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Lenora Loo, PhD

Faculty RankAssociate Researcher
InstitutionUniversity of Hawaii
DepartmentCancer Epidemiology
AddressUniversity of Hawaii Cancer Center
701 Ilalo St
Honolulu HI 96813
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    Collapse Research 
    Collapse research activities and funding
    F32GM018246     (LOO, LENORA W)Jun 30, 1997
    Role: Principal Investigator

    R21CA176555     (LOO, LENORA WM)Jul 8, 2014 - Jun 30, 2018
    Obesity and IGF-axis Activation in Native Hawaiian Women with Breast Cancer
    Role: Principal Investigator

    R01CA229815     (LOO, LENORA WM)Mar 1, 2019 - Feb 28, 2024
    The Role of 27-hydroxycholesterol in Breast Cancer: A Population-Based Multiethnic Study
    Role: Principal Investigator

    R01MD014862     (PARK, SUNGSHIM LANI)Feb 25, 2020 - Dec 31, 2024
    Comprehensive molecular characterization of lung cancers in five racial/ethnic groups with disparate risk
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Streicher SA, Lim U, Park SL, Li Y, Sheng X, Hom V, Xia L, Pooler L, Shepherd J, Loo LWM, Darst BF, Highland HM, Polfus LM, Bogumil D, Ernst T, Buchthal S, Franke AA, Setiawan VW, Tiirikainen M, Wilkens LR, Haiman CA, Stram DO, Cheng I, Le Marchand L. Genome-wide association study of pancreatic fat: The Multiethnic Cohort Adiposity Phenotype Study. PLoS One. 2021; 16(7):e0249615. PMID: 34329319.
      Citations:    Fields:    
    2. Hernandez BY, Rahman M, Loo LWM, Chan OTM, Horio D, Morita S, Bryant-Greenwood G. BRAFV600E, hypothyroidism, and human relaxin in thyroid carcinogenesis. J Cancer Res Clin Oncol. 2021 Jan; 147(1):183-194. PMID: 32995956.
      Citations:    Fields:    Translation:Humans
    3. Maskarinec G, Ju D, Shvetsov YB, Horio D, Chan O, Loo LWM, Hernandez BY. Breast tumor tissue inflammation but not lobular involution is associated with survival among breast cancer patients in the Multiethnic Cohort. Cancer Epidemiol. 2020 04; 65:101685. PMID: 32058311.
      Citations: 1     Fields:    Translation:Humans
    4. Loo LWM, Nishibun K, Welsh L, Makolo T, Chong CD, Pagano I, Yu H, Bantum EO. Using a cultural dance program to increase sustainable physical activity for breast cancer survivors-A pilot study. Complement Ther Med. 2019 Dec; 47:102197. PMID: 31780003.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    5. Wang Z, Katsaros D, Biglia N, Shen Y, Loo L, Yu X, Lin H, Fu Y, Chu WM, Fei P, Ni Y, Jia W, Deng X, Qian B, Yu H. ERa upregulates the expression of long non-coding RNA LINC00472 which suppresses the phosphorylation of NF-?B in breast cancer. Breast Cancer Res Treat. 2019 Jun; 175(2):353-368. PMID: 30830488.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    6. Loo LWM, Williams M, Hernandez BY. The high and heterogeneous burden of breast cancer in Hawaii: A unique multiethnic U.S. Population. Cancer Epidemiol. 2019 02; 58:71-76. PMID: 30503975.
      Citations: 1     Fields:    Translation:Humans
    7. Maskarinec G, Ju D, Fong J, Horio D, Chan O, Loo LWM, Hernandez BY. Mammographic density and breast tissue expression of inflammatory markers, growth factors, and vimentin. BMC Cancer. 2018 Nov 29; 18(1):1191. PMID: 30497427.
      Citations: 2     Fields:    Translation:Humans
    8. Loo LWM, Gao C, Shvetsov YB, Okoro DR, Hernandez BY, Bargonetti J. MDM2, MDM2-C, and mutant p53 expression influence breast cancer survival in a multiethnic population. Breast Cancer Res Treat. 2019 Feb; 174(1):257-269. PMID: 30470976.
      Citations: 3     Fields:    Translation:Humans
    9. Park SL, Patel YM, Loo LWM, Mullen DJ, Offringa IA, Maunakea A, Stram DO, Siegmund K, Murphy SE, Tiirikainen M, Le Marchand L. Association of internal smoking dose with blood DNA methylation in three racial/ethnic populations. Clin Epigenetics. 2018 08 23; 10(1):110. PMID: 30139389.
      Citations: 9     Fields:    Translation:HumansCells
    10. Cologne J, Loo L, Shvetsov YB, Misumi M, Lin P, Haiman CA, Wilkens LR, Le Marchand L. Stepwise approach to SNP-set analysis illustrated with the Metabochip and colorectal cancer in Japanese Americans of the Multiethnic Cohort. BMC Genomics. 2018 Jul 09; 19(1):524. PMID: 29986644.
      Citations: 2     Fields:    Translation:HumansCells
    11. Wang Z, Katsaros D, Biglia N, Shen Y, Fu Y, Loo LWM, Jia W, Obata Y, Yu H. High expression of long non-coding RNA MALAT1 in breast cancer is associated with poor relapse-free survival. Breast Cancer Res Treat. 2018 Sep; 171(2):261-271. PMID: 29845475.
      Citations: 24     Fields:    Translation:HumansCells
    12. Shimizu Y, Furuya H, Tamashiro PM, Iino K, Chan OTM, Goodison S, Pagano I, Hokutan K, Peres R, Loo LWM, Hernandez B, Naing A, Chong CDK, Rosser CJ, Kawamori T. Genetic deletion of sphingosine kinase 1 suppresses mouse breast tumor development in an HER2 transgenic model. Carcinogenesis. 2018 01 12; 39(1):47-55. PMID: 28968647.
      Citations: 8     Fields:    Translation:HumansAnimals
    13. Loo LWM, Lemire M, Le Marchand L. In silico pathway analysis and tissue specific cis-eQTL for colorectal cancer GWAS risk variants. BMC Genomics. 2017 05 15; 18(1):381. PMID: 28506205.
      Citations: 5     Fields:    Translation:Humans
    14. Maskarinec G, Ju D, Horio D, Loo LW, Hernandez BY. Involution of breast tissue and mammographic density. Breast Cancer Res. 2016 12 15; 18(1):128. PMID: 27978856.
      Citations: 3     Fields:    Translation:Humans
    15. Shen Y, Wang Z, Loo LW, Ni Y, Jia W, Fei P, Risch HA, Katsaros D, Yu H. LINC00472 expression is regulated by promoter methylation and associated with disease-free survival in patients with grade 2 breast cancer. Breast Cancer Res Treat. 2015 Dec; 154(3):473-82. PMID: 26564482.
      Citations: 29     Fields:    Translation:HumansCells
    16. Lemire M, Qu C, Loo LWM, Zaidi SHE, Wang H, Berndt SI, Bézieau S, Brenner H, Campbell PT, Chan AT, Chang-Claude J, Du M, Edlund CK, Gallinger S, Haile RW, Harrison TA, Hoffmeister M, Hopper JL, Hou L, Hsu L, Jacobs EJ, Jenkins MA, Jeon J, Küry S, Li L, Lindor NM, Newcomb PA, Potter JD, Rennert G, Rudolph A, Schoen RE, Schumacher FR, Seminara D, Severi G, Slattery ML, White E, Woods MO, Cotterchio M, Marchand LL, Casey G, Gruber SB, Peters U, Hudson TJ. A genome-wide association study for colorectal cancer identifies a risk locus in 14q23.1. Hum Genet. 2015 Nov; 134(11-12):1249-1262. PMID: 26404086.
      Citations: 18     Fields:    Translation:HumansCells
    17. Ni Y, Zhao L, Yu H, Ma X, Bao Y, Rajani C, Loo LW, Shvetsov YB, Yu H, Chen T, Zhang Y, Wang C, Hu C, Su M, Xie G, Zhao A, Jia W, Jia W. Circulating Unsaturated Fatty Acids Delineate the Metabolic Status of Obese Individuals. EBioMedicine. 2015 Oct; 2(10):1513-22. PMID: 26629547.
      Citations: 38     Fields:    Translation:Humans
    18. Shen Y, Lee YH, Panneerselvam J, Zhang J, Loo LW, Fei P. Mutated Fanconi anemia pathway in non-Fanconi anemia cancers. Oncotarget. 2015 Aug 21; 6(24):20396-403. PMID: 26015400.
      Citations: 15     Fields:    Translation:HumansCells
    19. Shen Y, Katsaros D, Loo LW, Hernandez BY, Chong C, Canuto EM, Biglia N, Lu L, Risch H, Chu WM, Yu H. Prognostic and predictive values of long non-coding RNA LINC00472 in breast cancer. Oncotarget. 2015 Apr 20; 6(11):8579-92. PMID: 25865225.
      Citations: 36     Fields:    Translation:HumansCells
    20. Loo LW, Fong AY, Cheng I, Le Marchand L. In silico functional pathway annotation of 86 established prostate cancer risk variants. PLoS One. 2015; 10(2):e0117873. PMID: 25658610.
      Citations: 3     Fields:    Translation:HumansCells
    21. Hernandez BY, Wilkens LR, Le Marchand L, Horio D, Chong CD, Loo LW. Differences in IGF-axis protein expression and survival among multiethnic breast cancer patients. Cancer Med. 2015 Mar; 4(3):354-62. PMID: 25619494.
      Citations: 11     Fields:    Translation:Humans
    22. Wang H, Burnett T, Kono S, Haiman CA, Iwasaki M, Wilkens LR, Loo LW, Van Den Berg D, Kolonel LN, Henderson BE, Keku TO, Sandler RS, Signorello LB, Blot WJ, Newcomb PA, Pande M, Amos CI, West DW, Bézieau S, Berndt SI, Zanke BW, Hsu L, Lindor NM, Haile RW, Hopper JL, Jenkins MA, Gallinger S, Casey G, Stenzel SL, Schumacher FR, Peters U, Gruber SB, Tsugane S, Stram DO, Le Marchand L. Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A. Nat Commun. 2014 Aug 08; 5:4613. PMID: 25105248.
      Citations: 44     Fields:    Translation:Humans
    23. Loo LW, Tiirikainen M, Cheng I, Lum-Jones A, Seifried A, Church JM, Gryfe R, Weisenberger DJ, Lindor NM, Gallinger S, Haile RW, Duggan DJ, Thibodeau SN, Casey G, Le Marchand L. Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer. Genes Chromosomes Cancer. 2013 May; 52(5):450-66. PMID: 23341073.
      Citations: 26     Fields:    Translation:HumansCells
    24. Kwee S, Song MA, Cheng I, Loo L, Tiirikainen M. Measurement of circulating cell-free DNA in relation to 18F-fluorocholine PET/CT imaging in chemotherapy-treated advanced prostate cancer. Clin Transl Sci. 2012 Feb; 5(1):65-70. PMID: 22376260.
      Citations: 16     Fields:    Translation:HumansCells
    25. Loo LW, Cheng I, Tiirikainen M, Lum-Jones A, Seifried A, Dunklee LM, Church JM, Gryfe R, Weisenberger DJ, Haile RW, Gallinger S, Duggan DJ, Thibodeau SN, Casey G, Le Marchand L. cis-Expression QTL analysis of established colorectal cancer risk variants in colon tumors and adjacent normal tissue. PLoS One. 2012; 7(2):e30477. PMID: 22363440.
      Citations: 34     Fields:    Translation:Humans
    26. Loo LW, Wang Y, Flynn EM, Lund MJ, Bowles EJ, Buist DS, Liff JM, Flagg EW, Coates RJ, Eley JW, Hsu L, Porter PL. Genome-wide copy number alterations in subtypes of invasive breast cancers in young white and African American women. Breast Cancer Res Treat. 2011 May; 127(1):297-308. PMID: 21264507.
      Citations: 24     Fields:    Translation:Humans
    27. Loo LW, Ton C, Wang YW, Grove DI, Bouzek H, Vartanian N, Lin MG, Yuan X, Lawton TL, Daling JR, Malone KE, Li CI, Hsu L, Porter PL. Differential patterns of allelic loss in estrogen receptor-positive infiltrating lobular and ductal breast cancer. Genes Chromosomes Cancer. 2008 Dec; 47(12):1049-66. PMID: 18720524.
      Citations: 10     Fields:    Translation:Humans
    28. Loo LW, Secombe J, Little JT, Carlos LS, Yost C, Cheng PF, Flynn EM, Edgar BA, Eisenman RN. The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster. Mol Cell Biol. 2005 Aug; 25(16):7078-91. PMID: 16055719.
      Citations: 28     Fields:    Translation:AnimalsCells
    29. Hsu L, Self SG, Grove D, Randolph T, Wang K, Delrow JJ, Loo L, Porter P. Denoising array-based comparative genomic hybridization data using wavelets. Biostatistics. 2005 Apr; 6(2):211-26. PMID: 15772101.
      Citations: 63     Fields:    Translation:HumansCells
    30. Loo LW, Grove DI, Williams EM, Neal CL, Cousens LA, Schubert EL, Holcomb IN, Massa HF, Glogovac J, Li CI, Malone KE, Daling JR, Delrow JJ, Trask BJ, Hsu L, Porter PL. Array comparative genomic hybridization analysis of genomic alterations in breast cancer subtypes. Cancer Res. 2004 Dec 01; 64(23):8541-9. PMID: 15574760.
      Citations: 80     Fields:    Translation:HumansCells
    31. Pierce SB, Yost C, Britton JS, Loo LW, Flynn EM, Edgar BA, Eisenman RN. dMyc is required for larval growth and endoreplication in Drosophila. Development. 2004 May; 131(10):2317-27. PMID: 15128666.
      Citations: 75     Fields:    Translation:AnimalsCells
    32. Orian A, van Steensel B, Delrow J, Bussemaker HJ, Li L, Sawado T, Williams E, Loo LW, Cowley SM, Yost C, Pierce S, Edgar BA, Parkhurst SM, Eisenman RN. Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network. Genes Dev. 2003 May 01; 17(9):1101-14. PMID: 12695332.
      Citations: 168     Fields:    Translation:Animals
    33. Loo LW, Kanemitsu MY, Lau AF. In vivo association of pp60v-src and the gap-junction protein connexin 43 in v-src-transformed fibroblasts. Mol Carcinog. 1999 Jul; 25(3):187-95. PMID: 10411145.
      Citations: 15     Fields:    Translation:AnimalsCells
    34. Kanemitsu MY, Loo LW, Simon S, Lau AF, Eckhart W. Tyrosine phosphorylation of connexin 43 by v-Src is mediated by SH2 and SH3 domain interactions. J Biol Chem. 1997 Sep 05; 272(36):22824-31. PMID: 9278444.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    35. Lau AF, Kurata WE, Kanemitsu MY, Loo LW, Warn-Cramer BJ, Eckhart W, Lampe PD. Regulation of connexin43 function by activated tyrosine protein kinases. J Bioenerg Biomembr. 1996 Aug; 28(4):359-68. PMID: 8844333.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    36. Warn-Cramer BJ, Lampe PD, Kurata WE, Kanemitsu MY, Loo LW, Eckhart W, Lau AF. Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein. J Biol Chem. 1996 Feb 16; 271(7):3779-86. PMID: 8631994.
      Citations: 83     Fields:    Translation:AnimalsCells
    37. Loo LW, Berestecky JM, Kanemitsu MY, Lau AF. pp60src-mediated phosphorylation of connexin 43, a gap junction protein. J Biol Chem. 1995 May 26; 270(21):12751-61. PMID: 7539006.
      Citations: 37     Fields:    Translation:AnimalsCells
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