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Francis Eko

Faculty RankProfessor
InstitutionMorehouse School of Medicine
DepartmentMicrobiology, Biochemistry, & Immunology
Address720 Westveiw Drive, SW
Hugh Gloster Building
Atlanta GA 30310
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    R01AI041231     (EKO, FRANCIS O.)Sep 1, 1996 - Aug 31, 2001
    Role: Principal Investigator

    R01AI126897     (EKO, FRANCIS O.)Jul 26, 2016 - Jun 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lundy SR, Richardson S, Ramsey A, Ellerson D, Fengxia Y, Onyeabor S, Kirlin W, Thompson W, Black CM, DeBruyne JP, Davidson AJ, Immergluck LC, Blas-Machado U, Eko FO, Igietseme JU, He Q, Omosun YO. Author Correction: Shift work influences the outcomes of Chlamydia infection and pathogenesis. Sci Rep. 2020 Dec 11; 10(1):22183. PMID: 33311582.
      Citations:    Fields:    
    2. Lundy SR, Richardson S, Ramsey A, Ellerson D, Fengxia Y, Onyeabor S, Kirlin W, Thompson W, Black CM, DeBruyne JP, Davidson AJ, Immergluck LC, Blas-Machado U, Eko FO, Igietseme JU, He Q, Omosun YO. Shift work influences the outcomes of Chlamydia infection and pathogenesis. Sci Rep. 2020 09 21; 10(1):15389. PMID: 32958779.
      Citations:    Fields:    Translation:AnimalsCells
    3. Chu J, Li X, Qu G, Wang Y, Li Q, Guo Y, Hou L, Liu J, Eko FO, He C. Correction: Chlamydia psittaci PmpD-N modulated Chicken Macrophage Function by Triggering Th2 Polarization and the TLR2/MyD88/NF-?B Signaling Pathway. Int J Mol Sci. 2020 Apr 10; 21(7). PMID: 32290117.
      Citations:    Fields:    
    4. Igietseme JU, Partin J, George Z, Omosun Y, Goldstein J, Joseph K, Ellerson D, Eko FO, Pohl J, Bandea C, Black CM. Epidermal Growth Factor Receptor and Transforming Growth Factor ß Signaling Pathways Cooperate To Mediate Chlamydia Pathogenesis. Infect Immun. 2020 03 23; 88(4). PMID: 31964750.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Chu J, Li X, Qu G, Wang Y, Li Q, Guo Y, Hou L, Liu J, Eko FO, He C. Chlamydia psittaci PmpD-N Exacerbated Chicken Macrophage Function by Triggering Th2 Polarization and the TLR2/MyD88/NF-?B Signaling Pathway. Int J Mol Sci. 2020 Mar 15; 21(6). PMID: 32183481.
      Citations:    Fields:    Translation:AnimalsCells
    6. Lundy SR, Ahmad T, Simoneaux T, Benyeogor I, Robinson Y, George Z, Ellerson D, Kirlin W, Omosun T, Eko FO, Black CM, Blas-Machado U, DeBruyne JP, Igietseme JU, He Q, Omosun YO. Effect of Time of Day of Infection on Chlamydia Infectivity and Pathogenesis. Sci Rep. 2019 08 06; 9(1):11405. PMID: 31388084.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    7. Pais R, Omosun Y, Igietseme JU, Fujihashi K, Eko FO. Route of Vaccine Administration Influences the Impact of Fms-Like Tyrosine Kinase 3 Ligand (Flt3L) on Chlamydial-Specific Protective Immune Responses. Front Immunol. 2019; 10:1577. PMID: 31333682.
      Citations:    Fields:    Translation:AnimalsCells
    8. Benyeogor I, Simoneaux T, Wu Y, Lundy S, George Z, Ryans K, McKeithen D, Pais R, Ellerson D, Lorenz WW, Omosun T, Thompson W, Eko FO, Black CM, Blas-Machado U, Igietseme JU, He Q, Omosun Y. A unique insight into the MiRNA profile during genital chlamydial infection. BMC Genomics. 2019 Feb 18; 20(1):143. PMID: 30777008.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    9. George Z, Omosun Y, Azenabor AA, Goldstein J, Partin J, Joseph K, Ellerson D, He Q, Eko F, McDonald MA, Reed M, Svoboda P, Stuchlik O, Pohl J, Lutter E, Bandea C, Black CM, Igietseme JU. The molecular mechanism of induction of unfolded protein response by Chlamydia. Biochem Biophys Res Commun. 2019 01 08; 508(2):421-429. PMID: 30503337.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    10. Igietseme JU, Omosun Y, Nagy T, Stuchlik O, Reed MS, He Q, Partin J, Joseph K, Ellerson D, George Z, Goldstein J, Eko FO, Bandea C, Pohl J, Black CM. Molecular Pathogenesis of Chlamydia Disease Complications: Epithelial-Mesenchymal Transition and Fibrosis. Infect Immun. 2018 01; 86(1). PMID: 29084894.
      Citations: 7     Fields:    Translation:AnimalsCells
    11. Pan Q, Zhang Q, Chu J, Pais R, Liu S, He C, Eko FO. Chlamydia abortus Pmp18.1 Induces IL-1ß Secretion by TLR4 Activation through the MyD88, NF-?B, and Caspase-1 Signaling Pathways. Front Cell Infect Microbiol. 2017; 7:514. PMID: 29326885.
      Citations: 5     Fields:    Translation:AnimalsCells
    12. McKeithen DN, Omosun YO, Ryans K, Mu J, Xie Z, Simoneaux T, Blas-Machado U, Eko FO, Black CM, Igietseme JU, He Q. The emerging role of ASC in dendritic cell metabolism during Chlamydia infection. PLoS One. 2017; 12(12):e0188643. PMID: 29216217.
      Citations: 2     Fields:    Translation:AnimalsCells
    13. Pais R, Omosun Y, He Q, Blas-Machado U, Black C, Igietseme JU, Fujihashi K, Eko FO. Rectal administration of a chlamydial subunit vaccine protects against genital infection and upper reproductive tract pathology in mice. PLoS One. 2017; 12(6):e0178537. PMID: 28570663.
      Citations: 6     Fields:    Translation:AnimalsCells
    14. Ryans K, Omosun Y, McKeithen DN, Simoneaux T, Mills CC, Bowen N, Eko FO, Black CM, Igietseme JU, He Q. The immunoregulatory role of alpha enolase in dendritic cell function during Chlamydia infection. BMC Immunol. 2017 05 19; 18(1):27. PMID: 28525970.
      Citations: 6     Fields:    Translation:AnimalsCells
    15. George Z, Omosun Y, Azenabor AA, Partin J, Joseph K, Ellerson D, He Q, Eko F, Bandea C, Svoboda P, Pohl J, Black CM, Igietseme JU. The Roles of Unfolded Protein Response Pathways in Chlamydia Pathogenesis. J Infect Dis. 2017 02 01; 215(3):456-465. PMID: 27932618.
      Citations: 8     Fields:    Translation:AnimalsCells
    16. Igietseme JU, Omosun Y, Stuchlik O, Reed MS, Partin J, He Q, Joseph K, Ellerson D, Bollweg B, George Z, Eko FO, Bandea C, Liu H, Yang G, Shieh WJ, Pohl J, Karem K, Black CM. Role of Epithelial-Mesenchyme Transition in Chlamydia Pathogenesis. PLoS One. 2015; 10(12):e0145198. PMID: 26681200.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    17. Omosun Y, McKeithen D, Ryans K, Kibakaya C, Blas-Machado U, Li D, Singh R, Inoue K, Xiong ZG, Eko F, Black C, Igietseme J, He Q. Interleukin-10 modulates antigen presentation by dendritic cells through regulation of NLRP3 inflammasome assembly during Chlamydia infection. Infect Immun. 2015 Dec; 83(12):4662-72. PMID: 26371131.
      Citations: 14     Fields:    Translation:AnimalsCells
    18. Eko FO, Mania-Pramanik J, Pais R, Pan Q, Okenu DM, Johnson A, Ibegbu C, He C, He Q, Russell R, Black CM, Igietseme JU. Vibrio cholerae ghosts (VCG) exert immunomodulatory effect on dendritic cells for enhanced antigen presentation and induction of protective immunity. BMC Immunol. 2014 Dec 31; 15:584. PMID: 25551828.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    19. Ou C, Tian D, Ling Y, Pan Q, He Q, Eko FO, He C. Evaluation of an ompA-based phage-mediated DNA vaccine against Chlamydia abortus in piglets. Int Immunopharmacol. 2013 Aug; 16(4):505-10. PMID: 23669337.
      Citations: 4     Fields:    Translation:AnimalsCells
    20. Pokam BT, Asuquo AE, Abia-Bassey LN, Idasa MB, Umoh NO, Eko FO, Rastogi N. Multidrug resistance and demography of newly diagnosed tuberculosis patients in Cross River State, Nigeria. Int J Mycobacteriol. 2013 Jun; 2(2):89-93. PMID: 26785895.
      Citations: 5     Fields:    
    21. Igietseme JU, Omosun Y, Partin J, Goldstein J, He Q, Joseph K, Ellerson D, Ansari U, Eko FO, Bandea C, Zhong G, Black CM. Prevention of Chlamydia-induced infertility by inhibition of local caspase activity. J Infect Dis. 2013 Apr; 207(7):1095-104. PMID: 23303804.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    22. He Q, Ananaba GA, Patrickson J, Pitts S, Yi Y, Yan F, Eko FO, Lyn D, Black CM, Igietseme JU, Thierry-Palmer M. Chlamydial infection in vitamin D receptor knockout mice is more intense and prolonged than in wild-type mice. J Steroid Biochem Mol Biol. 2013 May; 135:7-14. PMID: 23201171.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    23. Igietseme JU, Eko FO, Black CM. Chlamydia vaccines: recent developments and the role of adjuvants in future formulations. Expert Rev Vaccines. 2011 Nov; 10(11):1585-96. PMID: 22043957.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    24. Thumamo BP, Asuquo AE, Abia-Bassey LN, Lawson L, Hill V, Zozio T, Emenyonu N, Eko FO, Rastogi N. Molecular epidemiology and genetic diversity of Mycobacterium tuberculosis complex in the Cross River State, Nigeria. Infect Genet Evol. 2012 Jun; 12(4):671-7. PMID: 21878397.
      Citations: 25     Fields:    Translation:HumansCells
    25. Eko FO, Okenu DN, Singh UP, He Q, Black C, Igietseme JU. Evaluation of a broadly protective Chlamydia-cholera combination vaccine candidate. Vaccine. 2011 May 12; 29(21):3802-10. PMID: 21421002.
      Citations: 10     Fields:    Translation:AnimalsCells
    26. Eko FO, Ekong E, He Q, Black CM, Igietseme JU. Induction of immune memory by a multisubunit chlamydial vaccine. Vaccine. 2011 Feb 04; 29(7):1472-80. PMID: 21184858.
      Citations: 11     Fields:    Translation:AnimalsCells
    27. Eko FO, Talin BA, Lubitz W. Development of a Chlamydia trachomatis bacterial ghost vaccine to fight human blindness. Hum Vaccin. 2008 May-Jun; 4(3):176-83. PMID: 18382139.
      Citations: 6     Fields:    Translation:HumansCells
    28. Igietseme JU, He Q, Joseph K, Eko FO, Lyn D, Ananaba G, Campbell A, Bandea C, Black CM. Role of T lymphocytes in the pathogenesis of Chlamydia disease. J Infect Dis. 2009 Sep 15; 200(6):926-34. PMID: 19656067.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    29. Ramey K, Eko FO, Thompson WE, Armah H, Igietseme JU, Stiles JK. Immunolocalization and challenge studies using a recombinant Vibrio cholerae ghost expressing Trypanosoma brucei Ca(2+) ATPase (TBCA2) antigen. Am J Trop Med Hyg. 2009 Sep; 81(3):407-15. PMID: 19706905.
      Citations: 4     Fields:    Translation:AnimalsCells
    30. Ekong EE, Okenu DN, Mania-Pramanik J, He Q, Igietseme JU, Ananaba GA, Lyn D, Black C, Eko FO. A Vibrio cholerae ghost-based subunit vaccine induces cross-protective chlamydial immunity that is enhanced by CTA2B, the nontoxic derivative of cholera toxin. FEMS Immunol Med Microbiol. 2009 Mar; 55(2):280-91. PMID: 19040663.
      Citations: 11     Fields:    Translation:AnimalsCells
    31. He Q, Eko FO, Lyn D, Ananaba GA, Bandea C, Martinez J, Joseph K, Kellar K, Black CM, Igietseme JU. Involvement of LEK1 in dendritic cell regulation of T cell immunity against Chlamydia. J Immunol. 2008 Sep 15; 181(6):4037-42. PMID: 18768859.
      Citations: 3     Fields:    Translation:AnimalsCells
    32. Silva AJ, Eko FO, Benitez JA. Exploiting cholera vaccines as a versatile antigen delivery platform. Biotechnol Lett. 2008 Apr; 30(4):571-9. PMID: 18008168.
      Citations: 4     Fields:    Translation:Cells
    33. Ifere GO, He Q, Igietseme JU, Ananaba GA, Lyn D, Lubitz W, Kellar KL, Black CM, Eko FO. Immunogenicity and protection against genital Chlamydia infection and its complications by a multisubunit candidate vaccine. J Microbiol Immunol Infect. 2007 Jun; 40(3):188-200. PMID: 17639158.
      Citations: 18     Fields:    Translation:AnimalsCellsPHPublic Health
    34. He Q, Martinez-Sobrido L, Eko FO, Palese P, Garcia-Sastre A, Lyn D, Okenu D, Bandea C, Ananaba GA, Black CM, Igietseme JU. Live-attenuated influenza viruses as delivery vectors for Chlamydia vaccines. Immunology. 2007 Sep; 122(1):28-37. PMID: 17451464.
      Citations: 15     Fields:    Translation:AnimalsCellsPHPublic Health
    35. Igietseme JU, Eko FO, He Q, Black CM. Combination vaccines: design strategies and future trends. Expert Rev Vaccines. 2006 Dec; 5(6):739-45. PMID: 17184210.
      Citations:    Fields:    Translation:HumansPHPublic Health
    36. Macmillan L, Ifere GO, He Q, Igietseme JU, Kellar KL, Okenu DM, Eko FO. A recombinant multivalent combination vaccine protects against Chlamydia and genital herpes. FEMS Immunol Med Microbiol. 2007 Feb; 49(1):46-55. PMID: 17094789.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    37. Barr EL, Ouburg S, Igietseme JU, Morré SA, Okwandu E, Eko FO, Ifere G, Belay T, He Q, Lyn D, Nwankwo G, Lillard JW, Black CM, Ananaba GA. Host inflammatory response and development of complications of Chlamydia trachomatis genital infection in CCR5-deficient mice and subfertile women with the CCR5delta32 gene deletion. J Microbiol Immunol Infect. 2005 Aug; 38(4):244-54. PMID: 16118671.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    38. Igietseme J, Eko F, He Q, Bandea C, Lubitz W, Garcia-Sastre A, Black C. Delivery of Chlamydia vaccines. Expert Opin Drug Deliv. 2005 May; 2(3):549-62. PMID: 16296774.
      Citations: 2     Fields:    Translation:HumansAnimals
    39. He Q, Moore TT, Eko FO, Lyn D, Ananaba GA, Martin A, Singh S, James L, Stiles J, Black CM, Igietseme JU. Molecular basis for the potency of IL-10-deficient dendritic cells as a highly efficient APC system for activating Th1 response. J Immunol. 2005 Apr 15; 174(8):4860-9. PMID: 15814713.
      Citations: 20     Fields:    Translation:AnimalsCells
    40. Walcher P, Mayr UB, Azimpour-Tabrizi C, Eko FO, Jechlinger W, Mayrhofer P, Alefantis T, Mujer CV, DelVecchio VG, Lubitz W. Antigen discovery and delivery of subunit vaccines by nonliving bacterial ghost vectors. Expert Rev Vaccines. 2004 Dec; 3(6):681-91. PMID: 15606353.
      Citations: 14     Fields:    Translation:Cells
    41. Eko FO, He Q, Brown T, McMillan L, Ifere GO, Ananaba GA, Lyn D, Lubitz W, Kellar KL, Black CM, Igietseme JU. A novel recombinant multisubunit vaccine against Chlamydia. J Immunol. 2004 Sep 01; 173(5):3375-82. PMID: 15322201.
      Citations: 37     Fields:    Translation:AnimalsCells
    42. Igietseme JU, Eko FO, He Q, Bandea C, Black CM. Developing effective delivery systems for Chlamydia vaccines. Curr Opin Mol Ther. 2004 Apr; 6(2):182-94. PMID: 15195931.
      Citations:    Fields:    Translation:HumansCells
    43. Igietseme JU, Eko FO, He Q, Black CM. Antibody regulation of Tcell immunity: implications for vaccine strategies against intracellular pathogens. Expert Rev Vaccines. 2004 Feb; 3(1):23-34. PMID: 14761241.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    44. Eko FO, Schukovskaya T, Lotzmanova EY, Firstova VV, Emalyanova NV, Klueva SN, Kravtzov AL, Livanova LF, Kutyrev VV, Igietseme JU, Lubitz W. Evaluation of the protective efficacy of Vibrio cholerae ghost (VCG) candidate vaccines in rabbits. Vaccine. 2003 Sep 08; 21(25-26):3663-74. PMID: 12922096.
      Citations: 19     Fields:    Translation:AnimalsCells
    45. Moore T, Ekworomadu CO, Eko FO, MacMillan L, Ramey K, Ananaba GA, Patrickson JW, Nagappan PR, Lyn D, Black CM, Igietseme JU. Fc receptor-mediated antibody regulation of T cell immunity against intracellular pathogens. J Infect Dis. 2003 Aug 15; 188(4):617-24. PMID: 12898452.
      Citations: 55     Fields:    Translation:AnimalsCells
    46. Eko FO, Lubitz W, McMillan L, Ramey K, Moore TT, Ananaba GA, Lyn D, Black CM, Igietseme JU. Recombinant Vibrio cholerae ghosts as a delivery vehicle for vaccinating against Chlamydia trachomatis. Vaccine. 2003 Apr 02; 21(15):1694-703. PMID: 12639492.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    47. Jalava K, Eko FO, Riedmann E, Lubitz W. Bacterial ghosts as carrier and targeting systems for mucosal antigen delivery. Expert Rev Vaccines. 2003 Feb; 2(1):45-51. PMID: 12901596.
      Citations: 21     Fields:    Translation:CellsPHPublic Health
    48. Igietseme JU, Eko FO, Black CM. Contemporary approaches to designing and evaluating vaccines against Chlamydia. Expert Rev Vaccines. 2003 Feb; 2(1):129-46. PMID: 12901604.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    49. Moore T, Ananaba GA, Bolier J, Bowers S, Belay T, Eko FO, Igietseme JU. Fc receptor regulation of protective immunity against Chlamydia trachomatis. Immunology. 2002 Feb; 105(2):213-21. PMID: 11872097.
      Citations: 45     Fields:    Translation:AnimalsCells
    50. Belay T, Eko FO, Ananaba GA, Bowers S, Moore T, Lyn D, Igietseme JU. Chemokine and chemokine receptor dynamics during genital chlamydial infection. Infect Immun. 2002 Feb; 70(2):844-50. PMID: 11796619.
      Citations: 26     Fields:    Translation:AnimalsCells
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