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Tultul Nayyar

TitlePhD
Faculty RankAssociate Professor
InstitutionMeharry Medical College
DepartmentBiochem, Cancer Biology, Neuroscience & Pharmacology
Address1005, Dr. D. B. Todd Jr. Blvd
Nashville TN 37208
Phone6153276898
Fax6153276632
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    Other Positions
    TitleAdjunct Assistant Professor
    InstitutionVanderbilt University
    DepartmentObstetrics & Gynecology


    Collapse Biography 
    Collapse awards and honors
    2007ETS/Elsevier award for the for the best publication in Reproductive Toxicology , The Council of the European Teratology Society

    Collapse Overview 
    Collapse overview
    I started my research career in female reproductive endocrinology using an animal model to evaluate clomiphene citrate, and cyproterone acetate versus copper intrauterine devices, as birth control measures. During my post-doctoral training in the area of Biochemistry at Dr. Das’s laboratory at Meharry, I developed a guinea pig model for lung injuries caused by a vitamin A deficiency. The vitamin results indicated that injury was secondary to alterations in the density and binding capabilities of peripheral benzodiazepine receptors. Since then I have gained additional research experience related to environmental neurotoxicology, reproductive toxicology and Parkinson’s disease. I studied the functional impact of benzo(a)pyrene and/or dioxin exposure of pregnant rat dams on the subsequent development of brain glutamatergic cortical circuits in delivered pups. This led me to work Drs. Osteen and Bruner-Tran at Vanderbilt University on another first author paper in Reproductive Toxicology which concluded that the phenotype of mice exposed to dioxin was similar to that seen in women with endometriosis. More recently I have worked with Dr. Twum Ansah and Dr. Ariel Deutch on the effects of MPTP in mice (a model of Parkinson’s disease) on the cortical serotonin system. Because of all these experiences, I developed a keen interest in the role of ovarian steroids on the regulations of brain neurotransmitters, particularly serotonin, and its relationship to depression. Combining my basic science research backgrounds in neuroscience and reproductive endocrinology I therefore developed a translational research pilot project to determine the relationships between ovarian steroids and, leukocyte beta-arrestin levels (as a regulator of serotonin neurotransmission), and the severity of depression in reproductive women. To develop my skill on translational and clinical research, I am collaborating with clinical investigators Dr. Bailey and Dr. Richie at Elam Mental Health Center at Meharry, and also enrolled myself in Master of Science in Clinical Investigations Program at Meharry Medical College.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Smith K, Nayyar S, Rana T, Archibong AE, Looney KR, Nayyar T. Do Progestin-Only Contraceptives Contribute to the Risk of Developing Depression as Implied by Beta-Arrestin 1 Levels in Leukocytes? A Pilot Study. Int J Environ Res Public Health. 2018 09 09; 15(9). PMID: 30205587.
      Citations: 2     Fields:    Translation:HumansCells
    2. Alam F, Nayyar S, Richie W, Archibong A, Nayyar T. Beta-Arrestin1 Levels in Mononuclear Leukocytes Support Depression Scores for Women with Premenstrual Dysphoric Disorder. Int J Environ Res Public Health. 2015 Dec 22; 13(1):ijerph13010043. PMID: 26703643.
      Citations: 1     Fields:    Translation:HumansCells
    3. Ferguson MC, Nayyar T, Ansah TA. Reverse microdialysis of a 5-HT2A receptor antagonist alters extracellular glutamate levels in the striatum of the MPTP mouse model of Parkinson's disease. Neurochem Int. 2014 May; 71:36-46. PMID: 24704796.
      Citations: 1     Fields:    Translation:AnimalsCells
    4. Ansah TA, Ferguson MC, Nayyar T, Deutch AY. Age- and duration-dependent effects of MPTP on cortical serotonin systems. Neurosci Lett. 2011 Oct 24; 504(2):160-164. PMID: 21964387.
      Citations: 3     Fields:    Translation:Animals
    5. Ansah TA, Ferguson MC, Nayyar T. The 5-HT(2A) Receptor Antagonist M100907 Produces Antiparkinsonian Effects and Decreases Striatal Glutamate. Front Syst Neurosci. 2011; 5:48. PMID: 21716656.
      Citations:    
    6. Ferguson MC, Nayyar T, Deutch AY, Ansah TA. 5-HT2A receptor antagonists improve motor impairments in the MPTP mouse model of Parkinson's disease. Neuropharmacology. 2010 Jul-Aug; 59(1-2):31-6. PMID: 20361986.
      Citations: 11     Fields:    Translation:Animals
    7. Nayyar T, Bubser M, Ferguson MC, Neely MD, Shawn Goodwin J, Montine TJ, Deutch AY, Ansah TA. Cortical serotonin and norepinephrine denervation in parkinsonism: preferential loss of the beaded serotonin innervation. Eur J Neurosci. 2009 Jul; 30(2):207-16. PMID: 19659923.
      Citations: 11     Fields:    Translation:HumansAnimals
    8. Nayyar T, Bruner-Tran KL, Piestrzeniewicz-Ulanska D, Osteen KG. Developmental exposure of mice to TCDD elicits a similar uterine phenotype in adult animals as observed in women with endometriosis. Reprod Toxicol. 2007 Apr-May; 23(3):326-36. PMID: 17056225.
      Citations: 29     Fields:    Translation:HumansAnimals
    9. Wormley DD, Chirwa S, Nayyar T, Wu J, Johnson S, Brown LA, Harris E, Hood DB. Inhaled benzo(a)pyrene impairs long-term potentiation in the F1 generation rat dentate gyrus. Cell Mol Biol (Noisy-le-grand). 2004 Sep; 50(6):715-21. PMID: 15641162.
      Citations: 29     Fields:    Translation:AnimalsCellsPHPublic Health
    10. Nayyar T, Wu J, Hood DB. Downregulation of hippocampal NMDA receptor expression by prenatal exposure to dioxin. Cell Mol Biol (Noisy-le-grand). 2003 Dec; 49(8):1357-62. PMID: 14984010.
      Citations: 3     Fields:    Translation:AnimalsCells
    11. Wu J, Ramesh A, Nayyar T, Hood DB. Assessment of metabolites and AhR and CYP1A1 mRNA expression subsequent to prenatal exposure to inhaled benzo(a)pyrene. Int J Dev Neurosci. 2003 Oct; 21(6):333-46. PMID: 12927582.
      Citations: 14     Fields:    Translation:Animals
    12. Archibong AE, Inyang F, Ramesh A, Greenwood M, Nayyar T, Kopsombut P, Hood DB, Nyanda AM. Alteration of pregnancy related hormones and fetal survival in F-344 rats exposed by inhalation to benzo(a)pyrene. Reprod Toxicol. 2002 Nov-Dec; 16(6):801-8. PMID: 12401509.
      Citations: 36     Fields:    Translation:AnimalsPHPublic Health
    13. Nayyar T, Zawia NH, Hood DB. Transplacental effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the temporal modulation of Sp1 DNA binding in the developing cerebral cortex and cerebellum. Exp Toxicol Pathol. 2002 Feb; 53(6):461-8. PMID: 11926288.
      Citations: 8     Fields:    Translation:AnimalsPHPublic Health
    14. Nayyar T, Mukherjee S, Das SK. Alterations in binding characteristics of peripheral benzodiazepine receptors in testes by vitamin A deficiency in guinea pigs. Mol Cell Biochem. 2000 Aug; 211(1-2):47-50. PMID: 11055546.
      Citations: 2     Fields:    Translation:Animals
    15. Hood DB, Nayyar T, Ramesh A, Greenwood M, Inyang F. Modulation in the developmental expression profile of Sp1 subsequent to transplacental exposure of fetal rats to desorbed benzo[a]pyrene following maternal inhalation. Inhal Toxicol. 2000 Jun; 12(6):511-35. PMID: 10880142.
      Citations: 26     Fields:    Translation:AnimalsPHPublic Health
    16. Nayyar T, Mukherjee S, Das SK. Modulation of binding characteristics of peripheral benzodiazepine receptors in vitamin A-deficient guinea pig lung. Biochem Pharmacol. 1996 May 03; 51(9):1203-9. PMID: 8645344.
      Citations: 1     Fields:    Translation:Animals
    17. Mukherjee S, Nayyar T, Chytil F, Das SK. Mainstream and sidestream cigarette smoke exposure increases retinol in guinea pig lungs. Free Radic Biol Med. 1995 Mar; 18(3):507-14. PMID: 9101241.
      Citations: 4     Fields:    Translation:AnimalsPHPublic Health
    18. Mukherjee S, Ghosh S, Rodgers L, Nayyar T, Desai U, Das SK. Toxic effects of fatty acid anilides on the oxygen defense systems of guinea pig lungs and erythrocytes. J Biochem Toxicol. 1994 Feb; 9(1):1-7. PMID: 8151627.
      Citations: 1     Fields:    Translation:AnimalsCells
    19. Das SK, Chakrabarti P, Tsao FH, Nayyar T, Mukherjee S. Identification of calcium-dependent phospholipid-binding proteins (annexins) from guinea pig alveolar type II cells. Mol Cell Biochem. 1992 Sep 22; 115(1):79-84. PMID: 1435768.
      Citations: 4     Fields:    Translation:AnimalsCells
    20. Ghosh T, Nayyar SK. Effect of clomiphene citrate & its isomers on ovulation in 4-day cyclic rats. Indian J Exp Biol. 1980 Mar; 18(3):250-1. PMID: 7190129.
      Citations:    Fields:    Translation:AnimalsCells
    21. Nayyar SK, Ghosh T. Cyproterone acetate and seminal vesicles in the regulation of male fertility. Contraception. 1980 Feb; 21(2):183-90. PMID: 7371410.
      Citations:    Fields:    Translation:Animals
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