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Faculty RankAssociate Professor
InstitutionMeharry Medical College
DepartmentMicrobiology, Immunology, & Physiology
AddressDept of Microbiology & Immunology
Meharry Medical College
Nashville TN 37208
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    Collapse Overview 
    Collapse overview
    Dr. Pius N. Nde is an Associate Professor in the Department of Microbiology and Immunology at
    Meharry Medical College. He received his BSc and MSc degrees from the Biochemistry Department of the University of Ibadan, Nigeria and his PhD degree in Molecular Biology from Humboldt-University Berlin, Germany. Subsequently, he completed postdoctoral research training at Meharry Medical College in the laboratory of Dr. Fernando Villalta. Dr. Nde’s overall research interest focuses on “host pathogen interactions, molecular mechanisms of cardiac pathology induced by Trypanosoma cruzi and diagnosis of neglected tropical diseases.” His current SC1 research project entitled “Molecular mechanisms of Trypanosoma cruzi cardiopathogenesis ” is funded by NIAID, http://projectreporter.nih.gov/project_info_description.cfm?aid=9073494. The focus of the grant is to elucidate the molecular mechanisms utilized by T. cruzi to induce a fibrogenic response that can be exploited for the development of molecular intervention strategies. He is also a previous recipient of the SCORE SC2 grant from NIH. Currently, he is a member of ASBMB, American Society of Matrix Biology and American Heart Association. Dr. Nde’s, publications are available in the link: https://www.ncbi.nlm.nih.gov/sites/myncbi/pius.nde.1/bibliography/43068717/public/?sort=date&direction=ascending

    Title of Dr. Nde’s RTRN Spotlight presentation is “Molecular mechanisms of cardiac fibrosis induced by Trypanosoma cruzi infection”

    Collapse Research 
    Collapse research activities and funding
    SC2AI083925     (NDE, PIUS N)Feb 1, 2009 - Jan 31, 2013
    Novel trypanosome receptor for thrombospondin-1
    Role: Principal Investigator

    SC1AI127352     (NDE, PIUS N)May 5, 2016 - Apr 30, 2021
    Molecular mechanisms of Trypanosoma cruzi cardiopathogenesis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rayford KJ, Cooley A, Strode AW, Osi I, Arun A, Lima MF, Misra S, Pratap S, Nde PN. Trypanosoma cruzi dysregulates expression profile of piRNAs in primary human cardiac fibroblasts during early infection phase. Front Cell Infect Microbiol. 2023; 13:1083379. PMID: 36936778.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    2. Rumph JT, Stephens VR, Ameli S, Brown LK, Rayford KJ, Nde PN, Osteen KG, Bruner-Tran KL. A Paternal Fish Oil Diet Preconception Reduces Lung Inflammation in a Toxicant-Driven Murine Model of New Bronchopulmonary Dysplasia. Mar Drugs. 2023 Feb 27; 21(3). PMID: 36976210.
      Citations: 1     Fields:    Translation:HumansAnimals
    3. Cooley A, Rayford KJ, Arun A, Villalta F, Lima MF, Pratap S, Nde PN. Trypanosoma cruzi Dysregulates piRNAs Computationally Predicted to Target IL-6 Signaling Molecules During Early Infection of Primary Human Cardiac Fibroblasts. Immune Netw. 2022 Dec; 22(6):e51. PMID: 36627941.
    4. Rumph JT, Stephens VR, Ameli S, Gaines PN, Osteen KG, Bruner-Tran KL, Nde PN. A Paternal Fish Oil Diet Preconception Modulates the Gut Microbiome and Attenuates Necrotizing Enterocolitis in Neonatal Mice. Mar Drugs. 2022 Jun 13; 20(6). PMID: 35736193.
      Citations: 1     Fields:    Translation:HumansAnimals
    5. Arun A, Rayford KJ, Cooley A, Rana T, Rachakonda G, Villalta F, Pratap S, Lima MF, Sheibani N, Nde PN. Thrombospondin-1 expression and modulation of Wnt and hippo signaling pathways during the early phase of Trypanosoma cruzi infection of heart endothelial cells. PLoS Negl Trop Dis. 2022 01; 16(1):e0010074. PMID: 34986160.
      Citations: 3     Fields:    Translation:AnimalsCells
    6. Rumph JT, Rayford KJ, Stephens VR, Ameli S, Nde PN, Osteen KG, Bruner-Tran KL. A Preconception Paternal Fish Oil Diet Prevents Toxicant-Driven New Bronchopulmonary Dysplasia in Neonatal Mice. Toxics. 2021 Dec 27; 10(1). PMID: 35051049.
    7. Rayford KJ, Cooley A, Rumph JT, Arun A, Rachakonda G, Villalta F, Lima MF, Pratap S, Misra S, Nde PN. piRNAs as Modulators of Disease Pathogenesis. Int J Mol Sci. 2021 Feb 27; 22(5). PMID: 33673453.
      Citations: 19     Fields:    Translation:HumansAnimals
    8. Rayford KJ, Cooley A, Arun A, Rachakonda G, Kleschenko Y, Villalta F, Pratap S, Lima MF, Nde PN. Trypanosoma cruzi Modulates PIWI-Interacting RNA Expression in Primary Human Cardiac Myocytes during the Early Phase of Infection. Int J Mol Sci. 2020 Dec 11; 21(24). PMID: 33322418.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    9. Arun A, Rayford KJ, Cooley A, Rachakonda G, Villalta F, Pratap S, Lima MF, Sheibani N, Nde PN. Thrombospondin-1 Plays an Essential Role in Yes-Associated Protein Nuclear Translocation during the Early Phase of Trypanosoma cruzi Infection in Heart Endothelial Cells. Int J Mol Sci. 2020 Jul 12; 21(14). PMID: 32664627.
      Citations: 8     Fields:    Translation:AnimalsCells
    10. Suman S, Rachakonda G, Mandape SN, Sakhare SS, Villalta F, Pratap S, Lima MF, Nde PN. Phospho-proteomic analysis of primary human colon epithelial cells during the early Trypanosoma cruzi infection phase. PLoS Negl Trop Dis. 2018 09; 12(9):e0006792. PMID: 30222739.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    11. Matthews QL, Farrow AL, Rachakonda G, Gu L, Nde P, Krendelchtchikov A, Pratap S, Sakhare SS, Sabbaj S, Lima MF, Villalta F. Epitope Capsid-Incorporation: New Effective Approach for Vaccine Development for Chagas Disease. Pathog Immun. 2016 Fall-Winter; 1(2):214-233. PMID: 27709126.
    12. Udoko AN, Johnson CA, Dykan A, Rachakonda G, Villalta F, Mandape SN, Lima MF, Pratap S, Nde PN. Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0003747. PMID: 26771187.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    13. Lepesheva GI, Hargrove TY, Rachakonda G, Wawrzak Z, Pomel S, Cojean S, Nde PN, Nes WD, Locuson CW, Calcutt MW, Waterman MR, Daniels JS, Loiseau PM, Villalta F. VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis. J Infect Dis. 2015 Nov 01; 212(9):1439-48. PMID: 25883390.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    14. Farrow AL, Rachakonda G, Gu L, Krendelchtchikova V, Nde PN, Pratap S, Lima MF, Villalta F, Matthews QL. Immunization with Hexon modified adenoviral vectors integrated with gp83 epitope provides protection against Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2014 Aug; 8(8):e3089. PMID: 25144771.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    15. Johnson CA, Rachakonda G, Kleshchenko YY, Nde PN, Madison MN, Pratap S, Cardenas TC, Taylor C, Lima MF, Villalta F. Cellular response to Trypanosoma cruzi infection induces secretion of defensin a-1, which damages the flagellum, neutralizes trypanosome motility, and inhibits infection. Infect Immun. 2013 Nov; 81(11):4139-48. PMID: 23980110.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    16. Villalta F, Dobish MC, Nde PN, Kleshchenko YY, Hargrove TY, Johnson CA, Waterman MR, Johnston JN, Lepesheva GI. VNI cures acute and chronic experimental Chagas disease. J Infect Dis. 2013 Aug 01; 208(3):504-11. PMID: 23372180.
      Citations: 58     Fields:    Translation:Animals
    17. Villalta, F., Dobish, M.C., Nde, P.N., Kleshchenko, Y.Y., Hargrove, T.Y., Johnson, C.A., Waterman, M.R., Johnston, J.N., and Lepesheva.G.I. VNI cures the acute and chronic experimental Chagas disease. The Journal of Infectious Diseases. 2013; 208 (3):504-511. View Publication.
    18. Nde PN, Lima MF, Johnson CA, Pratap S, Villalta F. Regulation and use of the extracellular matrix by Trypanosoma cruzi during early infection. Front Immunol. 2012; 3:337. PMID: 23133440.
      Citations: 24     Fields:    
    19. Johnson CA, Kleshchenko YY, Ikejiani AO, Udoko AN, Cardenas TC, Pratap S, Duquette MA, Lima MF, Lawler J, Villalta F, Nde PN. Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular infection. PLoS One. 2012; 7(7):e40614. PMID: 22808206.
      Citations: 16     Fields:    Translation:AnimalsCells
    20. Nde PN, Johnson CA, Pratap S, Cardenas TC, Kleshchenko YY, Furtak VA, Simmons KJ, Lima MF, Villalta F. Gene network analysis during early infection of human coronary artery smooth muscle cells by Trypanosoma cruzi and Its gp83 ligand. Chem Biodivers. 2010 May; 7(5):1051-64. PMID: 20491065.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    21. Cardenas TC, Johnson CA, Pratap S, Nde PN, Furtak V, Kleshchenko YY, Lima MF, Villalta F. REGULATION of the EXTRACELLULAR MATRIX INTERACTOME by Trypanosoma cruzi. Open Parasitol J. 2010; 4:72-76. PMID: 21499436.
    22. Villalta F, Madison MN, Kleshchenko YY, Nde PN, Lima MF. Molecular analysis of early host cell infection by Trypanosoma cruzi. Front Biosci. 2008 May 01; 13:3714-34. PMID: 18508467.
      Citations: 13     Fields:    Translation:HumansAnimals
    23. Andrews JA, Bligh WJ, Chiodini PL, Bradley JE, Nde PN, Lucius R. The role of a recombinant hybrid protein based ELISA for the serodiagnosis of Onchocerca volvulus. J Clin Pathol. 2008 Mar; 61(3):347-51. PMID: 17923472.
      Citations: 3     Fields:    Translation:HumansAnimals
    24. Madison MN, Kleshchenko YY, Nde PN, Simmons KJ, Lima MF, Villalta F. Human defensin alpha-1 causes Trypanosoma cruzi membrane pore formation and induces DNA fragmentation, which leads to trypanosome destruction. Infect Immun. 2007 Oct; 75(10):4780-91. PMID: 17635867.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    25. Augustine SA, Kleshchenko YY, Nde PN, Pratap S, Ager EA, Burns JM, Lima MF, Villalta F. Molecular cloning of a Trypanosoma cruzi cell surface casein kinase II substrate, Tc-1, involved in cellular infection. Infect Immun. 2006 Jul; 74(7):3922-9. PMID: 16790765.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    26. Simmons KJ, Nde PN, Kleshchenko YY, Lima MF, Villalta F. Stable RNA interference of host thrombospondin-1 blocks Trypanosoma cruzi infection. FEBS Lett. 2006 Apr 17; 580(9):2365-70. PMID: 16616140.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    27. Nde PN, Simmons KJ, Kleshchenko YY, Pratap S, Lima MF, Villalta F. Silencing of the laminin gamma-1 gene blocks Trypanosoma cruzi infection. Infect Immun. 2006 Mar; 74(3):1643-8. PMID: 16495535.
      Citations: 25     Fields:    Translation:HumansAnimals
    28. Nde PN, Pogonka T, Bradley JE, Titanji VP, Lucius R. Sensitive and specific serodiagnosis of onchocerciasis with recombinant hybrid proteins. Am J Trop Med Hyg. 2002 May; 66(5):566-71. PMID: 12201591.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    29. Pogonka T, Brattig N, Nde PN, Adam R, Seeber F, Zipfel PF, Titanji VP, Lucius R. Localization of T and B cell stimulating domains of the immunodominant 33-kDa protein of Onchocerca volvulus (Ov33). Clin Immunol Immunopathol. 1997 Oct; 85(1):56-66. PMID: 9325070.
      Citations:    Fields:    Translation:HumansAnimalsCells
    30. Titanji VP, Nde PN, Ghogoinu SM, Tamo R, Lucius R, Perler F. The roles of IgG and defined antigens in cytoadherence and cytotoxicity reactions to onchocercal microfilariae. Afr J Health Sci. 1996 May; 3(2):33-6. PMID: 17451294.
      Citations:    Fields:    
    31. Zimmerman PA, Steiner LL, Titanji VP, Nde PN, Bradley JE, Pogonka T, Begovich AB. Three new DPB1 alleles identified in a Bantu-speaking population from central Cameroon. Tissue Antigens. 1996 Apr; 47(4):293-9. PMID: 8773318.
      Citations: 2     Fields:    Translation:HumansCells
    32. Titanji VP, Nde PN, Mbacham WF. Cell-mediated and monoclonal antibody-dependent killing of Onchocerca volvulus microfilariae. Scand J Immunol Suppl. 1992; 11:57-61. PMID: 1514052.
      Citations: 3     Fields:    Translation:HumansAnimals
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