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Richard LeBaron

TitleBiology Faculty
Faculty RankProfessor
InstitutionUniversity of Texas at San Antonio
AddressUniversity of Texas at San Antonio
One UTSA Circle
San Antonio TX 78249
Phone(210) 458-5841
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    Collapse Overview 
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    Dr. LeBaron’s interests are to understand how cells’ microenvironment contributes to disease progression. Changes in the microenvironment in the human body are defined, at least in part, by molecules of the extracellular matrix (ECM) and ECM interactions with cell surface signaling receptors called integrins. The lab’s recombinant protein technology has identified roles of ECM interaction on integrins in cell adhesion, migration, and cell death by apoptosis in disease states such as degenerative articular joint disease, diabetes, and cancer. Understating the complex relationship of ECM activation of cellular signaling pathways in diseased and healthy tissues is expected to provide opportunities for novel drug design and patient treatments.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Phelix CF, Bourdon AK, Villareal G, LeBaron RG. Modeling non-clinical and clinical drug tests in Gaucher disease. Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug; 2016:1434-1438. PMID: 28268595.
    2. Moritz RJ, LeBaron RG, Phelix CF, Rupaimoole R, Kim HS, Tsin A, Asmis R. Macrophage TGF-ß1 and the Proapoptotic Extracellular Matrix Protein BIGH3 Induce Renal Cell Apoptosis in Prediabetic and Diabetic Conditions. Int J Clin Med. 2016 Jul; 7(7):496-510. PMID: 28149671.
    3. Mondragon AA, Betts-Obregon BS, Moritz RJ, Parvathaneni K, Navarro MM, Kim HS, Lee CF, LeBaron RG, Asmis R, Tsin AT. BIGH3 protein and macrophages in retinal endothelial cell apoptosis. Apoptosis. 2015 Jan; 20(1):29-37. PMID: 25378215.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    4. McDaniel JS, Akula Suresh Babu R, Navarro MM, LeBaron RG. Transcriptional regulation of proteoglycan 4 by 17ß-estradiol in immortalized baboon temporomandibular joint disc cells. Eur J Oral Sci. 2014 Apr; 122(2):100-8. PMID: 24621258.
      Citations: 4     Fields:    Translation:AnimalsCells
    5. Phelix CF, Villareal G, LeBaron RG, Roberson DJ. Biomarkers from biosimulations: Transcriptome-To-Reactome™ Technology for individualized medicine. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:3452-5. PMID: 25570733.
    6. Bauereis B, Haskins WE, Lebaron RG, Renthal R. Proteomic insights into the protective mechanisms of an in vitro oxidative stress model of early stage Parkinson's disease. Neurosci Lett. 2011 Jan 13; 488(1):11-6. PMID: 21056633.
      Citations: 8     Fields:    Translation:HumansCells
    7. Ghosh S, Albitar L, LeBaron R, Welch WR, Samimi G, Birrer MJ, Berkowitz RS, Mok SC. Up-regulation of stromal versican expression in advanced stage serous ovarian cancer. Gynecol Oncol. 2010 Oct; 119(1):114-20. PMID: 20619446.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    8. Qiao M, Zhao Q, Lee CF, Tannock LR, Smart EJ, LeBaron RG, Phelix CF, Rangel Y, Asmis R. Thiol oxidative stress induced by metabolic disorders amplifies macrophage chemotactic responses and accelerates atherogenesis and kidney injury in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2009 Nov; 29(11):1779-86. PMID: 19592463.
      Citations: 26     Fields:    Translation:AnimalsCells
    9. Zamilpa R, Rupaimoole R, Phelix CF, Somaraki-Cormier M, Haskins W, Asmis R, LeBaron RG. C-terminal fragment of transforming growth factor beta-induced protein (TGFBIp) is required for apoptosis in human osteosarcoma cells. Matrix Biol. 2009 Jul; 28(6):347-53. PMID: 19505574.
      Citations: 9     Fields:    Translation:HumansCells
    10. True LD, Hawley S, Norwood TH, Braun KR, Evanko SP, Chan CK, LeBaron RC, Wight TN. The accumulation of versican in the nodules of benign prostatic hyperplasia. Prostate. 2009 Feb 01; 69(2):149-58. PMID: 18819099.
      Citations: 6     Fields:    Translation:HumansCells
    11. Riojas MA, Villanueva-Vedia RE, Zamilpa R, Chen X, Du LC, Phelix CF, LeBaron RG. Prevalence of diabetes mellitus and correlation of urinary transforming growth factor-beta1 with blood hemoglobin A1C in the Atascosa Diabetes Study. Ethn Dis. 2008; 18(2 Suppl 2):S2-54-9. PMID: 18646321.
      Citations: 1     Fields:    Translation:Humans
    12. Lemire JM, Chan CK, Bressler S, Miller J, LeBaron RG, Wight TN. Interleukin-1beta selectively decreases the synthesis of versican by arterial smooth muscle cells. J Cell Biochem. 2007 Jun 01; 101(3):753-66. PMID: 17226775.
      Citations: 20     Fields:    Translation:AnimalsCells
    13. Hernandez RV, Navarro MM, Rodriguez WA, Martinez JL, LeBaron RG. Differences in the magnitude of long-term potentiation produced by theta burst and high frequency stimulation protocols matched in stimulus number. Brain Res Brain Res Protoc. 2005 May; 15(1):6-13. PMID: 15878145.
      Citations: 12     Fields:    Translation:AnimalsCells
    14. Richards JS, Hernandez-Gonzalez I, Gonzalez-Robayna I, Teuling E, Lo Y, Boerboom D, Falender AE, Doyle KH, LeBaron RG, Thompson V, Sandy JD. Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation. Biol Reprod. 2005 May; 72(5):1241-55. PMID: 15659705.
      Citations: 36     Fields:    Translation:AnimalsCells
    15. Lebaron RG, Hernandez RV, Navarro MM, Curry LR, Orfila JE, Martinez JL. A focal adhesion-like process underlies induction of long-term potentiation in the Schaffer collateral-CA1 region of the hippocampus. Neuron Glia Biol. 2004 Nov; 1(4):385-93. PMID: 18634595.
      Citations:    Fields:    
    16. Temenoff JS, Park H, Jabbari E, Sheffield TL, LeBaron RG, Ambrose CG, Mikos AG. In vitro osteogenic differentiation of marrow stromal cells encapsulated in biodegradable hydrogels. J Biomed Mater Res A. 2004 Aug 01; 70(2):235-44. PMID: 15227668.
      Citations: 36     Fields:    Translation:AnimalsCells
    17. Suwiwat S, Ricciardelli C, Tammi R, Tammi M, Auvinen P, Kosma VM, LeBaron RG, Raymond WA, Tilley WD, Horsfall DJ. Expression of extracellular matrix components versican, chondroitin sulfate, tenascin, and hyaluronan, and their association with disease outcome in node-negative breast cancer. Clin Cancer Res. 2004 Apr 01; 10(7):2491-8. PMID: 15073129.
      Citations: 48     Fields:    Translation:HumansCells
    18. Sakko AJ, Ricciardelli C, Mayne K, Suwiwat S, LeBaron RG, Marshall VR, Tilley WD, Horsfall DJ. Modulation of prostate cancer cell attachment to matrix by versican. Cancer Res. 2003 Aug 15; 63(16):4786-91. PMID: 12941795.
      Citations: 26     Fields:    Translation:HumansCells
    19. Ferguson JW, Mikesh MF, Wheeler EF, LeBaron RG. Developmental expression patterns of Beta-ig (betaIG-H3) and its function as a cell adhesion protein. Mech Dev. 2003 Aug; 120(8):851-64. PMID: 12963107.
      Citations: 22     Fields:    Translation:AnimalsCells
    20. Ferguson JW, Thoma BS, Mikesh MF, Kramer RH, Bennett KL, Purchio A, Bellard BJ, LeBaron RG. The extracellular matrix protein betaIG-H3 is expressed at myotendinous junctions and supports muscle cell adhesion. Cell Tissue Res. 2003 Jul; 313(1):93-105. PMID: 12838408.
      Citations: 16     Fields:    Translation:AnimalsCells
    21. LeBaron RG, Hernandez RV, Orfila JE, Martinez JL. An integrin binding peptide reduces rat CA1 hippocampal long-term potentiation during the first few minutes following theta burst stimulation. Neurosci Lett. 2003 Mar 27; 339(3):199-202. PMID: 12633887.
      Citations: 2     Fields:    Translation:Animals
    22. Huang W, Anvari B, Torres JH, LeBaron RG, Athanasiou KA. Temporal effects of cell adhesion on mechanical characteristics of the single chondrocyte. J Orthop Res. 2003 Jan; 21(1):88-95. PMID: 12507584.
      Citations: 11     Fields:    Translation:AnimalsCells
    23. Hoben G, Huang W, Thoma BS, LeBaron RG, Athanasiou KA. Quantification of varying adhesion levels in chondrocytes using the cytodetacher. Ann Biomed Eng. 2002 May; 30(5):703-12. PMID: 12108844.
      Citations: 1     Fields:    Translation:AnimalsCells
    24. Ricciardelli C, Brooks JH, Suwiwat S, Sakko AJ, Mayne K, Raymond WA, Seshadri R, LeBaron RG, Horsfall DJ. Regulation of stromal versican expression by breast cancer cells and importance to relapse-free survival in patients with node-negative primary breast cancer. Clin Cancer Res. 2002 Apr; 8(4):1054-60. PMID: 11948113.
      Citations: 54     Fields:    Translation:HumansCells
    25. Temenoff JS, Athanasiou KA, LeBaron RG, Mikos AG. Effect of poly(ethylene glycol) molecular weight on tensile and swelling properties of oligo(poly(ethylene glycol) fumarate) hydrogels for cartilage tissue engineering. J Biomed Mater Res. 2002 Mar 05; 59(3):429-37. PMID: 11774300.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
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