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M. Veena N. Rao

Title
Faculty RankProfessor
InstitutionMorehouse School of Medicine
DepartmentObstetrics and Gynecology
Address80 Jesse Hill Jr.
Atlanta GA 30303
Phone4044899993
Fax4044899220
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    ONGOING RESEARCH
    Principal Investigator: Veena N Rao
    Molecular and Functional Dissection of ELK-1 and BRCA1 tumor suppressor genes in breast, ovarian and prostate cancers.
    One of the ongoing projects in my lab is centered on ELK-1 which is a member of the ETS super family of genes (ETS-1, ETS-2, ERG, TEL, PEA3, Fli-1, Elk-1, SAP1, etc.) which we have identified, cloned, characterized their functions and studied their role in leukemia's, lymphomas, and sarcomas. Deregulation and mutations of ETS proteins are predominantly found in human cancers. The defective functioning of this signaling network is the root cause of widespread diseases such as cancer. ELK-1 thus forms a central integration point for both growth as well as stress signals and plays a major role in cell proliferation, apoptosis, tumorigenesis, as well as differentiation. We have found the Elk-1 gene product to bind BRCA1 suppress growth and induce apoptosis of human breast and prostate cancer cells. We plan to study the molecular mechanism of growth inhibition and cell death induced by ELK-1 in cancer cells. The second project in my lab since 1994 has been on the Breast and Ovarian cancer susceptibility gene BRCA1. BRCA1 mutations predispose women to breast and ovarian cancers and men to increased risks for prostate cancers. Women with BRCA1 mutations are estrogen receptor –negative, progesterone receptor-negative and HER-2 receptor –negative (Triple Negative breast cancers). TNBC are highly aggressive, more common in young African American women and Hispanic women, have higher rates of distant metastasis and currently there are no targeted treatments against these cancers. There is significant overlap between TNBC and BRCA1 associated breast cancers which suggests that dysfunction in the BRCA1 pathway may be responsible for the development of these cancers. We have discovered two short forms of BRCA1 proteins named BRCA1a and BRCA1b which are expressed at reduced levels in breast and ovarian cancers and are also localized in the mitochondria. Recently we demonstrated for the first time using a gene therapy strategy that introducing BRCA1a protein into TNBC, hormone independent ovarian and prostate cancers induces cell death and stops tumor development. There was a national press release on this work. This major finding will provide new therapies in the future for the treatment of one of the biggest needs in TNBC, ovarian and prostate cancer research. We have recently found SUMO-E2-conjugating enzyme Ubc9 to be a new binding partner for BRCA1 proteins. Mutation in the Ubc9 binding site as well as BRCA1 cancer-predisposing mutation disrupted the ability to both bind as well as modulate ER-alpha transcriptional activity in breast cancer cells. BRCA1 thus belongs to a family of RING-finger Sumo-1 and Ubc9-dependent E3 Ubiquitin ligase that induce turnover of estrogen receptor following its sumoylation and disruption of this pathway in women with BRCA1 mutations can result in TNBC. There are currently no targeted treatments against TNBC. The results that will be obtained from these studies will uncover the paradox as to why BRCA1 dysfunction leads to estrogen receptor positive and triple negative breast cancers as well as develop single cell based assays that can be used to identify functionally relevant BRCA1 mutations that can validate their risk for developing aggressive breast cancers as well as design targeted small molecules that can mimic the function of BRCA1 to treat these TNBC. The implications of this study in Cancer health disparities are immense. We have filed several patents on this work.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Jingyao Xu; Collin Shumate; Yulong Qin; Vaishali Reddy; Yonte Burnam; Victoria Lopez; Joel Okoli; E. Shyam P. Reddy and Veena N. Rao. . Integrated Molecular Medicine, 4 (4): 1-7, 2017. A Novel Ubc9-dependent pathway regulates -SIRT1- ER-a Axis and BRCA1-Associated TNBC Lung Metastasis. 2017; 4(4):1-7. View Publication.
    2. Ashley Wiltshire; Diane Goh; Chukwuma I. Onyeije; and Veena N. Rao. . International Journal of Women’s Health Care,. A Ruptured spontaneous Heterotopic tubal Pregnancy with a viable Intrauterine Pregnancy. 2017; 2(2):1-3. View Publication.
    3. Jinbo Fang; Sharif Morsalin; Veena N. Rao and E. Shyam P. Reddy. J. Pharmaceutical Sciences and Pharmacology, 3, 23-27, 2017. Decoding of Non-Coding DNA and Non-Coding RNA: Pri-Micro RNA-Encoded Novel peptides regulate migration of cancer cells. 2017; 3:23-27. View Publication.
    4. Xu J, Footman A, Qin Y, Aysola K, Black S, Reddy V, Singh K, Grizzle W, You S, Moellering D, Reddy ES, Fu Y, Rao VN. BRCA1 Mutation Leads to Deregulated Ubc9 Levels which Triggers Proliferation and Migration of Patient-Derived High Grade Serous Ovarian Cancer and Triple Negative Breast Cancer Cells. Int J Chronic Dis Ther. 2016; 2(3):31-38. PMID: 28164176.
      Citations:    
    5. Danner OK, Matthews LR, Francis S, Rao VN, Harvey CP, Tobin RP, Wilson KL, Alema-Mensah E, Newell Rogers MK, Childs EW. Vitamin D3 Suppresses Class II Invariant Chain Peptide Expression on Activated B-Lymphocytes: A Plausible Mechanism for Downregulation of Acute Inflammatory Conditions. J Nutr Metab. 2016; 2016:4280876. PMID: 27313879.
      Citations:    
    6. Alexus Footman; Jingyao; Yulong Qin; Kartik Aysola; Diane Goh; Avinash Reddy; Karan Singh; Shaojin You; Derrick Beech; Joel Okoli; William E. Grizzle; E. Shyam P Reddy; Douglas Moellering; Yuchang Fu; Veena N. Rao. . Journal of women's Health. BRCA1 Mutations in Women with HGSOC and TNBC: Molecular Players that Drive transformation as Potential Therapeutic Targets. 2016; 4(25):A74. View Publication.
    7. Jingyao Xu; Shanekkia Black; Kartik Aysola; Yunlong Qin ; Vaishali Reddy; Karan Singh ; Joel Okoli ; Derrick Beech ; Uma Krishnamurthy; Gabriela Oprea; Valerie Montgomery Rice ; Shyam P Reddy; Douglas Moellering; Yuchang Fu; and Veena N Rao. Cancer Epidemiology, Biomarkers and Prevention,. BRCA1 Ring domain mutations and potential tools to predict risk for development of TNBC. 2016; (25):B33. View Publication.
    8. Morsalin S, Yang C, Fang J, Reddy S, Kayarthodi S, Childs E, Matthews R, Rao VN, Reddy ESP. Molecular Mechanism of ß-Catenin Signaling Pathway Inactivation in ETV1-Positive Prostate Cancers. J Pharm Sci Pharmacol. 2015 Sep; 2(3):208-216. PMID: 28497076.
      Citations:    
    9. Lokko C, Turner J, Yoo W, Wood D, Clark K, Childs E, Rao VN, Reddy ES, Clark C. Anal Squamous Cell Carcinoma in African Americans with and without HIV: A Comparative Study. J Cancer Epidemiol Treat. 2015; 1(1):6-10. PMID: 27774311.
      Citations:    
    10. Desai A, Xu J, Aysola K, Akinbobuyi O, White M, Reddy VE, Okoli J, Clark C, Partridge EE, Childs E, Beech DJ, Rice MV, Reddy E, Rao VN. Molecular Mechanism Linking BRCA1 Dysfunction to High Grade Serous Epithelial Ovarian Cancers with Peritoneal Permeability and Ascites. J Gynecol Res. 2015; 1(1). PMID: 26665166.
      Citations:    
    11. Fang J, Xu H, Yang C, Morsalin S, Kayarthodi S, Rungsrisuriyachai K, Gunnal U, Mckenzie B, Rao VN, Reddy ES. Ets Related Gene and Smad3 Proteins Collaborate to Activate Transforming Growth Factor-Beta Mediated Signaling Pathway in ETS Related Gene-Positive Prostate Cancer Cells. J Pharm Sci Pharmacol. 2014 Sep 01; 1(3):175-181. PMID: 25745638.
      Citations:    
    12. Kayarthodi S, Fujimura Y, Fang J, Morsalin S, Rao VN, Reddy ES. Anti-Epileptic Drug Targets Ewing Sarcoma. J Pharm Sci Pharmacol. 2014 Jun 01; 1(2):87-100. PMID: 25664332.
      Citations:    
    13. Yahirun JJ, Hamplová D. CHILDREN'S UNION STATUS AND CONTACT WITH MOTHERS: A CROSS-NATIONAL STUDY. Demogr Res. 2014 Jan-Jun; 30:1413-1444. PMID: 8510921.
      Citations: 17     Fields:    Translation:AnimalsCells
    14. Desai A, Xu J, Aysola K, Qin Y, Okoli C, Hariprasad R, Chinemerem U, Gates C, Reddy A, Danner O, Franklin G, Ngozi A, Cantuaria G, Singh K, Grizzle W, Landen C, Partridge EE, Rice VM, Reddy ES, Rao VN. Epithelial ovarian cancer: An overview. World J Transl Med. 2014 Apr 12; 3(1):1-8. PMID: 25525571.
      Citations:    
    15. Fang J, Xu H, Yang C, Kayarthodi S, Matthews R, Rao VN, Reddy ES. Molecular Mechanism of Activation of Transforming Growth Factor Beta/Smads Signaling Pathway in Ets Related Gene-Positive Prostate Cancers. J Pharm Sci Pharmacol. 2014 Mar; 1(1):82-85. PMID: 25679011.
      Citations:    
    16. Xu J, Agyemang S, Qin Y, Aysola K, Giles M, Oprea G, O'Regan RM, Partridge EE, Harris-Hooker S, Rice VM, Reddy ES, Rao VN. A Novel Pathway that Links Caveolin-1 Down-Regulation to BRCA1 Dysfunction in Serous Epithelial Ovarian Cancer Cells. Enliven Chall Cancer Detect Ther. 2014; 1(1). PMID: 25594072.
      Citations:    
    17. Kartik Aysola, Akshata Desai, Crystal Welch, Jingyao Xu, Yunlong Qin, Vaishali Reddy, Roland Matthews, Charlotte Owens, Joel Okoli , Derrick J Beech , Chandrika J Piyathilake, Shyam P Reddy and Veena N Rao. Triple Negative Breast Cancer – An Overview. Hereditary Genetics :Current Research. 2013; 1-4. View Publication.
    18. Qin Y, Xu J, Aysola K, Oprea G, Reddy A, Matthews R, Okoli J, Cantor A, Grizzle WE, Partridge EE, Reddy ES, Landen C, Rao VN. BRCA1 proteins regulate growth of ovarian cancer cells by tethering Ubc9. Am J Cancer Res. 2012; 2(5):540-8. PMID: 22957306.
      Citations:    
    19. Qin Y, Xu J, Aysola K, Begum N, Reddy V, Chai Y, Grizzle WE, Partridge EE, Reddy ES, Rao VN. Ubc9 mediates nuclear localization and growth suppression of BRCA1 and BRCA1a proteins. J Cell Physiol. 2011 Dec; 226(12):3355-67. PMID: 21344391.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    20. Fortson WS, Kayarthodi S, Fujimura Y, Xu H, Matthews R, Grizzle WE, Rao VN, Bhat GK, Reddy ES. Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells. Int J Oncol. 2011 Jul; 39(1):111-9. PMID: 21519790.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    21. Siddique H, Rao VN, Reddy ES. CBP-mediated post-translational N-glycosylation of BRCA2. Int J Oncol. 2009 Aug; 35(2):387-91. PMID: 19578754.
      Citations:    Fields:    Translation:HumansCells
    22. Maniccia AW, Lewis C, Begum N, Xu J, Cui J, Chipitsyna G, Aysola K, Reddy V, Bhat G, Fujimura Y, Henderson B, Reddy ES, Rao VN. Mitochondrial localization, ELK-1 transcriptional regulation and growth inhibitory functions of BRCA1, BRCA1a, and BRCA1b proteins. J Cell Physiol. 2009 Jun; 219(3):634-41. PMID: 19170108.
      Citations: 18     Fields:    Translation:HumansCells
    23. Xu J, Watkins T, Reddy A, Reddy ES, Rao VN. A novel mechanism whereby BRCA1/1a/1b fine tunes the dynamic complex interplay between SUMO-dependent/independent activities of Ubc9 on E2-induced ERalpha activation/repression and degradation in breast cancer cells. Int J Oncol. 2009 Apr; 34(4):939-49. PMID: 19287951.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    24. Yuli C, Shao N, Rao R, Aysola P, Reddy V, Oprea-llies G, Lee L, Okoli J, Partridge E, Reddy ES, Rao VN. BRCA1a has antitumor activity in TN breast, ovarian and prostate cancers. Oncogene. 2007 Sep 06; 26(41):6031-7. PMID: 17384678.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    25. Ramakrishnan R, Fujimura Y, Zou JP, Liu F, Lee L, Rao VN, Reddy ES. Role of protein-protein interactions in the antiapoptotic function of EWS-Fli-1. Oncogene. 2004 Sep 16; 23(42):7087-94. PMID: 15273724.
      Citations: 16     Fields:    Translation:HumansCells
    26. Spell C, Kölsch H, Lütjohann D, Kerksiek A, Hentschel F, Damian M, von Bergmann K, Rao ML, Maier W, Heun R. SREBP-1a polymorphism influences the risk of Alzheimer's disease in carriers of the ApoE4 allele. Dement Geriatr Cogn Disord. 2004; 18(3-4):245-9. PMID: 15286454.
      Citations: 4     Fields:    Translation:Humans
    27. Kölsch H, Ptok U, Majores M, Schmitz S, Rao ML, Maier W, Heun R. Putative association of polymorphism in the mannose 6-phosphate receptor gene with major depression and Alzheimer's disease. Psychiatr Genet. 2004 Jun; 14(2):97-100. PMID: 15167696.
      Citations:    
    28. von Bubnoff D, Matz H, Frahnert C, Rao ML, Hanau D, de la Salle H, Bieber T. FcepsilonRI induces the tryptophan degradation pathway involved in regulating T cell responses. J Immunol. 2002 Aug 15; 169(4):1810-6. PMID: 12165503.
      Citations:    
    29. Majores M, Kolsch H, Bagli M, Papassotiropoulos A, Lohmann PL, Schmitz S, Rao ML, Maier W, Heun R. Cathepsin D: screening for new polymorphisms using single-strand conformation polymorphism analysis. Int J Mol Med. 2002 Feb; 9(2):185-7. PMID: 11786931.
      Citations: 1     Fields:    Translation:HumansCells
    30. Fujimura Y, Siddique H, Lee L, Rao VN, Reddy ES. EWS-ATF-1 chimeric protein in soft tissue clear cell sarcoma associates with CREB-binding protein and interferes with p53-mediated trans-activation function. Oncogene. 2001 Oct 11; 20(46):6653-9. PMID: 11709699.
      Citations: 11     Fields:    Translation:HumansCells
    31. Chai Y, Chipitsyna G, Cui J, Liao B, Liu S, Aysola K, Yezdani M, Reddy ES, Rao VN. c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells. Oncogene. 2001 Mar 15; 20(11):1357-67. PMID: 11313879.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    32. Zou JP, Hirose Y, Siddique H, Rao VN, Reddy ES. Structure and expression of variant BRCA2a lacking the transactivation domain. Oncol Rep. 1999 Mar-Apr; 6(2):437-40. PMID: 10023017.
      Citations: 2     Fields:    Translation:HumansCells
    33. Chai YL, Cui J, Shao N, Shyam E, Reddy P, Rao VN. The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter. Oncogene. 1999 Jan 07; 18(1):263-8. PMID: 9926942.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    34. Dhulipala PD, Lee L, Rao VN, Reddy ES. Fli-1b is generated by usage of differential splicing and alternative promoter. Oncogene. 1998 Sep 03; 17(9):1149-57. PMID: 9764825.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    35. Shao N, Chai Y, Cui JQ, Wang N, Aysola K, Reddy ES, Rao VN. Induction of apoptosis by Elk-1 and deltaElk-1 proteins. Oncogene. 1998 Jul 30; 17(4):527-32. PMID: 9696047.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    36. Pereira DS, Dorrell C, Ito CY, Gan OI, Murdoch B, Rao VN, Zou JP, Reddy ES, Dick JE. Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells. Proc Natl Acad Sci U S A. 1998 Jul 07; 95(14):8239-44. PMID: 9653171.
      Citations: 24     Fields:    Translation:HumansCells
    37. Cui JQ, Wang H, Reddy ES, Rao VN. Differential transcriptional activation by the N-terminal region of BRCA1 splice variants BRCA1a and BRCA1b. Oncol Rep. 1998 May-Jun; 5(3):585-9. PMID: 9538156.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    38. Cui JQ, Shao N, Chai Y, Wang H, Reddy ES, Rao VN. BRCA1 splice variants BRCA1a and BRCA1b associate with CBP co-activator. Oncol Rep. 1998 May-Jun; 5(3):591-5. PMID: 9538157.
      Citations: 2     Fields:    Translation:HumansCells
    39. Siddique H, Zou JP, Rao VN, Reddy ES. The BRCA2 is a histone acetyltransferase. Oncogene. 1998 Apr 30; 16(17):2283-5. PMID: 9619837.
      Citations: 16     Fields:    Translation:HumansCells
    40. Wang H, Shao N, Ding QM, Cui J, Reddy ES, Rao VN. BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases. Oncogene. 1997 Jul 10; 15(2):143-57. PMID: 9244350.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    41. Yi H, Fujimura Y, Ouchida M, Prasad DD, Rao VN, Reddy ES. Inhibition of apoptosis by normal and aberrant Fli-1 and erg proteins involved in human solid tumors and leukemias. Oncogene. 1997 Mar 20; 14(11):1259-68. PMID: 9178886.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    42. Shao N, Chai YL, Shyam E, Reddy P, Rao VN. Induction of apoptosis by the tumor suppressor protein BRCA1. Oncogene. 1996 Jul 04; 13(1):1-7. PMID: 8700535.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    43. Rao VN, Shao N, Ahmad M, Reddy ES. Antisense RNA to the putative tumor suppressor gene BRCA1 transforms mouse fibroblasts. Oncogene. 1996 Feb 01; 12(3):523-8. PMID: 8637708.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    44. Fujimura Y, Ohno T, Siddique H, Lee L, Rao VN, Reddy ES. The EWS-ATF-1 gene involved in malignant melanoma of soft parts with t(12;22) chromosome translocation, encodes a constitutive transcriptional activator. Oncogene. 1996 Jan 04; 12(1):159-67. PMID: 8552387.
      Citations: 16     Fields:    Translation:HumansCells
    45. Ouchida M, Ohno T, Fujimura Y, Rao VN, Reddy ES. Loss of tumorigenicity of Ewing's sarcoma cells expressing antisense RNA to EWS-fusion transcripts. Oncogene. 1995 Sep 21; 11(6):1049-54. PMID: 7566963.
      Citations: 39     Fields:    Translation:Animals
    46. Prasad DD, Ouchida M, Lee L, Rao VN, Reddy ES. TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain. Oncogene. 1994 Dec; 9(12):3717-29. PMID: 7970732.
      Citations: 50     Fields:    Translation:HumansCells
    47. Ohno T, Ouchida M, Lee L, Gatalica Z, Rao VN, Reddy ES. The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains. Oncogene. 1994 Oct; 9(10):3087-97. PMID: 8084618.
      Citations: 54     Fields:    Translation:HumansCells
    48. Rao VN, Reddy ES. elk-1 proteins interact with MAP kinases. Oncogene. 1994 Jul; 9(7):1855-60. PMID: 8208531.
      Citations: 24     Fields:    Translation:AnimalsCells
    49. Prasad DD, Rao VN, Lee L, Reddy ES. Differentially spliced erg-3 product functions as a transcriptional activator. Oncogene. 1994 Feb; 9(2):669-73. PMID: 8290279.
      Citations: 7     Fields:    Translation:HumansCells
    50. Ohno T, Rao VN, Reddy ES. EWS/Fli-1 chimeric protein is a transcriptional activator. Cancer Res. 1993 Dec 15; 53(24):5859-63. PMID: 7503813.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    51. Bhattacharya G, Lee L, Reddy ES, Rao VN. Transcriptional activation domains of elk-1, delta elk-1 and SAP-1 proteins. Oncogene. 1993 Dec; 8(12):3459-64. PMID: 8247551.
      Citations:    Fields:    Translation:AnimalsCells
    52. Rao VN, Ohno T, Prasad DD, Bhattacharya G, Reddy ES. Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein. Oncogene. 1993 Aug; 8(8):2167-73. PMID: 8336942.
      Citations: 28     Fields:    Translation:HumansCells
    53. Rao VN, Reddy ES. Elk-1 proteins are phosphoproteins and activators of mitogen-activated protein kinase. Cancer Res. 1993 Aug 01; 53(15):3449-54. PMID: 8339245.
      Citations: 3     Fields:    Translation:AnimalsCells
    54. Rao VN, Reddy ES. Delta elk-1, a variant of elk-1, fails to interact with the serum response factor and binds to DNA with modulated specificity. Cancer Res. 1993 Jan 15; 53(2):215-20. PMID: 8417810.
      Citations: 3     Fields:    Translation:AnimalsCells
    55. Rao VN, Reddy ES. elk-1 domains responsible for autonomous DNA binding, SRE:SRF interaction and negative regulation of DNA binding. Oncogene. 1992 Nov; 7(11):2335-40. PMID: 1437156.
      Citations: 11     Fields:    
    56. Prasad DD, Rao VN, Reddy ES. Structure and expression of human Fli-1 gene. Cancer Res. 1992 Oct 15; 52(20):5833-7. PMID: 1394211.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    57. Dudek H, Tantravahi RV, Rao VN, Reddy ES, Reddy EP. Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter. Proc Natl Acad Sci U S A. 1992 Feb 15; 89(4):1291-5. PMID: 1741383.
      Citations: 41     Fields:    Translation:Cells
    58. Rao VN, Reddy ES. A divergent ets-related protein, elk-1, recognizes similar c-ets-1 proto-oncogene target sequences and acts as a transcriptional activator. Oncogene. 1992 Jan; 7(1):65-70. PMID: 1741166.
      Citations: 20     Fields:    Translation:Cells
    59. Reddy ES, Rao VN. erg, an ets-related gene, codes for sequence-specific transcriptional activators. Oncogene. 1991 Dec; 6(12):2285-9. PMID: 1766675.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    60. Hipskind RA, Rao VN, Mueller CG, Reddy ES, Nordheim A. Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF. Nature. 1991 Dec 19-26; 354(6354):531-4. PMID: 1722028.
      Citations: 154     Fields:    Translation:AnimalsCells
    61. Reddy ES, Rao VN. Localization and modulation of the DNA-binding activity of the human c-ets-1 protooncogene. Cancer Res. 1990 Aug 15; 50(16):5013-6. PMID: 2165853.
      Citations: 2     Fields:    Translation:AnimalsCells
    62. Rao VN, Huebner K, Isobe M, ar-Rushdi A, Croce CM, Reddy ES. elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints. Science. 1989 Apr 07; 244(4900):66-70. PMID: 2539641.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    63. Rao VN, Modi WS, Drabkin HD, Patterson D, O'Brien SJ, Papas TS, Reddy ES. The human erg gene maps to chromosome 21, band q22: relationship to the 8; 21 translocation of acute myelogenous leukemia. Oncogene. 1988 Nov; 3(5):497-500. PMID: 3274086.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    64. Reddy ES, Rao VN. Structure, expression and alternative splicing of the human c-ets-1 proto-oncogene. Oncogene Res. 1988; 3(3):239-46. PMID: 3060801.
      Citations: 11     Fields:    Translation:HumansCells
    65. Reddy ES, Rao VN, Papas TS. The erg gene: a human gene related to the ets oncogene. Proc Natl Acad Sci U S A. 1987 Sep; 84(17):6131-5. PMID: 3476934.
      Citations: 55     Fields:    Translation:HumansCells
    66. Rao VN, Papas TS, Reddy ES. erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation. Science. 1987 Aug 07; 237(4815):635-9. PMID: 3299708.
      Citations: 63     Fields:    Translation:HumansCells
    67. Rao VN, Zweig M, Papas TS, Reddy ES. Expression in E. coli of erg: a novel gene in humans related to the ets oncogene. Oncogene Res. 1987; 2(1):95-101. PMID: 2851121.
      Citations:    Fields:    Translation:HumansCells
    68. Rao VN, Ghosh PK, Weissman SM. Expression of the late gene of simian virus 40 under the control of the simian virus 40 early-region promoter in monkey and mouse cells. J Virol. 1986 Jan; 57(1):91-100. PMID: 3001368.
      Citations: 1     Fields:    Translation:AnimalsCells
    69. Rao VN, Bhargava PM. Isolation, characterization and possible mode of action of antiseminalplasmin, a new protein that inhibits the antimicrobial activity of seminalplasmin. Biochem J. 1985 Apr 15; 227(2):609-19. PMID: 2408604.
      Citations:    Fields:    Translation:Cells
    70. Rao VN, Reddy ES, Torriani A, Bhargava PM. Seminalplasmin inhibits transcription and translation of phi80 DNA in vitro. FEBS Lett. 1983 Feb 07; 152(1):6-10. PMID: 6840278.
      Citations: 2     Fields:    Translation:Cells
    71. Kwiatkowska J. [Erythrocyte metabolism in hereditary spherocytosis]. Acta Haematol Pol. 1971 Apr-Jun; 2(2):187-93. PMID: 4267287.
      Citations:    Fields:    Translation:HumansCells
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