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Jaime Matta

Faculty RankProfessor
InstitutionPonce Health Sciences University
DepartmentBasic Sciences
AddressP.O. Box 7025
Ponce PR 00737
Phone7878402575 Ext. 2190
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    Other Positions
    TitleAffiliate Member
    InstitutionH. Lee Moffitt Cancer & Research Institute

    TitleAdjunct Professor
    InstitutionUniversity of Puerto Rico
    Department Medical Sciences Campus

    TitleResearch Professor in Surgery
    InstitutionPonce Health Sciences University

    TitlePrincipal Investigator
    InstitutionPonce Health Sciences University
    DepartmentPonce Research Institute

    InstitutionUniversity of Pittsburgh
    DepartmentR25 Grant

    InstitutionPuerto Rico Comprehensive Cancer Center

    Collapse Biography 
    Collapse awards and honors
    1980National Science Foundation Honor Award
    1982Bermuda Biological Station Scholarship, Bermuda
    1984Pauley Foundation Scholarship Award, Los Angeles, CA
    1985Standford University Graduate Scholarship Award, Standford University
    1986Ford Foundation Honor Award
    1986 - 1987National Hispanic Scholarhip Award
    1988Graduate Division Research Assistantship, UCLA
    1992RCMI Faculty Enhancement Award, Ponce School of Medicine
    2004Faculty Scholar Award in Cancer Research, American Association for Cancer Research - Minority Serving Institution
    2010Internal Advisory Committee Member, Puerto Rico Clinical and Translational Research Consortium
    2010Internal Advisory Committee Member, RCMI Program, Ponce School of Medicine
    2011Research Professor in Surgery, Dept. of Surgery, Ponce School of Medicine
    2014Internal Advisory Board Member, Puerto Rico Comprehensive Cancer Center

    Collapse Overview 
    Collapse overview
    After receiving my D.SC. (1987) and Ph.D. degree (1988) from the University of California in Los Angeles and being a University of California President’s Postdoctoral Fellow (1988-1992) at the University of California, Santa Barbara, I was recruited by Ponce School of Medicine and Health Sciences (PSMHS) as Assistant Research Professor in 1992. I currently serve as Professor of Pharmacology and Toxicology and Principal Investigator (contact PI) in the PSM-MCC (Moffitt Cancer Center) U54 Partnership, initiated in 2012. I have been a leader in the development of research and teaching programs at PSMHS, particularly in areas relevant to cancer research and pharmacology/toxicology. I am an active cancer researcher funded by NIGMS and the NCI. After losing several close family members to cancer in the 1990s, in 1999 I decided to switch the focus of my laboratory from toxicology to cancer. At that time, there was no cancer research at PSMHS. In 2003, I initiated the development of what eventually became the U56 and U54 Partnerships, largely the outcome of the efforts of many faculty and administrators. These are the premier cancer programs of PSMHS which function as a Partnership with Moffitt Cancer Center and the NCI. In the U56 Partnership (planning grant) that was funded from 2006-2011, I was Co-Principal Investigator and was involved in decision making, communication, research, and planning, both within PSMHS and with MCC. More recently, in the U54 Partnership, in which I serve as the contact PI for PSMHS. With resources from the Partnership and other programs, I continue to develop a critical mass of cancer research scientists both basic and clinical with emphasis on cancer health disparities. I am responsible for overseeing the entire operation of the Administrative Core, its Planning and Evaluation Core, in close collaboration with the other three members. I serve as the direct link with the other contact PI at MCC (Dr. T. Antonia), the Program Steering Committee (PSC) as well as the NCI officials and with all members of the Partnership.

    I have extensive experience mentoring undergraduate, graduate, medical students, physician residents, post-doctoral researchers, resident fellows, and faculty. I currently serve as thesis mentor or co-mentor for two Ph.D. students in our Biomedical Sciences Program, two undergraduate students, medical students, several Hematology-Oncology Fellows and three faculty members from two institutions. My mentoring skills have been substantially enhanced through the U56 Partnership Career and Mentorship component, in which I serve as a mentor for Dr. Julie Dutil, a geneticist, and collaborator in breast cancer research. I also serve as a mentor for Dr. Martinez for her K01 grant and for Dr. Pablo Vivas (K22 grant) both faculty members at the Puerto Rico Cancer Center.

    I am a member of the American Association for Cancer Research, the Society of Toxicology and the Association of Medical School Pharmacology Chairs (ASMPC). I serve on the chemotherapeutics, toxicology and vitamins subcommittees of the ASMPC that establishes the learning objectives in pharmacology for all medical schools in the USA, Canada, and Puerto Rico. I have taught for many years the cancer chemotherapeutic drugs in the medical pharmacology course. My laboratory was the first one to publish the finding that a low DNA repair is an important risk factor for breast cancer (Ramos et al. 2004, Matta et al. 2012). For the last 14 years, my laboratory has focused on conducting translational cancer research in large-scale population studies, with emphasis on the role of DNA repair as a risk factor for breast and skin cancer, identifying DNA repair genes involved in cancer susceptibility, and studying epigenetic mechanisms by which such genes are regulated and silenced. I have been very successful in maintaining active collaborations with scientists from research intensive institutions, from the University of Puerto Rico and intramurally (PSMHS). I am a member of the Editorial Board of Biological Trace Element Research and the Puerto Rico Health Sciences Journal.

    Collapse Research 
    Collapse research activities and funding
    S06GM008239     (MATTA, JAIME L)Sep 30, 1986 - May 31, 2010
    MBRS SCORE Program at the Ponce School of Medicine
    Role: Principal Investigator

    SC1CA157250     (MATTA, JAIME L)Aug 4, 2010 - Jul 31, 2013
    Molecular epidemiology studies on the role of DNA repair breast cancer
    Role: Principal Investigator

    U54CA163068     (WRIGHT, KENNETH LYNN)Sep 24, 2012 - Aug 31, 2023
    2/2 Ponce School of Medicine-Moffitt Cancer Center Partnership
    Role: Co-Principal Investigator

    U54CA163071     (MATTA, JAIME L)Sep 25, 2012 - Aug 31, 2023
    (1/2) Ponce Health Sciences University-Moffitt Cancer Center Partnership
    Role: Principal Investigator

    SC1CA182846     (MATTA, JAIME L)Aug 1, 2013 - Jul 31, 2019
    Factors associated with variability in DNA repair capacity in their effect on bre
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Encarnaci?n-Medina J, Godoy L, Matta J, Ortiz-S?nchez C. Identification of Exo-miRNAs: A Summary of the Efforts in Translational Studies Involving Triple-Negative Breast Cancer. Cells. 2023 05 07; 12(9). PMID: 37174739.
      Citations:    Fields:    Translation:Humans
    2. Ottman R, Ganapathy K, Lin HY, Osterman CD, Dutil J, Matta J, Ruiz-Deya G, Wang L, Yamoah K, Berglund A, Chakrabarti R, Park JY. Differential Expression of miRNAs Contributes to Tumor Aggressiveness and Racial Disparity in African American Men with Prostate Cancer. Cancers (Basel). 2023 Apr 17; 15(8). PMID: 37190259.
    3. Crespo-Orta I, Ortiz C, Encarnaci?n J, Su?rez E, Matta J. Association between DNA repair capacity and body mass index in women. Mutat Res. 2023 Jan-Jun; 826:111813. PMID: 36621052.
      Citations: 1     Fields:    Translation:HumansCells
    4. Ortiz-S?nchez C, Encarnaci?n-Medina J, Park JY, Moreno N, Ruiz-Deya G, Matta J. Reduced DNA Repair Capacity in Prostate Cancer Patients: A Phenotypic Approach Using the CometChip. Cancers (Basel). 2022 Jun 25; 14(13). PMID: 35804887.
    5. Ramirez-Fort MK, Naveh A, McClelland S, Gilman CK, Fort M, Mendez M, Matta J, Bomzon Z, Lange CS. Computational simulations establish a novel transducer array placement arrangement that extends delivery of therapeutic TTFields to the infratentorium of patients with brainstem gliomas. Rep Pract Oncol Radiother. 2021; 26(6):1045-1050. PMID: 34992879.
    6. Berglund A, Matta J, Encarnaci?n-Medina J, Ortiz-Sanch?z C, Dutil J, Linares R, Marcial J, Abreu-Takemura C, Moreno N, Putney R, Chakrabarti R, Lin HY, Yamoah K, Osterman CD, Wang L, Dhillon J, Kim Y, Kim SJ, Ruiz-Deya G, Park JY. Dysregulation of DNA Methylation and Epigenetic Clocks in Prostate Cancer among Puerto Rican Men. Biomolecules. 2021 12 21; 12(1). PMID: 35053153.
      Citations: 1     Fields:    Translation:HumansCells
    7. Ruiz-Deya G, Matta J, Encarnaci?n-Medina J, Ortiz-Sanch?z C, Dutil J, Putney R, Berglund A, Dhillon J, Kim Y, Park JY. Differential DNA Methylation in Prostate Tumors from Puerto Rican Men. Int J Mol Sci. 2021 Jan 13; 22(2). PMID: 33450964.
      Citations: 1     Fields:    Translation:HumansCells
    8. Ortiz-S?nchez C, Encarnaci?n-Medina J, Vergne R, Padilla L, Matta J. Circulating Vitamin D Levels and DNA Repair Capacity in Four Molecular Subtypes of Women with Breast Cancer. Int J Mol Sci. 2020 Sep 19; 21(18). PMID: 32961801.
      Citations:    Fields:    Translation:HumansCellsCTClinical Trials
    9. N??ez-Marrero A, Arroyo N, Godoy L, Rahman MZ, Matta JL, Dutil J. SNPs in the interleukin-12 signaling pathway are associated with breast cancer risk in Puerto Rican women. Oncotarget. 2020 Sep 15; 11(37):3420-3431. PMID: 32973967.
      Citations: 6     Fields:    
    10. Lamboy-Caraballo R, Ortiz-Sanchez C, Acevedo-Santiago A, Matta J, N A Monteiro A, N Armaiz-Pena G. Norepinephrine-Induced DNA Damage in Ovarian Cancer Cells. Int J Mol Sci. 2020 Mar 24; 21(6). PMID: 32213975.
      Citations: 14     Fields:    Translation:HumansCells
    11. Dutil J, Teer JK, Golubeva V, Yoder S, Tong WL, Arroyo N, Karam R, Echenique M, Matta JL, Monteiro AN. Germline variants in cancer genes in high-risk non-BRCA patients from Puerto Rico. Sci Rep. 2019 11 28; 9(1):17769. PMID: 31780696.
      Citations: 9     Fields:    Translation:Humans
    12. Encarnaci?n-Medina J, Ortiz C, Vergne R, Padilla L, Matta J. MicroRNA Expression Changes in Women with Breast Cancer Stratified by DNA Repair Capacity Levels. J Oncol. 2019; 2019:7820275. PMID: 31191653.
    13. Rasaii S, Sohrabian N, Gianfaldoni S, Hadibarhaghtalab M, Pazyar N, Bakhshaeekia A, Lotti T, Ramirez-Pacheco LA, Lange CS, Matta J, Seifi V, Ramirez-Fort MK, Feily A. Intralesional triamcinolone alone or in combination with botulinium toxin A is ineffective for the treatment of formed keloid scar: A double blind controlled pilot study. Dermatol Ther. 2019 03; 32(2):e12781. PMID: 30422367.
      Citations: 13     Fields:    Translation:Humans
    14. Diaz-Zabala HJ, Ortiz AP, Garland L, Jones K, Perez CM, Mora E, Arroyo N, Oleksyk TK, Echenique M, Matta JL, Dean M, Dutil J. A Recurrent BRCA2 Mutation Explains the Majority of Hereditary Breast and Ovarian Cancer Syndrome Cases in Puerto Rico. Cancers (Basel). 2018 Nov 02; 10(11). PMID: 30400234.
    15. Dutil J, Godoy L, Rivera-Lugo R, Arroyo N, Albino E, Negr?n L, Monteiro AN, Matta JL, Echenique M. No Evidence for the Pathogenicity of the BRCA2 c.6937?+?594T>G Deep Intronic Variant: A Case-Control Analysis. Genet Test Mol Biomarkers. 2018 Feb; 22(2):85-89. PMID: 29356578.
      Citations: 2     Fields:    Translation:Humans
    16. Matta J, Ortiz C, Encarnaci?n J, Dutil J, Su?rez E. Variability in DNA Repair Capacity Levels among Molecular Breast Cancer Subtypes: Triple Negative Breast Cancer Shows Lowest Repair. Int J Mol Sci. 2017 Jul 12; 18(7). PMID: 28704967.
      Citations: 10     Fields:    Translation:HumansCells
    17. Encarnaci?n J, Ortiz C, Vergne R, Vargas W, Coppola D, Matta JL. High DRC Levels Are Associated with Let-7b Overexpression in Women with Breast Cancer. Int J Mol Sci. 2016 Jun 02; 17(6). PMID: 27271599.
      Citations: 6     Fields:    Translation:HumansCells
    18. Ortiz C, Morales L, Sastre M, Haskins WE, Matta J. Cytotoxicity and Genotoxicity Assessment of Sandalwood Essential Oil in Human Breast Cell Lines MCF-7 and MCF-10A. Evid Based Complement Alternat Med. 2016; 2016:3696232. PMID: 27293457.
    19. Matta J, Morales L, Ortiz C, Adams D, Vargas W, Casbas P, Dutil J, Echenique M, Su?rez E. Estrogen Receptor Expression Is Associated with DNA Repair Capacity in Breast Cancer. PLoS One. 2016; 11(3):e0152422. PMID: 27032101.
      Citations: 15     Fields:    Translation:HumansCells
    20. Dutil J, Golubeva VA, Pacheco-Torres AL, Diaz-Zabala HJ, Matta JL, Monteiro AN. The spectrum of BRCA1 and BRCA2 alleles in Latin America and the Caribbean: a clinical perspective. Breast Cancer Res Treat. 2015 Dec; 154(3):441-53. PMID: 26564481.
      Citations: 42     Fields:    Translation:Humans
    21. P?rez WI, Soto Y, Ort?z C, Matta J, Mel?ndez E. Ferrocenes as potential chemotherapeutic drugs: synthesis, cytotoxic activity, reactive oxygen species production and micronucleus assay. Bioorg Med Chem. 2015 Feb 01; 23(3):471-9. PMID: 25555734.
      Citations: 10     Fields:    Translation:HumansCells
    22. Guerrero-Preston R, Hadar T, Ostrow KL, Soudry E, Echenique M, Ili-Gangas C, P?rez G, Perez J, Brebi-Mieville P, Deschamps J, Morales L, Bayona M, Sidransky D, Matta J. Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity. Oncol Rep. 2014 Aug; 32(2):505-12. PMID: 24927296.
      Citations: 30     Fields:    Translation:HumansCells
    23. Vera JL, Rull?n J, Santos N, Jim?nez J, Rivera J, Santana A, Briggs J, Rheingold AL, Matta J, Mel?ndez E. Functionalized ferrocenes: The role of the para substituent on the phenoxy pendant group. J Organomet Chem. 2014 Jan 01; 749:204-214. PMID: 27453588.
    24. Wells KJ, Lima DS, Meade CD, Mu?oz-Antonia T, Scarinci I, McGuire A, Gwede CK, Pledger WJ, Partridge E, Lipscomb J, Matthews R, Matta J, Flores I, Weiner R, Turner T, Miele L, Wiese TE, Fouad M, Moreno CS, Lacey M, Christie DW, Price-Haywood EG, Quinn GP, Coppola D, Sodeke SO, Green BL, Lichtveld MY. Assessing needs and assets for building a regional network infrastructure to reduce cancer related health disparities. Eval Program Plann. 2014 Jun; 44:14-25. PMID: 24486917.
      Citations: 9     Fields:    Translation:Humans
    25. Matta JL, Flores I, Morales LM, Monteiro J, Alvarez-Garriga C, Bayona M. Women with endometriosis have a higher DNA repair capacity and diminished breast cancer risk. Mol Cancer Biol. 2013 Dec 20; 1(1). PMID: 25473592.
    26. Morales L, Alvarez-Garriga C, Matta J, Ortiz C, Vergne Y, Vargas W, Acosta H, Ram?rez J, Perez-Mayoral J, Bayona M. Factors associated with breast cancer in Puerto Rican women. J Epidemiol Glob Health. 2013 Dec; 3(4):205-15. PMID: 24206792.
      Citations: 24     Fields:    Translation:HumansCells
    27. P?rez-Mayoral J, Pacheco-Torres AL, Morales L, Acosta-Rodr?guez H, Matta JL, Dutil J. Genetic polymorphisms in RAD23B and XPC modulate DNA repair capacity and breast cancer risk in Puerto Rican women. Mol Carcinog. 2013 Nov; 52 Suppl 1:E127-38. PMID: 23776089.
      Citations: 14     Fields:    Translation:HumansCells
    28. Vergne Y, Matta J, Morales L, Vargas W, Alvarez-Garriga C, Bayona M. Breast Cancer and DNA Repair Capacity: Association With Use of Multivitamin and Calcium Supplements. Integr Med (Encinitas). 2013 Jun; 12(3):38-46. PMID: 24817834.
    29. Perez-Mayoral J, Pacheco-Torres A, Morales L, Acosta-Rodriguez H, Matta JL, Dutil J . Genetic Polymorphisms in RAD23B and XPC Modulate DNA Repair Capacity and Breast Cancer Risk in Puerto Rican Women, Molecular Carcinogenesis (Journal). 2013.
    30. Vergne Y, Matta J, Morales L, Vargas V, Alvarez-Garriga C, Bayona M. I. Breast Cancer and DNA Repair Capacity: Association with use of multivitamin and calcium supplements. Integrative Medicine: A Clinician's Journal. 2013; 3(12):38-46.
    31. Matta J. International Innovation. A Better Understanding of Breast Cancer. 2013; 39-43.
    32. Wells KJ, Lima DS, Meade CD, Muñoz-Antonia T, Scarinci I, McGuire A, Gwede CK, Pledger WJ, Partridge E, Lipscomb J, Matthews R, Matta J, Flores I, Weiner R, Turner T, Miele L, Wiese TE, Fouad M, Moreno CS, Lacey M, Christie DW, Price-Haywood E, Quinn GP, Coppola D, Sodeke SO, Green BL, Lichtveld MY. Assessing Needs and Assets for Building a Regional Network Infrastructure to Reduce Cancer Related Health Disparities. Eval Program Plann. 2013.
    33. Matta J, Morales L, Dutil J, Bayona M, Alvarez C, Suarez E. Differential expression of DNA repair genes in Hispanic women with breast cancer. Mol Cancer Biol. 2013 Feb 01; 1(1):54. PMID: 25309843.
    34. Matta J, Echenique M, Negron E, Morales L, Vargas W, Gaetan FS, Lizardi ER, Torres A, Rosado JO, Bola?os G, Cruz JG, Laboy J, Barnes R, Medina SS, Romero A, Martinez R, Dutil J, Suarez E, Alvarez-Garriga C, Bayona M. The association of DNA Repair with breast cancer risk in women. A comparative observational study. BMC Cancer. 2012 Oct 22; 12:490. PMID: 23088658.
      Citations: 28     Fields:    Translation:HumansCells
    35. Dutil J, Colon-Colon JL, Matta JL, Sutphen R, Echenique M. Identification of the prevalent BRCA1 and BRCA2 mutations in the female population of Puerto Rico. Cancer Genet. 2012 May; 205(5):242-8. PMID: 22682623.
      Citations: 22     Fields:    Translation:Humans
    36. Avena S, Via M, Ziv E, P?rez-Stable EJ, Gignoux CR, Dejean C, Huntsman S, Torres-Mej?a G, Dutil J, Matta JL, Beckman K, Burchard EG, Parolin ML, Goicoechea A, Acreche N, Boquet M, R?os Part Mdel C, Fern?ndez V, Rey J, Stern MC, Carnese RF, Fejerman L. Heterogeneity in genetic admixture across different regions of Argentina. PLoS One. 2012; 7(4):e34695. PMID: 22506044.
      Citations: 52     Fields:    Translation:Humans
    37. Avena S, Via M, Ziv E, Pérez-Stable EJ, Gignoux CR, Dejean C, Huntsman S, Torres-Mejía G, Dutil J, Matta JL, Beckman K, Burchard EG, Parolin ML, Goicoechea A, Acreche N, Boquet M, Ríos Part Mdel C, Fernández V, Rey J, Stern MC, Carnese RF, Fejerman L. Heterogeneity in Genetic Admixture across Different Regions of Argentina. PLoS One. 2012; 4(7).
    38. Jaime Matta, Miguel Echenique, Esperanza Negron, Luisa Morales, Wanda Vargas, Felipe Sánchez Gaetan, Eduardo Ramírez Lizardi, Aníbal Torres, Jose Ortiz Rosado, Guillermo Bolaños, Juan González Cruz, Joaquín Laboy, Ricardo Barnes, Santos Santiago Medina, Ángel Romero, Rosendo Martinez, Julie Dutil, Erick Suarez Carolina Alvarez-Garriga and Manuel Bayona. The association of DNA Repair with breast cancer risk in women. A comparative observational study. BMC Cancer. 2012; 490(12).
    39. Flores I, Muñoz-Antonia T, Matta J, García M, Fenstermacher D, Gutierrez S, Seijo E, Torres-Ruiz J, Pledger J, Coppola D. The Establishment of the First Cancer Tissue Biobank at a Hispanic-Serving Institution: An NCI Funded Initiative between Moffitt Cancer Center in Florida and the PSM in Puerto Rico. Biopreservation and Biobanking. 2011; 4(9):363-371.
    40. Flores I, Mu?oz-Antonia T, Matta J, Garc?a M, Fenstermacher D, Gutierrez S, Seijo E, Torres-Ruiz J, Pledger WJ, Coppola D. The Establishment of the First Cancer Tissue Biobank at a Hispanic-Serving Institution: A National Cancer Institute-Funded Initiative between Moffitt Cancer Center in Florida and the Ponce School of Medicine and Health Sciences in Puerto Rico. Biopreserv Biobank. 2011 Dec; 9(4):363-71. PMID: 24836632.
      Citations: 2     Fields:    
    41. Vera J, Gao LM, Santana A, Matta J, Mel?ndez E. Vectorized ferrocenes with estrogens and vitamin D2: synthesis, cytotoxic activity and docking studies. Dalton Trans. 2011 Oct 07; 40(37):9557-65. PMID: 21850331.
      Citations: 9     Fields:    Translation:HumansCells
    42. Kao WH, Riker AI, Kushwaha DS, Ng K, Enkemann SA, Jove R, Buettner R, Zinn PO, S?nchez NP, Villa JL, D'Andrea AD, S?nchez JL, Kennedy RD, Chen CC, Matta JL. Upregulation of Fanconi anemia DNA repair genes in melanoma compared with non-melanoma skin cancer. J Invest Dermatol. 2011 Oct; 131(10):2139-42. PMID: 21697891.
      Citations: 13     Fields:    Translation:HumansCells
    43. Acevedo-Acevedo D, Matta J, Mel?ndez E. Synthesis, characterization and cytotoxic studies of water soluble [(?-C(5)H(5))(2)Mo(thionucleobase/thionucleoside)]Cl complexes in breast and colon cancer cell lines. J Organomet Chem. 2011 Mar 01; 696(5):1032-1037. PMID: 21399723.
    44. Olivero OA, Larramendy M, Soloneski S, Menck CF, Matta J, Folle GA, Zamorano-Ponce E, Spivak G. Impact of EMS outreach: successful developments in Latin America. Environ Mol Mutagen. 2010 Oct-Dec; 51(8-9):763-73. PMID: 20213840.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    45. Porrata-Doria T, Matta JL, Acevedo SF. Apolipoprotein E Allelic Frequency Altered in Women with Early-onset Breast Cancer. Breast Cancer (Auckl). 2010 May 24; 4:43-8. PMID: 20697532.
    46. Gao LM, Vera JL, Matta J, Mel?ndez E. Synthesis and cytotoxicity studies of steroid-functionalized titanocenes as potential anticancer drugs: sex steroids as potential vectors for titanocenes. J Biol Inorg Chem. 2010 Aug; 15(6):851-9. PMID: 20349254.
      Citations: 14     Fields:    Translation:HumansCells
    47. Matta JL, Rodriguez G, Villa J, Ruiz A. The role of DNA repair capacity in melanoma skin cancer risk in a population chronically exposed to high levels of sunlight. Ochsner J. 2010; 10(2):75-82. PMID: 21603361.
    48. Gao LM, Matta J, Rheingold AL, Mel?ndez E. Synthesis, Structure and Biological Activity of Amide-Functionalized Titanocenyls: Improving their Cytotoxic Properties. J Organomet Chem. 2009 Dec 15; 694(26):4134-4139. PMID: 20177431.
    49. Feliciano I, Matta J, Mel?ndez E. Water-soluble molybdenocene complexes with both proliferative and antiproliferative effects on cancer cell lines and their binding interactions with human serum albumin. J Biol Inorg Chem. 2009 Sep; 14(7):1109-17. PMID: 19536567.
      Citations: 7     Fields:    Translation:HumansCells
    50. Gao LM, Hern?ndez R, Matta J, Mel?ndez E. Synthesis, structure, electrochemistry, and cytotoxic properties of ferrocenyl ester derivatives. Met Based Drugs. 2009; 2009:420784. PMID: 19325925.
    51. Riker AI, Enkemann SA, Fodstad O, Liu S, Ren S, Morris C, Xi Y, Howell P, Metge B, Samant RS, Shevde LA, Li W, Eschrich S, Daud A, Ju J, Matta J. The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis. BMC Med Genomics. 2008 Apr 28; 1:13. PMID: 18442402.
      Citations: 282     Fields:    
    52. Hern?ndez R, Lamboy J, Gao LM, Matta J, Rom?n FR, Mel?ndez E. Structure-activity studies of Ti(IV) complexes: aqueous stability and cytotoxic properties in colon cancer HT-29 cells. J Biol Inorg Chem. 2008 Jun; 13(5):685-92. PMID: 18288505.
      Citations: 14     Fields:    Translation:HumansCells
    53. Su?rez-Mart?nez EB, Ruiz A, Mat?as J, Morales L, Cruz A, V?zquez D, Villa J, Matta JL. Early-onset of sporadic basal-cell carcinoma: germline mutations in the TP53, PTCH, and XPD genes. P R Health Sci J. 2007 Dec; 26(4):349-54. PMID: 18246963.
      Citations: 7     Fields:    Translation:Humans
    54. Gao LM, Hern?ndez R, Matta J, Mel?ndez E. Synthesis, Ti(IV) intake by apotransferrin and cytotoxic properties of functionalized titanocene dichlorides. J Biol Inorg Chem. 2007 Sep; 12(7):959-67. PMID: 17566797.
      Citations: 11     Fields:    Translation:HumansCells
    55. Kessel D, Conley M, Vicente MG, Reiners JJ. Studies on the subcellular localization of the porphycene CPO. Photochem Photobiol. 2005 May-Jun; 81(3):569-72. PMID: 15745423.
      Citations: 5     Fields:    Translation:AnimalsCells
    56. Ramos J, Villa J, Ruiz A, Armstrong R, Matta J. UV dose determines key characteristics of nonmelanoma skin cancer. Cancer Epidemiol Biomarkers Prev. 2004 Dec; 13(12):2006-11. PMID: 15598755.
      Citations: 38     Fields:    Translation:Humans
    57. Ramos JM, Ruiz A, Colen R, Lopez ID, Grossman L, Matta JL. DNA repair and breast carcinoma susceptibility in women. Cancer. 2004 Apr 01; 100(7):1352-7. PMID: 15042667.
      Citations: 46     Fields:    Translation:HumansCells
    58. Matta JL, Villa JL, Ramos JM, Sanchez J, Chompr? G, Ruiz A, Grossman L. DNA repair and nonmelanoma skin cancer in Puerto Rican populations. J Am Acad Dermatol. 2003 Sep; 49(3):433-9. PMID: 12963906.
      Citations: 22     Fields:    Translation:HumansCells
    59. Gonz?lez MJ, Mora EM, Miranda-Massari JR, Matta J, Riordan HD, Riordan NH. Inhibition of human breast carcinoma cell proliferation by ascorbate and copper. P R Health Sci J. 2002 Mar; 21(1):21-3. PMID: 12013676.
      Citations: 1     Fields:    Translation:HumansCells
    60. Matta J, Navas J, Milad M, Manger R, Hupka A, Frazer T. A pilot study for the detection of acute ciguatera intoxication in human blood. J Toxicol Clin Toxicol. 2002; 40(1):49-57. PMID: 11990204.
      Citations: 4     Fields:    Translation:HumansAnimalsCTClinical Trials
    61. Matta JL, Milad M, Manger R, Tosteson T . Heavy metals, lipid peroxidation and ciguatera toxicity in the liver of the Caribbean barracuda (Sphyraena barracuda). Biological Trace Element Research. 1999; 70:69-79.
    62. Matta JL, Nazario CM, Armstrong RA, Navas J . Epidemiological trends of melanoma in Puerto Rico from 1975-1991. Boletin de la Asociacion Medica de Puerto Rico Journal. 1998; 90(1-3):8-11.
    63. Matta JL, Chapman DJ . Effects of light, temperature and desiccation on the net emersed productivity of the intertidal macroalga Colpomenia peregrina Sauv. (Hamel). Journal Experimental Marine Biology & Ecology. 1995; 189(1-2):13-27.
    64. Matta JL, Tosteson TR . Preliminary studies on the role of oxygen-derived free radicals and lipid peroxidation in ciguatera poisoning. 1994; 189(1-2):13-27.
    65. Matta JL, Tosteson TR . Oxygen-derived free radicals as regulators of toxicity in the benthic dinoflagellate Ostreopsis lenticularis. 1993; 189(1-2):13-27.
    66. Iglesias-Prieto R, Matta JL, Robins WA, Trench RK . Proc Natl Acad of Sci U.S.A. Photosynthetic response to elevated temperature in the symbiotic dinoflagellate Symbiodinium microadriaticum in culture. 1992; 89(21):10302-10305. View Publication.
    67. Matta JL, Govind NS, Trench TR . Journal of Phycology. Polyclonal antibodies against iron-superoxide dismutases from E. coli B cross-react with superoxide dismutases from the symbiotic dinoflagellate Symbiodinium microadriaticum. 1992; 28(3):353-356. View Publication.
    68. Matta JL, Trench TR . Symbiosis. The enzymatic response of the symbiotic dinoflagellate Symbiodinium microadriaticum (Freudenthal) to growth in vitro under varied oxygen tensions. 1991; 11:31-45.
    69. Matta JL, Chapman DJ . Marine Biology. Photosynthetic performance and daily carbon balance of Colpomenia peregrina: seasonal variations and differences between intertidal and subtidal populations. 1991; 108(2):303-313. View Publication.
    70. Lewin RA, Cheng L, Matta JL . Phycologia. Diurnal rhythm in the cell division frequency of Prochloron (Prochlorophyta) innature. 1991; 23(4):505-507. View Publication.
    71. Rojas C, Matos B, Santiago N, Reymunde A, Matta JL . Hepatitis C patients in Puerto Rico have an altered iron balance. Biological Trace Element Research. 1991; 84:239-245.
    72. Elegbeleye OO, Femi-Pearse D. Ventilatory response to carbon dioxide in tetanus. Clin Sci Mol Med. 1976 Jan; 50(1):83-6. PMID: 2407.
      Citations:    Fields:    Translation:Humans
    73. Sanchez G, Alderete JF. The effect of host adrenalectomy on the physiology of Trypanosoma rhodesiense. Comp Biochem Physiol A Comp Physiol. 1975 Dec 01; 52(4):623-6. PMID: 1186.
      Citations: 1     Fields:    Translation:Animals
    74. Uretsky NJ, Snodgrass SR, Lorenzo AV. Studies on the mechanism of depletion of striatal dopamine by alpha-methyl-m-tyrosine. J Pharmacol Exp Ther. 1975 Dec; 195(3):465-79. PMID: 490.
      Citations: 3     Fields:    Translation:Animals
    75. Dawson RM. The reaction of choline and 3,3-dimethyl-1-butanol with the acetylenzyme from acetylcholinesterase. J Neurochem. 1975 Dec; 25(6):783-7. PMID: 1471.
      Citations:    Fields:    Translation:Cells
    76. Stein JM. The effect of adrenaline and of alpha- and beta-adrenergic blocking agents on ATP concentration and on incorporation of 32Pi into ATP in rat fat cells. Biochem Pharmacol. 1975 Sep 15; 24(18):1659-62. PMID: 12.
      Citations: 7     Fields:    Translation:Animals
    77. Schmoldt A, Benthe HF, Haberland G. Digitoxin metabolism by rat liver microsomes. Biochem Pharmacol. 1975 Sep 01; 24(17):1639-41. PMID: 10.
      Citations: 44     Fields:    Translation:AnimalsCells
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