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Carlos A. Paladini

TitleAssociate Professor
InstitutionUniversity of Texas at San Antonio
Address1 UTSA Cir
San Antonio TX 78249
Phone(210) 458-4474
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    The dopaminergic neurons located within the ventral mesencephalon encode perhaps one of the most important signals for reinforcement learning in the brain: reward prediction error. This signal is encoded by the firing pattern of dopaminergic neurons, which controls the release of dopamine at target regions, and this signal connects disruptions of dopamine function to many of the symptoms of a wide range of psychiatric diseases, drug addiction, and in the extreme case of the degeneration of these cells, to Parkinson's Disease. Using electrophysiology, optogenetics, cellular imaging, and behavioral neuroscience, Dr. Paladini's lab investigates the synaptic and cellular mechanisms by which identified inputs in the circuitry of the brain influence the physiology of dopaminergic neurons and resulting reward-related behavior.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Otomo K, Perkins J, Kulkarni A, Stojanovic S, Roeper J, Paladini CA. In vivo patch-clamp recordings reveal distinct subthreshold signatures and threshold dynamics of midbrain dopamine neurons. Nat Commun. 2020 12 08; 11(1):6286. PMID: 33293613.
      Citations:    Fields:    Translation:AnimalsCells
    2. Martinotti G, Barlati S, Prestia D, Palumbo C, Giordani M, Cuomo A, Miuli A, Paladini C, Amore M, Bondi E, Vita A, Fagiolini A, Di Giannantonio M. Psychomotor agitation and hyperactive delirium in COVID-19 patients treated with aripiprazole 9.75 mg/1.3 ml immediate release. Psychopharmacology (Berl). 2020 11; 237(11):3497-3501. PMID: 32821983.
      Citations: 2     Fields:    
    3. Porter-Stransky KA, Petko AK, Karne SL, Liles LC, Urs NM, Caron MG, Paladini CA, Weinshenker D. Loss of ß-arrestin2 in D2 cells alters neuronal excitability in the nucleus accumbens and behavioral responses to psychostimulants and opioids. Addict Biol. 2020 11; 25(6):e12823. PMID: 31441201.
      Citations: 1     Fields:    
    4. Gomez JA, Perkins JM, Beaudoin GM, Cook NB, Quraishi SA, Szoeke EA, Thangamani K, Tschumi CW, Wanat MJ, Maroof AM, Beckstead MJ, Rosenberg PA, Paladini CA. Ventral tegmental area astrocytes orchestrate avoidance and approach behavior. Nat Commun. 2019 03 29; 10(1):1455. PMID: 30926783.
      Citations: 6     Fields:    Translation:AnimalsCells
    5. Manvich DF, Petko AK, Branco RC, Foster SL, Porter-Stransky KA, Stout KA, Newman AH, Miller GW, Paladini CA, Weinshenker D. Selective D2 and D3 receptor antagonists oppositely modulate cocaine responses in mice via distinct postsynaptic mechanisms in nucleus accumbens. Neuropsychopharmacology. 2019 07; 44(8):1445-1455. PMID: 30879021.
      Citations:    Fields:    Translation:AnimalsCells
    6. Wang HL, Zhang S, Qi J, Wang H, Cachope R, Mejias-Aponte CA, Gomez JA, Mateo-Semidey GE, Beaudoin GMJ, Paladini CA, Cheer JF, Morales M. Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons. Cell Rep. 2019 01 29; 26(5):1128-1142.e7. PMID: 30699344.
      Citations: 18     Fields:    Translation:AnimalsCells
    7. Offei SD, Arman HD, Baig MO, Chavez LS, Paladini CA, Yoshimoto FK. Chemical synthesis of 7-oxygenated 12a-hydroxy steroid derivatives to enable the biochemical characterization of cytochrome P450 8B1, the oxysterol 12a-hydroxylase enzyme implicated in cardiovascular health and obesity. Steroids. 2018 12; 140:185-195. PMID: 30399365.
      Citations:    Fields:    
    8. Quraishi SA, Paladini CA. Could GABA, with a side of glycine, control glutamate receptors? Eur J Neurosci. 2018 05; 47(10):1206-1207. PMID: 29729221.
      Citations:    Fields:    Translation:Cells
    9. Beaudoin GMJ, Gomez JA, Perkins J, Bland JL, Petko AK, Paladini CA. Cocaine Selectively Reorganizes Excitatory Inputs to Substantia Nigra Pars Compacta Dopamine Neurons. J Neurosci. 2018 01 31; 38(5):1151-1159. PMID: 29263240.
      Citations: 3     Fields:    Translation:AnimalsCells
    10. Paladini C, Baron F, Jorissen A, Le Bouquin JB, Freytag B, Van Eck S, Wittkowski M, Hron J, Chiavassa A, Berger JP, Siopis C, Mayer A, Sadowski G, Kravchenko K, Shetye S, Kerschbaum F, Kluska J, Ramstedt S. Large granulation cells on the surface of the giant star p1 Gruis. Nature. 2018 01 18; 553(7688):310-312. PMID: 29258298.
      Citations: 2     Fields:    
    11. Simmons DV, Petko AK, Paladini CA. Differential expression of long-term potentiation among identified inhibitory inputs to dopamine neurons. J Neurophysiol. 2017 10 01; 118(4):1998-2008. PMID: 28701538.
      Citations: 6     Fields:    Translation:AnimalsCells
    12. Grow DA, Simmons DV, Gomez JA, Wanat MJ, McCarrey JR, Paladini CA, Navara CS. Differentiation and Characterization of Dopaminergic Neurons From Baboon Induced Pluripotent Stem Cells. Stem Cells Transl Med. 2016 09; 5(9):1133-44. PMID: 27343168.
      Citations: 5     Fields:    Translation:AnimalsCells
    13. Quraishi SA, Paladini CA. A Central Move for CB2 Receptors. Neuron. 2016 05 18; 90(4):670-1. PMID: 27196970.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    14. Goertz RB, Wanat MJ, Gomez JA, Brown ZJ, Phillips PE, Paladini CA. Cocaine increases dopaminergic neuron and motor activity via midbrain a1 adrenergic signaling. Neuropsychopharmacology. 2015 Mar 13; 40(5):1151-62. PMID: 25374094.
      Citations: 20     Fields:    Translation:AnimalsCells
    15. Gaval-Cruz M, Goertz RB, Puttick DJ, Bowles DE, Meyer RC, Hall RA, Ko D, Paladini CA, Weinshenker D. Chronic loss of noradrenergic tone produces ß-arrestin2-mediated cocaine hypersensitivity and alters cellular D2 responses in the nucleus accumbens. Addict Biol. 2016 Jan; 21(1):35-48. PMID: 25123018.
      Citations: 5     Fields:    Translation:AnimalsCells
    16. Paladini CA, Roeper J. Generating bursts (and pauses) in the dopamine midbrain neurons. Neuroscience. 2014 Dec 12; 282:109-21. PMID: 25073045.
      Citations: 39     Fields:    Translation:AnimalsCells
    17. Frezzotti A, Galeazzi M, Paladini C, Tocchini M. Haemoglobinopathies in nonendemic areas in recent years. Clin Chem Lab Med. 2014 Feb; 52(2):e17-9. PMID: 24088612.
      Citations:    Fields:    Translation:Humans
    18. Branch SY, Goertz RB, Sharpe AL, Pierce J, Roy S, Ko D, Paladini CA, Beckstead MJ. Food restriction increases glutamate receptor-mediated burst firing of dopamine neurons. J Neurosci. 2013 Aug 21; 33(34):13861-72. PMID: 23966705.
      Citations: 32     Fields:    Translation:AnimalsCells
    19. Galeazzi M, Frezzotti A, Paladini C, Leoni P, Tocchini M. A case of monoclonal gammopathy of undetermined significance (MGUS): type IgD-lambda. Clin Chem Lab Med. 2013 Jun; 51(6):e123-5. PMID: 23314543.
      Citations:    Fields:    Translation:Humans
    20. Maercker M, Mohamed S, Vlemmings WH, Ramstedt S, Groenewegen MA, Humphreys E, Kerschbaum F, Lindqvist M, Olofsson H, Paladini C, Wittkowski M, de Gregorio-Monsalvo I, Nyman LA. Unexpectedly large mass loss during the thermal pulse cycle of the red giant star R Sculptoris. Nature. 2012 Oct 11; 490(7419):232-4. PMID: 23060194.
      Citations: 3     Fields:    
    21. Savini G, Lorusso A, Paladini C, Migliaccio P, Di Gennaro A, Di Provvido A, Scacchia M, Monaco F. Bluetongue serotype 2 and 9 modified live vaccine viruses as causative agents of abortion in livestock: a retrospective analysis in Italy. Transbound Emerg Dis. 2014 Feb; 61(1):69-74. PMID: 22937914.
      Citations: 10     Fields:    Translation:AnimalsCellsPHPublic Health
    22. Ko D, Wilson CJ, Lobb CJ, Paladini CA. Detection of bursts and pauses in spike trains. J Neurosci Methods. 2012 Oct 15; 211(1):145-58. PMID: 22939922.
      Citations: 18     Fields:    Translation:AnimalsCells
    23. Mencacci C. Efficacy and tolerability of switching to ziprasidone in italian patients with acute exacerbation of schizophrenia: an open-label trial. Pharmacopsychiatry. 2012 Sep; 45(6):236-40. PMID: 22592506.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    24. Morikawa H, Paladini CA. Dynamic regulation of midbrain dopamine neuron activity: intrinsic, synaptic, and plasticity mechanisms. Neuroscience. 2011 Dec 15; 198:95-111. PMID: 21872647.
      Citations: 46     Fields:    Translation:AnimalsCells
    25. Lobb CJ, Troyer TW, Wilson CJ, Paladini CA. Disinhibition bursting of dopaminergic neurons. Front Syst Neurosci. 2011; 5:25. PMID: 21617731.
    26. Lobb CJ, Wilson CJ, Paladini CA. High-frequency, short-latency disinhibition bursting of midbrain dopaminergic neurons. J Neurophysiol. 2011 May; 105(5):2501-11. PMID: 21367999.
      Citations: 18     Fields:    Translation:AnimalsCells
    27. Lobb CJ, Paladini CA. Application of a NMDA receptor conductance in rat midbrain dopaminergic neurons using the dynamic clamp technique. J Vis Exp. 2010 Dec 21; (46). PMID: 21206469.
      Citations: 4     Fields:    Translation:AnimalsCells
    28. Lobb CJ, Wilson CJ, Paladini CA. A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. J Neurophysiol. 2010 Jul; 104(1):403-13. PMID: 20445035.
      Citations: 49     Fields:    Translation:AnimalsCells
    29. Kuznetsova AY, Huertas MA, Kuznetsov AS, Paladini CA, Canavier CC. Regulation of firing frequency in a computational model of a midbrain dopaminergic neuron. J Comput Neurosci. 2010 Jun; 28(3):389-403. PMID: 20217204.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    30. Deister CA, Teagarden MA, Wilson CJ, Paladini CA. An intrinsic neuronal oscillator underlies dopaminergic neuron bursting. J Neurosci. 2009 Dec 16; 29(50):15888-97. PMID: 20016105.
      Citations: 50     Fields:    Translation:AnimalsCells
    31. Zweifel LS, Parker JG, Lobb CJ, Rainwater A, Wall VZ, Fadok JP, Darvas M, Kim MJ, Mizumori SJ, Paladini CA, Phillips PE, Palmiter RD. Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behavior. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7281-8. PMID: 19342487.
      Citations: 193     Fields:    Translation:AnimalsCells
    32. Listes E, Monaco F, Labrovic A, Paladini C, Leone A, Di Gialleonardo L, Cammá C, Savini G. First evidence of bluetongue virus serotype 16 in Croatia. Vet Microbiol. 2009 Jul 02; 138(1-2):92-7. PMID: 19376658.
      Citations: 5     Fields:    Translation:AnimalsCells
    33. Arencibia-Albite F, Paladini C, Williams JT, Jiménez-Rivera CA. Noradrenergic modulation of the hyperpolarization-activated cation current (Ih) in dopamine neurons of the ventral tegmental area. Neuroscience. 2007 Oct 26; 149(2):303-14. PMID: 17884297.
      Citations: 26     Fields:    Translation:AnimalsCells
    34. Paladini CA, Beckstead MJ, Weinshenker D. Electrophysiological properties of catecholaminergic neurons in the norepinephrine-deficient mouse. Neuroscience. 2007 Feb 09; 144(3):1067-74. PMID: 17156935.
      Citations: 10     Fields:    Translation:AnimalsCells
    35. Dall'Acqua F, Paladini C, Meiswinkel R, Savini L, Calistri P. Description and implementation of a surveillance network for bluetongue in the Balkans and in adjoining areas of south-eastern Europe. Vet Ital. 2006 Apr-Jun; 42(2):103-18. PMID: 20429055.
      Citations:    Fields:    
    36. Conte A, Colangeli P, Ippoliti C, Paladini C, Ambrosini M, Savini L, Dall'Acqua F, Calistri P. The use of a web-based interactive geographical information system for the surveillance of bluetongue in Italy. Rev Sci Tech. 2005 Dec; 24(3):857-68. PMID: 16642756.
      Citations: 2     Fields:    Translation:AnimalsPHPublic Health
    37. Di Francesco CE, Leone A, Lombari V, Luciani M, Paladini C. Cell-mediated response in cattle experimentally infected with bluetongue virus serotype 2. Vet Ital. 2005 Jan-Mar; 41(1):34-45. PMID: 20437370.
      Citations:    Fields:    
    38. Giovannini A, Calistri P, Nannini D, Paladini C, Santucci U, Patta C, Caporale V. Bluetongue in Italy: Part II. Vet Ital. 2004 Jul-Sep; 40(3):252-9. PMID: 20419673.
      Citations: 3     Fields:    
    39. Giovannini A, Paladini C, Calistri P, Conte A, Colangeli P, Santucci U, Nannini D, Caporale V. Surveillance system of bluetongue in Italy. Vet Ital. 2004 Jul-Sep; 40(3):369-84. PMID: 20419695.
      Citations: 3     Fields:    
    40. Paladini CA, Mitchell JM, Williams JT, Mark GP. Cocaine self-administration selectively decreases noradrenergic regulation of metabotropic glutamate receptor-mediated inhibition in dopamine neurons. J Neurosci. 2004 Jun 02; 24(22):5209-15. PMID: 15175391.
      Citations: 7     Fields:    Translation:AnimalsCells
    41. Gambi F, Reale M, Iarlori C, Salone A, Toma L, Paladini C, De Luca G, Feliciani C, Salvatore M, Salerno RM, Theoharides TC, Conti P, Exton M, Gambi D. Alzheimer patients treated with an AchE inhibitor show higher IL-4 and lower IL-1 beta levels and expression in peripheral blood mononuclear cells. J Clin Psychopharmacol. 2004 Jun; 24(3):314-21. PMID: 15118486.
      Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
    42. Paladini CA, Williams JT. Noradrenergic inhibition of midbrain dopamine neurons. J Neurosci. 2004 May 12; 24(19):4568-75. PMID: 15140928.
      Citations: 39     Fields:    Translation:AnimalsCells
    43. Paladini CA, Robinson S, Morikawa H, Williams JT, Palmiter RD. Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2866-71. PMID: 12604788.
      Citations: 24     Fields:    Translation:AnimalsCells
    44. Zambelli D, Caneppele B, Bassi S, Paladini C. Ultrasound aspects of fetal and extrafetal structures in pregnant cats. J Feline Med Surg. 2002 Jun; 4(2):95-106. PMID: 12027508.
      Citations:    Fields:    Translation:Animals
    45. Biavasco F, Paladini C, Vignaroli C, Foglia G, Manso E, Varaldo PE. Recovery from a single blood culture of two enterococcus gallinarum isolates carrying both vanC-1 and vanA cluster genes and differing in glycopeptide susceptibility. Eur J Clin Microbiol Infect Dis. 2001 May; 20(5):309-14. PMID: 11453590.
      Citations: 3     Fields:    Translation:HumansCells
    46. Paladini CA, Fiorillo CD, Morikawa H, Williams JT. Amphetamine selectively blocks inhibitory glutamate transmission in dopamine neurons. Nat Neurosci. 2001 Mar; 4(3):275-81. PMID: 11224544.
      Citations: 49     Fields:    Translation:AnimalsCells
    47. Paladini CA, Iribe Y, Tepper JM. GABAA receptor stimulation blocks NMDA-induced bursting of dopaminergic neurons in vitro by decreasing input resistance. Brain Res. 1999 Jun 19; 832(1-2):145-51. PMID: 10375660.
      Citations: 18     Fields:    Translation:AnimalsCells
    48. Paladini CA, Tepper JM. GABA(A) and GABA(B) antagonists differentially affect the firing pattern of substantia nigra dopaminergic neurons in vivo. Synapse. 1999 Jun 01; 32(3):165-76. PMID: 10340627.
      Citations: 42     Fields:    Translation:AnimalsCells
    49. Paladini CA, Celada P, Tepper JM. Striatal, pallidal, and pars reticulata evoked inhibition of nigrostriatal dopaminergic neurons is mediated by GABA(A) receptors in vivo. Neuroscience. 1999 Mar; 89(3):799-812. PMID: 10199614.
      Citations: 31     Fields:    Translation:AnimalsCells
    50. Celada P, Paladini CA, Tepper JM. GABAergic control of rat substantia nigra dopaminergic neurons: role of globus pallidus and substantia nigra pars reticulata. Neuroscience. 1999 Mar; 89(3):813-25. PMID: 10199615.
      Citations: 35     Fields:    Translation:AnimalsCells
    51. Bocola V, Trecco MD, Fabbrini G, Paladini C, Sollecito A, Martucci N. Antipanic effect of fluoxetine measured by CO2 challenge test. Biol Psychiatry. 1998 Apr 15; 43(8):612-5. PMID: 9564447.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    52. Tepper JM, Paladini CA, Celada P. GABAergic control of the firing pattern of substantia nigra dopaminergic neurons. Adv Pharmacol. 1998; 42:694-9. PMID: 9327994.
      Citations: 10     Fields:    Translation:AnimalsCells
    53. Bocola V, Fabbrini G, Sollecito A, Paladini C, Martucci N. Neuroleptic induced parkinsonism: MRI findings in relation to clinical course after withdrawal of neuroleptic drugs. J Neurol Neurosurg Psychiatry. 1996 Feb; 60(2):213-6. PMID: 8708659.
      Citations: 2     Fields:    Translation:Humans
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