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Fernando Villalta

TitlePhD, Chair
Faculty RankProfessor
InstitutionMeharry Medical College
DepartmentMicrobiology, Immunology, & Physiology
Address1005 Dr. D. B. Todd BLVD
Nashville TN 37208-3501
Phone6153276667
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    Collapse Biography 
    Collapse awards and honors
    1972 - 1974Ford Foundation Fellow
    1976H. Unanue Award in Biomedical Sciences
    1977 - 1981WHO fellow
    1978H. Unanue Award in Biomedical Sciences
    1988NAFEO/USAID Award
    1992Michael J. Bent Scholarship Award for Scientific Excellence, Meharry Medical College (MMC)
    1997American Heart Association Scientific Service Award
    1997Cover Page Scientific Highlight article “Parasites: Master of Molecular Manipulation”, NIH/NCRR Reporter
    1998Scientific Service Award , FDA
    2001Distinguished Mentorship Award, Meharry Medical College (MMC)
    2006Distinguished Mentorship Award, Meharry Medical College (MMC)
    2004 - 2007Faculty Mentor Award , American Association of Immunologists
    2009 - 2010Faculty Mentor Award , American Association of Immunologists
    2007Distinguished Professor Award, Meharry Medical College (MMC)

    Collapse Overview 
    Collapse overview
    My professional and research experience qualifies me well to serve as the MeTRC Deputy Director for this grant application. I have served in this capacity for the last 5 years and successfully supervised several activities of the MeTRC Program, to effectively achieve its goals, such as (i) Collaborations and Partnerships, that enhanced internal and external collaborations; (ii) Biomedical Informatics, that developed an informatics infrastructure to facilitate the translation of research discoveries into clinical applications; (iii) Technologies and Resources for Core Laboratories, that developed a proteomics core to incorporate proteomics into translational and clinical research to advance protein discovery in clinical and translational settings; and (iv) MeTRC “Structural Activities” such Journal Clubs, Quarterly Joint Research Meetings of MeTRC-funded investigators, Clinical and Translational Research Seminar Series. Furthermore, I have significantly enhanced the career development of MeTRC investigators who had MeTRC small pilot Projects and Big Science Pilot projects. Under my mentorship these MeTRC investigators published a significant number of papers in high impact journals, obtained extramural grant support such as NIH R56, several R21s, SC1s, two NCATS UH2 supplements, among others. Under my mentorship I revised their funded grants and published papers before submissions. Their papers made the cover page of the Journal issues, were spotlighted in the journals and highlighted by the FACULTY 1000, including the NIH.

    In my capacity of Co-Leader of the Pilot Projects Activity my role will be to successfully achieve the goals of the Pilot Projects Activity in order to significantly advance the conduct of translational research activity in the science of health disparities. I will also facilitate the transition of research discoveries into clinical applications in the MeTRC program by networking T1 researchers with clinical researchers.

    I have strong training and expertise in infectious diseases and immunology. My research focuses on the treatment of incurable infectious diseases with novel drugs and on the prevention of them with new vaccines. My research program has been supported by NIH grants for 26 years and I have published large numbers of papers in my field in high impact journals. I have a strong history of mentoring junior faculty members who obtained NIH extramural grant support as a chair of the Department of Microbiology and Immunology, Interim Director of the Center for AIDS Health Disparities Research and as a MeTRC Deputy Director at Meharry Medical College. This together with my large history of serving on NIH study sections for over 25 years put me in a unique position to serve as Co-Leader of the Pilot Projects Activity to successfully achieve its goals which will enhance research discoveries in the translational and clinical enterprises of the MeTRC Program. My long-term goal as MeTRC leader is to continue mentoring faculty to be more successful in obtaining grants and publications in clinical and translational research to improve the treatment and prevention of health disparities in disadvantages populations.

    In my capacity of MeTRC leader I will also continue to supervise the Biomedical Informatics activity, Technologies and Resources for Core Laboratories and the structural activity of Clinical and Translational Research Seminar Series to ensure that these activities successfully achieve their goals. My previous experience in supervising these activities in the MeTRC program will be instrumental for this task.

    In summary, I have a demonstrated record of successful and productive MeTRC leadership in the Pilot Projects activity as well as in other MeTRC activities that I supervised listed above and my expertise and experience have prepared me well to lead these MeTRC activities in the program.


    Collapse Research 
    Collapse research activities and funding
    R29AI025637     (VILLALTA, FERNANDO)Sep 30, 1988 - Aug 31, 1993
    NIH
    HOST CELL INVASION BY TRYPANOSOMA CRUZI
    Role: Principal Investigator

    T32HL007737     (VILLALTA, FERNANDO)Jul 1, 1993 - Nov 30, 2019
    NIH
    Research Training in Cardiovascular Biology at Meharry
    Role: Principal Investigator

    K14HL003149     (VILLALTA, FERNANDO)Sep 1, 1994 - Aug 31, 1997
    NIH
    FACULTY DEVELOPMENT AWARD
    Role: Principal Investigator

    T32AI007281     (VILLALTA, FERNANDO)Jul 1, 2003 - Sep 29, 1990
    NIH
    Molecular Microbial Pathogenesis Training Program
    Role: Principal Investigator

    SC1GM081168     (VILLALTA, FERNANDO)Sep 1, 2007 - Aug 31, 2011
    NIH
    Molecular Analysis of Trypanosome Infection
    Role: Principal Investigator

    SC1AI080580     (VILLALTA, FERNANDO)Sep 1, 2007 - Aug 31, 2013
    NIH
    Molecular Analysis of Trypanosome Infection
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yanagihara R, Berry MJ, Carson MJ, Chang SP, Corliss H, Cox MB, Haddad G, Hohmann C, Kelley ST, Lee ESY, Link BG, Noel RJ, Pickrel J, Porter JT, Quirk GJ, Samuel T, Stiles JK, Sy AU, Taira DA, Trepka MJ, Villalta F, Wiese TE. Building a Diverse Workforce and Thinkforce to Reduce Health Disparities. Int J Environ Res Public Health. 2021 Feb 07; 18(4). PMID: 33562262.
      Citations:    Fields:    
    2. Jones B, Balasubramaniam M, Lebowitz JJ, Taylor A, Villalta F, Khoshbouei H, Grueter C, Grueter B, Dash C, Pandhare J. Activation of proline biosynthesis is critical to maintain glutamate homeostasis during acute methamphetamine exposure. Sci Rep. 2021 Jan 14; 11(1):1422. PMID: 33446840.
      Citations:    Fields:    
    3. Rayford KJ, Cooley A, Arun A, Rachakonda G, Kleschenko Y, Villalta F, Pratap S, Lima MF, Nde PN. Trypanosoma cruzi Modulates PIWI-Interacting RNA Expression in Primary Human Cardiac Myocytes during the Early Phase of Infection. Int J Mol Sci. 2020 Dec 11; 21(24). PMID: 33322418.
      Citations: 1     Fields:    
    4. Arun A, Rayford KJ, Cooley A, Rachakonda G, Villalta F, Pratap S, Lima MF, Sheibani N, Nde PN. Thrombospondin-1 Plays an Essential Role in Yes-Associated Protein Nuclear Translocation during the Early Phase of Trypanosoma cruzi Infection in Heart Endothelial Cells. Int J Mol Sci. 2020 Jul 12; 21(14). PMID: 32664627.
      Citations:    Fields:    
    5. Dash S, Balasubramaniam M, Martínez-Rivera FJ, Godino A, Peck EG, Patnaik S, Suar M, Calipari ES, Nestler EJ, Villalta F, Dash C, Pandhare J. Cocaine-regulated microRNA miR-124 controls poly (ADP-ribose) polymerase-1 expression in neuronal cells. Sci Rep. 2020 07 08; 10(1):11197. PMID: 32641757.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Chaudhuri E, Dash S, Balasubramaniam M, Padron A, Holland J, Sowd GA, Villalta F, Engelman AN, Pandhare J, Dash C. The HIV-1 capsid-binding host factor CPSF6 is post-transcriptionally regulated by the cellular microRNA miR-125b. J Biol Chem. 2020 04 10; 295(15):5081-5094. PMID: 32152226.
      Citations:    Fields:    Translation:HumansCells
    7. Villalta F, Rachakonda G. Advances in preclinical approaches to Chagas disease drug discovery. Expert Opin Drug Discov. 2019 11; 14(11):1161-1174. PMID: 31411084.
      Citations: 6     Fields:    Translation:HumansAnimals
    8. Ysrayl BB, Balasubramaniam M, Albert I, Villalta F, Pandhare J, Dash C. A Novel Role of Prolidase in Cocaine-Mediated Breach in the Barrier of Brain Microvascular Endothelial Cells. Sci Rep. 2019 02 22; 9(1):2567. PMID: 30796241.
      Citations: 3     Fields:    Translation:HumansCells
    9. Guedes-da-Silva FH, Batista DDGJ, Da Silva CF, Pavão BP, Batista MM, Moreira OC, Souza LRQ, Britto C, Rachakonda G, Villalta F, Lepesheva GI, Soeiro MNC. Successful Aspects of the Coadministration of Sterol 14a-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi. ACS Infect Dis. 2019 03 08; 5(3):365-371. PMID: 30625275.
      Citations: 2     Fields:    Translation:HumansAnimals
    10. Friggeri L, Hargrove TY, Rachakonda G, Blobaum AL, Fisher P, de Oliveira GM, da Silva CF, Soeiro MNC, Nes WD, Lindsley CW, Villalta F, Guengerich FP, Lepesheva GI. Sterol 14a-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae. J Med Chem. 2018 12 13; 61(23):10910-10921. PMID: 30451500.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    11. Suman S, Rachakonda G, Mandape SN, Sakhare SS, Villalta F, Pratap S, Lima MF, Nde PN. Phospho-proteomic analysis of primary human colon epithelial cells during the early Trypanosoma cruzi infection phase. PLoS Negl Trop Dis. 2018 09; 12(9):e0006792. PMID: 30222739.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    12. Friggeri L, Hargrove TY, Wawrzak Z, Blobaum AL, Rachakonda G, Lindsley CW, Villalta F, Nes WD, Botta M, Guengerich FP, Lepesheva GI. Sterol 14a-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis. J Med Chem. 2018 07 12; 61(13):5679-5691. PMID: 29894182.
      Citations: 2     Fields:    Translation:AnimalsCells
    13. Dash S, Balasubramaniam M, Rana T, Godino A, Peck EG, Goodwin JS, Villalta F, Calipari ES, Nestler EJ, Dash C, Pandhare J. Poly (ADP-Ribose) Polymerase-1 (PARP-1) Induction by Cocaine Is Post-Transcriptionally Regulated by miR-125b. eNeuro. 2017 Jul-Aug; 4(4). PMID: 28828398.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    14. Hargrove TY, Garvey EP, Hoekstra WJ, Yates CM, Wawrzak Z, Rachakonda G, Villalta F, Lepesheva GI. Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14a-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity. Antimicrob Agents Chemother. 2017 07; 61(7). PMID: 28461309.
      Citations: 11     Fields:    Translation:Animals
    15. Matthews QL, Farrow AL, Rachakonda G, Gu L, Nde P, Krendelchtchikov A, Pratap S, Sakhare SS, Sabbaj S, Lima MF, Villalta F. Epitope Capsid-Incorporation: New Effective Approach for Vaccine Development for Chagas Disease. Pathog Immun. 2016 Fall-Winter; 1(2):214-233. PMID: 27709126.
      Citations:    
    16. Udoko AN, Johnson CA, Dykan A, Rachakonda G, Villalta F, Mandape SN, Lima MF, Pratap S, Nde PN. Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0003747. PMID: 26771187.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    17. Dotson D, Woodruff EA, Villalta F, Dong X. Filamin A Is Involved in HIV-1 Vpu-mediated Evasion of Host Restriction by Modulating Tetherin Expression. J Biol Chem. 2016 Feb 19; 291(8):4236-46. PMID: 26742839.
      Citations: 3     Fields:    Translation:HumansCells
    18. Hoekstra WJ, Hargrove TY, Wawrzak Z, da Gama Jaen Batista D, da Silva CF, Nefertiti AS, Rachakonda G, Schotzinger RJ, Villalta F, Soeiro Mde N, Lepesheva GI. Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi. Antimicrob Agents Chemother. 2016 Feb; 60(2):1058-66. PMID: 26643331.
      Citations: 8     Fields:    Translation:AnimalsCells
    19. Dash S, Balasubramaniam M, Villalta F, Dash C, Pandhare J. Impact of cocaine abuse on HIV pathogenesis. Front Microbiol. 2015; 6:1111. PMID: 26539167.
      Citations:    
    20. Pandhare J, Dash S, Jones B, Villalta F, Dash C. A Novel Role of Proline Oxidase in HIV-1 Envelope Glycoprotein-induced Neuronal Autophagy. J Biol Chem. 2015 Oct 16; 290(42):25439-51. PMID: 26330555.
      Citations: 9     Fields:    Translation:HumansCells
    21. Lepesheva GI, Hargrove TY, Rachakonda G, Wawrzak Z, Pomel S, Cojean S, Nde PN, Nes WD, Locuson CW, Calcutt MW, Waterman MR, Daniels JS, Loiseau PM, Villalta F. VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis. J Infect Dis. 2015 Nov 01; 212(9):1439-48. PMID: 25883390.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    22. Haubrich BA, Singha UK, Miller MB, Nes CR, Anyatonwu H, Lecordier L, Patkar P, Leaver DJ, Villalta F, Vanhollebeke B, Chaudhuri M, Nes WD. Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth. J Lipid Res. 2015 Feb; 56(2):331-41. PMID: 25424002.
      Citations: 12     Fields:    Translation:Animals
    23. Farrow AL, Rachakonda G, Gu L, Krendelchtchikova V, Nde PN, Pratap S, Lima MF, Villalta F, Matthews QL. Immunization with Hexon modified adenoviral vectors integrated with gp83 epitope provides protection against Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2014 Aug; 8(8):e3089. PMID: 25144771.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    24. Friggeri L, Hargrove TY, Rachakonda G, Williams AD, Wawrzak Z, Di Santo R, De Vita D, Waterman MR, Tortorella S, Villalta F, Lepesheva GI. Structural basis for rational design of inhibitors targeting Trypanosoma cruzi sterol 14a-demethylase: two regions of the enzyme molecule potentiate its inhibition. J Med Chem. 2014 Aug 14; 57(15):6704-17. PMID: 25033013.
      Citations: 13     Fields:    Translation:AnimalsCells
    25. Pandhare J, Addai AB, Mantri CK, Hager C, Smith RM, Barnett L, Villalta F, Kalams SA, Dash C. Cocaine enhances HIV-1-induced CD4(+) T-cell apoptosis: implications in disease progression in cocaine-abusing HIV-1 patients. Am J Pathol. 2014 Apr; 184(4):927-936. PMID: 24486327.
      Citations: 18     Fields:    Translation:HumansCells
    26. Johnson CA, Rachakonda G, Kleshchenko YY, Nde PN, Madison MN, Pratap S, Cardenas TC, Taylor C, Lima MF, Villalta F. Cellular response to Trypanosoma cruzi infection induces secretion of defensin a-1, which damages the flagellum, neutralizes trypanosome motility, and inhibits infection. Infect Immun. 2013 Nov; 81(11):4139-48. PMID: 23980110.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    27. Villalta F, Dobish MC, Nde PN, Kleshchenko YY, Hargrove TY, Johnson CA, Waterman MR, Johnston JN, Lepesheva GI. VNI cures acute and chronic experimental Chagas disease. J Infect Dis. 2013 Aug 01; 208(3):504-11. PMID: 23372180.
      Citations: 49     Fields:    Translation:Animals
    28. Dobish MC, Villalta F, Waterman MR, Lepesheva GI, Johnston JN. Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease. Org Lett. 2012 Dec 21; 14(24):6322-5. PMID: 23214987.
      Citations: 16     Fields:    Translation:AnimalsCells
    29. Nde PN, Lima MF, Johnson CA, Pratap S, Villalta F. Regulation and use of the extracellular matrix by Trypanosoma cruzi during early infection. Front Immunol. 2012; 3:337. PMID: 23133440.
      Citations: 15     Fields:    
    30. Liu L, Sutton J, Woodruff E, Villalta F, Spearman P, Dong X. Defective HIV-1 particle assembly in AP-3-deficient cells derived from patients with Hermansky-Pudlak syndrome type 2. J Virol. 2012 Oct; 86(20):11242-53. PMID: 22875976.
      Citations: 10     Fields:    Translation:HumansCells
    31. Johnson CA, Kleshchenko YY, Ikejiani AO, Udoko AN, Cardenas TC, Pratap S, Duquette MA, Lima MF, Lawler J, Villalta F, Nde PN. Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular infection. PLoS One. 2012; 7(7):e40614. PMID: 22808206.
      Citations: 11     Fields:    Translation:AnimalsCells
    32. Nes CR, Singha UK, Liu J, Ganapathy K, Villalta F, Waterman MR, Lepesheva GI, Chaudhuri M, Nes WD. Novel sterol metabolic network of Trypanosoma brucei procyclic and bloodstream forms. Biochem J. 2012 Apr 01; 443(1):267-77. PMID: 22176028.
      Citations: 20     Fields:    Translation:AnimalsCells
    33. Lepesheva GI, Villalta F, Waterman MR. Targeting Trypanosoma cruzi sterol 14a-demethylase (CYP51). Adv Parasitol. 2011; 75:65-87. PMID: 21820552.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    34. Kleschenko YE, Karpenko LP, Villalta F. Effects of human defensin-a(1)on Trypanosoma cruzi trypomastigotes in vitro. Bull Exp Biol Med. 2010 Nov; 149(6):731-3. PMID: 21165432.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    35. Lepesheva GI, Hargrove TY, Anderson S, Kleshchenko Y, Furtak V, Wawrzak Z, Villalta F, Waterman MR. Structural insights into inhibition of sterol 14alpha-demethylase in the human pathogen Trypanosoma cruzi. J Biol Chem. 2010 Aug 13; 285(33):25582-90. PMID: 20530488.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    36. Nde PN, Johnson CA, Pratap S, Cardenas TC, Kleshchenko YY, Furtak VA, Simmons KJ, Lima MF, Villalta F. Gene network analysis during early infection of human coronary artery smooth muscle cells by Trypanosoma cruzi and Its gp83 ligand. Chem Biodivers. 2010 May; 7(5):1051-64. PMID: 20491065.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    37. Cardenas TC, Johnson CA, Pratap S, Nde PN, Furtak V, Kleshchenko YY, Lima MF, Villalta F. REGULATION of the EXTRACELLULAR MATRIX INTERACTOME by Trypanosoma cruzi. Open Parasitol J. 2010; 4:72-76. PMID: 21499436.
      Citations:    
    38. Lepesheva GI, Park HW, Hargrove TY, Vanhollebeke B, Wawrzak Z, Harp JM, Sundaramoorthy M, Nes WD, Pays E, Chaudhuri M, Villalta F, Waterman MR. Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. J Biol Chem. 2010 Jan 15; 285(3):1773-80. PMID: 19923211.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    39. Konkle ME, Hargrove TY, Kleshchenko YY, von Kries JP, Ridenour W, Uddin MJ, Caprioli RM, Marnett LJ, Nes WD, Villalta F, Waterman MR, Lepesheva GI. Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase. J Med Chem. 2009 May 14; 52(9):2846-53. PMID: 19354253.
      Citations: 18     Fields:    Translation:AnimalsCells
    40. Villalta F, Scharfstein J, Ashton AW, Tyler KM, Guan F, Mukherjee S, Lima MF, Alvarez S, Weiss LM, Huang H, Machado FS, Tanowitz HB. Perspectives on the Trypanosoma cruzi-host cell receptor interactions. Parasitol Res. 2009 Jun; 104(6):1251-60. PMID: 19283409.
      Citations: 15     Fields:    Translation:HumansAnimals
    41. Lepesheva GI, Hargrove TY, Kleshchenko Y, Nes WD, Villalta F, Waterman MR. CYP51: A major drug target in the cytochrome P450 superfamily. Lipids. 2008 Dec; 43(12):1117-25. PMID: 18769951.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    42. Villalta F, Madison MN, Kleshchenko YY, Nde PN, Lima MF. Molecular analysis of early host cell infection by Trypanosoma cruzi. Front Biosci. 2008 May 01; 13:3714-34. PMID: 18508467.
      Citations: 10     Fields:    Translation:HumansAnimals
    43. Theodore M, Kawai Y, Yang J, Kleshchenko Y, Reddy SP, Villalta F, Arinze IJ. Multiple nuclear localization signals function in the nuclear import of the transcription factor Nrf2. J Biol Chem. 2008 Apr 04; 283(14):8984-94. PMID: 18238777.
      Citations: 65     Fields:    Translation:HumansCells
    44. Lepesheva GI, Ott RD, Hargrove TY, Kleshchenko YY, Schuster I, Nes WD, Hill GC, Villalta F, Waterman MR. Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth. Chem Biol. 2007 Nov; 14(11):1283-93. PMID: 18022567.
      Citations: 62     Fields:    Translation:Animals
    45. Madison MN, Kleshchenko YY, Nde PN, Simmons KJ, Lima MF, Villalta F. Human defensin alpha-1 causes Trypanosoma cruzi membrane pore formation and induces DNA fragmentation, which leads to trypanosome destruction. Infect Immun. 2007 Oct; 75(10):4780-91. PMID: 17635867.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    46. Augustine SA, Kleshchenko YY, Nde PN, Pratap S, Ager EA, Burns JM, Lima MF, Villalta F. Molecular cloning of a Trypanosoma cruzi cell surface casein kinase II substrate, Tc-1, involved in cellular infection. Infect Immun. 2006 Jul; 74(7):3922-9. PMID: 16790765.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    47. Simmons KJ, Nde PN, Kleshchenko YY, Lima MF, Villalta F. Stable RNA interference of host thrombospondin-1 blocks Trypanosoma cruzi infection. FEBS Lett. 2006 Apr 17; 580(9):2365-70. PMID: 16616140.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    48. Nde PN, Simmons KJ, Kleshchenko YY, Pratap S, Lima MF, Villalta F. Silencing of the laminin gamma-1 gene blocks Trypanosoma cruzi infection. Infect Immun. 2006 Mar; 74(3):1643-8. PMID: 16495535.
      Citations: 24     Fields:    Translation:HumansAnimals
    49. Kleshchenko YY, Moody TN, Furtak VA, Ochieng J, Lima MF, Villalta F. Human galectin-3 promotes Trypanosoma cruzi adhesion to human coronary artery smooth muscle cells. Infect Immun. 2004 Nov; 72(11):6717-21. PMID: 15501810.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    50. Alexander AD, Villalta F, Lima MF. Transforming growth factor alpha binds to Trypanosoma cruzi amastigotes to induce signaling and cellular proliferation. Infect Immun. 2003 Jul; 71(7):4201-5. PMID: 12819119.
      Citations: 4     Fields:    Translation:AnimalsCells
    51. Ghansah TJ, Ager EC, Freeman-Junior P, Villalta F, Lima MF. Epidermal growth factor binds to a receptor on Trypanosoma cruzi amastigotes inducing signal transduction events and cell proliferation. J Eukaryot Microbiol. 2002 Sep-Oct; 49(5):383-90. PMID: 12425525.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    52. Turner CW, Lima MF, Villalta F. Trypanosoma cruzi uses a 45-kDa mucin for adhesion to mammalian cells. Biochem Biophys Res Commun. 2002 Jan 11; 290(1):29-34. PMID: 11779128.
      Citations: 11     Fields:    Translation:AnimalsCells
    53. Villalta F, Smith CM, Ruiz-Ruano A, Lima MF. A ligand that Trypanosoma cruzi uses to bind to mammalian cells to initiate infection. FEBS Lett. 2001 Sep 21; 505(3):383-8. PMID: 11576533.
      Citations: 19     Fields:    Translation:AnimalsCells
    54. Moody TN, Ochieng J, Villalta F. Novel mechanism that Trypanosoma cruzi uses to adhere to the extracellular matrix mediated by human galectin-3. FEBS Lett. 2000 Mar 31; 470(3):305-8. PMID: 10745086.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    55. Noisin EL, Villalta F. Fibronectin increases Trypanosoma cruzi amastigote binding to and uptake by murine macrophages and human monocytes. Infect Immun. 1989 Apr; 57(4):1030-4. PMID: 2522418.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
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