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Sukbir Mokha

Faculty RankProfessor
InstitutionMeharry Medical College
DepartmentBiochem, Cancer Biology, Neuroscience & Pharmacology
AddressNashville TN 37208
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    Collapse Biography 
    Collapse awards and honors
    1977 - 1980Research Scholar, University of Edinburgh
    1979Birrell Gray Traveling Scholar of the University of Edinburgh at the School of Pharmacy, University of London
    1980 - 1983Research Fellowship, Science and Engineering Research Council (UK)
    1982The Royal Society (London) Study Visit to the University of Goteborg
    2001Faculty Scholar Award, Meharry Medical College
    2008Distinguished Professor, Meharry Medical College, School of Graduate Studies and Research,, Meharry Medical College
    2012Exemplary Teacher Award, General Board of Higher Education and the Ministry of the United Methodist , Meharry Medical College

    Collapse Overview 
    Collapse overview
    Dr. Mokha has been engaged in pain and analgesia research for over 30 years and has spent the last 10 years in advancing our understanding of the biological mechanisms, a) that make women more susceptible to the development of pain syndromes such as migraine, irritable bowel syndrome and fibromyalgia, and b) that generate sex-related differences in the response to analgesics. These investigations at systems, cellular and molecular levels have provided evidence that estrogen attenuates the analgesic function of many G- protein- coupled receptors (GPCRs) present in the spinal cord. These GPCRs include opioid receptors and a2-adrenoceptors, and many are known to mediate descending inhibition of pain in the spinal cord. Estrogen attenuates or abolishes the analgesic response elicited by activation of opioid receptor like 1 (ORL1) receptor and a2-adrenoceptors in the female whereas testosterone is required for the expression of the analgesic response in the male. Although we showed previously that estrogen attenuates the expression of the ORL1 receptor gene, more recent studies in the laboratory are also unraveling the contribution of membrane estrogen receptors in attenuating the analgesic response through non-genomic mechanisms. These studies will provide important new perspective into the treatment of pain, particularly in women at different phases of their life (pre-puberty, reproductive years, pregnancy and menopause) and in aging men. Considering the widespread distribution of these GPCRs in the brain and their involvement in multiple functions, these findings will have a broader relevance. Presently, I serve as the Chair of the Internal Advisory Committee for the RCMI grant.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nag S, Mokha SS. Activation of a Gq-coupled membrane estrogen receptor rapidly attenuates a2-adrenoceptor-induced antinociception via an ERK I/II-dependent, non-genomic mechanism in the female rat. Neuroscience. 2014 May 16; 267:122-34. PMID: 24613724.
      Citations: 14     Fields:    Translation:AnimalsCells
    2. Small KM, Nag S, Mokha SS. Activation of membrane estrogen receptors attenuates opioid receptor-like1 receptor-mediated antinociception via an ERK-dependent non-genomic mechanism. Neuroscience. 2013; 255:177-90. PMID: 24452062.
      Citations: 18     Fields:    Translation:AnimalsCells
    3. Lawson KP, Nag S, Thompson AD, Mokha SS. Sex-specificity and estrogen-dependence of kappa opioid receptor-mediated antinociception and antihyperalgesia. Pain. 2010 Dec; 151(3):806-815. PMID: 20926192.
      Citations: 28     Fields:    Translation:Animals
    4. Nag S, Mokha SS. Testosterone is essential for alpha(2)-adrenoceptor-induced antinociception in the trigeminal region of the male rat. Neurosci Lett. 2009 Dec 18; 467(1):48-52. PMID: 19819297.
      Citations: 8     Fields:    Translation:Animals
    5. Claiborne JA, Nag S, Mokha SS. Estrogen-dependent, sex-specific modulation of mustard oil-induced secondary thermal hyperalgesia by orphanin FQ in the rat. Neurosci Lett. 2009 Jun 05; 456(2):59-63. PMID: 19429134.
      Citations: 7     Fields:    Translation:Animals
    6. Nag S, Wang Q, Limbird LE, Mokha SS. Knockout of spinophilin, an endogenous antagonist of arrestin-dependent alpha2-adrenoceptor functions, enhances receptor-mediated antinociception yet does not eliminate sex-related differences. Behav Brain Res. 2009 Feb 11; 197(2):457-61. PMID: 18957308.
      Citations: 2     Fields:    Translation:Animals
    7. Thompson AD, Angelotti T, Nag S, Mokha SS. Sex-specific modulation of spinal nociception by alpha2-adrenoceptors: differential regulation by estrogen and testosterone. Neuroscience. 2008 Jun 02; 153(4):1268-77. PMID: 18434028.
      Citations: 18     Fields:    Translation:Animals
    8. Claiborne J, Nag S, Mokha SS. Activation of opioid receptor like-1 receptor in the spinal cord produces sex-specific antinociception in the rat: estrogen attenuates antinociception in the female, whereas testosterone is required for the expression of antinociception in the male. J Neurosci. 2006 Dec 13; 26(50):13048-53. PMID: 17167094.
      Citations: 27     Fields:    Translation:Animals
    9. Nag S, Mokha SS. Activation of alpha2-adrenoceptors in the trigeminal region produces sex-specific modulation of nociception in the rat. Neuroscience. 2006 Nov 03; 142(4):1255-62. PMID: 16934408.
      Citations: 22     Fields:    Translation:AnimalsCells
    10. Nag S, Mokha SS. Estrogen attenuates antinociception produced by stimulation of K?lliker-Fuse nucleus in the rat. Eur J Neurosci. 2004 Dec; 20(11):3203-7. PMID: 15579177.
      Citations: 11     Fields:    Translation:AnimalsCells
    11. Flores CA, Shughrue P, Petersen SL, Mokha SS. Sex-related differences in the distribution of opioid receptor-like 1 receptor mRNA and colocalization with estrogen receptor mRNA in neurons of the spinal trigeminal nucleus caudalis in the rat. Neuroscience. 2003; 118(3):769-78. PMID: 12710984.
      Citations: 25     Fields:    Translation:AnimalsCells
    12. Wang XM, Zhang ZJ, Bains R, Mokha SS. Effect of antisense knock-down of alpha(2a)- and alpha(2c)-adrenoceptors on the antinociceptive action of clonidine on trigeminal nociception in the rat. Pain. 2002 Jul; 98(1-2):27-35. PMID: 12098614.
      Citations: 12     Fields:    Translation:AnimalsCells
    13. Flores CA, Wang XM, Zhang KM, Mokha SS. Orphanin FQ produces gender-specific modulation of trigeminal nociception: behavioral and electrophysiological observations. Neuroscience. 2001; 105(2):489-98. PMID: 11672614.
      Citations: 15     Fields:    Translation:AnimalsCells
    14. Wang XM, Zhang KM, Long LO, Flores CA, Mokha SS. Endomorphin-1 and endomorphin-2 modulate responses of trigeminal neurons evoked by N-methyl-D-aspartic acid and somatosensory stimuli. J Neurophysiol. 2000 Jun; 83(6):3570-4. PMID: 10848572.
      Citations: 1     Fields:    Translation:AnimalsCells
    15. Wang XM, Zhang KM, Long LO, Mokha SS. Orphanin FQ (nociceptin) modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli, and blocks the substance P-induced facilitation of N-methyl-D-aspartate-evoked responses. Neuroscience. 1999; 93(2):703-12. PMID: 10465454.
      Citations: 6     Fields:    Translation:AnimalsCells
    16. Zhang KM, Wang XM, Peterson AM, Chen WY, Mokha SS. alpha2-adrenoceptors modulate NMDA-evoked responses of neurons in superficial and deeper dorsal horn of the medulla. J Neurophysiol. 1998 Oct; 80(4):2210-4. PMID: 9772273.
      Citations: 6     Fields:    Translation:AnimalsCells
    17. Wang XM, Yan JQ, Zhang KM, Mokha SS. Role of opioid receptors (mu, delta 1, delta 2) in modulating responses of nociceptive neurons in the superficial and deeper dorsal horn of the medulla (trigeminal nucleus caudalis) in the rat. Brain Res. 1996 Nov 11; 739(1-2):235-43. PMID: 8955943.
      Citations: 5     Fields:    Translation:AnimalsCells
    18. Wang XM, Zhang KM, Mokha SS. Nociceptin (orphanin FQ), an endogenous ligand for the QRL1 (opioid-receptor-like1) receptor; modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli. J Neurophysiol. 1996 Nov; 76(5):3568-72. PMID: 8930296.
      Citations: 5     Fields:    Translation:Animals
    19. Wang XM, Mokha SS. Opioids modulate N-methyl-D-aspartic acid (NMDA)-evoked responses of trigeminothalamic neurons. J Neurophysiol. 1996 Sep; 76(3):2093-6. PMID: 8890319.
      Citations: 7     Fields:    Translation:AnimalsCells
    20. Zhang KM, Wang XM, Mokha SS. Opioids modulate N-methyl-D-aspartic acid (NMDA)-evoked responses of neurons in the superficial and deeper dorsal horn of the medulla (trigeminal nucleus caudalis). Brain Res. 1996 May 06; 719(1-2):229-33. PMID: 8782887.
      Citations: 5     Fields:    Translation:AnimalsCells
    21. Mokha SS. Morphine differentially modulates nociceptive input in the superficial versus the deeper dorsal horn of the medulla (trigeminal nucleus caudalis) in the rat. Brain Res. 1993 Oct 29; 626(1-2):318-21. PMID: 8281443.
      Citations:    Fields:    Translation:Animals
    22. Mokha SS. Morphine alters the firing of cold-receptive neurons in the superficial dorsal horn of the medulla in the rat. Brain Res. 1993 Feb 05; 602(2):205-14. PMID: 8448667.
      Citations:    Fields:    Translation:AnimalsCells
    23. Mokha SS. Differential influence of naloxone on the responses of nociceptive neurons in the superficial versus the deeper dorsal horn of the medulla in the rat. Pain. 1992 Jun; 49(3):405-413. PMID: 1408306.
      Citations: 2     Fields:    Translation:AnimalsCells
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