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Akiko Shimamoto

Faculty RankAssistant Professor
InstitutionMeharry Medical College
DepartmentBiochem, Cancer Biology, Neuroscience & Pharmacology
Address1005 Dr. D.B. Todd Jr. Blvd.
Nashville TN 37208-3599
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    Other Positions
    TitleAssistant Professor
    InstitutionYamaguchi University
    DepartmentLegal Medicine

    TitlePostdoctoral Associate
    InstitutionTufts University
    DepartmentPsychology Department

    Collapse Biography 
    Collapse awards and honors
    2007 - 2008INVEST Drug Abuse Research Fellowship
    2011Young Investigator Travel Award for 2011 American Psychology Association
    2016RTRN Research Enhancement Award

    Collapse Overview 
    Collapse overview
    I am a junior faculty in the Department of Neuroscience and Pharmacology at Meharry Medical College since January 2014. I was recruited as a new investigator through a Meharry Research Center for Minority Institution (RCMI) Program in Women's Health Research sponsored by National Institute on Minority Health and Health Disparities (NIMHD) (G12 MD007586, 2014-2016). Before appointed as Assistant Professor at Meharry, I was a post-doctoral fellow at a lab led by Dr. Klaus A. Miczek at the Department of Psychology at Tufts University, who is specialized in psychopharmacology and behavioral neuroscience. I am an awardee on NIDA INVEST Drug Abuse Research Fellowship that initiated my postdoctoral work with Dr. Miczek. Before I came to Tufts, I was an Assistant Professor in field of forensic toxicology at Yamaguchi University School of Medicine. I received my Ph.D. and Master’s degrees in forensic science with a specialty in forensic toxicology. My current focus is on astrocytes, glutamate, and its amidated form glutamine, glutamate transporter-1 (GLT-1), sodium-coupled neutral amino acid transporters 1/2 (SNAT1/2), and presynaptic mitochondria in brain areas including the prefrontal cortex (PFC) and the nucleus accumbens (NAc). I have an expertise in in vivo microdialysis, immunohistochemistry, western blot, and behavioral assays, including locomotor activity, social defeat behaviors, and operant self-administration and relapsing behavior.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Uzhachenko R, Shimamoto A, Chirwa SS, Ivanov SV, Ivanova AV, Shanker A. Mitochondrial Fus1/Tusc2 and cellular Ca2+ homeostasis: tumor suppressor, anti-inflammatory and anti-aging implications. Cancer Gene Ther. 2022 10; 29(10):1307-1320. PMID: 35181743.
      Citations: 3     Fields:    Translation:Humans
    2. Hodo TW, de Aquino MTP, Shimamoto A, Shanker A. Critical Neurotransmitters in the Neuroimmune Network. Front Immunol. 2020; 11:1869. PMID: 32973771.
      Citations: 40     Fields:    Translation:HumansAnimals
    3. Shimamoto A, Rappeneau V, Munjal H, Farris T, Davis C, Wilson A, Edwards M, Moore C, Reynolds C, Meshul CK. Glutamate-Glutamine Transfer and Chronic Stress-Induced Sex Differences in Cocaine Responses. Neuroscience. 2018 11 01; 391:104-119. PMID: 30240589.
      Citations: 3     Fields:    Translation:AnimalsCells
    4. Shimamoto A. Social Defeat Stress, Sex, and Addiction-Like Behaviors. Int Rev Neurobiol. 2018; 140:271-313. PMID: 30193707.
      Citations: 12     Fields:    Translation:Animals
    5. Shimamoto A, Rappeneau V. Sex-dependent mental illnesses and mitochondria. Schizophr Res. 2017 09; 187:38-46. PMID: 28279571.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    6. Rappeneau V, Blaker A, Petro JR, Yamamoto BK, Shimamoto A. Disruption of the Glutamate-Glutamine Cycle Involving Astrocytes in an Animal Model of Depression for Males and Females. Front Behav Neurosci. 2016; 10:231. PMID: 28018190.
    7. Hwa LS, Nathanson AJ, Shimamoto A, Tayeh JK, Wilens AR, Holly EN, Newman EL, DeBold JF, Miczek KA. Aggression and increased glutamate in the mPFC during withdrawal from intermittent alcohol in outbred mice. Psychopharmacology (Berl). 2015 Aug; 232(16):2889-902. PMID: 25899790.
      Citations: 26     Fields:    Translation:Animals
    8. Hwa LS, Shimamoto A, Kayyali T, Norman KJ, Valentino RJ, DeBold JF, Miczek KA. Dissociation of ?-opioid receptor and CRF-R1 antagonist effects on escalated ethanol consumption and mPFC serotonin in C57BL/6J mice. Addict Biol. 2016 Jan; 21(1):111-24. PMID: 25262980.
      Citations: 15     Fields:    Translation:Animals
    9. Han X, Albrechet-Souza L, Doyle MR, Shimamoto A, DeBold JF, Miczek KA. Social stress and escalated drug self-administration in mice II. Cocaine and dopamine in the nucleus accumbens. Psychopharmacology (Berl). 2015 Mar; 232(6):1003-10. PMID: 25216798.
      Citations: 20     Fields:    Translation:Animals
    10. Shimamoto A, Holly EN, Boyson CO, DeBold JF, Miczek KA. Individual differences in anhedonic and accumbal dopamine responses to chronic social stress and their link to cocaine self-administration in female rats. Psychopharmacology (Berl). 2015 Feb; 232(4):825-34. PMID: 25178816.
      Citations: 27     Fields:    Translation:Animals
    11. Quadros IM, Hwa LS, Shimamoto A, Carlson J, DeBold JF, Miczek KA. Prevention of alcohol-heightened aggression by CRF-R1 antagonists in mice: critical role for DRN-PFC serotonin pathway. Neuropsychopharmacology. 2014 Nov; 39(12):2874-83. PMID: 24917195.
      Citations: 13     Fields:    Translation:Animals
    12. Boyson CO, Holly EN, Shimamoto A, Albrechet-Souza L, Weiner LA, DeBold JF, Miczek KA. Social stress and CRF-dopamine interactions in the VTA: role in long-term escalation of cocaine self-administration. J Neurosci. 2014 May 07; 34(19):6659-67. PMID: 24806691.
      Citations: 46     Fields:    Translation:Animals
    13. Holly EN, Shimamoto A, Debold JF, Miczek KA. Sex differences in behavioral and neural cross-sensitization and escalated cocaine taking as a result of episodic social defeat stress in rats. Psychopharmacology (Berl). 2012 Nov; 224(1):179-88. PMID: 22926005.
      Citations: 53     Fields:    Translation:AnimalsCells
    14. Miczek KA, Nikulina EM, Shimamoto A, Covington HE. Escalated or suppressed cocaine reward, tegmental BDNF, and accumbal dopamine caused by episodic versus continuous social stress in rats. J Neurosci. 2011 Jul 06; 31(27):9848-57. PMID: 21734276.
      Citations: 95     Fields:    Translation:Animals
    15. Shimamoto A, Debold JF, Holly EN, Miczek KA. Blunted accumbal dopamine response to cocaine following chronic social stress in female rats: exploring a link between depression and drug abuse. Psychopharmacology (Berl). 2011 Nov; 218(1):271-9. PMID: 21638221.
      Citations: 43     Fields:    Translation:Animals
    16. Miczek KA, Nikulina EM, Takahashi A, Covington HE, Yap JJ, Boyson CO, Shimamoto A, de Almeida RM. Gene expression in aminergic and peptidergic cells during aggression and defeat: relevance to violence, depression and drug abuse. Behav Genet. 2011 Nov; 41(6):787-802. PMID: 21416141.
      Citations: 20     Fields:    Translation:Animals
    17. Takahashi A, Shimamoto A, Boyson CO, DeBold JF, Miczek KA. GABA(B) receptor modulation of serotonin neurons in the dorsal raph? nucleus and escalation of aggression in mice. J Neurosci. 2010 Sep 01; 30(35):11771-80. PMID: 20810897.
      Citations: 52     Fields:    Translation:AnimalsCells
    18. Shimamoto A, Liu JY, Fujimiya T. SIAM-Like phenomenon caused by low doses of alcohol. Alcohol Clin Exp Res. 2010 Feb; 34 Suppl 1:S2-6. PMID: 19382898.
      Citations: 2     Fields:    Translation:Animals
    19. Kozawa S, Yukawa N, Liu J, Shimamoto A, Kakizaki E, Fujimiya T. Effect of chronic ethanol administration on disposition of ethanol and its metabolites in rat. Alcohol. 2007 Mar; 41(2):87-93. PMID: 17517325.
      Citations: 5     Fields:    Translation:AnimalsCells
    20. Liu J, Yano M, Shimamoto A, Noma T, Matsuzaki M, Fujimiya T. Chronic effects of ethanol on pharmacokinetics and left ventricular systolic function in rats. Alcohol Clin Exp Res. 2007 Mar; 31(3):493-9. PMID: 17295735.
      Citations: 1     Fields:    Translation:Animals
    21. Shimamoto A, Liu J, Kozawa S, Fujimiya T. Determination of endogenous testosterone in rat tissues following fetal alcohol exposure using HPLC with UV detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 May 19; 836(1-2):69-73. PMID: 16574507.
      Citations: 1     Fields:    Translation:AnimalsPHPublic Health
    22. Kiyoshima A, Kudo K, Goto Y, Tobimatsu S, Ikeda N. Cerebral concentrations of myo-inositol in rats with induced brain death. Leg Med (Tokyo). 2005 Mar; 7(2):110-2. PMID: 15708334.
      Citations:    Fields:    Translation:Animals
    23. Ishida T, Kudo K, Kiyoshima A, Inoue H, Tsuji A, Ikeda N. Sensitive determination of alpha-methyltryptamine (AMT) and 5-methoxy-N,N-diisopropyltryptamine (5MeO-DIPT) in whole blood and urine using gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Aug 25; 823(1):47-52. PMID: 16055053.
      Citations: 1     Fields:    Translation:Humans
    24. Kudo K, Nishida N, Kiyoshima A, Ikeda N. A fatal case of poisoning by lidocaine overdosage--analysis of lidocaine in formalin-fixed tissues: a case report. Med Sci Law. 2004 Jul; 44(3):266-71. PMID: 15296252.
      Citations: 5     Fields:    Translation:HumansAnimals
    25. Kiyoshima A, Kudo K, Goto Y, Tobimatsu S, Ikeda N. Changes of the cerebral mannitol concentrations in the course of brain death of a rodent model. Leg Med (Tokyo). 2004 Apr; 6(2):117-24. PMID: 15039055.
      Citations:    Fields:    Translation:Animals
    26. Kudo K, Kiyoshima A, Ohtsuka Y, Ikeda N. Simultaneous determination of bromvalerylurea and allylisopropylacetylurea in human blood and urine by gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jul 05; 791(1-2):171-7. PMID: 12798177.
      Citations:    Fields:    Translation:Humans
    27. Nishida N, Ikeda N, Kudo K, Tsuji A, Kiyoshima A. Forensic significance of conduction system abnormalities as a precise cause of accidental death. Int J Legal Med. 2002 Dec; 116(6):344-9. PMID: 12461642.
      Citations: 9     Fields:    Translation:Humans
    28. Kudo K, Ikeda N, Kiyoshima A, Hino Y, Nishida N, Inoue N. Toxicological analysis of chlorhexidine in human serum using HPLC on a polymer-coated ODS column. J Anal Toxicol. 2002 Mar; 26(2):119-22. PMID: 11916014.
      Citations: 3     Fields:    Translation:Humans
    29. Hino Y, Kudo K, Kiyoshima A, Ikeda N. A sudden death following tetracaine-induced spinal anesthesia. Leg Med (Tokyo). 2002 Mar; 4(1):55-9. PMID: 12935694.
      Citations:    Fields:    
    30. Kiyoshima A, Kudo K, Nishida N, Ikeda N. HPLC simultaneous determination of glycerol and mannitol in human tissues for forensic analysis. Forensic Sci Int. 2002 Feb 18; 125(2-3):127-33. PMID: 11909653.
      Citations: 2     Fields:    Translation:Humans
    31. Kiyoshima A, Kudo K, Hino Y, Ikeda N. Sensitive and simple determination of mannitol in human brain tissues by gas chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl. 2001 Jul 05; 758(1):103-8. PMID: 11482728.
      Citations: 1     Fields:    Translation:Humans
    32. Tanaka E, Shimamoto A, Nakamura T, Terao K, Misawa S. Differences in chlorzoxazone metabolism in full mature male and female Sprague-Dawley rat, Beagle dog and Cynomolgus monkey liver. Hum Exp Toxicol. 2000 Feb; 19(2):122-5. PMID: 10773842.
      Citations:    Fields:    Translation:AnimalsCells
    33. Takenouchi T, Fujimoto M, Shimamoto A, Munekata E. Isolation and characterization of Cox17p from porcine heart by determining its survival-promoting activity in NIH3T3 cells. Biochim Biophys Acta. 1999 Nov 16; 1472(3):498-508. PMID: 10564764.
      Citations: 2     Fields:    Translation:AnimalsCells
    34. Shimamoto A, Tanaka E, Mizuno D, Misawa S. Age- and sex-related changes in toluene metabolism by rat hepatic microsomes in vitro. Res Commun Mol Pathol Pharmacol. 1999; 104(3):265-76. PMID: 10741377.
      Citations: 1     Fields:    Translation:AnimalsCells
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