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Stephen P. Saville

TitleProfessor
InstitutionUniversity of Texas at San Antonio
DepartmentBiology
Address1 UTSA Cir
San Antonio TX 78249
Phone(210) 458-6197
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    Collapse Overview 
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    Dr. Saville’s lab focuses on the genetic regulation of Candida albicans cell shape and determining how morphological changes impact the ability of the fungus to cause disease in both mucosal and disseminated infection models. C. albicans is an opportunistic fungal pathogen which is found as part of the normal microflora in the human digestive tract and is just one of approximately 200 species in the genus Candida. Dr. Saville’s primary research interest involves exploring the mechanisms via which this pathogenic fungus causes human disease. Candidiasis is one of the most frequent nosocomial infections both in the U.S. and worldwide.
    Dr. Saville’s research investigates the genetic regulation of C. albicans hypha formation and seeks to develop methods of inhibiting this process as this has the potential to provide novel treatment options against these serious, and often life-threatening, infections. Research in his lab involves: 1) identifying genes which have altered expression as the fungus transitions from the commensal to the pathogenic state, 2) constructing modified strains of C. albicans which either lack these genes or inappropriately express them, and 3) testing their pathogenic potential in both disseminated and mucosal models of disease.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Romo JA, Zhang H, Cai H, Kadosh D, Koehler JR, Saville SP, Wang Y, Lopez-Ribot JL. Global Transcriptomic Analysis of the Candida albicans Response to Treatment with a Novel Inhibitor of Filamentation. mSphere. 2019 09 11; 4(5). PMID: 31511371.
      Citations: 1     Fields:    Translation:AnimalsCells
    2. Montelongo-Jauregui D, Saville SP, Lopez-Ribot JL. Contributions of Candida albicans Dimorphism, Adhesive Interactions, and Extracellular Matrix to the Formation of Dual-Species Biofilms with Streptococcus gordonii. mBio. 2019 06 18; 10(3). PMID: 31213561.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Vellanki S, Huh EY, Saville SP, Lee SC. Candida albicans Morphology-Dependent Host FGF-2 Response as a Potential Therapeutic Target. J Fungi (Basel). 2019 Mar 05; 5(1). PMID: 30841504.
      Citations:    
    4. Cardona SM, Kim SV, Church KA, Torres VO, Cleary IA, Mendiola AS, Saville SP, Watowich SS, Parker-Thornburg J, Soto-Ospina A, Araque P, Ransohoff RM, Cardona AE. Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1I249/M280 Variant. Front Cell Neurosci. 2018; 12:365. PMID: 30386211.
      Citations:    
    5. Romo JA, Pierce CG, Esqueda M, Hung CY, Saville SP, Lopez-Ribot JL. In Vitro Characterization of a Biaryl Amide Anti-virulence Compound Targeting Candida albicans Filamentation and Biofilm Formation. Front Cell Infect Microbiol. 2018; 8:227. PMID: 30042929.
      Citations: 1     Fields:    Translation:HumansAnimals
    6. Romo JA, Pierce CG, Chaturvedi AK, Lazzell AL, McHardy SF, Saville SP, Lopez-Ribot JL. Development of Anti-Virulence Approaches for Candidiasis via a Novel Series of Small-Molecule Inhibitors of Candida albicans Filamentation. mBio. 2017 Dec 05; 8(6). PMID: 29208749.
      Citations: 9     Fields:    Translation:Animals
    7. Vila T, Romo JA, Pierce CG, McHardy SF, Saville SP, Lopez-Ribot JL. Targeting Candida albicans filamentation for antifungal drug development. Virulence. 2017 02 17; 8(2):150-158. PMID: 27268130.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    8. Cleary IA, Reinhard SM, Lazzell AL, Monteagudo C, Thomas DP, Lopez-Ribot JL, Saville SP. Examination of the pathogenic potential of Candida albicans filamentous cells in an animal model of haematogenously disseminated candidiasis. FEMS Yeast Res. 2016 Mar; 16(2):fow011. PMID: 26851404.
      Citations: 2     Fields:    Translation:Animals
    9. Pierce CG, Chaturvedi AK, Lazzell AL, Powell AT, Saville SP, McHardy SF, Lopez-Ribot JL. A Novel Small Molecule Inhibitor of Candida albicans Biofilm Formation, Filamentation and Virulence with Low Potential for the Development of Resistance. NPJ Biofilms Microbiomes. 2015; 1. PMID: 26691764.
      Citations: 28     Fields:    
    10. Pierce CG, Saville SP, Lopez-Ribot JL. High-content phenotypic screenings to identify inhibitors of Candida albicans biofilm formation and filamentation. Pathog Dis. 2014 Apr; 70(3):423-31. PMID: 24623598.
      Citations: 11     Fields:    Translation:HumansAnimals
    11. Cleary IA, Lazzell AL, Monteagudo C, Thomas DP, Saville SP. BRG1 and NRG1 form a novel feedback circuit regulating Candida albicans hypha formation and virulence. Mol Microbiol. 2012 Aug; 85(3):557-73. PMID: 22757963.
      Citations: 24     Fields:    Translation:AnimalsCells
    12. Cleary IA, MacGregor NB, Saville SP, Thomas DP. Investigating the function of Ddr48p in Candida albicans. Eukaryot Cell. 2012 Jun; 11(6):718-24. PMID: 22523369.
      Citations:    Fields:    Translation:HumansAnimals
    13. Chaturvedi AK, Lazzell AL, Saville SP, Wormley FL, Monteagudo C, Lopez-Ribot JL. Validation of the tetracycline regulatable gene expression system for the study of the pathogenesis of infectious disease. PLoS One. 2011; 6(5):e20449. PMID: 21633704.
      Citations: 3     Fields:    Translation:AnimalsCells
    14. Cleary IA, Reinhard SM, Miller CL, Murdoch C, Thornhill MH, Lazzell AL, Monteagudo C, Thomas DP, Saville SP. Candida albicans adhesin Als3p is dispensable for virulence in the mouse model of disseminated candidiasis. Microbiology. 2011 Jun; 157(Pt 6):1806-1815. PMID: 21436220.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    15. Yadev NP, Murdoch C, Saville SP, Thornhill MH. Evaluation of tissue engineered models of the oral mucosa to investigate oral candidiasis. Microb Pathog. 2011 Jun; 50(6):278-85. PMID: 21296654.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    16. Uppuluri P, Pierce CG, Thomas DP, Bubeck SS, Saville SP, Lopez-Ribot JL. The transcriptional regulator Nrg1p controls Candida albicans biofilm formation and dispersion. Eukaryot Cell. 2010 Oct; 9(10):1531-7. PMID: 20709787.
      Citations: 34     Fields:    Translation:Animals
    17. Cleary IA, Mulabagal P, Reinhard SM, Yadev NP, Murdoch C, Thornhill MH, Lazzell AL, Monteagudo C, Thomas DP, Saville SP. Pseudohyphal regulation by the transcription factor Rfg1p in Candida albicans. Eukaryot Cell. 2010 Sep; 9(9):1363-73. PMID: 20656914.
      Citations: 11     Fields:    Translation:HumansAnimals
    18. Cleary IA, Saville SP. An analysis of the impact of NRG1 overexpression on the Candida albicans response to specific environmental stimuli. Mycopathologia. 2010 Jul; 170(1):1-10. PMID: 20232156.
      Citations: 5     Fields:    Translation:Animals
    19. Grubb SE, Murdoch C, Sudbery PE, Saville SP, Lopez-Ribot JL, Thornhill MH. Adhesion of Candida albicans to endothelial cells under physiological conditions of flow. Infect Immun. 2009 Sep; 77(9):3872-8. PMID: 19581400.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    20. Saville SP, Lazzell AL, Chaturvedi AK, Monteagudo C, Lopez-Ribot JL. Efficacy of a genetically engineered Candida albicans tet-NRG1 strain as an experimental live attenuated vaccine against hematogenously disseminated candidiasis. Clin Vaccine Immunol. 2009 Mar; 16(3):430-2. PMID: 19144791.
      Citations: 13     Fields:    Translation:AnimalsCells
    21. Grubb SE, Murdoch C, Sudbery PE, Saville SP, Lopez-Ribot JL, Thornhill MH. Candida albicans-endothelial cell interactions: a key step in the pathogenesis of systemic candidiasis. Infect Immun. 2008 Oct; 76(10):4370-7. PMID: 18573891.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    22. Saville SP, Lazzell AL, Chaturvedi AK, Monteagudo C, Lopez-Ribot JL. Use of a genetically engineered strain to evaluate the pathogenic potential of yeast cell and filamentous forms during Candida albicans systemic infection in immunodeficient mice. Infect Immun. 2008 Jan; 76(1):97-102. PMID: 17967861.
      Citations: 15     Fields:    Translation:Animals
    23. Thomas DP, Viudes A, Monteagudo C, Lazzell AL, Saville SP, López-Ribot JL. A proteomic-based approach for the identification of Candida albicans protein components present in a subunit vaccine that protects against disseminated candidiasis. Proteomics. 2006 Nov; 6(22):6033-41. PMID: 17051645.
      Citations: 8     Fields:    Translation:AnimalsPHPublic Health
    24. Saville SP, Lazzell AL, Bryant AP, Fretzen A, Monreal A, Solberg EO, Monteagudo C, Lopez-Ribot JL, Milne GT. Inhibition of filamentation can be used to treat disseminated candidiasis. Antimicrob Agents Chemother. 2006 Oct; 50(10):3312-6. PMID: 17005810.
      Citations: 42     Fields:    Translation:Animals
    25. Arumilli BR, Koneru P, Garg NK, Davies R, Saville S, Sampath J, Bruce C. Is secondary radiological follow-up of infants with a family history of developmental dysplasia of the hip necessary? J Bone Joint Surg Br. 2006 Sep; 88(9):1224-7. PMID: 16943477.
      Citations: 5     Fields:    Translation:Humans
    26. Saville SP, Thomas DP, López Ribot JL. A role for Efg1p in Candida albicans interactions with extracellular matrices. FEMS Microbiol Lett. 2006 Mar; 256(1):151-8. PMID: 16487333.
      Citations: 10     Fields:    Translation:AnimalsCells
    27. Chamilos G, Lionakis MS, Lewis RE, Lopez-Ribot JL, Saville SP, Albert ND, Halder G, Kontoyiannis DP. Drosophila melanogaster as a facile model for large-scale studies of virulence mechanisms and antifungal drug efficacy in Candida species. J Infect Dis. 2006 Apr 01; 193(7):1014-22. PMID: 16518764.
      Citations: 42     Fields:    Translation:Animals
    28. Saville SP, Thomas DP, López-Ribot JL. Use of genome information for the study of the pathogenesis of fungal infections and the development of diagnostic tools. Rev Iberoam Micol. 2005 Dec; 22(4):238-41. PMID: 16499417.
      Citations: 3     Fields:    Translation:Humans
    29. Ramage G, Saville SP, Thomas DP, López-Ribot JL. Candida biofilms: an update. Eukaryot Cell. 2005 Apr; 4(4):633-8. PMID: 15821123.
      Citations: 184     Fields:    Translation:Animals
    30. Saville SP, Lazzell AL, Monteagudo C, Lopez-Ribot JL. Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection. Eukaryot Cell. 2003 Oct; 2(5):1053-60. PMID: 14555488.
      Citations: 245     Fields:    Translation:AnimalsCells
    31. Antón IM, Saville SP, Byrne MJ, Curcio C, Ramesh N, Hartwig JH, Geha RS. WIP participates in actin reorganization and ruffle formation induced by PDGF. J Cell Sci. 2003 Jun 15; 116(Pt 12):2443-51. PMID: 12724353.
      Citations: 20     Fields:    Translation:AnimalsCells
    32. Redding SW, Kirkpatrick WR, Saville S, Coco BJ, White W, Fothergill A, Rinaldi M, Eng T, Patterson TF, Lopez-Ribot J. Multiple patterns of resistance to fluconazole in Candida glabrata isolates from a patient with oropharyngeal candidiasis receiving head and neck radiation. J Clin Microbiol. 2003 Feb; 41(2):619-22. PMID: 12574256.
      Citations: 28     Fields:    Translation:HumansAnimalsPHPublic Health
    33. Ramage G, Saville SP, Wickes BL, López-Ribot JL. Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule. Appl Environ Microbiol. 2002 Nov; 68(11):5459-63. PMID: 12406738.
      Citations: 172     Fields:    Translation:Animals
    34. Martinez-Quiles N, Rohatgi R, Antón IM, Medina M, Saville SP, Miki H, Yamaguchi H, Takenawa T, Hartwig JH, Geha RS, Ramesh N. WIP regulates N-WASP-mediated actin polymerization and filopodium formation. Nat Cell Biol. 2001 May; 3(5):484-91. PMID: 11331876.
      Citations: 74     Fields:    Translation:AnimalsCells
    35. Fisher AR, Jones P, Barlow P, Kennington S, Saville S, Farrimond J, Yacoub M. The influence of mannitol on renal function during and after open-heart surgery. Perfusion. 1998 May; 13(3):181-6. PMID: 9638715.
      Citations: 6     Fields:    Translation:HumansCTClinical Trials
    36. Simon AJ, Saville SP, Jamieson L, Pocklington MJ, Donnelly SF, Ron D, Milner Y, Mochly-Rosent D, Orr-Sternlicht E. Characterization of PKC2, a gene encoding a second protein kinase C isotype of Saccharomyces cerevisiae. Curr Biol. 1993 Dec 01; 3(12):813-21. PMID: 15335814.
      Citations: 2     Fields:    
    37. Simon AJ, Milner Y, Saville SP, Dvir A, Mochly-Rosen D, Orr E. The identification and purification of a mammalian-like protein kinase C in the yeast Saccharomyces cerevisiae. Proc Biol Sci. 1991 Feb 22; 243(1307):165-71. PMID: 1676520.
      Citations: 8     Fields:    Translation:AnimalsCells
    38. SAVILLE S. Pentamethonium in hypertension. Lancet. 1950 Sep 02; 2(6627):358-60. PMID: 15437947.
      Citations: 12     Fields:    
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