Bull Environ Contam Toxicol. 2001 Feb; 66(2):206-13. PMID: 11116316.
      Citations:    Fields:    Translation:AnimalsPHPublic Health
    26. Jiménez BD, Quattrochi LC, Yockey CB, Guzelian PS. Identification by differential display of the IF1 inhibitor peptide of ATP synthase/ATPase as a gene inducible in rat liver by pregnenolone 16alpha-carbonitrile. Life Sci. 2000 Sep 01; 67(15):1825-32. PMID: 11043605.
      Citations: 4     Fields:    Translation:AnimalsCells
    27. Reyes DR, Rosario O, Rodriguez JF, Jimenez BD. Toxic evaluation of organic extracts from airborne particulate matter in Puerto Rico. Environ Health Perspect. 2000 Jul; 108(7):635-40. PMID: 10903617.
      Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
    28. Meléndez PA, Longo N, Jimenez BD, Cadilla CL. Insulin-induced gene 33 mRNA expression in Chinese hamster ovary cells is insulin receptor dependent. J Cell Biochem. 2000 Apr; 77(3):432-44. PMID: 10760951.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    29. Romero N, Jiménez BD, Cadilla CL. Insulin and phorbol ester regulation of gene 33 expression in CHO cells. P R Health Sci J. 1999 Sep; 18(3):257-65. PMID: 10547870.
      Citations:    Fields:    Translation:HumansAnimalsCells
    30. 43. McCarthy, J.F., Shugart, L.R. and Jiménez, B.D. Hazardons Waste Site Investigation: Toward Better Decision. Biomarker Based Biomonitors for Evaluating Health and Ecological Effects of Environmental Contaminants. 1992; 177-207 .
    31. Jiménez, B.D., Oikari, A., Adams, S.M., Hinton, D.E. and McCarthy, J.F. Chapter 6; Biological Markers of Environmental Contaminants. Hepatic enzymes as biomarkers: Interpreting the effects of environmental, physiological, and toxicological variables. 1990; 123-142 .
    32. Jiménez, B. D. and J.J. Stegeman. Biological Indicators of Sress in Fish. Detoxication enzymes as indicators of environmental stress in fish. 1990; 67-79.
    33. McCarthy JF, Jimenez BD. Interactions between polycyclic aromatic hydrocarbons and dissolved humic material: binding and dissociation. Environ Sci Technol. 1985 Nov 01; 19(11):1072-6. PMID: 22288752.
      Citations: 8     Fields:    
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