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Mahavir Chougule, PhD, MPharm, B Pharm

Title
Faculty RankAssistant Professor
InstitutionUniversity of Hawaii
DepartmentPharmaceutical Sciences
AddressUniversity of Hawaii at Hilo
The Daniel K. Inouye College of Pharmacy
34 Rainbow Drive
Hilo HI 96720
Phone8089814518
Fax8089814520
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    Other Positions
    TitleMember
    InstitutionUniversity of Hawaii Cancer Center
    Department Natural Products and Experimental Therapeutics Program


    Collapse Biography 
    Collapse awards and honors
    1999 - 2000Gold Medalist- B Pharm, P. Wadhawani College of Pharmacy, India
    2000 - 2001Best Student Award, P. Wadhawani College of Pharmacy, India
    2004 - 2005Junior Research Fellowship , Lady Tata Memorial Trust, Mumbai, India.
    2005 - 2006Senior Research Fellowship , Indian Council of Medical Research (ICMR), Delhi, India
    2006Travel Award- Respiratory Drug Delivery X Conference, Boca Raton FL, USA, Department of Science and Technology, Department of Biotechnology, Govt. of India
    2010AAPS Council Travel Award , American Association of Pharmaceutical Scientist (AAPS), USA.
    2012AACR Minority-Serving Institution Faculty Scholar in Cancer Research , American Association of Cancer Research , USA
    2013AACR Minority-Serving Institution Faculty Scholar in Cancer Research, American Association of Cancer Research (AACR) , USA

    Collapse Overview 
    Collapse overview
    Mahavir B. Chougule, Assistant Professor of the Department of Pharmaceutical Sciences, College of Pharmacy, University of Hawaii at Hilo, HI, USA, investigates the use of therapeutic agent, siRNA, proteins and targeted nanotechnology based formulations for treatment of cancer and pulmonary disorders. His research work is focused on targeted delivery using nanocarriers to improve the efficacy and minimize the adverse side effects. Chougule has shown that the inhalation delivery of anticancer drug loaded nanoparticle significantly inhibits tumor growth compared to aerosolized solution. Chougule has also investigated the anticancer activity and molecular mechanism of natural compounds against lung and breast cancer. He also developed the spray dried nano-liposomal dry powder inhalers and topical nanocarrier cream formulation for treatment of skin disorders.

    Dr. Chougule has more than 7 years of professional experience in developmental therapeutics and biopharmaceuticals. he has has published 21 research articles, 2 review article, 4 book chapters, and presented work in more than 50 scientific conferences. In addition, he is also an inventor in the 8 patents. He is also serving as member of editorial board on 5 international journals and recipient of several awards including AACR Minority-Serving Institution Faculty Scholar in Cancer Research Awards.

    Research Interests: Cancer, asthma, nanotechnology, small compound and gene/protein based drug delivery, Inhalation delivery, topical/transdermal delivery, Molecular biology, cell culture, and animal models.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bhatt P, Narvekar P, Lalani R, Chougule MB, Pathak Y, Sutariya V. Correction to: An in vitro Assessment of Thermo-Reversible Gel Formulation Containing Sunitinib Nanoparticles for Neovascular Age-Related Macular Degeneration. AAPS PharmSciTech. 2024 Mar 14; 25(3):62. PMID: 38485865.
      Citations:    Fields:    
    2. Chougule MB, Brogden NK. Introducing the Molecular Pharmaceutics Special Issue on "Interdisciplinary Integration of Biomaterials for Drug and Gene Therapy". Mol Pharm. 2022 12 05; 19(12):4391. PMID: 36465013.
      Citations:    Fields:    
    3. Shah S, Famta P, Tiwari V, Kotha AK, Kashikar R, Chougule MB, Chung YH, Steinmetz NF, Uddin M, Singh SB, Srivastava S. Instigation of the epoch of nanovaccines in cancer immunotherapy. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2023 May-Jun; 15(3):e1870. PMID: 36410742.
      Citations: 3     Fields:    Translation:HumansAnimals
    4. Shah S, Famta P, Bagasariya D, Charankumar K, Sikder A, Kashikar R, Kotha AK, Chougule MB, Khatri DK, Asthana A, Raghuvanshi RS, Singh SB, Srivastava S. Tuning Mesoporous Silica Nanoparticles in Novel Avenues of Cancer Therapy. Mol Pharm. 2022 12 05; 19(12):4428-4452. PMID: 36109099.
      Citations: 8     Fields:    Translation:Humans
    5. Kashikar R, Kotha AK, Shah S, Famta P, Singh SB, Srivastava S, Chougule MB. Advances in nanoparticle mediated targeting of RNA binding protein for cancer. Adv Drug Deliv Rev. 2022 06; 185:114257. PMID: 35381306.
      Citations: 1     Fields:    Translation:Humans
    6. Harris HM, Boyet KL, Liu H, Dwivedi R, Ashpole NM, Tandon R, Bidwell GL, Cheng Z, Fassero LA, Yu CS, Pomin VH, Mitra D, Harrison KA, Dahl E, Gurley BJ, Kotha AK, Chougule MB, Sharp JS. Safety and Pharmacokinetics of Intranasally Administered Heparin. Pharm Res. 2022 Mar; 39(3):541-551. PMID: 35237922.
      Citations: 1     Fields:    Translation:HumansAnimals
    7. Harris HM, Boyet KL, Liu H, Dwivedi R, Ashpole NM, Tandon R, Bidwell GL, Cheng Z, Fassero LA, Yu CS, Pomin VH, Mitra D, Harrison KA, Dahl E, Gurley BJ, Kotha AK, Chougule MB, Sharp JS. Safety and Pharmacokinetics of Intranasally Administered Heparin. medRxiv. 2022 Feb 17. PMID: 35194614.
      Citations:    
    8. Shah S, Chougule MB, Kotha AK, Kashikar R, Godugu C, Raghuvanshi RS, Singh SB, Srivastava S. Nanomedicine based approaches for combating viral infections. J Control Release. 2021 10 10; 338:80-104. PMID: 34375690.
      Citations: 8     Fields:    Translation:Humans
    9. Shadambikar G, Marathe S, Ji N, Almutairi M, Bandari S, Zhang F, Chougule M, Repka M. Formulation development of itraconazole PEGylated nano-lipid carriers for pulmonary aspergillosis using hot-melt extrusion technology. Int J Pharm X. 2021 Dec; 3:100074. PMID: 33748741.
      Citations:    
    10. Shahin H, Vinjamuri BP, Mahmoud AA, Mansour SM, Chougule MB, Chablani L. Formulation and optimization of sildenafil citrate-loaded PLGA large porous microparticles using spray freeze-drying technique: A factorial design and in-vivo pharmacokinetic study. Int J Pharm. 2021 Mar 15; 597:120320. PMID: 33539999.
      Citations: 5     Fields:    Translation:Humans
    11. Chandrasiri I, Abebe DG, Loku Yaddehige M, Williams JSD, Zia MF, Dorris A, Barker A, Simms BL, Parker A, Vinjamuri BP, Le N, Gayton JN, Chougule MB, Hammer NI, Flynt A, Delcamp JH, Watkins DL. Self-Assembling PCL-PAMAM Linear Dendritic Block Copolymers (LDBCs) for Bioimaging and Phototherapeutic Applications. ACS Appl Bio Mater. 2020 Sep 21; 3(9):5664-5677. PMID: 35021798.
      Citations: 7     Fields:    
    12. Alexander A, Agrawal M, Saraf S, Saraf S, Chougule MB. Formulation Strategies of Nano Lipid Carrier for Effective Brain Targeting of Anti-AD Drugs. Curr Pharm Des. 2020; 26(27):3269-3280. PMID: 32048957.
      Citations:    Fields:    Translation:Humans
    13. Bhatt P, Narvekar P, Lalani R, Chougule MB, Pathak Y, Sutariya V. An in vitro Assessment of Thermo-Reversible Gel Formulation Containing Sunitinib Nanoparticles for Neovascular Age-Related Macular Degeneration. AAPS PharmSciTech. 2019 Aug 09; 20(7):281. PMID: 31399890.
      Citations: 18     Fields:    Translation:Humans
    14. Mahaparale PR, Vinjamuri BP, Chavan MS, Chougule MB, Haware RV. Computational Predictability of Microsponge Properties Using Different Multivariate Models. AAPS PharmSciTech. 2019 Apr 23; 20(5):172. PMID: 31016473.
      Citations:    Fields:    Translation:AnimalsCells
    15. Shahin HI, Vinjamuri BP, Mahmoud AA, Shamma RN, Mansour SM, Ammar HO, Ghorab MM, Chougule MB, Chablani L. Design and evaluation of novel inhalable sildenafil citrate spray-dried microparticles for pulmonary arterial hypertension. J Control Release. 2019 05 28; 302:126-139. PMID: 30940497.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    16. Haware RV, Vinjamuri BP, Gavireddi M, Dave VS, Gupta D, Chougule MB, Stagner WC. Physical properties and solubility studies of Nifedipine-PEG 1450/HPMCAS-HF solid dispersions. Pharm Dev Technol. 2019 Jun; 24(5):550-559. PMID: 30175691.
      Citations: 2     Fields:    Translation:Cells
    17. Gandhi NS, Godeshala S, Koomoa-Lange DT, Miryala B, Rege K, Chougule MB. Correction to: Bioreducible Poly(Amino Ethers) Based mTOR siRNA Delivery for Lung Cancer. Pharm Res. 2018 09 05; 35(11):202. PMID: 30187140.
      Citations:    Fields:    
    18. Gandhi NS, Godeshala S, Koomoa-Lange DT, Miryala B, Rege K, Chougule MB. Bioreducible Poly(Amino Ethers) Based mTOR siRNA Delivery for Lung Cancer. Pharm Res. 2018 Aug 13; 35(10):188. PMID: 30105526.
      Citations: 3     Fields:    Translation:HumansCells
    19. Agrawal M, Saraf S, Saraf S, Antimisiaris SG, Chougule MB, Shoyele SA, Alexander A. Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs. J Control Release. 2018 07 10; 281:139-177. PMID: 29772289.
      Citations: 134     Fields:    Translation:HumansAnimalsCells
    20. Agrawal M, Saraf S, Saraf S, Antimisiaris SG, Hamano N, Li SD, Chougule M, Shoyele SA, Gupta U, Alexander A. Recent advancements in the field of nanotechnology for the delivery of anti-Alzheimer drug in the brain region. Expert Opin Drug Deliv. 2018 06; 15(6):589-617. PMID: 29733231.
      Citations: 22     Fields:    Translation:HumansAnimals
    21. Yang R, Nam K, Kim SW, Turkson J, Zou Y, Zuo YY, Haware RV, Chougule MB. Correction to "Factorial Design Based Multivariate Modeling and Optimization of Tunable Bioresponsive Arginine Grafted Poly(cystaminebis(acrylamide)-diaminohexane) Polymeric Matrix Based Nanocarriers". Mol Pharm. 2018 03 05; 15(3):1377. PMID: 29470076.
      Citations:    Fields:    
    22. Youngren-Ortiz SR, Chougule MB. The Daniel K. Inouye College of Pharmacy Scripts: Targeted Nanocarrier Based Systems for the Treatment of Lung Cancer. Hawaii J Med Public Health. 2017 11; 76(11):318-325. PMID: 29164017.
      Citations:    Fields:    Translation:Humans
    23. Dave VS, Shahin HI, Youngren-Ortiz SR, Chougule MB, Haware RV. Emerging technologies for the non-invasive characterization of physical-mechanical properties of tablets. Int J Pharm. 2017 Oct 30; 532(1):299-312. PMID: 28888977.
      Citations: 4     Fields:    
    24. Youngren-Ortiz SR, Hill DB, Hoffmann PR, Morris KR, Barrett EG, Forest MG, Chougule MB. Development of Optimized, Inhalable, Gemcitabine-Loaded Gelatin Nanocarriers for Lung Cancer. J Aerosol Med Pulm Drug Deliv. 2017 Oct; 30(5):299-321. PMID: 28277892.
      Citations: 10     Fields:    Translation:HumansCells
    25. Yang R, Nam K, Kim SW, Turkson J, Zou Y, Zuo YY, Haware RV, Chougule MB. Factorial Design Based Multivariate Modeling and Optimization of Tunable Bioresponsive Arginine Grafted Poly(cystaminebis(acrylamide)-diaminohexane) Polymeric Matrix Based Nanocarriers. Mol Pharm. 2017 01 03; 14(1):252-263. PMID: 28043134.
      Citations: 1     Fields:    
    26. Espana-Serrano L, Chougule MB. Enhanced Anticancer Activity of PF-04691502, a Dual PI3K/mTOR Inhibitor, in Combination With VEGF siRNA Against Non-small-cell Lung Cancer. Mol Ther Nucleic Acids. 2016 Nov 15; 5(11):e384. PMID: 27845769.
      Citations:    
    27. Youngren-Ortiz SR, Gandhi NS, Espa?a-Serrano L, Chougule MB. Aerosol Delivery of siRNA to the Lungs. Part 2: Nanocarrier-based Delivery Systems. Kona. 2017; 34:44-69. PMID: 28392618.
      Citations:    
    28. Andey T, Patel A, Marepally S, Chougule M, Spencer SD, Rishi AK, Singh M. Formulation, Pharmacokinetic, and Efficacy Studies of Mannosylated Self-Emulsifying Solid Dispersions of Noscapine. PLoS One. 2016; 11(1):e0146804. PMID: 26757437.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    29. Chougule MB. Foreword. Prog Drug Res. 2016; 71:vii. PMID: 26939257.
      Citations:    Fields:    Translation:HumansAnimals
    30. Glasgow MD, Chougule MB. Recent Developments in Active Tumor Targeted Multifunctional Nanoparticles for Combination Chemotherapy in Cancer Treatment and Imaging. J Biomed Nanotechnol. 2015 Nov; 11(11):1859-98. PMID: 26554150.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    31. Youngren-Ortiz SR, Gandhi NS, Espa?a-Serrano L, Chougule MB. Aerosol Delivery of siRNA to the Lungs. Part 1: Rationale for Gene Delivery Systems. Kona. 2016 Feb 28; 33:63-85. PMID: 27081214.
      Citations:    
    32. Aldawsari M, Chougule MB, Babu RJ. Progress in Topical siRNA Delivery Approaches for Skin Disorders. Curr Pharm Des. 2015; 21(31):4594-605. PMID: 26362644.
      Citations: 3     Fields:    Translation:HumansAnimals
    33. Chougule MB, Tan C. Translational application of nano delivery systems: emerging cancer therapy. AAPS PharmSciTech. 2015 Feb; 16(1):3-4. PMID: 25549791.
      Citations:    Fields:    Translation:Humans
    34. Tekade RK, Youngren-Ortiz SR, Yang H, Haware R, Chougule MB. Designing hybrid onconase nanocarriers for mesothelioma therapy: a Taguchi orthogonal array and multivariate component driven analysis. Mol Pharm. 2014 Oct 06; 11(10):3671-83. PMID: 25179221.
      Citations: 6     Fields:    Translation:HumansCells
    35. Gandhi NS, Tekade RK, Chougule MB. Nanocarrier mediated delivery of siRNA/miRNA in combination with chemotherapeutic agents for cancer therapy: current progress and advances. J Control Release. 2014 Nov 28; 194:238-56. PMID: 25204288.
      Citations: 112     Fields:    Translation:HumansAnimals
    36. Patel AR, Chougule M, Singh M. EphA2 targeting pegylated nanocarrier drug delivery system for treatment of lung cancer. Pharm Res. 2014 Oct; 31(10):2796-809. PMID: 24867421.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    37. Chougule MB, Patel AR, Patlolla R, Jackson T, Singh M. Epithelial transport of noscapine across cell monolayer and influence of absorption enhancers on in vitro permeation and bioavailability: implications for intestinal absorption. J Drug Target. 2014 Jul; 22(6):498-508. PMID: 24731057.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    38. Patel AR, Chougule MB, Lim E, Francis KP, Safe S, Singh M. Theranostic tumor homing nanocarriers for the treatment of lung cancer. Nanomedicine. 2014 Jul; 10(5):1053-63. PMID: 24355163.
      Citations: 5     Fields:    Translation:HumansAnimals
    39. Youngren SR, Tekade RK, Gustilo B, Hoffmann PR, Chougule MB. STAT6 siRNA matrix-loaded gelatin nanocarriers: formulation, characterization, and ex vivo proof of concept using adenocarcinoma cells. Biomed Res Int. 2013; 2013:858946. PMID: 24191252.
      Citations: 9     Fields:    Translation:HumansCells
    40. Tekade RK, Chougule MB. Formulation development and evaluation of hybrid nanocarrier for cancer therapy: Taguchi orthogonal array based design. Biomed Res Int. 2013; 2013:712678. PMID: 24106715.
      Citations: 15     Fields:    Translation:Humans
    41. Youngren SR, Mulik R, Jun B, Hoffmann PR, Morris KR, Chougule MB. Freeze-dried targeted mannosylated selenium-loaded nanoliposomes: development and evaluation. AAPS PharmSciTech. 2013 Sep; 14(3):1012-24. PMID: 23797303.
      Citations: 7     Fields:    Translation:AnimalsCells
    42. Patel AR, Chougule MB, I T, Patlolla R, Wang G, Singh M. Efficacy of aerosolized celecoxib encapsulated nanostructured lipid carrier in non-small cell lung cancer in combination with docetaxel. Pharm Res. 2013 May; 30(5):1435-46. PMID: 23361589.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    43. Patel AR, Spencer SD, Chougule MB, Safe S, Singh M. Pharmacokinetic evaluation and in vitro-in vivo correlation (IVIVC) of novel methylene-substituted 3,3' diindolylmethane (DIM). Eur J Pharm Sci. 2012 May 12; 46(1-2):8-16. PMID: 22342559.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    44. Chougule MB, Patel A, Sachdeva P, Jackson T, Singh M. Enhanced anticancer activity of gemcitabine in combination with noscapine via antiangiogenic and apoptotic pathway against non-small cell lung cancer. PLoS One. 2011; 6(11):e27394. PMID: 22102891.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    45. Chougule MB, Patel AR, Jackson T, Singh M. Antitumor activity of Noscapine in combination with Doxorubicin in triple negative breast cancer. PLoS One. 2011 Mar 15; 6(3):e17733. PMID: 21423660.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    46. Ichite N, Chougule M, Patel AR, Jackson T, Safe S, Singh M. Inhalation delivery of a novel diindolylmethane derivative for the treatment of lung cancer. Mol Cancer Ther. 2010 Nov; 9(11):3003-14. PMID: 20978159.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    47. Chougule M, Patel AR, Sachdeva P, Jackson T, Singh M. Anticancer activity of Noscapine, an opioid alkaloid in combination with Cisplatin in human non-small cell lung cancer. Lung Cancer. 2011 Mar; 71(3):271-82. PMID: 20674069.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    48. Patlolla RR, Chougule M, Patel AR, Jackson T, Tata PN, Singh M. Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriers. J Control Release. 2010 Jun 01; 144(2):233-41. PMID: 20153385.
      Citations: 58     Fields:    Translation:Animals
    49. Ichite N, Chougule MB, Jackson T, Fulzele SV, Safe S, Singh M. Enhancement of docetaxel anticancer activity by a novel diindolylmethane compound in human non-small cell lung cancer. Clin Cancer Res. 2009 Jan 15; 15(2):543-52. PMID: 19147759.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    50. Misra A, Jinturkar K, Patel D, Lalani J, Chougule M. Recent advances in liposomal dry powder formulations: preparation and evaluation. Expert Opin Drug Deliv. 2009 Jan; 6(1):71-89. PMID: 19236209.
      Citations: 13     Fields:    Translation:HumansAnimals
    51. Patel G, Chougule M, Singh M, Misra A. Chapter 9 - Nanoliposomal dry powder formulations. Methods Enzymol. 2009; 464:167-91. PMID: 19903555.
      Citations: 7     Fields:    Translation:HumansAnimals
    52. Padhi BK, Chougule MB, Misra A. Aerosol performance of large respirable particles of amikacin sulfate produced by spray and freeze drying techniques. Curr Drug Deliv. 2009 Jan; 6(1):8-16. PMID: 19418951.
      Citations: 3     Fields:    
    53. Jackson T, Chougule MB, Ichite N, Patlolla RR, Singh M. Antitumor activity of noscapine in human non-small cell lung cancer xenograft model. Cancer Chemother Pharmacol. 2008 Dec; 63(1):117-26. PMID: 18338172.
      Citations: 34     Fields:    Translation:Animals
    54. Chougule M, Padhi B, Misra A. Development of spray dried liposomal dry powder inhaler of Dapsone. AAPS PharmSciTech. 2008; 9(1):47-53. PMID: 18446460.
      Citations: 17     Fields:    Translation:Cells
    55. Chougule M, Padhi B, Misra A. Nano-liposomal dry powder inhaler of tacrolimus: preparation, characterization, and pulmonary pharmacokinetics. Int J Nanomedicine. 2007; 2(4):675-88. PMID: 18203434.
      Citations: 21     Fields:    Translation:Animals
    56. Chougule MB, Padhi BK, Jinturkar KA, Misra A. Development of dry powder inhalers. Recent Pat Drug Deliv Formul. 2007; 1(1):11-21. PMID: 19075871.
      Citations: 14     Fields:    Translation:Humans
    57. Chougule MB, Padhi BK, Misra A. Nano-liposomal dry powder inhaler of Amiloride Hydrochloride. J Nanosci Nanotechnol. 2006 Sep-Oct; 6(9-10):3001-9. PMID: 17048511.
      Citations: 12     Fields:    Translation:AnimalsCells
    58. Padhi BK, Chougule MB, Misra A. Optimization of formulation components and characterization of large respirable powders containing high therapeutic payload. Pharm Dev Technol. 2006; 11(4):465-75. PMID: 17101517.
      Citations: 5     Fields:    Translation:Cells
    59. Naik S, Chougule M, Padhi BK, Misra A. Development of novel lyophilized mixed micelle amphotericin B formulation for treatment of systemic fungal infection. Curr Drug Deliv. 2005 Apr; 2(2):177-84. PMID: 16305418.
      Citations:    Fields:    Translation:HumansAnimals
    60. Kalariya M, Padhi BK, Chougule M, Misra A. Clobetasol propionate solid lipid nanoparticles cream for effective treatment of eczema: formulation and clinical implications. Indian J Exp Biol. 2005 Mar; 43(3):233-40. PMID: 15816409.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
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