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Karl E. Klose

InstitutionUniversity of Texas at San Antonio
Address1 UTSA Cir
San Antonio TX 78249
Phone(210) 458-6140
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    Collapse Overview 
    Collapse overview
    Dr. Klose’s lab is interested in bacterial pathogenesis -- how bacteria cause disease. Dr. Klose has worked most extensively with Vibrio cholerae, the bacterium that causes cholera, and is also researching Francisella tularensis, the bacterium that causes tularemia, or rabbit fever.
    Cholera is found only where there are widespread problems with sanitation, so improving water and food supplies would eliminate the disease. Since that is unlikely to occur, a safe, cheap, effective vaccine is needed that would protect people. To design such a vaccine, the lab is addressing questions such as: How does V. cholerae know that it is in a human body and that is the place to express genes necessary for its survival and disease potential? What are the genetic factors responsible for V. cholerae to cause disease? How does this organism persist in aquatic environments, which lead to human infection?
    Very little is known about F. tularensis or about tularemia. It is a highly virulent organism and can easily be aerosolized, so it is classified by the Centers for Disease Control (CDC) as a Category A select agent with the highest potential to be used as a biological weapon. The lab is working to identify genetic factors responsible for F. tularensis to cause disease and to develop suitable vaccine candidates to protect against tularemia infection.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mejia-Santana A, Lloyd CJ, Klose KE. New cloning vectors to facilitate quick allelic exchange in gram-negative bacteria. Biotechniques. 2021 Feb; 70(2):116-119. PMID: 33492170.
      Citations:    Fields:    
    2. May HC, Yu JJ, Shrihari S, Seshu J, Klose KE, Cap AP, Chambers JP, Guentzel MN, Arulanandam BP. Thioredoxin Modulates Cell Surface Hydrophobicity in Acinetobacter baumannii. Front Microbiol. 2019; 10:2849. PMID: 31921031.
    3. Kitts G, Giglio KM, Zamorano-Sánchez D, Park JH, Townsley L, Cooley RB, Wucher BR, Klose KE, Nadell CD, Yildiz FH, Sondermann H. A Conserved Regulatory Circuit Controls Large Adhesins in Vibrio cholerae. mBio. 2019 12 03; 10(6). PMID: 31796544.
      Citations: 3     Fields:    Translation:Cells
    4. Echazarreta MA, Klose KE. Vibrio Flagellar Synthesis. Front Cell Infect Microbiol. 2019; 9:131. PMID: 31119103.
      Citations: 9     Fields:    Translation:Cells
    5. Ketter PM, Yu JJ, Guentzel MN, May HC, Gupta R, Eppinger M, Klose KE, Seshu J, Chambers JP, Cap AP, Arulanandam BP. Acinetobacter baumannii Gastrointestinal Colonization Is Facilitated by Secretory IgA Which Is Reductively Dissociated by Bacterial Thioredoxin A. mBio. 2018 07 10; 9(4). PMID: 29991584.
      Citations: 3     Fields:    Translation:AnimalsCells
    6. Echazarreta MA, Kepple JL, Yen LH, Chen Y, Klose KE. A Critical Region in the FlaA Flagellin Facilitates Filament Formation of the Vibrio cholerae Flagellum. J Bacteriol. 2018 08 01; 200(15). PMID: 29581407.
      Citations: 4     Fields:    Translation:Cells
    7. Klose KE, Satchell KJF. Vibrio2017: the seventh international conference on the biology of Vibrios. J Bacteriol. 2018 06 04; 200(15):e00304-18. PMID: 29866809.
      Citations: 1     Fields:    
    8. Allué-Guardia A, Echazarreta M, Koenig SSK, Klose KE, Eppinger M. Closed Genome Sequence of Vibrio cholerae O1 El Tor Inaba Strain A1552. Genome Announc. 2018 Mar 01; 6(9). PMID: 29496831.
    9. Protz K, Reich-Schupke S, Klose K, Augustin M, Heyer K. [Compression devices for decongestion therapy : A cross-sectional observational survey of handling, pressure, and comfort]. Hautarzt. 2018 Mar; 69(3):232-241. PMID: 29184983.
      Citations: 3     Fields:    Translation:Humans
    10. Gutknecht M, Herberger K, Klose K, Purwins S, Dietz D, Blome C, Augustin M. Cost-of-illness of patients with lymphoedema. J Eur Acad Dermatol Venereol. 2017 Nov; 31(11):1930-1935. PMID: 28662302.
      Citations: 5     Fields:    Translation:Humans
    11. Nguyen JQ, Zogaj X, Adelani AA, Chu P, Yu JJ, Arulanandam BP, Klose KE. Intratracheal Inoculation of Fischer 344 Rats with Francisella tularensis. J Vis Exp. 2017 09 30; (127). PMID: 28994770.
      Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    12. Sarva ST, Waldo RH, Belland RJ, Klose KE. Comparative Transcriptional Analyses of Francisella tularensis and Francisella novicida. PLoS One. 2016; 11(8):e0158631. PMID: 27537327.
      Citations: 1     Fields:    Translation:HumansCells
    13. Cunningham AL, Guentzel MN, Yu JJ, Hung CY, Forsthuber TG, Navara CS, Yagita H, Williams IR, Klose KE, Eaves-Pyles TD, Arulanandam BP. M-Cells Contribute to the Entry of an Oral Vaccine but Are Not Essential for the Subsequent Induction of Protective Immunity against Francisella tularensis. PLoS One. 2016; 11(4):e0153402. PMID: 27100824.
      Citations:    Fields:    Translation:AnimalsCells
    14. Chu P, Cunningham AL, Yu JJ, Nguyen JQ, Barker JR, Lyons CR, Wilder J, Valderas M, Sherwood RL, Arulanandam BP, Klose KE. Live attenuated Francisella novicida vaccine protects against Francisella tularensis pulmonary challenge in rats and non-human primates. PLoS Pathog. 2014 Oct; 10(10):e1004439. PMID: 25340543.
      Citations: 17     Fields:    Translation:AnimalsCellsPHPublic Health
    15. Mazel D, Colwell R, Klose K, Oliver J, Crumlish M, McDougald D, Bland MJ, Austin B. VIBRIO 2014 meeting report. Res Microbiol. 2014 Dec; 165(10):857-64. PMID: 25463383.
      Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
    16. Weber GG, Kortmann J, Narberhaus F, Klose KE. RNA thermometer controls temperature-dependent virulence factor expression in Vibrio cholerae. Proc Natl Acad Sci U S A. 2014 Sep 30; 111(39):14241-6. PMID: 25228776.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    17. Cunningham AL, Dang KM, Yu JJ, Guentzel MN, Heidner HW, Klose KE, Arulanandam BP. Enhancement of vaccine efficacy by expression of a TLR5 ligand in the defined live attenuated Francisella tularensis subsp. novicida strain U112?iglB::fljB. Vaccine. 2014 Sep 08; 32(40):5234-40. PMID: 25050972.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    18. Fischer F, Krämer A, Klose K. [Relevance of quality of life as a quality indicator in guideline development]. Gesundheitswesen. 2015 May; 77(5):e119-32. PMID: 25025288.
      Citations: 1     Fields:    
    19. Nguyen JQ, Gilley RP, Zogaj X, Rodriguez SA, Klose KE. Lipidation of the FPI protein IglE contributes to Francisella tularensis ssp. novicida intramacrophage replication and virulence. Pathog Dis. 2014 Oct; 72(1):10-8. PMID: 24616435.
      Citations: 7     Fields:    Translation:AnimalsCells
    20. Jubair M, Atanasova KR, Rahman M, Klose KE, Yasmin M, Yilmaz O, Morris JG, Ali A. Vibrio cholerae persisted in microcosm for 700 days inhibits motility but promotes biofilm formation in nutrient-poor lake water microcosms. PLoS One. 2014; 9(3):e92883. PMID: 24667909.
      Citations: 5     Fields:    Translation:CellsPHPublic Health
    21. Eppinger M, McNair K, Zogaj X, Dinsdale EA, Edwards RA, Klose KE. Draft Genome Sequence of the Fish Pathogen Piscirickettsia salmonis. Genome Announc. 2013 Nov 07; 1(6). PMID: 24201203.
    22. Miner KD, Klose KE, Kurtz DM. An HD-GYP cyclic di-guanosine monophosphate phosphodiesterase with a non-heme diiron-carboxylate active site. Biochemistry. 2013 Aug 13; 52(32):5329-31. PMID: 23883166.
      Citations: 10     Fields:    Translation:Cells
    23. Signarovitz AL, Ray HJ, Yu JJ, Guentzel MN, Chambers JP, Klose KE, Arulanandam BP. Mucosal immunization with live attenuated Francisella novicida U112?iglB protects against pulmonary F. tularensis SCHU S4 in the Fischer 344 rat model. PLoS One. 2012; 7(10):e47639. PMID: 23118885.
      Citations: 14     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    24. Schaller RA, Ali SK, Klose KE, Kurtz DM. A bacterial hemerythrin domain regulates the activity of a Vibrio cholerae diguanylate cyclase. Biochemistry. 2012 Oct 30; 51(43):8563-70. PMID: 23057727.
      Citations: 11     Fields:    Translation:Cells
    25. Zogaj X, Wyatt GC, Klose KE. Cyclic di-GMP stimulates biofilm formation and inhibits virulence of Francisella novicida. Infect Immun. 2012 Dec; 80(12):4239-47. PMID: 22988021.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    26. Arulanandam BP, Chetty SL, Yu JJ, Leonard S, Klose K, Seshu J, Cap A, Valdes JJ, Chambers JP. Francisella DnaK inhibits tissue-nonspecific alkaline phosphatase. J Biol Chem. 2012 Oct 26; 287(44):37185-94. PMID: 22923614.
      Citations:    Fields:    Translation:AnimalsCells
    27. Rodriguez AR, Yu JJ, Guentzel MN, Navara CS, Klose KE, Forsthuber TG, Chambers JP, Berton MT, Arulanandam BP. Mast cell TLR2 signaling is crucial for effective killing of Francisella tularensis. J Immunol. 2012 Jun 01; 188(11):5604-11. PMID: 22529298.
      Citations: 9     Fields:    Translation:AnimalsCells
    28. Sanapala S, Yu JJ, Murthy AK, Li W, Guentzel MN, Chambers JP, Klose KE, Arulanandam BP. Perforin- and granzyme-mediated cytotoxic effector functions are essential for protection against Francisella tularensis following vaccination by the defined F. tularensis subsp. novicida ?fopC vaccine strain. Infect Immun. 2012 Jun; 80(6):2177-85. PMID: 22493083.
      Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    29. Hankins JV, Madsen JA, Giles DK, Childers BM, Klose KE, Brodbelt JS, Trent MS. Elucidation of a novel Vibrio cholerae lipid A secondary hydroxy-acyltransferase and its role in innate immune recognition. Mol Microbiol. 2011 Sep; 81(5):1313-29. PMID: 21752109.
      Citations: 40     Fields:    Translation:HumansCells
    30. Childers BM, Cao X, Weber GG, Demeler B, Hart PJ, Klose KE. N-terminal residues of the Vibrio cholerae virulence regulatory protein ToxT involved in dimerization and modulation by fatty acids. J Biol Chem. 2011 Aug 12; 286(32):28644-55. PMID: 21673111.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    31. Chu P, Rodriguez AR, Arulanandam BP, Klose KE. Tryptophan prototrophy contributes to Francisella tularensis evasion of gamma interferon-mediated host defense. Infect Immun. 2011 Jun; 79(6):2356-61. PMID: 21464086.
      Citations: 6     Fields:    Translation:AnimalsCells
    32. Nallaparaju KC, Yu JJ, Rodriguez SA, Zogaj X, Manam S, Guentzel MN, Seshu J, Murthy AK, Chambers JP, Klose KE, Arulanandam BP. Evasion of IFN-? signaling by Francisella novicida is dependent upon Francisella outer membrane protein C. PLoS One. 2011 Mar 31; 6(3):e18201. PMID: 21483828.
      Citations: 13     Fields:    Translation:AnimalsCells
    33. Murthy AK, Chaganty BK, Troutman T, Guentzel MN, Yu JJ, Ali SK, Lauriano CM, Chambers JP, Klose KE, Arulanandam BP. Mannose-containing oligosaccharides of non-specific human secretory immunoglobulin A mediate inhibition of Vibrio cholerae biofilm formation. PLoS One. 2011 Feb 09; 6(2):e16847. PMID: 21347387.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    34. Weber GG, Klose KE. The complexity of ToxT-dependent transcription in Vibrio cholerae. Indian J Med Res. 2011 Feb; 133:201-6. PMID: 21415495.
      Citations: 7     Fields:    Translation:HumansCells
    35. Zogaj X, Klose KE. Genetic manipulation of francisella tularensis. Front Microbiol. 2010; 1:142. PMID: 21607086.
    36. Karna SL, Zogaj X, Barker JR, Seshu J, Dove SL, Klose KE. A bacterial two-hybrid system that utilizes Gateway cloning for rapid screening of protein-protein interactions. Biotechniques. 2010 Nov; 49(5):831-3. PMID: 21091448.
      Citations: 9     Fields:    Translation:AnimalsCells
    37. Rodriguez AR, Yu JJ, Murthy AK, Guentzel MN, Klose KE, Forsthuber TG, Chambers JP, Berton MT, Arulanandam BP. Mast cell/IL-4 control of Francisella tularensis replication and host cell death is associated with increased ATP production and phagosomal acidification. Mucosal Immunol. 2011 Mar; 4(2):217-26. PMID: 20861832.
      Citations: 16     Fields:    Translation:AnimalsCells
    38. Thompson FL, Thompson CC, Vicente AC, Klose KE. Vibrio2009: the third international conference on the biology of Vibrios. Mol Microbiol. 2010 Sep; 77(5):1065-71. PMID: 20633232.
      Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
    39. Fong JCN, Syed KA, Klose KE, Yildiz FH. Role of Vibrio polysaccharide (vps) genes in VPS production, biofilm formation and Vibrio cholerae pathogenesis. Microbiology (Reading). 2010 Sep; 156(Pt 9):2757-2769. PMID: 20466768.
    40. Ray HJ, Chu P, Wu TH, Lyons CR, Murthy AK, Guentzel MN, Klose KE, Arulanandam BP. The Fischer 344 rat reflects human susceptibility to francisella pulmonary challenge and provides a new platform for virulence and protection studies. PLoS One. 2010 Apr 01; 5(4):e9952. PMID: 20376351.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    41. Yu JJ, Goluguri T, Guentzel MN, Chambers JP, Murthy AK, Klose KE, Forsthuber TG, Arulanandam BP. Francisella tularensis T-cell antigen identification using humanized HLA-DR4 transgenic mice. Clin Vaccine Immunol. 2010 Feb; 17(2):215-22. PMID: 20016043.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    42. Barker JR, Chong A, Wehrly TD, Yu JJ, Rodriguez SA, Liu J, Celli J, Arulanandam BP, Klose KE. The Francisella tularensis pathogenicity island encodes a secretion system that is required for phagosome escape and virulence. Mol Microbiol. 2009 Dec; 74(6):1459-70. PMID: 20054881.
      Citations: 105     Fields:    Translation:AnimalsCells
    43. Chaparro AP, Ali SK, Klose KE. The ToxT-dependent methyl-accepting chemoreceptors AcfB and TcpI contribute to Vibrio cholerae intestinal colonization. FEMS Microbiol Lett. 2010 Jan; 302(2):99-105. PMID: 19929967.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    44. Moisi M, Jenul C, Butler SM, New A, Tutz S, Reidl J, Klose KE, Camilli A, Schild S. A novel regulatory protein involved in motility of Vibrio cholerae. J Bacteriol. 2009 Nov; 191(22):7027-38. PMID: 19767434.
      Citations: 16     Fields:    Translation:AnimalsCells
    45. Syed KA, Beyhan S, Correa N, Queen J, Liu J, Peng F, Satchell KJ, Yildiz F, Klose KE. The Vibrio cholerae flagellar regulatory hierarchy controls expression of virulence factors. J Bacteriol. 2009 Nov; 191(21):6555-70. PMID: 19717600.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    46. Cong Y, Yu JJ, Guentzel MN, Berton MT, Seshu J, Klose KE, Arulanandam BP. Vaccination with a defined Francisella tularensis subsp. novicida pathogenicity island mutant (DeltaiglB) induces protective immunity against homotypic and heterotypic challenge. Vaccine. 2009 Sep 18; 27(41):5554-61. PMID: 19651173.
      Citations: 23     Fields:    Translation:AnimalsCells
    47. Rodriguez SA, Davis G, Klose KE. Targeted gene disruption in Francisella tularensis by group II introns. Methods. 2009 Nov; 49(3):270-4. PMID: 19398003.
      Citations: 16     Fields:    Translation:Cells
    48. Ray HJ, Cong Y, Murthy AK, Selby DM, Klose KE, Barker JR, Guentzel MN, Arulanandam BP. Oral live vaccine strain-induced protective immunity against pulmonary Francisella tularensis challenge is mediated by CD4+ T cells and antibodies, including immunoglobulin A. Clin Vaccine Immunol. 2009 Apr; 16(4):444-52. PMID: 19211773.
      Citations: 26     Fields:    Translation:AnimalsCells
    49. Sorci L, Martynowski D, Rodionov DA, Eyobo Y, Zogaj X, Klose KE, Nikolaev EV, Magni G, Zhang H, Osterman AL. Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):3083-8. PMID: 19204287.
      Citations: 24     Fields:    Translation:Cells
    50. Chatterjee S, Ghosh K, Raychoudhuri A, Chowdhury G, Bhattacharya MK, Mukhopadhyay AK, Ramamurthy T, Bhattacharya SK, Klose KE, Nandy RK. Incidence, virulence factors, and clonality among clinical strains of non-O1, non-O139 Vibrio cholerae isolates from hospitalized diarrheal patients in Kolkata, India. J Clin Microbiol. 2009 Apr; 47(4):1087-95. PMID: 19158257.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    51. Chong A, Wehrly TD, Nair V, Fischer ER, Barker JR, Klose KE, Celli J. The early phagosomal stage of Francisella tularensis determines optimal phagosomal escape and Francisella pathogenicity island protein expression. Infect Immun. 2008 Dec; 76(12):5488-99. PMID: 18852245.
      Citations: 104     Fields:    Translation:AnimalsCells
    52. Zogaj X, Chakraborty S, Liu J, Thanassi DG, Klose KE. Characterization of the Francisella tularensis subsp. novicida type IV pilus. Microbiology (Reading). 2008 Jul; 154(Pt 7):2139-2150. PMID: 18599841.
    53. Ketavarapu JM, Rodriguez AR, Yu JJ, Cong Y, Murthy AK, Forsthuber TG, Guentzel MN, Klose KE, Berton MT, Arulanandam BP. Mast cells inhibit intramacrophage Francisella tularensis replication via contact and secreted products including IL-4. Proc Natl Acad Sci U S A. 2008 Jul 08; 105(27):9313-8. PMID: 18591675.
      Citations: 32     Fields:    Translation:AnimalsCells
    54. Mohapatra NP, Soni S, Reilly TJ, Liu J, Klose KE, Gunn JS. Combined deletion of four Francisella novicida acid phosphatases attenuates virulence and macrophage vacuolar escape. Infect Immun. 2008 Aug; 76(8):3690-9. PMID: 18490464.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    55. Powell HJ, Cong Y, Yu JJ, Guentzel MN, Berton MT, Klose KE, Murthy AK, Arulanandam BP. CD4+ T cells are required during priming but not the effector phase of antibody-mediated IFN-gamma-dependent protective immunity against pulmonary Francisella novicida infection. Immunol Cell Biol. 2008 Aug-Sep; 86(6):515-22. PMID: 18427567.
      Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    56. Rodriguez SA, Yu JJ, Davis G, Arulanandam BP, Klose KE. Targeted inactivation of francisella tularensis genes by group II introns. Appl Environ Microbiol. 2008 May; 74(9):2619-26. PMID: 18310413.
      Citations: 34     Fields:    Translation:Cells
    57. Yu JJ, Raulie EK, Murthy AK, Guentzel MN, Klose KE, Arulanandam BP. The presence of infectious extracellular Francisella tularensis subsp. novicida in murine plasma after pulmonary challenge. Eur J Clin Microbiol Infect Dis. 2008 Apr; 27(4):323-5. PMID: 18087734.
      Citations: 24     Fields:    Translation:AnimalsCells
    58. Morris DC, Peng F, Barker JR, Klose KE. Lipidation of an FlrC-dependent protein is required for enhanced intestinal colonization by Vibrio cholerae. J Bacteriol. 2008 Jan; 190(1):231-9. PMID: 17981980.
      Citations: 11     Fields:    Translation:HumansCells
    59. Liu J, Zogaj X, Barker JR, Klose KE. Construction of targeted insertion mutations in Francisella tularensis subsp. novicida. Biotechniques. 2007 Oct; 43(4):487-90, 492. PMID: 18019340.
      Citations: 22     Fields:    Translation:Cells
    60. Waldo RH, Cummings ED, Sarva ST, Brown JM, Lauriano CM, Rose LA, Belland RJ, Klose KE, Hilliard GM. Proteome cataloging and relative quantification of Francisella tularensis tularensis strain Schu4 in 2D PAGE using preparative isoelectric focusing. J Proteome Res. 2007 Sep; 6(9):3484-90. PMID: 17658781.
      Citations: 3     Fields:    Translation:Cells
    61. Childers BM, Klose KE. Regulation of virulence in Vibrio cholerae: the ToxR regulon. Future Microbiol. 2007 Jun; 2(3):335-44. PMID: 17661707.
      Citations: 78     Fields:    Translation:HumansCells
    62. Santic M, Molmeret M, Barker JR, Klose KE, Dekanic A, Doric M, Abu Kwaik Y. A Francisella tularensis pathogenicity island protein essential for bacterial proliferation within the host cell cytosol. Cell Microbiol. 2007 Oct; 9(10):2391-403. PMID: 17517064.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    63. Barker JR, Klose KE. Molecular and genetic basis of pathogenesis in Francisella tularensis. Ann N Y Acad Sci. 2007 Jun; 1105:138-59. PMID: 17395737.
      Citations: 42     Fields:    Translation:Cells
    64. Childers BM, Weber GG, Prouty MG, Castaneda MM, Peng F, Klose KE. Identification of residues critical for the function of the Vibrio cholerae virulence regulator ToxT by scanning alanine mutagenesis. J Mol Biol. 2007 Apr 13; 367(5):1413-30. PMID: 17320105.
      Citations: 22     Fields:    Translation:Cells
    65. Xicohtencatl-Cortés J, Lyons S, Chaparro AP, Hernández DR, Saldaña Z, Ledesma MA, Rendón MA, Gewirtz AT, Klose KE, Girón JA. Identification of proinflammatory flagellin proteins in supernatants of Vibrio cholerae O1 by proteomics analysis. Mol Cell Proteomics. 2006 Dec; 5(12):2374-83. PMID: 16998199.
      Citations: 20     Fields:    Translation:HumansCells
    66. Thompson FL, Klose KE. Vibrio2005: the First International Conference on the Biology of Vibrios. J Bacteriol. 2006 Jul; 188(13):4592-6. PMID: 16788166.
      Citations: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    67. Pammit MA, Raulie EK, Lauriano CM, Klose KE, Arulanandam BP. Intranasal vaccination with a defined attenuated Francisella novicida strain induces gamma interferon-dependent antibody-mediated protection against tularemia. Infect Immun. 2006 Apr; 74(4):2063-71. PMID: 16552035.
      Citations: 32     Fields:    Translation:AnimalsCells
    68. Klose KE. Increased chatter: cyclic dipeptides as molecules of chemical communication in Vibrio spp. J Bacteriol. 2006 Mar; 188(6):2025-6. PMID: 16513731.
      Citations: 5     Fields:    Translation:Cells
    69. Santic M, Molmeret M, Klose KE, Abu Kwaik Y. Francisella tularensis travels a novel, twisted road within macrophages. Trends Microbiol. 2006 Jan; 14(1):37-44. PMID: 16356719.
      Citations: 64     Fields:    Translation:HumansCells
    70. Prouty MG, Osorio CR, Klose KE. Characterization of functional domains of the Vibrio cholerae virulence regulator ToxT. Mol Microbiol. 2005 Nov; 58(4):1143-56. PMID: 16262796.
      Citations: 31     Fields:    Translation:Cells
    71. Correa NE, Peng F, Klose KE. Roles of the regulatory proteins FlhF and FlhG in the Vibrio cholerae flagellar transcription hierarchy. J Bacteriol. 2005 Sep; 187(18):6324-32. PMID: 16159765.
      Citations: 55     Fields:    Translation:Cells
    72. Schild S, Lamprecht AK, Fourestier C, Lauriano CM, Klose KE, Reidl J. Characterizing lipopolysaccharide and core lipid A mutant O1 and O139 Vibrio cholerae strains for adherence properties on mucus-producing cell line HT29-Rev MTX and virulence in mice. Int J Med Microbiol. 2005 Aug; 295(4):243-51. PMID: 16128399.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    73. Santic M, Molmeret M, Klose KE, Jones S, Kwaik YA. The Francisella tularensis pathogenicity island protein IglC and its regulator MglA are essential for modulating phagosome biogenesis and subsequent bacterial escape into the cytoplasm. Cell Microbiol. 2005 Jul; 7(7):969-79. PMID: 15953029.
      Citations: 132     Fields:    Translation:HumansCells
    74. Correa NE, Klose KE. Characterization of enhancer binding by the Vibrio cholerae flagellar regulatory protein FlrC. J Bacteriol. 2005 May; 187(9):3158-70. PMID: 15838043.
      Citations: 15     Fields:    Translation:Cells
    75. Kern WV, Klose K, Jellen-Ritter AS, Oethinger M, Bohnert J, Kern P, Reuter S, von Baum H, Marre R. Fluoroquinolone resistance of Escherichia coli at a cancer center: epidemiologic evolution and effects of discontinuing prophylactic fluoroquinolone use in neutropenic patients with leukemia. Eur J Clin Microbiol Infect Dis. 2005 Feb; 24(2):111-8. PMID: 15714332.
      Citations: 31     Fields:    Translation:HumansCells
    76. Pammit MA, Budhavarapu VN, Raulie EK, Klose KE, Teale JM, Arulanandam BP. Intranasal interleukin-12 treatment promotes antimicrobial clearance and survival in pulmonary Francisella tularensis subsp. novicida infection. Antimicrob Agents Chemother. 2004 Dec; 48(12):4513-9. PMID: 15561819.
      Citations: 26     Fields:    Translation:AnimalsCells
    77. Nano FE, Zhang N, Cowley SC, Klose KE, Cheung KK, Roberts MJ, Ludu JS, Letendre GW, Meierovics AI, Stephens G, Elkins KL. A Francisella tularensis pathogenicity island required for intramacrophage growth. J Bacteriol. 2004 Oct; 186(19):6430-6. PMID: 15375123.
      Citations: 179     Fields:    Translation:AnimalsCells
    78. Lauriano CM, Ghosh C, Correa NE, Klose KE. The sodium-driven flagellar motor controls exopolysaccharide expression in Vibrio cholerae. J Bacteriol. 2004 Aug; 186(15):4864-74. PMID: 15262923.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    79. Correa NE, Barker JR, Klose KE. The Vibrio cholerae FlgM homologue is an anti-sigma28 factor that is secreted through the sheathed polar flagellum. J Bacteriol. 2004 Jul; 186(14):4613-9. PMID: 15231794.
      Citations: 19     Fields:    Translation:AnimalsCells
    80. Lauriano CM, Barker JR, Yoon SS, Nano FE, Arulanandam BP, Hassett DJ, Klose KE. MglA regulates transcription of virulence factors necessary for Francisella tularensis intraamoebae and intramacrophage survival. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4246-9. PMID: 15010524.
      Citations: 151     Fields:    Translation:AnimalsCells
    81. Lauriano CM, Barker JR, Nano FE, Arulanandam BP, Klose KE. Allelic exchange in Francisella tularensis using PCR products. FEMS Microbiol Lett. 2003 Dec 12; 229(2):195-202. PMID: 14680699.
      Citations: 50     Fields:    Translation:AnimalsCells
    82. Hassett DJ, Limbach PA, Hennigan RF, Klose KE, Hancock RE, Platt MD, Hunt DF. Bacterial biofilms of importance to medicine and bioterrorism: proteomic techniques to identify novel vaccine components and drug targets. Expert Opin Biol Ther. 2003 Dec; 3(8):1201-7. PMID: 14640945.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    83. Prouty MG, Correa NE, Barker LP, Jagadeeswaran P, Klose KE. Zebrafish-Mycobacterium marinum model for mycobacterial pathogenesis. FEMS Microbiol Lett. 2003 Aug 29; 225(2):177-82. PMID: 12951238.
      Citations: 36     Fields:    Translation:AnimalsCells
    84. Simonet VC, Baslé A, Klose KE, Delcour AH. The Vibrio cholerae porins OmpU and OmpT have distinct channel properties. J Biol Chem. 2003 May 09; 278(19):17539-45. PMID: 12606562.
      Citations: 24     Fields:    Translation:Cells
    85. Nesper J, Schild S, Lauriano CM, Kraiss A, Klose KE, Reidl J. Role of Vibrio cholerae O139 surface polysaccharides in intestinal colonization. Infect Immun. 2002 Nov; 70(11):5990-6. PMID: 12379674.
      Citations: 23     Fields:    Translation:AnimalsCells
    86. Reidl J, Klose KE. Vibrio cholerae and cholera: out of the water and into the host. FEMS Microbiol Rev. 2002 Jun; 26(2):125-39. PMID: 12069878.
      Citations: 125     Fields:    Translation:HumansCellsPHPublic Health
    87. Nesper J, Kraiss A, Schild S, Blass J, Klose KE, Bockemühl J, Reidl J. Comparative and genetic analyses of the putative Vibrio cholerae lipopolysaccharide core oligosaccharide biosynthesis (wav) gene cluster. Infect Immun. 2002 May; 70(5):2419-33. PMID: 11953379.
      Citations: 23     Fields:    Translation:HumansCells
    88. Wibbenmeyer JA, Provenzano D, Landry CF, Klose KE, Delcour AH. Vibrio cholerae OmpU and OmpT porins are differentially affected by bile. Infect Immun. 2002 Jan; 70(1):121-6. PMID: 11748172.
      Citations: 32     Fields:    Translation:AnimalsCells
    89. Julio SM, Heithoff DM, Provenzano D, Klose KE, Sinsheimer RL, Low DA, Mahan MJ. DNA adenine methylase is essential for viability and plays a role in the pathogenesis of Yersinia pseudotuberculosis and Vibrio cholerae. Infect Immun. 2001 Dec; 69(12):7610-5. PMID: 11705940.
      Citations: 52     Fields:    Translation:AnimalsCells
    90. Provenzano D, Lauriano CM, Klose KE. Characterization of the role of the ToxR-modulated outer membrane porins OmpU and OmpT in Vibrio cholerae virulence. J Bacteriol. 2001 Jun; 183(12):3652-62. PMID: 11371530.
      Citations: 40     Fields:    Translation:AnimalsCells
    91. Klose KE. Regulation of virulence in Vibrio cholerae. Int J Med Microbiol. 2001 May; 291(2):81-8. PMID: 11437342.
      Citations: 22     Fields:    Translation:HumansCells
    92. Prouty MG, Correa NE, Klose KE. The novel sigma54- and sigma28-dependent flagellar gene transcription hierarchy of Vibrio cholerae. Mol Microbiol. 2001 Mar; 39(6):1595-609. PMID: 11260476.
      Citations: 103     Fields:    Translation:Cells
    93. Nesper J, Lauriano CM, Klose KE, Kapfhammer D, Kraiss A, Reidl J. Characterization of Vibrio cholerae O1 El tor galU and galE mutants: influence on lipopolysaccharide structure, colonization, and biofilm formation. Infect Immun. 2001 Jan; 69(1):435-45. PMID: 11119535.
      Citations: 72     Fields:    Translation:AnimalsCells
    94. Watnick PI, Lauriano CM, Klose KE, Croal L, Kolter R. The absence of a flagellum leads to altered colony morphology, biofilm development and virulence in Vibrio cholerae O139. Mol Microbiol. 2001 Jan; 39(2):223-35. PMID: 11136445.
      Citations: 111     Fields:    Translation:HumansAnimalsCells
    95. Nesper J, Kapfhammer D, Klose KE, Merkert H, Reidl J. Characterization of vibrio cholerae O1 antigen as the bacteriophage K139 receptor and identification of IS1004 insertions aborting O1 antigen biosynthesis. J Bacteriol. 2000 Sep; 182(18):5097-104. PMID: 10960093.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    96. Provenzano D, Klose KE. Altered expression of the ToxR-regulated porins OmpU and OmpT diminishes Vibrio cholerae bile resistance, virulence factor expression, and intestinal colonization. Proc Natl Acad Sci U S A. 2000 Aug 29; 97(18):10220-4. PMID: 10944196.
      Citations: 89     Fields:    Translation:AnimalsCells
    97. Klose KE. The suckling mouse model of cholera. Trends Microbiol. 2000 Apr; 8(4):189-91. PMID: 10754579.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    98. Provenzano D, Schuhmacher DA, Barker JL, Klose KE. The virulence regulatory protein ToxR mediates enhanced bile resistance in Vibrio cholerae and other pathogenic Vibrio species. Infect Immun. 2000 Mar; 68(3):1491-7. PMID: 10678965.
      Citations: 63     Fields:    Translation:HumansCells
    99. Correa NE, Lauriano CM, McGee R, Klose KE. Phosphorylation of the flagellar regulatory protein FlrC is necessary for Vibrio cholerae motility and enhanced colonization. Mol Microbiol. 2000 Feb; 35(4):743-55. PMID: 10692152.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    100. Ryan ET, Crean TI, Kochi SK, John M, Luciano AA, Killeen KP, Klose KE, Calderwood SB. Development of a DeltaglnA balanced lethal plasmid system for expression of heterologous antigens by attenuated vaccine vector strains of Vibrio cholerae. Infect Immun. 2000 Jan; 68(1):221-6. PMID: 10603391.
      Citations: 14     Fields:    Translation:AnimalsCells
    101. Osorio CR, Klose KE. A region of the transmembrane regulatory protein ToxR that tethers the transcriptional activation domain to the cytoplasmic membrane displays wide divergence among Vibrio species. J Bacteriol. 2000 Jan; 182(2):526-8. PMID: 10629204.
      Citations: 23     Fields:    Translation:Cells
    102. Schuhmacher DA, Klose KE. Environmental signals modulate ToxT-dependent virulence factor expression in Vibrio cholerae. J Bacteriol. 1999 Mar; 181(5):1508-14. PMID: 10049382.
      Citations: 74     Fields:    Translation:HumansCells
    103. Klose KE, Novik V, Mekalanos JJ. Identification of multiple sigma54-dependent transcriptional activators in Vibrio cholerae. J Bacteriol. 1998 Oct; 180(19):5256-9. PMID: 9748465.
      Citations: 14     Fields:    Translation:AnimalsCells
    104. Klose KE, Mekalanos JJ. Distinct roles of an alternative sigma factor during both free-swimming and colonizing phases of the Vibrio cholerae pathogenic cycle. Mol Microbiol. 1998 May; 28(3):501-20. PMID: 9632254.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    105. Klose KE, Mekalanos JJ. Differential regulation of multiple flagellins in Vibrio cholerae. J Bacteriol. 1998 Jan; 180(2):303-16. PMID: 9440520.
      Citations: 64     Fields:    Translation:Cells
    106. Klose KE, Mekalanos JJ. Simultaneous prevention of glutamine synthesis and high-affinity transport attenuates Salmonella typhimurium virulence. Infect Immun. 1997 Feb; 65(2):587-96. PMID: 9009317.
      Citations: 49     Fields:    Translation:AnimalsCells
    107. Klose KE, North AK, Stedman KM, Kustu S. The major dimerization determinants of the nitrogen regulatory protein NTRC from enteric bacteria lie in its carboxy-terminal domain. J Mol Biol. 1994 Aug 12; 241(2):233-45. PMID: 8057363.
      Citations: 22     Fields:    Translation:Cells
    108. Klose KE, Weiss DS, Kustu S. Glutamate at the site of phosphorylation of nitrogen-regulatory protein NTRC mimics aspartyl-phosphate and activates the protein. J Mol Biol. 1993 Jul 05; 232(1):67-78. PMID: 8331671.
      Citations: 75     Fields:    Translation:Cells
    109. North AK, Klose KE, Stedman KM, Kustu S. Prokaryotic enhancer-binding proteins reflect eukaryote-like modularity: the puzzle of nitrogen regulatory protein C. J Bacteriol. 1993 Jul; 175(14):4267-73. PMID: 8331061.
      Citations: 72     Fields:    Translation:Cells
    110. Weiss DS, Batut J, Klose KE, Keener J, Kustu S. The phosphorylated form of the enhancer-binding protein NTRC has an ATPase activity that is essential for activation of transcription. Cell. 1991 Oct 04; 67(1):155-67. PMID: 1833069.
      Citations: 128     Fields:    Translation:Cells
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