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Stephan Bach

TitleCore Leader of the Protein Biomarker Core
Faculty RankAssociate Professor
InstitutionUniversity of Texas at San Antonio
Departmentchemistry
AddressOne UTSA Circle
San Antonio TX 78249
Phone210-458-6896
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    Collapse Overview 
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    Mass spectrometry has critical applications in a wide variety of diverse scientific disciplines. It is the analytical engine that powers proteomics, drug discovery, and environmental assessment, to name a few. Our interests are focused on several unique and challenging areas using a variety of mass spectrometry techniques. At the forefront is research with the Bruker Ultraflextreme matrix assisted laser desorption ionization (MALDI) time-of-flight mass spectrometer which was acquired through a NSF-MRI grant. The research has as its focus developing new MALDI based techniques to advance the coverage and diversity of materials that are accessible to analysis by MALDI. We are developing new MALDI based methods to enable the acquisition of a more complete analytical picture of monolayer protected nanoparticles at various stages of synthesis to give researchers timely information regarding their synthesizes with Chemistry and Physics faculty. The results from the work will impact chemistry, physics, material science and biology. The group also is involved in collaborative projects utilizing the MALDI TOF/TOF with a number of Biology faculty members for imaging Alzheimer’s brain tissue imaging fire ant tissue (clubs), imaging and analyzing retinal tissue. We are also continuing our investigations into the aqueous chemistry of transition metal complexes (cis-platin derivatives) and developing analytical methods for small molecules of medical interest (anti-inflammatory and anti-oxidant).

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kelley AR, Colley M, Dyer S, Bach SBH, Zhu X, Perry G. Ethanol-Fixed, Paraffin-Embedded Tissue Imaging: Implications for Alzheimer's Disease Research. J Am Soc Mass Spectrom. 2020 Dec 02; 31(12):2416-2420. PMID: 32803969.
      Citations:    Fields:    
    2. Colley M, Liang S, Tan C, Trobough KP, Bach SBH, Chun YP. Mapping and Identification of Native Proteins of Developing Teeth in Mouse Mandibles. Anal Chem. 2020 06 02; 92(11):7630-7637. PMID: 32362116.
      Citations:    Fields:    Translation:Animals
    3. Kelley AR, Bach SBH, Perry G. Analysis of post-translational modifications in Alzheimer's disease by mass spectrometry. Biochim Biophys Acta Mol Basis Dis. 2019 08 01; 1865(8):2040-2047. PMID: 30481587.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    4. Kelley AR, Colley ME, Perry G, Bach SBH. Incubation with Cu(II) and Zn(II) salts enhances MALDI-TOF mass spectra of amyloid-beta and a-synuclein toward in vivo analysis. J Mass Spectrom. 2018 Feb; 53(2):162-171. PMID: 29111606.
      Citations:    Fields:    Translation:HumansCells
    5. Black DM, Robles G, Lopez P, Bach SBH, Alvarez M, Whetten RL. Liquid Chromatography Separation and Mass Spectrometry Detection of Silver-Lipoate Ag29(LA)12 Nanoclusters: Evidence of Isomerism in the Solution Phase. Anal Chem. 2018 02 06; 90(3):2010-2017. PMID: 29260853.
      Citations: 3     Fields:    Translation:Cells
    6. Kelley AR, Perry G, Bach SBH. Characterization of Proteins Present in Isolated Senile Plaques from Alzheimer's Diseased Brains by MALDI-TOF MS with MS/MS. ACS Chem Neurosci. 2018 04 18; 9(4):708-714. PMID: 29301075.
      Citations: 1     Fields:    
    7. Kelley AR, Perry G, Bethea C, Castellani RJ, Bach SB. Molecular Mapping Alzheimer's Disease: MALDI Imaging of Formalin-fixed, Paraffin-embedded Human Hippocampal Tissue. Open Neurol J. 2016; 10:88-98. PMID: 27843502.
      Citations:    
    8. Black DM, Bhattarai N, Bach SB, Whetten RL. Selection and Identification of Molecular Gold Clusters at the Nano(gram) Scale: Reversed Phase HPLC-ESI-MS of a Mixture of Au-Peth MPCs. J Phys Chem Lett. 2016 Aug 18; 7(16):3199-205. PMID: 27476322.
      Citations:    Fields:    
    9. Black DM, Bach SB, Whetten RL. Capillary Liquid Chromatography Mass Spectrometry Analysis of Intact Monolayer-Protected Gold Clusters in Complex Mixtures. Anal Chem. 2016 06 07; 88(11):5631-6. PMID: 27216373.
      Citations: 1     Fields:    
    10. Kelley AR, Perry G, Castellani RJ, Bach SB. Laser-Induced In-Source Decay Applied to the Determination of Amyloid-Beta in Alzheimer's Brains. ACS Chem Neurosci. 2016 Mar 16; 7(3):261-8. PMID: 26720297.
      Citations: 3     Fields:    Translation:Humans
    11. Black DM, Bhattarai N, Whetten RL, Bach SB. Collision-induced dissociation of monolayer protected clusters Au144 and Au130 in an electrospray time-of-flight mass spectrometer. J Phys Chem A. 2014 Nov 13; 118(45):10679-87. PMID: 25317476.
      Citations: 2     Fields:    Translation:Cells
    12. Tlahuice-Flores A, Black DM, Bach SB, Jose-Yacamán M, Whetten RL. Structure & bonding of the gold-subhalide cluster I-Au144Cl60[z]. Phys Chem Chem Phys. 2013 Nov 28; 15(44):19191-5. PMID: 24105400.
      Citations: 11     Fields:    Translation:Cells
    13. Tlahuice-Flores A, Santiago U, Bahena D, Vinogradova E, Conroy CV, Ahuja T, Bach SB, Ponce A, Wang G, José-Yacamán M, Whetten RL. Structure of the thiolated Au130 cluster. J Phys Chem A. 2013 Oct 10; 117(40):10470-6. PMID: 24004091.
      Citations: 5     Fields:    
    14. Bahena D, Bhattarai N, Santiago U, Tlahuice A, Ponce A, Bach SB, Yoon B, Whetten RL, Landman U, Jose-Yacaman M. STEM Electron Diffraction and High Resolution Images Used in the Determination of the Crystal Structure of Au144(SR)60 Cluster. J Phys Chem Lett. 2013 Mar 07; 4(6):975-981. PMID: 23687562.
      Citations: 16     Fields:    
    15. Andra SS, Makris KC, Quazi S, Sarkar D, Datta R, Bach SB. Organocopper complexes during roxarsone degradation in wastewater lagoons. Environ Sci Pollut Res Int. 2010 Jun; 17(5):1167-73. PMID: 20099042.
      Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
    16. Makris KC, Andra SS, Hardy M, Sarkar D, Datta R, Bach SB, Mullens CP. Nitrous oxide supersaturation at the liquid/air interface of animal waste. Environ Pollut. 2009 Dec; 157(12):3508-13. PMID: 19573962.
      Citations:    Fields:    Translation:Animals
    17. Andra SS, Datta R, Sarkar D, Makris KC, Mullens CP, Sahi SV, Bach SB. Induction of lead-binding phytochelatins in vetiver grass [Vetiveria zizanioides (L.)]. J Environ Qual. 2009 May-Jun; 38(3):868-77. PMID: 19329675.
      Citations: 5     Fields:    Translation:Animals
    18. Andra SS, Datta R, Sarkar D, Saminathan SK, Mullens CP, Bach SB. Analysis of phytochelatin complexes in the lead tolerant vetiver grass [Vetiveria zizanioides (L.)] using liquid chromatography and mass spectrometry. Environ Pollut. 2009 Jul; 157(7):2173-83. PMID: 19282075.
      Citations: 6     Fields:    Translation:AnimalsPHPublic Health
    19. Makris KC, Sarkar D, Andra SS, Bach SB, Datta R. Do lagoons near concentrated animal feeding operations promote nitrous oxide supersaturation? Environ Pollut. 2009 Jun; 157(6):1957-60. PMID: 19246141.
      Citations:    Fields:    Translation:AnimalsPHPublic Health
    20. Yoshikawa A, Bach SB, Merrill GN. An experimental and theoretical investigation into the hydrolysis of dichloro(ethylenediamine)platinum(II) via electrospray mass spectrometry and density functional theory. J Am Soc Mass Spectrom. 2009 Jun; 20(6):1015-29. PMID: 19285881.
      Citations: 1     Fields:    Translation:Cells
    21. Makris KC, Salazar J, Quazi S, Andra SS, Sarkar D, Bach SB, Datta R. Controlling the fate of roxarsone and inorganic arsenic in poultry litter. J Environ Qual. 2008 May-Jun; 37(3):963-71. PMID: 18453419.
      Citations: 3     Fields:    Translation:Animals
    22. Bach SB, Green CE, Nagore LI, Sepeda TG, Merrill GN. Complexes of dichloro(ethylenediamine)palladium(II) observed from aqueous solutions by electrospray mass spectrometry. J Am Soc Mass Spectrom. 2007 Apr; 18(4):769-77. PMID: 17317212.
      Citations: 2     Fields:    
    23. Bach SBH, Sepeda TG, Merrill GN, Walmsley JA. Complexes of dibromo(ethylenediamine)-palladium(II) observed from aqueous solutions by electrospray mass spectrometry. J Am Soc Mass Spectrom. 2005 Sep; 16(9):1461-1469. PMID: 16024254.
      Citations: 6     Fields:    Translation:Cells
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