RCMI Coordinating Center (RCMI CC) Header Logo

mahavir Chougule

TitleAssistant Professor
InstitutionUniversity of Hawaii
DepartmentPharmaceutical Sciences
Address34 Rainbow Dr.
STE 300
Hilo HI 96720
Phone8089814518
Fax8089814520
vCardDownload vCard
    Other Positions
    TitleMember
    InstitutionUniversity of Hawaii Cancer Center
    Department Natural Products and Experimental Therapeutics Program


    Collapse Biography 
    Collapse awards and honors
    1999 - 2000Gold Medalist- B Pharm, P. Wadhawani College of Pharmacy, India
    2000 - 2001Best Student Award, P. Wadhawani College of Pharmacy, India
    2004 - 2005Junior Research Fellowship , Lady Tata Memorial Trust, Mumbai, India.
    2005 - 2006Senior Research Fellowship , Indian Council of Medical Research (ICMR), Delhi, India
    2006Travel Award- Respiratory Drug Delivery X Conference, Boca Raton FL, USA, Department of Science and Technology, Department of Biotechnology, Govt. of India
    2010AAPS Council Travel Award , American Association of Pharmaceutical Scientist (AAPS), USA.
    2012AACR Minority-Serving Institution Faculty Scholar in Cancer Research , American Association of Cancer Research , USA
    2013AACR Minority-Serving Institution Faculty Scholar in Cancer Research, American Association of Cancer Research (AACR) , USA

    Collapse Overview 
    Collapse overview
    Mahavir B. Chougule, Assistant Professor of the Department of Pharmaceutical Sciences, College of Pharmacy, University of Hawaii at Hilo, HI, USA, investigates the use of therapeutic agent, siRNA, proteins and targeted nanotechnology based formulations for treatment of cancer and pulmonary disorders. His research work is focused on targeted delivery using nanocarriers to improve the efficacy and minimize the adverse side effects. Chougule has shown that the inhalation delivery of anticancer drug loaded nanoparticle significantly inhibits tumor growth compared to aerosolized solution. Chougule has also investigated the anticancer activity and molecular mechanism of natural compounds against lung and breast cancer. He also developed the spray dried nano-liposomal dry powder inhalers and topical nanocarrier cream formulation for treatment of skin disorders.

    Dr. Chougule has more than 7 years of professional experience in developmental therapeutics and biopharmaceuticals. he has has published 21 research articles, 2 review article, 4 book chapters, and presented work in more than 50 scientific conferences. In addition, he is also an inventor in the 8 patents. He is also serving as member of editorial board on 5 international journals and recipient of several awards including AACR Minority-Serving Institution Faculty Scholar in Cancer Research Awards.

    Research Interests: Cancer, asthma, nanotechnology, small compound and gene/protein based drug delivery, Inhalation delivery, topical/transdermal delivery, Molecular biology, cell culture, and animal models.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Alexander A, Agrawal M, Saraf S, Saraf S, Chougule MB. Formulation strategies of nano lipid carrier for effective brain targeting of anti-AD drugs. Curr Pharm Des. 2020 Feb 12. PMID: 32048957.
      Citations:    Fields:    
    2. Bhatt P, Narvekar P, Lalani R, Chougule MB, Pathak Y, Sutariya V. An in vitro Assessment of Thermo-Reversible Gel Formulation Containing Sunitinib Nanoparticles for Neovascular Age-Related Macular Degeneration. AAPS PharmSciTech. 2019 Aug 09; 20(7):281. PMID: 31399890.
      Citations:    Fields:    Translation:Humans
    3. Mahaparale PR, Vinjamuri BP, Chavan MS, Chougule MB, Haware RV. Computational Predictability of Microsponge Properties Using Different Multivariate Models. AAPS PharmSciTech. 2019 Apr 23; 20(5):172. PMID: 31016473.
      Citations:    Fields:    Translation:AnimalsCells
    4. Shahin HI, Vinjamuri BP, Mahmoud AA, Shamma RN, Mansour SM, Ammar HO, Ghorab MM, Chougule MB, Chablani L. Design and evaluation of novel inhalable sildenafil citrate spray-dried microparticles for pulmonary arterial hypertension. J Control Release. 2019 05 28; 302:126-139. PMID: 30940497.
      Citations:    Fields:    
    5. Haware RV, Vinjamuri BP, Gavireddi M, Dave VS, Gupta D, Chougule MB, Stagner WC. Physical properties and solubility studies of Nifedipine-PEG 1450/HPMCAS-HF solid dispersions. Pharm Dev Technol. 2019 Jun; 24(5):550-559. PMID: 30175691.
      Citations:    Fields:    Translation:Cells
    6. Gandhi NS, Godeshala S, Koomoa-Lange DT, Miryala B, Rege K, Chougule MB. Correction to: Bioreducible Poly(Amino Ethers) Based mTOR siRNA Delivery for Lung Cancer. Pharm Res. 2018 09 05; 35(11):202. PMID: 30187140.
      Citations:    Fields:    
    7. Gandhi NS, Godeshala S, Koomoa-Lange DT, Miryala B, Rege K, Chougule MB. Bioreducible Poly(Amino Ethers) Based mTOR siRNA Delivery for Lung Cancer. Pharm Res. 2018 Aug 13; 35(10):188. PMID: 30105526.
      Citations: 1     Fields:    Translation:HumansCells
    8. Agrawal M, Saraf S, Saraf S, Antimisiaris SG, Chougule MB, Shoyele SA, Alexander A. Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs. J Control Release. 2018 07 10; 281:139-177. PMID: 29772289.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    9. Agrawal M, Saraf S, Saraf S, Antimisiaris SG, Hamano N, Li SD, Chougule M, Shoyele SA, Gupta U, Alexander A. Recent advancements in the field of nanotechnology for the delivery of anti-Alzheimer drug in the brain region. Expert Opin Drug Deliv. 2018 06; 15(6):589-617. PMID: 29733231.
      Citations: 2     Fields:    Translation:HumansAnimals
    10. Yang R, Nam K, Kim SW, Turkson J, Zou Y, Zuo YY, Haware RV, Chougule MB. Correction to "Factorial Design Based Multivariate Modeling and Optimization of Tunable Bioresponsive Arginine Grafted Poly(cystaminebis(acrylamide)-diaminohexane) Polymeric Matrix Based Nanocarriers". Mol Pharm. 2018 03 05; 15(3):1377. PMID: 29470076.
      Citations:    Fields:    
    11. Youngren-Ortiz SR, Chougule MB. The Daniel K. Inouye College of Pharmacy Scripts: Targeted Nanocarrier Based Systems for the Treatment of Lung Cancer. Hawaii J Med Public Health. 2017 11; 76(11):318-325. PMID: 29164017.
      Citations:    Fields:    Translation:Humans
    12. Dave VS, Shahin HI, Youngren-Ortiz SR, Chougule MB, Haware RV. Emerging technologies for the non-invasive characterization of physical-mechanical properties of tablets. Int J Pharm. 2017 Oct 30; 532(1):299-312. PMID: 28888977.
      Citations: 1     Fields:    
    13. Youngren-Ortiz SR, Hill DB, Hoffmann PR, Morris KR, Barrett EG, Forest MG, Chougule MB. Development of Optimized, Inhalable, Gemcitabine-Loaded Gelatin Nanocarriers for Lung Cancer. J Aerosol Med Pulm Drug Deliv. 2017 Oct; 30(5):299-321. PMID: 28277892.
      Citations: 1     Fields:    Translation:HumansCells
    14. Yang R, Nam K, Kim SW, Turkson J, Zou Y, Zuo YY, Haware RV, Chougule MB. Factorial Design Based Multivariate Modeling and Optimization of Tunable Bioresponsive Arginine Grafted Poly(cystaminebis(acrylamide)-diaminohexane) Polymeric Matrix Based Nanocarriers. Mol Pharm. 2017 01 03; 14(1):252-263. PMID: 28043134.
      Citations: 1     Fields:    
    15. Espana-Serrano L, Chougule MB. Enhanced Anticancer Activity of PF-04691502, a Dual PI3K/mTOR Inhibitor, in Combination With VEGF siRNA Against Non-small-cell Lung Cancer. Mol Ther Nucleic Acids. 2016 Nov 15; 5(11):e384. PMID: 27845769.
      Citations:    
    16. Youngren-Ortiz SR, Gandhi NS, España-Serrano L, Chougule MB. Aerosol Delivery of siRNA to the Lungs. Part 2: Nanocarrier-based Delivery Systems. Kona. 2017; 34:44-69. PMID: 28392618.
      Citations:    
    17. Andey T, Patel A, Marepally S, Chougule M, Spencer SD, Rishi AK, Singh M. Formulation, Pharmacokinetic, and Efficacy Studies of Mannosylated Self-Emulsifying Solid Dispersions of Noscapine. PLoS One. 2016; 11(1):e0146804. PMID: 26757437.
      Citations:    Fields:    Translation:HumansAnimalsCells
    18. Chougule MB. Foreword. Prog Drug Res. 2016; 71:vii. PMID: 26939257.
      Citations:    Fields:    Translation:HumansAnimals
    19. Glasgow MD, Chougule MB. Recent Developments in Active Tumor Targeted Multifunctional Nanoparticles for Combination Chemotherapy in Cancer Treatment and Imaging. J Biomed Nanotechnol. 2015 Nov; 11(11):1859-98. PMID: 26554150.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    20. Youngren-Ortiz SR, Gandhi NS, España-Serrano L, Chougule MB. Aerosol Delivery of siRNA to the Lungs. Part 1: Rationale for Gene Delivery Systems. Kona. 2016 Feb 28; 33:63-85. PMID: 27081214.
      Citations:    
    21. Aldawsari M, Chougule MB, Babu RJ. Progress in Topical siRNA Delivery Approaches for Skin Disorders. Curr Pharm Des. 2015; 21(31):4594-605. PMID: 26362644.
      Citations:    Fields:    Translation:HumansAnimals
    22. Chougule MB, Tan C. Translational application of nano delivery systems: emerging cancer therapy. AAPS PharmSciTech. 2015 Feb; 16(1):3-4. PMID: 25549791.
      Citations:    Fields:    Translation:Humans
    23. Tekade RK, Youngren-Ortiz SR, Yang H, Haware R, Chougule MB. Designing hybrid onconase nanocarriers for mesothelioma therapy: a Taguchi orthogonal array and multivariate component driven analysis. Mol Pharm. 2014 Oct 06; 11(10):3671-83. PMID: 25179221.
      Citations: 3     Fields:    Translation:HumansCells
    24. Gandhi NS, Tekade RK, Chougule MB. Nanocarrier mediated delivery of siRNA/miRNA in combination with chemotherapeutic agents for cancer therapy: current progress and advances. J Control Release. 2014 Nov 28; 194:238-56. PMID: 25204288.
      Citations: 62     Fields:    Translation:HumansAnimals
    25. Patel AR, Chougule M, Singh M. EphA2 targeting pegylated nanocarrier drug delivery system for treatment of lung cancer. Pharm Res. 2014 Oct; 31(10):2796-809. PMID: 24867421.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    26. Chougule MB, Patel AR, Patlolla R, Jackson T, Singh M. Epithelial transport of noscapine across cell monolayer and influence of absorption enhancers on in vitro permeation and bioavailability: implications for intestinal absorption. J Drug Target. 2014 Jul; 22(6):498-508. PMID: 24731057.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    27. Patel AR, Chougule MB, Lim E, Francis KP, Safe S, Singh M. Theranostic tumor homing nanocarriers for the treatment of lung cancer. Nanomedicine. 2014 Jul; 10(5):1053-63. PMID: 24355163.
      Citations: 2     Fields:    Translation:HumansAnimals
    28. Youngren SR, Tekade RK, Gustilo B, Hoffmann PR, Chougule MB. STAT6 siRNA matrix-loaded gelatin nanocarriers: formulation, characterization, and ex vivo proof of concept using adenocarcinoma cells. Biomed Res Int. 2013; 2013:858946. PMID: 24191252.
      Citations: 6     Fields:    Translation:HumansCells
    29. Tekade RK, Chougule MB. Formulation development and evaluation of hybrid nanocarrier for cancer therapy: Taguchi orthogonal array based design. Biomed Res Int. 2013; 2013:712678. PMID: 24106715.
      Citations: 7     Fields:    Translation:Humans
    30. Youngren SR, Mulik R, Jun B, Hoffmann PR, Morris KR, Chougule MB. Freeze-dried targeted mannosylated selenium-loaded nanoliposomes: development and evaluation. AAPS PharmSciTech. 2013 Sep; 14(3):1012-24. PMID: 23797303.
      Citations: 4     Fields:    Translation:AnimalsCells
    31. Patel AR, Chougule MB, I T, Patlolla R, Wang G, Singh M. Efficacy of aerosolized celecoxib encapsulated nanostructured lipid carrier in non-small cell lung cancer in combination with docetaxel. Pharm Res. 2013 May; 30(5):1435-46. PMID: 23361589.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    32. Patel AR, Spencer SD, Chougule MB, Safe S, Singh M. Pharmacokinetic evaluation and in vitro-in vivo correlation (IVIVC) of novel methylene-substituted 3,3' diindolylmethane (DIM). Eur J Pharm Sci. 2012 May 12; 46(1-2):8-16. PMID: 22342559.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    33. Chougule MB, Patel A, Sachdeva P, Jackson T, Singh M. Enhanced anticancer activity of gemcitabine in combination with noscapine via antiangiogenic and apoptotic pathway against non-small cell lung cancer. PLoS One. 2011; 6(11):e27394. PMID: 22102891.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    34. Chougule MB, Patel AR, Jackson T, Singh M. Antitumor activity of Noscapine in combination with Doxorubicin in triple negative breast cancer. PLoS One. 2011 Mar 15; 6(3):e17733. PMID: 21423660.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    35. Ichite N, Chougule M, Patel AR, Jackson T, Safe S, Singh M. Inhalation delivery of a novel diindolylmethane derivative for the treatment of lung cancer. Mol Cancer Ther. 2010 Nov; 9(11):3003-14. PMID: 20978159.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    36. Chougule M, Patel AR, Sachdeva P, Jackson T, Singh M. Anticancer activity of Noscapine, an opioid alkaloid in combination with Cisplatin in human non-small cell lung cancer. Lung Cancer. 2011 Mar; 71(3):271-82. PMID: 20674069.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    37. Patlolla RR, Chougule M, Patel AR, Jackson T, Tata PN, Singh M. Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriers. J Control Release. 2010 Jun 01; 144(2):233-41. PMID: 20153385.
      Citations: 33     Fields:    Translation:Animals
    38. Ichite N, Chougule MB, Jackson T, Fulzele SV, Safe S, Singh M. Enhancement of docetaxel anticancer activity by a novel diindolylmethane compound in human non-small cell lung cancer. Clin Cancer Res. 2009 Jan 15; 15(2):543-52. PMID: 19147759.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    39. Misra A, Jinturkar K, Patel D, Lalani J, Chougule M. Recent advances in liposomal dry powder formulations: preparation and evaluation. Expert Opin Drug Deliv. 2009 Jan; 6(1):71-89. PMID: 19236209.
      Citations: 7     Fields:    Translation:HumansAnimals
    40. Patel G, Chougule M, Singh M, Misra A. Chapter 9 - Nanoliposomal dry powder formulations. Methods Enzymol. 2009; 464:167-91. PMID: 19903555.
      Citations: 4     Fields:    Translation:HumansAnimals
    41. Padhi BK, Chougule MB, Misra A. Aerosol performance of large respirable particles of amikacin sulfate produced by spray and freeze drying techniques. Curr Drug Deliv. 2009 Jan; 6(1):8-16. PMID: 19418951.
      Citations: 3     Fields:    
    42. Jackson T, Chougule MB, Ichite N, Patlolla RR, Singh M. Antitumor activity of noscapine in human non-small cell lung cancer xenograft model. Cancer Chemother Pharmacol. 2008 Dec; 63(1):117-26. PMID: 18338172.
      Citations: 27     Fields:    Translation:Animals
    43. Chougule M, Padhi B, Misra A. Development of spray dried liposomal dry powder inhaler of Dapsone. AAPS PharmSciTech. 2008; 9(1):47-53. PMID: 18446460.
      Citations: 12     Fields:    Translation:Cells
    44. Chougule M, Padhi B, Misra A. Nano-liposomal dry powder inhaler of tacrolimus: preparation, characterization, and pulmonary pharmacokinetics. Int J Nanomedicine. 2007; 2(4):675-88. PMID: 18203434.
      Citations: 17     Fields:    Translation:Animals
    45. Chougule MB, Padhi BK, Jinturkar KA, Misra A. Development of dry powder inhalers. Recent Pat Drug Deliv Formul. 2007; 1(1):11-21. PMID: 19075871.
      Citations: 10     Fields:    Translation:Humans
    46. Chougule MB, Padhi BK, Misra A. Nano-liposomal dry powder inhaler of Amiloride Hydrochloride. J Nanosci Nanotechnol. 2006 Sep-Oct; 6(9-10):3001-9. PMID: 17048511.
      Citations: 10     Fields:    Translation:AnimalsCells
    47. Padhi BK, Chougule MB, Misra A. Optimization of formulation components and characterization of large respirable powders containing high therapeutic payload. Pharm Dev Technol. 2006; 11(4):465-75. PMID: 17101517.
      Citations: 4     Fields:    Translation:Cells
    48. Naik S, Chougule M, Padhi BK, Misra A. Development of novel lyophilized mixed micelle amphotericin B formulation for treatment of systemic fungal infection. Curr Drug Deliv. 2005 Apr; 2(2):177-84. PMID: 16305418.
      Citations:    Fields:    Translation:HumansAnimals
    49. Kalariya M, Padhi BK, Chougule M, Misra A. Clobetasol propionate solid lipid nanoparticles cream for effective treatment of eczema: formulation and clinical implications. Indian J Exp Biol. 2005 Mar; 43(3):233-40. PMID: 15816409.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    Chougule's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (207)
    Explore
    _
    Co-Authors (3)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

    For technical support please contact support