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Samuel Adunyah

TitlePhD
Faculty RankChair and Professor
InstitutionMeharry Medical College
DepartmentBiochem, Cancer Biology, Neuroscience & Pharmacology
Address1005 Dr. D B Todd Jr. Blvd., 3228 WSB Building,
Nashville TN 37208
Phone6153276446
Fax6153276440
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    Other Positions
    TitleCo-Director
    InstitutionMeharry Medical College/Vanderbilt-Ingram Cancer Partnership

    TitleCo-Director
    InstitutionMeharry Medical College/Vanderbilt-Ingram Cancer Partnership

    TitleCo-Director
    InstitutionMeharry Medical College/Vanderbilt-Ingram Cancer Partnership

    TitleCo-Director
    InstitutionMeharry Medical College/Vanderbilt-Ingram Cancer Partnership
    DepartmentMMC/VICC

    TitleCo-Director
    InstitutionMMC/VICC
    DepartmentMMC/VICC


    Collapse Affiliation 

    Collapse Biography 
    Collapse awards and honors
    1987USA Achievement Acad. Award, National Collegiate Natural Sciences
    1988 - 1989Travel Awards, NCI Biomedical Travel Awards
    1988Travel Awards, American Society of Hematology
    1989Travel Awards, American Society of Hematology
    1993Dean's Awards for Excellence in Teaching Nominee, Exemplary Teacher of the Year, Meharry Medical College
    1995Dean's Awards for Excellence in Teaching Nominee, Exemplary Teacher of the Year, Meharry Medical College
    1997Dean's Awards for Excellence in Teaching Nominee, Exemplary Teacher of the Year, Meharry Medical College
    1994 - 1995Minority School Faculty Development Award, NCI
    2000Nominee, Exemplary Teacher of the Year, Nominee, Exemplary Teacher of the Year, Meharry Medical College
    2001Distinguished Alumni Fellow, Univ. of Louisville
    2004Graduate Mentorship Award of the Year, School. Of Graduate Studies and Research, Meharry Medical College
    2005Appreciation Award from the Black Biomedical Graduate Students Association , Univ. of Louisville
    2005Distinction in Advocacy Award, American Society of Hematology (ASH)
    2005Appreciation Award for Active Membership in the Government Affairs Committee , American Society of Hematology (ASH)
    2007Distinguished Chairmanship, Meharry Medical College

    Collapse Overview 
    Collapse overview
    Dr. Samuel Evans Adunyah is the Contact-PI/PD for the Meharry RCMI Health Disparities Research Center with Dr. James Hildreth, President and CEO of Meharry Medical College, as the MPI. Together, they provide leadership as PIs/PDs and Admin Core Directors for the current NIMHD U54 grant from 2022 to 2027. Dr. Adunyah received his PhD degree in Biochemistry from University of Louisville, KY in 1987 followed by a postdoctoral training in cancer research at the Cancer Treatment and Research Center in the University of New Mexico, Albuquerque, NM. He joined Meharry in 1991 as a tenure-track Assistant Professor. He became a tenured full professor in 2003. Previously, Dr. Adunyah served as the PD/PI of Meharry Clinical Translational Research Center (MeTRC) U54 grant from 2009 to 2020. In 1999, Dr. Adunyah and Dr. Hal Moses, the Founding Director and PI of the Vanderbilt-Ingram Cancer Center, started the cancer partnership between Meharry and Vanderbilt-Ingram Cancer Center and received their first U54 funding in 2001 to address cancer health disparities in Tennessee. In 2011, they admitted Tennessee State University to this partnership to create Meharry-Vanderbilt-TSU (MVT) Cancer partnership. This partnership’s U54 grant has successfully been renewed for five cycles and Dr. Adunyah continues to serve as a PI for the Meharry’s component. As the PI of the MVT partnership U54 grant for 22 years, Dr. Adunyah has led the Admin Core for Meharry’s component. He has extensive experience with leading, directing, managing, and advancing the growth of NCI U54-funded Cancer Partnership Programs. As the Contact-PI and Director of the Admin Core for Meharry’s RCMI U54 Program, Dr. Adunyah will work closely with Dr. James Hildreth (MPI/PD) and together they will provide outstanding leadership to ensure the success of the RCMI program. This extensive leadership of U54-funded programs has enriched his experiences in managing 3 U54 grants from two NIH institutes. Dr. Adunyah is also the Chair of Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology at Meharry. As chair of department for over 23 years, he has successfully recruited, supervised, and mentored many successful Early-Stage Investigators at Meharry Medical College. Previously, he was the PI for his department’s NHLBI T32 Pre-doctoral Training grant for 21 years. As a mentor for pre-doctoral trainees, he has trained and graduated 13 PhD trainees including 9 minorities and mentored several postdoctoral trainees from his laboratory. Most of his PhD trainees have become successful including three who are now Hematologists/Oncologists and three professors. He has served on over 64 PhD Thesis Advisory Committees. He has served on several NIH Study Sections and Special Emphasis Review Panels including the NCI’s former Cancer Molecular Pathobiology Study Section, NHLBI T32, T35 Review Panel, F30/F31/F32 NRSA Fellowship Review Panels, NCI’s Review Panel for Diversity R21 grants, NCI’s P20 SPORE program, NIGMS IDeA-CTR (U54) program, as well as Howard Hughes Medical Fellowship Application Review Panel. Furthermore, he is a PI for ACS grant from 20021 to 2025. At the national level, he previously served on the AACR’s Science Policy Committee and the Government Affairs Committee of ASH for 2 years. He was a recent reviewer for AACR abstracts for the 2022 annual meeting and currently a member of Review Panel for the AACR Immunology Fellowship.

    Collapse Research 
    Collapse research activities and funding
    T32HL007735     (ADUNYAH, SAMUEL E.)Jul 1, 1992 - Jun 30, 2016
    NIH
    Minority Institution Research Training Program
    Role: Principal Investigator

    K14CA060722     (ADUNYAH, SAMUEL E.)Feb 1, 1994 - Jul 31, 2000
    NIH
    MECHANISMS OF ERYTHROPOIETIN IN GROWTH CONTROL
    Role: Principal Investigator

    R03CA068980     (ADUNYAH, SAMUEL E.)Sep 1, 1995 - Aug 31, 1999
    NIH
    MECHANISMS OF INTERLEUKIN 11 IN GROWTH CONTROL
    Role: Principal Investigator

    U54MD007586     (ADUNYAH, SAMUEL E.)Sep 30, 1997 - Jun 30, 2022
    NIH
    The RCMI Program in Health Disparities Research at Meharry Medical College
    Role: Principal Investigator

    R03AR046384     (ADUNYAH, SAMUEL E.)Sep 15, 1999 - Aug 31, 2004
    NIH
    INVOLVEMENT OF JAK/STAT PATHWAY IN IL-17R SIGNALING
    Role: Principal Investigator

    U54CA091408     (ADUNYAH, SAMUEL E.)Aug 3, 2001 - Sep 29, 2013
    NIH
    MMC and VICC: Partners in Eliminating Cancer Disparities
    Role: Principal Investigator

    U54RR026140     (ADUNYAH, SAMUEL)Sep 25, 2009 - Jun 30, 2014
    NIH
    Meharry Clinical and Translational Research Center (MeTRC)
    Role: Principal Investigator

    U54MD007593     (ADUNYAH, SAMUEL E.)Sep 30, 2009 - Apr 30, 2021
    NIH
    Meharry Clinical and Translational Research Center (MeTRC)
    Role: Principal Investigator

    U54CA163069     (ADUNYAH, SAMUEL E.)Sep 26, 2011 - Aug 31, 2021
    NIH
    MMC, VICC & TSU: Partners in Eliminating Cancer Disparities (1 of 3)
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Choe D, Lee ES, Beeghly-Fadiel A, Wilson AJ, Whalen MM, Adunyah SE, Son DS. High-Fat Diet-Induced Obese Effects of Adipocyte-Specific CXCR2 Conditional Knockout in the Peritoneal Tumor Microenvironment of Ovarian Cancer. Cancers (Basel). 2021 Oct 08; 13(19). PMID: 34638514.
      Citations:    
    2. Kanagasabai T, Li G, Shen TH, Gladoun N, Castillo-Martin M, Celada SI, Xie Y, Brown LK, Mark ZA, Ochieng J, Ballard BR, Cordon-Cardo C, Adunyah SE, Jin R, Matusik RJ, Chen Z. MicroRNA-21 deficiency suppresses prostate cancer progression through downregulation of the IRS1-SREBP-1 signaling pathway. Cancer Lett. 2022 01 28; 525:46-54. PMID: 34610416.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    3. Li G, Kanagasabai T, Lu W, Zou MR, Zhang SM, Celada SI, Izban MG, Liu Q, Lu T, Ballard BR, Zhou X, Adunyah SE, Matusik RJ, Yan Q, Chen Z. KDM5B Is Essential for the Hyperactivation of PI3K/AKT Signaling in Prostate Tumorigenesis. Cancer Res. 2020 11 01; 80(21):4633-4643. PMID: 32868382.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    4. Son DS, Lee ES, Adunyah SE. The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs. Immune Netw. 2020 Aug; 20(4):e29. PMID: 32895616.
      Citations:    
    5. Harris KJ, Subbiah S, Tabatabai M, Archibong AE, Singh KP, Anderson TA, Adunyah SE, Ramesh A. Pressurized liquid extraction followed by liquid chromatography coupled to a fluorescence detector and atmospheric pressure chemical ionization mass spectrometry for the determination of benzo(a)pyrene metabolites in liver tissue of an animal model of colon cancer. J Chromatogr A. 2020 Jul 05; 1622:461126. PMID: 32376019.
      Citations:    Fields:    Translation:Animals
    6. Ignacio RMC, Gibbs CR, Kim S, Lee ES, Adunyah SE, Son DS. Serum amyloid A predisposes inflammatory tumor microenvironment in triple negative breast cancer. Oncotarget. 2019 Jan 11; 10(4):511-526. PMID: 30728901.
      Citations: 8     Fields:    
    7. Dinakaran V, Mandape SN, Shuba K, Pratap S, Sakhare SS, Tabatabai MA, Smoot DT, Farmer-Dixon CM, Kesavalu LN, Adunyah SE, Southerland JH, Gangula PR. Identification of Specific Oral and Gut Pathogens in Full Thickness Colon of Colitis Patients: Implications for Colon Motility. Front Microbiol. 2018; 9:3220. PMID: 30666239.
      Citations:    
    8. Ochieng J, Nangami G, Sakwe A, Rana T, Ingram S, Goodwin JS, Moye C, Lammers P, Adunyah SE. Extracellular histones are the ligands for the uptake of exosomes and hydroxyapatite-nanoparticles by tumor cells via syndecan-4. FEBS Lett. 2018 10; 592(19):3274-3285. PMID: 30179249.
      Citations: 13     Fields:    Translation:HumansCells
    9. Huderson AC, Rekha Devi PV, Niaz MS, Adunyah SE, Ramesh A. Alteration of benzo(a)pyrene biotransformation by resveratrol in ApcMin/+ mouse model of colon carcinogenesis. Invest New Drugs. 2019 04; 37(2):238-251. PMID: 29931584.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    10. Ignacio RM, Kabir SM, Lee ES, Adunyah SE, Son DS. NF-?B-Mediated CCL20 Reigns Dominantly in CXCR2-Driven Ovarian Cancer Progression. PLoS One. 2016; 11(10):e0164189. PMID: 27723802.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    11. Pulliam SR, Pellom ST, Shanker A, Adunyah SE. Butyrate regulates the expression of inflammatory and chemotactic cytokines in human acute leukemic cells during apoptosis. Cytokine. 2016 08; 84:74-87. PMID: 27253488.
      Citations: 6     Fields:    Translation:HumansCells
    12. Harris KL, Pulliam SR, Okoro E, Guo Z, Washington MK, Adunyah SE, Amos-Landgraf JM, Ramesh A. Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer. Oncotarget. 2016 May 17; 7(20):28947-60. PMID: 26959117.
      Citations: 4     Fields:    Translation:Animals
    13. Pulliam SR, Uzhachenko RV, Adunyah SE, Shanker A. Common gamma chain cytokines in combinatorial immune strategies against cancer. Immunol Lett. 2016 Jan; 169:61-72. PMID: 26597610.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    14. Banks LD, Amoah P, Niaz MS, Washington MK, Adunyah SE, Ramesh A. Olive oil prevents benzo(a)pyrene [B(a)P]-induced colon carcinogenesis through altered B(a)P metabolism and decreased oxidative damage in Apc(Min) mouse model. J Nutr Biochem. 2016 Feb; 28:37-50. PMID: 26878781.
      Citations: 4     Fields:    Translation:Animals
    15. Booker BE, Clark RS, Pellom ST, Adunyah SE. Interleukin-34 induces monocytic-like differentiation in leukemia cell lines. Int J Biochem Mol Biol. 2015; 6(1):1-16. PMID: 26045972.
      Citations:    
    16. Son DS, Kabir SM, Dong Y, Lee E, Adunyah SE. Characteristics of chemokine signatures elicited by EGF and TNF in ovarian cancer cells. J Inflamm (Lond). 2013 Jun 25; 10(1):25. PMID: 23800251.
      Citations:    
    17. Smith JC, Schäffer MW, Ballard BR, Smoot DT, Herline AJ, Adunyah SE, M'Koma AE. Adenocarcinomas After Prophylactic Surgery For Familial Adenomatous Polyposis. J Cancer Ther. 2013; 4(1):260-270. PMID: 23875116.
      Citations:    
    18. M'Koma AE, Herline AJ, Adunyah SE. Subsequent Adenomas of Ileal Pouch and Anorectal Segment after Prophylactic Surgery for Familial Adenomatous Polyposis. World J Colorectal Surg. 2013; 3(2). PMID: 24817992.
      Citations:    
    19. Son DS, Kabir SM, Dong YL, Lee E, Adunyah SE. Inhibitory effect of tumor suppressor p53 on proinflammatory chemokine expression in ovarian cancer cells by reducing proteasomal degradation of I?B. PLoS One. 2012; 7(12):e51116. PMID: 23300534.
      Citations: 29     Fields:    Translation:HumansCells
    20. Boadi WY, Harris S, Anderson JB, Adunyah SE. Lipid peroxides and glutathione status in human progenitor mononuclear (U937) cells following exposure to low doses of nickel and copper. Drug Chem Toxicol. 2013 Apr; 36(2):155-62. PMID: 22632594.
      Citations: 4     Fields:    Translation:HumansCells
    21. M'Koma AE, Moses HL, Adunyah SE. Inflammatory bowel disease-associated colorectal cancer: proctocolectomy and mucosectomy do not necessarily eliminate pouch-related cancer incidences. Int J Colorectal Dis. 2011 May; 26(5):533-52. PMID: 21311893.
      Citations: 18     Fields:    Translation:HumansPHPublic Health
    22. Sampson JJ, Donkor IO, Huang TL, Adunyah SE. Novel piperazine induces apoptosis in U937 cells. Int J Biochem Mol Biol. 2011; 2(1):78-88. PMID: 21968418.
      Citations:    
    23. Adunyah SE, Beech BM, Moses HL. Meharry Medical College-Vanderbilt-Ingram Cancer Center partnership: its history and role in cancer health disparities research. J Health Care Poor Underserved. 2010 Feb; 21(1 Suppl):1-4. PMID: 20173279.
      Citations: 1     Fields:    Translation:Humans
    24. Fuqua CF, Akomeah R, Price JO, Adunyah SE. Involvement of ERK-1/2 in IL-21-induced cytokine production in leukemia cells and human monocytes. Cytokine. 2008 Oct; 44(1):101-7. PMID: 18707899.
      Citations: 10     Fields:    Translation:HumansCells
    25. Boadi WY, Iyere PA, Adunyah SE. In vitro exposure to quercetin and genistein alters lipid peroxides and prevents the loss of glutathione in human progenitor mononuclear (U937) cells. J Appl Toxicol. 2005 Jan-Feb; 25(1):82-8. PMID: 15669027.
      Citations: 9     Fields:    Translation:HumansCells
    26. Boadi WY, Iyere PA, Adunyah SE. Effect of quercetin and genistein on copper- and iron-induced lipid peroxidation in methyl linolenate. J Appl Toxicol. 2003 Sep-Oct; 23(5):363-9. PMID: 12975775.
      Citations: 7     Fields:    Translation:Cells
    27. Iyamu EW, Adunyah SE, Fasold H, Horiuchi K, Baliga S, Ohene-Frempong K, Turner EA, Asakura T. Combined use of nonmyelosuppressive nitrosourea analogues with hydroxyurea in the induction of F-cell production in a human erythroleukemic cell line. Exp Hematol. 2003 Jul; 31(7):592-600. PMID: 12842704.
      Citations:    Fields:    Translation:HumansCells
    28. Iyamu WE, Adunyah SE, Fasold H, Horiuchi K, Elford HL, Asakura T, Turner EA. Enhancement of hemoglobin and F-cell production by targeting growth inhibition and differentiation of K562 cells with ribonucleotide reductase inhibitors (didox and trimidox) in combination with streptozotocin. Am J Hematol. 2000 Apr; 63(4):176-83. PMID: 10706760.
      Citations: 6     Fields:    Translation:HumansCells
    29. Subramaniam SV, Cooper RS, Adunyah SE. Evidence for the involvement of JAK/STAT pathway in the signaling mechanism of interleukin-17. Biochem Biophys Res Commun. 1999 Aug 19; 262(1):14-9. PMID: 10448060.
      Citations: 31     Fields:    Translation:HumansCells
    30. Subramaniam SV, Pearson LL, Adunyah SE. Interleukin-17 induces rapid tyrosine phosphorylation and activation of raf-1 kinase in human monocytic progenitor cell line U937. Biochem Biophys Res Commun. 1999 May 27; 259(1):172-7. PMID: 10334935.
      Citations: 3     Fields:    Translation:HumansCells
    31. Rivero JA, Adunyah SE. Sodium butyrate stimulates PKC activation and induces differential expression of certain PKC isoforms during erythroid differentiation. Biochem Biophys Res Commun. 1998 Jul 30; 248(3):664-8. PMID: 9703983.
      Citations: 12     Fields:    Translation:HumansCells
    32. Adunyah SE, Wheeler BJ, Cooper RS. Evidence for the involvement of LCK and MAP kinase (ERK-1) in the signal transduction mechanism of interleukin-15. Biochem Biophys Res Commun. 1997 Mar 27; 232(3):754-8. PMID: 9126349.
      Citations: 9     Fields:    Translation:HumansCells
    33. Rivero JA, Adunyah SE. Sodium butyrate induces tyrosine phosphorylation and activation of MAP kinase (ERK-1) in human K562 cells. Biochem Biophys Res Commun. 1996 Jul 25; 224(3):796-801. PMID: 8713125.
      Citations: 10     Fields:    Translation:HumansCells
    34. Adunyah SE, Spencer GC, Cooper RS, Rivero JA, Ceesay K. Interleukin-11 induces tyrosine phosphorylation, and c-jun and c-fos mRNA expression in human K562 and U937 cells. Ann N Y Acad Sci. 1995 Sep 07; 766:296-9. PMID: 7486676.
      Citations: 1     Fields:    Translation:HumansCells
    35. Adunyah SE, Chander R, Barner VK, Cooper RS, Copper RS. Regulation of c-jun mRNA expression by hydroxyurea in human K562 cells during erythroid differentiation. Biochim Biophys Acta. 1995 Aug 22; 1263(2):123-32. PMID: 7640302.
      Citations: 8     Fields:    Translation:HumansCells
    36. Adunyah SE, Pegram ML, Cooper RS. Interleukin-13 induces rapid tyrosine phosphorylation and activation of Raf-1 kinase in human monocytic progenitor cell line U937. Biochem Biophys Res Commun. 1995 Jan 05; 206(1):103-11. PMID: 7529495.
      Citations:    Fields:    Translation:HumansCells
    37. Adunyah SE. Granulocyte-macrophage colony stimulating factor stimulates rapid phosphorylation of proteins on tyrosines in human U937 and HL-60 leukemic cells. Biochem Biophys Res Commun. 1993 Jun 30; 193(3):890-6. PMID: 7686754.
      Citations: 1     Fields:    Translation:HumansCells
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