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Pedro Santiago

TitleAssociate Professor, Biochemistry
InstitutionPonce School of Medicine
DepartmentBasic Sciences, Biochemistry Division
AddressPonce School of Medicine
P.O. Box 7004
Ponce PR 00732
Phone(787) 840-2575
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    Collapse Biography 
    Collapse awards and honors
    2011AACR Minority-Serving Institution Faculty Scholar in Cancer Research Award, AACR
    2012Distinguished Professor in Biochemistry, Ponce Health Sciences University-Ponce Research Institute., Ponce Health Sciences University
    2012Teaching Excellence recognition award, Frontiers in Stem Cells in Cancer, advanced training course H
    2013AACR Minority-Serving Institution Faculty Scholar in Cancer Research Award, AACR
    2013Distinguished Professor in Biochemistry, Ponce Health Sciences University-Ponce Research Institute., Ponce Health Sciences University

    Collapse Overview 
    Collapse overview
    Dr. Pedro Santiago obtained his Bachelor’s Degree in Biology and his Ph. D. in Developmental Neurobiology, both from the University of Puerto Rico. After completing his Ph. D., he obtained postdoctoral training in molecular cancer biology, first at the Pathology Department at Harvard Medical School, and then at the Molecular Oncology Research Institute in the Tufts Medical Center. His postdoctoral training focused on cell cycle control and the molecular aspects of the tumor suppressive functions of the retinoblastoma protein (pRb). He is a trained molecular cancer biologist, with expertise in cell cycle control and signal transduction pathways, and is currently one of the few researchers on the pRb field in Puerto Rico. He currently is an Associate Professor at the Basic Sciences Department, BiochemistryDivision at Ponce Health Science University, where he is actively involved in both teaching and research. Research in his laboratory is focused on the characterization of a novel role for pRb, which is traditionally known as a cell cycle repressor, as a regulator of cellular adhesion. Specifically, his research is focused on the characterization of the molecular mechanisms and cellular pathways by which pRb regulates cellular adhesion and blocks cancer metastasis. He also investigates the genetics and molecular biology of lung cancer in Puerto Ricans.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kantar RS, Breugem CC, Keith K, Kassam S, Vijayakumar C, Bow M, Alfonso AR, Chahine EM, Ghotmi LH, Patel KG, Shetye PR, Santiago PE, Losee JE, Steinbacher DM, Rossell-Perry P, Garib DG, Alonso N, Mann RJ, Prada-Madrid JR, Esenlik E, Pamplona MDC, Collares MVM, Bennun RD, Kummer A, Giugliano C, Padwa BL, Raposo-Amaral CE, Tse R, Sommerlad B, Flores RL, Hamdan US. Simulation-Based Comprehensive Cleft Care Workshops: A Reproducible Model for Sustainable Education. Cleft Palate Craniofac J. 2020 Jul 30; 1055665620944781. PMID: 32729337.
      Citations:    Fields:    
    2. Soares GH, Santiago PHR, Michel-Crosato E, Jamieson L. The utility of network analysis in the context of Indigenous Australian oral health literacy. PLoS One. 2020; 15(6):e0233972. PMID: 32492049.
      Citations:    Fields:    
    3. Haag DG, Santiago PHR, Macedo DM, Bastos JL, Paradies Y, Jamieson L. Development and initial psychometric assessment of the race-related attitudes and multiculturalism scale in Australia. PLoS One. 2020; 15(4):e0230724. PMID: 32236121.
      Citations:    Fields:    Translation:Humans
    4. Esenlik E, Gibson T, Kassam S, Sato Y, Garfinkle J, Figueroa AA, AlQatami F, Runyan C, Alperovich M, Golinko MS, Lee C, Chatzigianni A, Zafeiriadis AA, Santiago P, Hosseinian B, Kaygisiz EU, Üçüncü N, Aslan BI, Uzuner FD, Gülsen A, Akkurt A, Arslan SG, Sabás M, Muñoz-Mendoza MA, Masis D, Holguin L, Granados A, Rojas NE, Campo B, Keskin K, Akçam MO, Lowe KM, Morselli PG, Pannuto L, Yarza IN, Martinez AT, Coskun EY, Nissan S. NAM Therapy-Evidence-Based Results. Cleft Palate Craniofac J. 2020 Apr; 57(4):529-531. PMID: 31960709.
      Citations:    Fields:    
    5. Santiago PHR, Roberts R, Smithers LG, Jamieson L. Stress beyond coping? A Rasch analysis of the Perceived Stress Scale (PSS-14) in an Aboriginal population. PLoS One. 2019; 14(5):e0216333. PMID: 31050685.
      Citations:    Fields:    Translation:Humans
    6. Santiago-Cardona PG, Pérez-Morales J, González-Flores J. Detection of Retinoblastoma Protein Phosphorylation by Immunoblot Analysis. Methods Mol Biol. 2018; 1726:49-64. PMID: 29468543.
      Citations: 1     Fields:    Translation:HumansCells
    7. Marcus JR, Allori AC, Santiago PE. Principles of Cleft Lip Repair: Conventions, Commonalities, and Controversies. Plast Reconstr Surg. 2017 Mar; 139(3):764e-780e. PMID: 28234859.
      Citations:    Fields:    Translation:Humans
    8. Sosa-García B, Vázquez-Rivera V, González-Flores JN, Engel BE, Cress WD, Santiago-Cardona PG. The Retinoblastoma Tumor Suppressor Transcriptionally Represses Pak1 in Osteoblasts. PLoS One. 2015; 10(11):e0142406. PMID: 26555075.
      Citations: 1     Fields:    Translation:AnimalsCells
    9. Allori AC, Cragan JD, Della Porta GC, Mulliken JB, Meara JG, Bruun R, Shusterman S, Cassell CH, Raynor E, Santiago P, Marcus JR. Clinician's Primer to ICD-10-CM Coding for Cleft Lip/Palate Care. Cleft Palate Craniofac J. 2017 01; 54(1):e7-e13. PMID: 26523325.
      Citations:    Fields:    Translation:Humans
    10. Brienne E Engel, W Douglas Cress, Pedro G Santiago-Cardona. The retinoblastoma protein: a master tumor suppressor acts as a link between cell cycle and cell adhesion. 2014; 7:1-10.
    11. Santiago PE, Schuster LA, Levy-Bercowski D. Management of the alveolar cleft. Clin Plast Surg. 2014 Apr; 41(2):219-32. PMID: 24607190.
      Citations: 4     Fields:    Translation:Humans
    12. Appleyard CB, Antonia SJ, Sullivan DM, Santiago-Cardona PG, Cáceres W, Velez H, Torres-Ruiz JA, Wright KL. Building a long distance training program to enhance clinical cancer research capacity in Puerto Rico. Rev Recent Clin Trials. 2014; 9(4):254-62. PMID: 25626061.
      Citations: 1     Fields:    Translation:Humans
    13. Cress WD, Chiappori A, Santiago P, Muñoz-Antonia T. Lung cancer mutations and use of targeted agents in Hispanics. Rev Recent Clin Trials. 2014; 9(4):225-32. PMID: 25626064.
      Citations: 5     Fields:    Translation:Humans
    14. Engel BE, Welsh E, Emmons MF, Santiago-Cardona PG, Cress WD. Expression of integrin alpha 10 is transcriptionally activated by pRb in mouse osteoblasts and is downregulated in multiple solid tumors. Cell Death Dis. 2013 Nov 28; 4:e938. PMID: 24287699.
      Citations: 9     Fields:    Translation:AnimalsCells
    15. Sosa-García B, Gunduz V, Vázquez-Rivera V, Cress WD, Wright G, Bian H, Hinds PW, Santiago-Cardona PG. A role for the retinoblastoma protein as a regulator of mouse osteoblast cell adhesion: implications for osteogenesis and osteosarcoma formation. PLoS One. 2010 Nov 11; 5(11):e13954. PMID: 21085651.
      Citations: 19     Fields:    Translation:AnimalsCells
    16. Levy-Bercowski D, Abreu A, DeLeon E, Looney S, Stockstill J, Weiler M, Santiago PE. Complications and solutions in presurgical nasoalveolar molding therapy. Cleft Palate Craniofac J. 2009 Sep; 46(5):521-8. PMID: 19929090.
      Citations: 8     Fields:    Translation:Humans
    17. Singh GD, Levy-Bercowski D, Santiago PE. Three-dimensional nasal changes following nasoalveolar molding in patients with unilateral cleft lip and palate: geometric morphometrics. Cleft Palate Craniofac J. 2005 Jul; 42(4):403-9. PMID: 16001922.
      Citations: 13     Fields:    Translation:Humans
    18. Santiago PE, Grayson BH, Degen M, Brecht LE, Singh GD, McCarthy JG. The effect of an early Le Fort III surgery on permanent molar eruption. Plast Reconstr Surg. 2005 Feb; 115(2):423-7. PMID: 15692345.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    19. Yang HS, Alexander K, Santiago P, Hinds PW. ERM proteins and Cdk5 in cellular senescence. Cell Cycle. 2003 Nov-Dec; 2(6):517-20. PMID: 14504464.
      Citations: 6     Fields:    Translation:HumansCells
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