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Lorenzo Brancaleon

Faculty RankAssociate Professor
InstitutionUniversity of Texas at San Antonio
DepartmentPhysics and Astronomy
AddressUniversity of Texas at San antonio
1 Utsa Cir
San Antonio TX 78249
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    Our group investigates various protein/dye systems. The goal is to establish and understand the mechanisms by which photoactive dyes non-covalently attached to proteins can prompt conformational changes of the protein upon irradiation with visible light. These studies are then used to either inactivate
    specific proteins or introduce photosensitive, “artificial” properties (structural, enzymatic, etc.) to globular proteins.
    We also use the same approach, in conjunction with self-assembly with nanoparticles, to study protein/dye complexes that in aqueous solution would be capable of converting solar energy into molecular hydrogen in a photosynthetic mimic that could be developed for biomolecular fuel cells.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Fenner K, Redgate A, Brancaleon L. A 200 nanoseconds all-atom simulation of the pH-dependent EF loop transition in bovine ß-lactoglobulin. The role of the orientation of the E89 side chain. J Biomol Struct Dyn. 2020 Sep 10; 1-16. PMID: 32909899.
      Citations:    Fields:    
    2. Cozzolino M, Pesce L, Pezzuoli D, Montali C, Brancaleon L, Cavanna L, Abbruzzetti S, Diaspro A, Bianchini P, Viappiani C. Apomyoglobin is an efficient carrier for zinc phthalocyanine in photodynamic therapy of tumors. Biophys Chem. 2019 10; 253:106228. PMID: 31349136.
      Citations: 1     Fields:    Translation:HumansCells
    3. Hu J, Hernandez Soraiz E, Johnson CN, Demeler B, Brancaleon L. Novel combinations of experimental and computational analysis tested on the binding of metalloprotoporphyrins to albumin. Int J Biol Macromol. 2019 Aug 01; 134:445-457. PMID: 31078597.
      Citations: 1     Fields:    Translation:HumansCells
    4. Johnson CN, Gorbet GE, Ramsower H, Urquidi J, Brancaleon L, Demeler B. Multi-wavelength analytical ultracentrifugation of human serum albumin complexed with porphyrin. Eur Biophys J. 2018 Oct; 47(7):789-797. PMID: 29675648.
      Citations: 5     Fields:    Translation:Humans
    5. Hu J, Allen R, Rozinek S, Brancaleon L. Experimental and computational characterization of photosensitized conformational effects mediated by protoporphyrin ligands on human serum albumin. Photochem Photobiol Sci. 2017 May 17; 16(5):694-710. PMID: 28287230.
      Citations: 2     Fields:    Translation:HumansCells
    6. Farooqi MJ, Penick MA, Negrete GR, Brancaleon L. Human serum albumin as vehicle for the solubilization of perylene diimides in aqueous solutions. Int J Biol Macromol. 2017 Jan; 94(Pt A):246-257. PMID: 27720966.
      Citations: 1     Fields:    Translation:HumansCells
    7. Vall-Sagarra A, McMicken B, Nonell S, Brancaleon L. Effects of Visible-Light Irradiation of Protoporphyrin IX on the Self-Assembly of Tubulin Heterodimers. Chemphyschem. 2016 Oct 18; 17(20):3269-3282. PMID: 27490308.
      Citations:    Fields:    Translation:Cells
    8. Rozinek SC, Thomas RJ, Brancaleon L. Biophysical characterization of the interaction of human albumin with an anionic porphyrin. Biochem Biophys Rep. 2016 Sep; 7:295-302. PMID: 28955918.
    9. McMicken B, Thomas RJ, Brancaleon L. Partial Unfolding of Tubulin Heterodimers Induced by Two-Photon Excitation of Bound meso-Tetrakis(sulfonatophenyl)porphyrin. J Phys Chem B. 2016 04 21; 120(15):3653-65. PMID: 27035156.
      Citations:    Fields:    Translation:Cells
    10. McMicken B, Parker JE, Thomas RJ, Brancaleon L. Resonance Raman and vibrational mode analysis used to predict ligand geometry for docking simulations of a water soluble porphyrin and tubulin. J Biomol Struct Dyn. 2016 Sep; 34(9):1998-2010. PMID: 26431467.
      Citations:    Fields:    Translation:Cells
    11. Farooqi MJ, Penick MA, Burch J, Negrete GR, Brancaleon L. Characterization of novel perylene diimides containing aromatic amino acid side chains. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 15; 153:124-31. PMID: 26298679.
      Citations: 1     Fields:    
    12. Babcock JJ, Brancaleon L. The effect of local dynamics of Atto 390-labeled lysozyme on fluorescence anisotropy modeling. Biopolymers. 2015 May; 103(5):285-95. PMID: 25431279.
      Citations:    Fields:    Translation:AnimalsCells
    13. Barron GA, Valentine R, Moseley H, Brancaleon L, Hill C, Woods JA. Porphyrin profile in four human cell lines after supplementation with 5-aminolaevulinic acid and its methyl ester. Photodiagnosis Photodyn Ther. 2013 Dec; 10(4):654-63. PMID: 24284124.
      Citations: 2     Fields:    Translation:HumansCells
    14. Farooqi MJ, Penick MA, Negrete GR, Brancaleon L. Interaction of human serum albumin with novel 3,9-disubstituted perylenes. Protein J. 2013 Aug; 32(6):493-504. PMID: 23975144.
      Citations: 3     Fields:    Translation:HumansCells
    15. McMicken B, Thomas RJ, Brancaleon L. Photoinduced partial unfolding of tubulin bound to meso-tetrakis(sulfonatophenyl) porphyrin leads to inhibition of microtubule formation in vitro. J Biophotonics. 2014 Nov; 7(11-12):874-88. PMID: 23893937.
      Citations: 2     Fields:    Translation:AnimalsCells
    16. Brancaleon L. Combined use of optical spectroscopy and computational methods to study the binding and the photoinduced conformational modification of proteins when NMR and X-ray structural determinations are not an option. Adv Protein Chem Struct Biol. 2013; 93:95-152. PMID: 24018324.
      Citations:    Fields:    Translation:Cells
    17. Babcock JJ, Brancaleon L. Bovine serum albumin oligomers in the E- and B-forms at low protein concentration and ionic strength. Int J Biol Macromol. 2013 Feb; 53:42-53. PMID: 23148944.
      Citations: 2     Fields:    Translation:AnimalsCells
    18. Parker JE, Thomas RJ, Morisson D, Brancaleon L. Combination of resonance Raman spectroscopy and docking simulations to study the nonspecific binding of a free-base porphyrin to a globular protein. J Phys Chem B. 2012 Sep 13; 116(36):11032-40. PMID: 22889017.
      Citations: 2     Fields:    Translation:AnimalsCells
    19. Renthal R, Brancaleon L, Peña I, Silva F, Chen LY. Interaction of a two-transmembrane-helix peptide with lipid bilayers and dodecyl sulfate micelles. Biophys Chem. 2011 Dec; 159(2-3):321-7. PMID: 21924540.
      Citations: 4     Fields:    Translation:Cells
    20. Fuini JF, Surampudi AB, Penick MA, Mahindaratne MP, Negrete GR, Brancaleon L. The photophysical Characterisation of Novel 3,9-Dialkyloxy- and Diacyloxyperylenes. Dyes Pigm. 2011 Feb 01; 88(2):204-211. PMID: 25473140.
    21. Valdez R, Johnson EM, Belcher JA, Fuini JF, Brancaleon L. Porphyrins affect the self-assembly of tubulin in solution. Biophys Chem. 2009 Dec; 145(2-3):98-104. PMID: 19819610.
      Citations:    Fields:    Translation:AnimalsCells
    22. Belcher J, Sansone S, Fernandez NF, Haskins WE, Brancaleon L, Brancaleona L. Photoinduced unfolding of beta-lactoglobulin mediated by a water-soluble porphyrin. J Phys Chem B. 2009 Apr 30; 113(17):6020-30. PMID: 19351165.
      Citations: 5     Fields:    Translation:Cells
    23. Silva I, Sansone S, Brancaleon L. An anionic porphyrin binds beta-lactoglobulin A at a superficial site rich in lysine residues. Protein J. 2009 Jan; 28(1):1-13. PMID: 19130195.
      Citations: 2     Fields:    Translation:Cells
    24. Fernandez NF, Sansone S, Mazzini A, Brancaleon L. Irradiation of the porphyrin causes unfolding of the protein in the protoporphyrin IX/beta-lactoglobulin noncovalent complex. J Phys Chem B. 2008 Jun 26; 112(25):7592-600. PMID: 18517238.
      Citations: 8     Fields:    Translation:Cells
    25. Moseley H, Brancaleon L, Lesar AE, Ferguson J, Ibbotson SH. Does surface preparation alter ALA uptake in superficial non-melanoma skin cancer in vivo? Photodermatol Photoimmunol Photomed. 2008 Apr; 24(2):72-5. PMID: 18353086.
      Citations: 1     Fields:    Translation:Humans
    26. Tian F, Johnson EM, Zamarripa M, Sansone S, Brancaleon L. Binding of porphyrins to tubulin heterodimers. Biomacromolecules. 2007 Dec; 8(12):3767-78. PMID: 18020394.
      Citations: 10     Fields:    Translation:Cells
    27. Harvey BJ, Bell E, Brancaleon L. A tryptophan rotamer located in a polar environment probes pH-dependent conformational changes in bovine beta-lactoglobulin A. J Phys Chem B. 2007 Mar 15; 111(10):2610-20. PMID: 17300189.
      Citations: 10     Fields:    Translation:AnimalsCells
    28. Moseley H, Ibbotson S, Woods J, Brancaleon L, Lesar A, Goodman C, Ferguson J. Clinical and research applications of photodynamic therapy in dermatology: experience of the Scottish PDT Centre. Lasers Surg Med. 2006 Jun; 38(5):403-16. PMID: 16788933.
      Citations: 5     Fields:    Translation:Humans
    29. Tian F, Johnson K, Lesar AE, Moseley H, Ferguson J, Samuel ID, Mazzini A, Brancaleon L. The pH-dependent conformational transition of beta-lactoglobulin modulates the binding of protoporphyrin IX. Biochim Biophys Acta. 2006 Jan; 1760(1):38-46. PMID: 16297563.
      Citations: 5     Fields:    Translation:AnimalsCells
    30. Ibbotson SH, Moseley H, Brancaleon L, Padgett M, O'Dwyer M, Woods JA, Lesar A, Goodman C, Ferguson J. Photodynamic therapy in dermatology: Dundee clinical and research experience. Photodiagnosis Photodyn Ther. 2004 Nov; 1(3):211-23. PMID: 25048335.
      Citations: 3     Fields:    
    31. Brancaleon L, Magennis SW, Samuel ID, Namdas E, Lesar A, Moseley H. Characterization of the photoproducts of protoporphyrin IX bound to human serum albumin and immunoglobulin G. Biophys Chem. 2004 Jun 01; 109(3):351-60. PMID: 15110933.
      Citations: 7     Fields:    Translation:HumansCells
    32. Woods JA, Traynor NJ, Brancaleon L, Moseley H. The effect of photofrin on DNA strand breaks and base oxidation in HaCaT keratinocytes: a comet assay study. Photochem Photobiol. 2004 Jan; 79(1):105-13. PMID: 14974722.
      Citations: 11     Fields:    Translation:HumansCells
    33. Brancaleon L, Moseley H. Effects of photoproducts on the binding properties of protoporphyrin IX to proteins. Biophys Chem. 2002 Apr 10; 96(1):77-87. PMID: 11975994.
      Citations: 14     Fields:    Translation:Cells
    34. Brancaleon L, Moseley H. Laser and non-laser light sources for photodynamic therapy. Lasers Med Sci. 2002; 17(3):173-86. PMID: 12181632.
      Citations: 52     Fields:    Translation:Humans
    35. Brancaleon L, Durkin AJ, Tu JH, Menaker G, Fallon JD, Kollias N. In vivo fluorescence spectroscopy of nonmelanoma skin cancer. Photochem Photobiol. 2001 Feb; 73(2):178-83. PMID: 11272732.
      Citations: 20     Fields:    Translation:Humans
    36. Ricchelli F, Gobbo S, Moreno G, Salet C, Brancaleon L, Mazzini A. Photophysical properties of porphyrin planar aggregates in liposomes. Eur J Biochem. 1998 May 01; 253(3):760-5. PMID: 9654076.
      Citations: 6     Fields:    
    37. Brancaleon L, Gasparini G, Manfredi M, Mazzini A. A model for the explanation of the thermally induced increase of the overall fluorescence in tryptophan-X peptides. Arch Biochem Biophys. 1997 Dec 01; 348(1):125-33. PMID: 9390182.
      Citations: 2     Fields:    
    38. Brancaleon L, Crippa PR, Diemmi D. Anomalous temperature fluorescence quenching of N-Trp terminal peptides. Biopolymers. 1995 Dec; 36(6):723-33. PMID: 8555420.
      Citations: 2     Fields:    Translation:Cells
    39. Losi A, Bedotti R, Brancaleon L, Viappiani C. Porphyrin-melanin interaction: effect on fluorescence and non-radiative relaxations. J Photochem Photobiol B. 1993 Nov; 21(1):69-76. PMID: 8289114.
      Citations: 3     Fields:    
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